EA021897B1 - Циклические пептиды, специфичные к рецептору меланокортина-1 - Google Patents
Циклические пептиды, специфичные к рецептору меланокортина-1 Download PDFInfo
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- EA021897B1 EA021897B1 EA201290296A EA201290296A EA021897B1 EA 021897 B1 EA021897 B1 EA 021897B1 EA 201290296 A EA201290296 A EA 201290296A EA 201290296 A EA201290296 A EA 201290296A EA 021897 B1 EA021897 B1 EA 021897B1
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Classifications
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- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
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- C07—ORGANIC CHEMISTRY
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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Landscapes
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| KR20120102716A (ko) | 2009-11-23 | 2012-09-18 | 팔라틴 테크놀로지스 인코포레이티드 | 멜라노코르틴-1 수용체 특이적 선형 펩티드 |
| US9534018B2 (en) | 2012-03-13 | 2017-01-03 | Tensive Controls Inc. | Melanocortin analogs having enhanced activity and transport |
| ES2768423T3 (es) * | 2012-11-21 | 2020-06-22 | Univ Cincinnati | Composiciones y métodos para el cuidado de la piel que comprenden agonistas selectivos del receptor de melanocortina 1 |
| WO2015063099A1 (en) | 2013-10-28 | 2015-05-07 | Clinuvel Ag | Alpha-msh analogues for use in the treatment of hailey-hailey disease |
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| WO2015067503A1 (en) | 2013-11-07 | 2015-05-14 | Clinuvel Ag | Alpha-msh analogues for use in the treatment of psoriasis |
| WO2015123493A2 (en) * | 2014-02-13 | 2015-08-20 | Northwestern University | Compositions and methods for modulatuion of immune response |
| EP3212219A1 (en) | 2014-10-28 | 2017-09-06 | Clinuvel AG | New indication for alpha-msh analogues |
| EP3212220A1 (en) | 2014-10-28 | 2017-09-06 | Clinuvel AG | Inflammatory disease |
| CA3220466A1 (en) | 2014-10-29 | 2016-05-06 | Bicyclerd Limited | Bicyclic peptide ligands specific for mt1-mmp |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| EP3328372A4 (en) | 2015-07-28 | 2019-03-20 | University Of Iowa Research Foundation | COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
| AU2017281940C1 (en) | 2016-06-24 | 2024-11-07 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| JP7039814B2 (ja) * | 2016-10-04 | 2022-03-23 | ディーエスエム アイピー アセッツ ビー.ブイ. | メラノコルチン-1-受容体アゴニスト |
| ES2985745T3 (es) * | 2017-02-01 | 2024-11-07 | Vallaurix Mc S A R L | Análogos de alfa-MSH utilizados en el tratamiento de Xeroderma Pigmentosum |
| US11261214B2 (en) | 2017-08-04 | 2022-03-01 | Bicycletx Limited | Bicyclic peptide ligand specific for CD137 |
| MX2020008791A (es) | 2018-02-23 | 2021-01-08 | Bicycletx Ltd | Ligandos de peptidos biciclicos multimericos. |
| AU2019239300A1 (en) * | 2018-03-23 | 2020-11-19 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery |
| GB201810327D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to IL-17 |
| GB201810316D0 (en) * | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201810325D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to PSMA |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| WO2020110011A1 (en) | 2018-11-27 | 2020-06-04 | Novartis Ag | Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| US11529335B2 (en) | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| WO2023091689A1 (en) | 2021-11-19 | 2023-05-25 | University Of Iowa Research Foundation | Combined use of mcr1-directed radiotherapy and immune checkpoint inhibition in the treatment of melanoma |
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