EA020886B1 - Гуманизированные антитела против tl1a - Google Patents
Гуманизированные антитела против tl1a Download PDFInfo
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- EA020886B1 EA020886B1 EA201070596A EA201070596A EA020886B1 EA 020886 B1 EA020886 B1 EA 020886B1 EA 201070596 A EA201070596 A EA 201070596A EA 201070596 A EA201070596 A EA 201070596A EA 020886 B1 EA020886 B1 EA 020886B1
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| PCT/US2008/083362 WO2009064854A2 (en) | 2007-11-13 | 2008-11-13 | Humanized antibodies against tl1a |
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| WO2007039256A2 (de) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
| FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| US9896511B2 (en) | 2007-01-10 | 2018-02-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| WO2011027349A1 (en) | 2009-09-06 | 2011-03-10 | Protab Ltd. | Humanized antibodies specific for hsp65-derived peptide-6 methods and uses thereof |
| EP2510001B1 (en) | 2009-12-08 | 2015-12-02 | AbbVie Deutschland GmbH & Co KG | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
| WO2011138392A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
| PH12012502193A1 (en) | 2010-05-06 | 2021-08-09 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| US8766034B2 (en) | 2010-09-22 | 2014-07-01 | Cedars-Sinai Medical Center | TL1A model of inflammation fibrosis and autoimmunity |
| JO3375B1 (ar) | 2010-11-08 | 2019-03-13 | Regeneron Pharma | أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a) |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| US20140050733A1 (en) | 2011-02-07 | 2014-02-20 | Dale B. Schenk | Apoe immunotherapy |
| WO2012109624A2 (en) | 2011-02-11 | 2012-08-16 | Zyngenia, Inc. | Monovalent and multivalent multispecific complexes and uses thereof |
| CA2836898A1 (en) * | 2011-05-20 | 2012-11-29 | Government Of The United States, As Represented By The Secretary, Department Of Health And Human Services | Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof |
| WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| JP6281163B2 (ja) | 2011-08-22 | 2018-02-21 | エメルゲント バイオソリューションズ カナダ | クロストリジウム・ディフィシレ抗体 |
| KR101982899B1 (ko) * | 2011-09-30 | 2019-05-27 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | ＴＬ1ａ에 대한 항체 및 그의 용도 |
| WO2013067355A1 (en) | 2011-11-04 | 2013-05-10 | Novartis Ag | Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs |
| EP3369746A1 (en) | 2012-01-27 | 2018-09-05 | AbbVie Deutschland GmbH & Co KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
| TWI595007B (zh) | 2012-09-10 | 2017-08-11 | Neotope Biosciences Ltd | 抗ｍｃａｍ抗體及相關使用方法 |
| WO2014055967A2 (en) * | 2012-10-05 | 2014-04-10 | Neotope Biosciences Limited | Compositions and methods for treating diseases of protein aggregation involving ic3b deposition |
| EA201591153A1 (ru) * | 2013-01-02 | 2016-01-29 | Гленмарк Фармасьютикалс С.А. | Антитела, связывающиеся с tl1a, и их применение |
| CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
| CA2908553A1 (en) * | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways |
| KR102042174B1 (ko) | 2013-03-29 | 2019-11-08 | 삼성전자주식회사 | 인간화 및 친화도 성숙된 항 ｃ-Ｍｅｔ 항체 및 그의 용도 |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| TWI777196B (zh) * | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（五） |
| US20160264684A1 (en) * | 2013-10-10 | 2016-09-15 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| BR112016009797A2 (pt) * | 2013-11-13 | 2017-12-05 | Bristol Myers Squibb Co | anticorpos específicos de ligante 1a do tipo fator de necrose tumoral e composições e usos dos mesmos |
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| WO2015136472A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
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| CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
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| MX2010005282A (es) | 2010-08-31 |
| EP2500362A3 (en) | 2012-10-24 |
| BRPI0819205A2 (pt) | 2015-06-23 |
| EP2220122A2 (en) | 2010-08-25 |
| ZA201003361B (en) | 2011-02-23 |
| CA2705292A1 (en) | 2009-05-22 |
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| US8728482B2 (en) | 2014-05-20 |
| US20140315250A1 (en) | 2014-10-23 |
| IL205502A0 (en) | 2010-12-30 |
| KR101248422B1 (ko) | 2013-04-09 |
| AU2008320987A1 (en) | 2009-05-22 |
| AU2008320987B2 (en) | 2014-04-17 |
| WO2009064854A2 (en) | 2009-05-22 |
| CA2705292C (en) | 2016-06-21 |
| EP2500362A2 (en) | 2012-09-19 |
| NZ585559A (en) | 2012-11-30 |
| UA104132C2 (en) | 2014-01-10 |
| CN101903402A (zh) | 2010-12-01 |
| US8263743B2 (en) | 2012-09-11 |
| JP5745854B2 (ja) | 2015-07-08 |
| US20120308480A1 (en) | 2012-12-06 |
| US20090280116A1 (en) | 2009-11-12 |
| JP2011502522A (ja) | 2011-01-27 |
| CN101903402B (zh) | 2014-07-16 |
| KR20100097683A (ko) | 2010-09-03 |
| WO2009064854A3 (en) | 2009-07-30 |
| EA201070596A1 (ru) | 2010-12-30 |
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