EA023344B1 - Способ лечения или предотвращения нейтропении или лейкопении или снижения частоты возникновения инфекции, проявляющейся фебрильной нейтропенией - Google Patents

Способ лечения или предотвращения нейтропении или лейкопении или снижения частоты возникновения инфекции, проявляющейся фебрильной нейтропенией Download PDF

Info

Publication number
EA023344B1
EA023344B1 EA201190080A EA201190080A EA023344B1 EA 023344 B1 EA023344 B1 EA 023344B1 EA 201190080 A EA201190080 A EA 201190080A EA 201190080 A EA201190080 A EA 201190080A EA 023344 B1 EA023344 B1 EA 023344B1
Authority
EA
Eurasian Patent Office
Prior art keywords
neutropenia
dose
νευο
pegfilgrastim
treatment
Prior art date
Application number
EA201190080A
Other languages
English (en)
Russian (ru)
Other versions
EA201190080A1 (ru
Inventor
Джейсон Бенджамин Бок
Адам Карр Белл
Джеффри Херпст
Original Assignee
Тева Фармасьютикал Индастриз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикал Индастриз Лтд. filed Critical Тева Фармасьютикал Индастриз Лтд.
Publication of EA201190080A1 publication Critical patent/EA201190080A1/ru
Publication of EA023344B1 publication Critical patent/EA023344B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • A61K38/385Serum albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201190080A 2009-01-16 2010-01-15 Способ лечения или предотвращения нейтропении или лейкопении или снижения частоты возникновения инфекции, проявляющейся фебрильной нейтропенией EA023344B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14543609P 2009-01-16 2009-01-16
US14544009P 2009-01-16 2009-01-16
PCT/US2010/021241 WO2010083439A2 (en) 2009-01-16 2010-01-15 Recombinant human albumin-human granulocyte colony stimulating factor for the prevention of neutropenia

Publications (2)

Publication Number Publication Date
EA201190080A1 EA201190080A1 (ru) 2014-03-31
EA023344B1 true EA023344B1 (ru) 2016-05-31

Family

ID=42260335

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201190080A EA023344B1 (ru) 2009-01-16 2010-01-15 Способ лечения или предотвращения нейтропении или лейкопении или снижения частоты возникновения инфекции, проявляющейся фебрильной нейтропенией
EA201190079A EA201190079A1 (ru) 2009-01-16 2010-01-15 Новые стабильные составы рекомбинантного альбумина человека-гранулоцитарного колониестимулирующего фактора человека

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201190079A EA201190079A1 (ru) 2009-01-16 2010-01-15 Новые стабильные составы рекомбинантного альбумина человека-гранулоцитарного колониестимулирующего фактора человека

Country Status (16)

Country Link
US (4) US20100227818A1 (https=)
EP (2) EP2387420A2 (https=)
JP (2) JP5753095B2 (https=)
KR (2) KR20110132327A (https=)
CN (2) CN102378635A (https=)
AU (2) AU2010204547B2 (https=)
BR (2) BRPI1004940A2 (https=)
CA (2) CA2749786A1 (https=)
EA (2) EA023344B1 (https=)
IL (2) IL214051A0 (https=)
MX (2) MX2011007582A (https=)
NZ (2) NZ594056A (https=)
SG (3) SG196821A1 (https=)
UA (2) UA103221C2 (https=)
WO (2) WO2010083439A2 (https=)
ZA (1) ZA201105171B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018187786A1 (en) * 2017-04-07 2018-10-11 La Jolla Institute For Allergy And Immunology Unipotent neutrophil progenitor cells, methods of preparation, and uses thereof

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102378635A (zh) 2009-01-16 2012-03-14 特瓦制药工业有限公司 重组人白蛋白-人粒细胞集落刺激因子融合蛋白的新稳定制剂
EP2384759A1 (en) 2010-05-06 2011-11-09 Suomen Punainen Risti Veripalvelu Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
SG186094A1 (en) * 2010-06-07 2013-01-30 Amgen Inc Drug delivery device
CN102628869B (zh) * 2012-04-19 2014-04-02 上海蓝怡科技有限公司 提高甲胎蛋白抗体冻干稳定性的制剂
EP2945703A4 (en) * 2013-01-15 2016-08-31 Teva Pharma ALBU-BCHE FORMULATIONS, PREPARATION THEREOF AND USES THEREOF
WO2014147489A2 (en) 2013-03-15 2014-09-25 Teva Pharmaceutical Industries Ltd. Recombinant human albumin-human granulocyte colony stimulating factor for the prevention of neutropenia in pediatric patients
MA40904A (fr) * 2014-11-03 2017-09-12 Hygeia Tech Inc Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
BE1023343B1 (nl) * 2015-05-20 2017-02-09 Mycartis Nv Opslagbuffer
JP6969848B2 (ja) 2015-07-13 2021-11-24 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド プリナブリン組成物
US11020455B2 (en) * 2015-07-30 2021-06-01 Endor Technologies, S.L Colony stimulating factor for use in pancreatic or colon cancer treatment
KR20180105685A (ko) 2016-02-08 2018-09-28 비욘드스프링 파마수티컬스, 인코포레이티드. 투카레솔 또는 이의 유사체를 함유하는 조성물
JP7025416B2 (ja) 2016-06-06 2022-02-24 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド 好中球減少症を低減させるための組成物および方法
CN106222221A (zh) * 2016-08-05 2016-12-14 山东科兴生物制品有限公司 制备重组人粒细胞刺激因子原液的纯化方法
ES2985905T3 (es) 2016-11-22 2024-11-07 Lts Device Tech Ltd Aparato para suministrar una sustancia terapéutica
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
CN109420159A (zh) * 2017-08-23 2019-03-05 江苏泰康生物医药有限公司 一种重组蛋白药物的新型稳定制剂
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
US20210030843A1 (en) * 2018-02-01 2021-02-04 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing chemotherapy-induced neutropenia via the administration of plinabulin and a g-csf agent
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
EP3632487B1 (en) 2018-10-05 2024-06-12 LTS Device Technologies Ltd Triggering sequence
CN111383745A (zh) * 2018-12-29 2020-07-07 医渡云(北京)技术有限公司 计算机数据处理方法、装置、存储介质及设备
US11267858B2 (en) 2019-05-31 2022-03-08 Spectrum Pharmaceuticals, Inc. Methods of treatment using G-CSF protein complex
US11684655B2 (en) 2019-05-31 2023-06-27 Spectrum Pharmaceuticals, Inc. Methods of treating neutorpenia using G-CSF protein complex
CN112316120A (zh) * 2019-08-05 2021-02-05 天津派格生物技术有限公司 使用低动员型g-csf有效且安全治疗粒细胞减少症的方法
CN114746104A (zh) * 2019-12-05 2022-07-12 韩美药品株式会社 治疗由化疗或放疗引起的中性粒细胞减少症的方法
KR102485892B1 (ko) * 2020-04-09 2023-01-09 주식회사 에이프릴바이오 고양이 과립구 집락 자극인자 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질 및 이의 용도
CN111751552B (zh) * 2020-06-18 2022-09-16 广州市伊川生物科技有限公司 一种缺血修饰白蛋白测定试剂盒及其使用方法
KR102375269B1 (ko) * 2021-01-27 2022-03-17 한미약품 주식회사 단백질 액상 제제 및 이의 제조방법
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015199A1 (fr) * 1992-01-31 1993-08-05 Rhone-Poulenc Rorer S.A. Nouveaux polypeptides biologiquement actifs, leur preparation et composition pharmaceutique les contenant
US5665863A (en) * 1992-01-31 1997-09-09 Rhone-Poulenc Rorer S.A. Polypeptides having granulocyte colony stimulating activity, their preparation and pharmaceutical compositions containing them
US20030118612A1 (en) * 2000-01-10 2003-06-26 Maxygen Holdings Ltd. G-CSF conjugates
US20080153751A1 (en) * 2001-12-21 2008-06-26 Human Genome Sciences, Inc. Albumin Fusion Proteins

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2873012B2 (ja) 1987-04-09 1999-03-24 デルタ バイオテクノロジー リミテッド 酵母ベクター
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
DE19549232C2 (de) * 1995-12-20 1998-05-20 Boehringer Mannheim Gmbh Verwendung von G-CSF in Kombination mit einem Chemotherapeutikum bei der Behandlung von Erkrankungen, die eine periphere Stammzelltransplantation erfordern
US7321023B2 (en) * 1997-11-07 2008-01-22 Incyte Corporation SP16 protein
WO1999044630A1 (en) * 1998-03-06 1999-09-10 Chugai Seiyaku Kabushiki Kaisha Protein-free preparations
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
EP2213743A1 (en) 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Albumin fusion proteins
WO2002101412A2 (en) * 2001-06-08 2002-12-19 Powderject Vaccines, Inc. Spray freeze-dried compositions
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
AU2003210806A1 (en) * 2002-03-05 2003-09-22 Eli Lilly And Company Heterologous g-csf fusion proteins
CN1241946C (zh) * 2002-07-01 2006-02-15 美国福源集团 对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
WO2004082640A2 (en) * 2003-03-19 2004-09-30 New Century Pharmaceuticals, Inc. Human serum albumin conjugates with therapeutic compounds
US6972332B1 (en) * 2004-05-20 2005-12-06 Acura Pharmaceuticals, Inc. Process for the production of opiates
WO2007021494A2 (en) * 2005-08-12 2007-02-22 Human Genome Sciences, Inc. Albumin fusion proteins
CA2584927C (en) * 2006-04-13 2011-02-08 Wix Filtration Corp. A body for actuating a standpipe of a replaceable filter element
JP2008146587A (ja) * 2006-12-13 2008-06-26 Sony Corp 表示装置、表示プログラム、表示方法、画像提供装置、画像提供プログラム、画像提供方法及び記録媒体
CN102378635A (zh) 2009-01-16 2012-03-14 特瓦制药工业有限公司 重组人白蛋白-人粒细胞集落刺激因子融合蛋白的新稳定制剂

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015199A1 (fr) * 1992-01-31 1993-08-05 Rhone-Poulenc Rorer S.A. Nouveaux polypeptides biologiquement actifs, leur preparation et composition pharmaceutique les contenant
US5665863A (en) * 1992-01-31 1997-09-09 Rhone-Poulenc Rorer S.A. Polypeptides having granulocyte colony stimulating activity, their preparation and pharmaceutical compositions containing them
US20030118612A1 (en) * 2000-01-10 2003-06-26 Maxygen Holdings Ltd. G-CSF conjugates
US20080153751A1 (en) * 2001-12-21 2008-06-26 Human Genome Sciences, Inc. Albumin Fusion Proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Dave Mead: "Novozymes Biopharma-Rethinking Tomorrow", October 2008 (2008-10), XP002589546, Retrieved from the Internet:URL:http://www.biopharma.novozymes.com/Admin/Public/DWSDownload.aspx?File=%2FFiles%2FFiler%2FPresentations%2FBPE08_DaveMead_Oct08.pdf [retrieved on 2010-06-29], Slides 14, 16 *
HALPERN WENDY ET AL.: "Albugranin, a recombinant human granulocyte colony stimulating factor (G-CSF) genetically fused to recombinant human albumin induces prolonged myelopoietic effects in mice andmonkeys." PHARMACEUTICAL RESEARCH NOV 2002 LNKD-PUBMED:12458679, vol. 19, no. 11, November 2002 (2002-11), pages 1720-1729, XP002589130, ISSN: 0724-8741, the whole document *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018187786A1 (en) * 2017-04-07 2018-10-11 La Jolla Institute For Allergy And Immunology Unipotent neutrophil progenitor cells, methods of preparation, and uses thereof

Also Published As

Publication number Publication date
IL214051A0 (en) 2011-08-31
CA2749786A1 (en) 2010-07-22
ZA201105171B (en) 2015-12-23
CN102395379B (zh) 2015-07-22
UA105201C2 (uk) 2014-04-25
CA2749802A1 (en) 2010-07-22
SG172941A1 (en) 2011-08-29
BRPI1005159A2 (pt) 2018-04-03
CA2749802C (en) 2016-08-23
UA103221C2 (uk) 2013-09-25
WO2010083434A2 (en) 2010-07-22
IL214052A0 (en) 2011-08-31
AU2010204547B2 (en) 2014-01-23
WO2010083439A3 (en) 2010-09-10
NZ594055A (en) 2013-03-28
CN102378635A (zh) 2012-03-14
AU2010204552A1 (en) 2011-08-04
JP2012515221A (ja) 2012-07-05
US20100227818A1 (en) 2010-09-09
CN102395379A (zh) 2012-03-28
US8993519B2 (en) 2015-03-31
SG172940A1 (en) 2011-08-29
AU2010204552B2 (en) 2014-05-01
JP2012515222A (ja) 2012-07-05
US20100297062A1 (en) 2010-11-25
EA201190080A1 (ru) 2014-03-31
US20150202268A1 (en) 2015-07-23
WO2010083434A3 (en) 2010-09-10
US8323634B2 (en) 2012-12-04
JP5753095B2 (ja) 2015-07-22
SG196821A1 (en) 2014-02-13
EP2387419A2 (en) 2011-11-23
BRPI1004940A2 (pt) 2018-06-19
EP2387420A2 (en) 2011-11-23
MX2011007582A (es) 2011-12-14
US20130129669A1 (en) 2013-05-23
KR20110132326A (ko) 2011-12-07
EA201190079A1 (ru) 2013-02-28
KR20110132327A (ko) 2011-12-07
MX2011007583A (es) 2011-12-14
WO2010083439A2 (en) 2010-07-22
NZ594056A (en) 2013-03-28
AU2010204547A1 (en) 2011-07-28

Similar Documents

Publication Publication Date Title
EA023344B1 (ru) Способ лечения или предотвращения нейтропении или лейкопении или снижения частоты возникновения инфекции, проявляющейся фебрильной нейтропенией
ES3056525T3 (en) High concentration vegf receptor fusion protein containing formulations
US11358995B2 (en) Compositions and methods of use for treating metabolic disorders
JP2017519009A (ja) 製剤化された受容体ポリペプチドおよび関連する方法
KR20150121715A (ko) Csf1 치료제
UA128757C2 (uk) Антитіла, які містять тільки важкі ланцюги, що зв'язуються з cd22
JP2015518835A (ja) 癌幹細胞を標的とした癌ワクチン
US20210100877A1 (en) Use of il-22 in treating necrotizing enterocolitis
US20190241660A1 (en) Immune-stimulating peptides and checkpoint inhibitors, and uses thereof for treating cancer
JP7842532B2 (ja) 再生不良性貧血を治療するための医薬組成物
US20160152710A1 (en) Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
US10967047B2 (en) Mitochondrial antiviral-signaling (MAVS) polypeptides and detection and use thereof
BR112020024683A2 (pt) Métodos de uso de cd24 para a prevenção e tratamento de doença do enxerto versus hospedeiro e mucosite
US20170298108A1 (en) Compositions comprising grim-19 therapeutics and methods of use
US20250295587A1 (en) Complex lipid nanoparticles encapsulating polypeptides and uses thereof
Kijanka et al. Development of ADA against recombinant human interferon beta in immune tolerant mice requires rapid recruitment of CD4+ T cells, induces formation of germinal centers but lacks susceptibility for (most) adjuvants
US20230167162A1 (en) Homing peptide-guided decorin conjugates for use in treating epidermolysis bullosa
US10765720B2 (en) Composition for preventing or treating hyperoxia-induced lung injury comprising WKYMVm peptide as an active ingredient
US20140271538A1 (en) Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor for the Prevention of Neutropenia in Pediatric Patients
AU2014208224A1 (en) New Stable Formulations of Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor Fusion Protein
AU2014202190B2 (en) New Stable Formulations of Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor Fusion Protein
BR112017001789B1 (pt) Polipeptídeos, dímero, método de produção dos mesmos, composição farmacêutica, uso dos mesmos e recipiente estéril para tratamento de distúrbios metabólicos

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU