EA019405B1 - Лекарственное средство, активное в отношении невропатической боли - Google Patents

Лекарственное средство, активное в отношении невропатической боли Download PDF

Info

Publication number
EA019405B1
EA019405B1 EA201070603A EA201070603A EA019405B1 EA 019405 B1 EA019405 B1 EA 019405B1 EA 201070603 A EA201070603 A EA 201070603A EA 201070603 A EA201070603 A EA 201070603A EA 019405 B1 EA019405 B1 EA 019405B1
Authority
EA
Eurasian Patent Office
Prior art keywords
acid
compound
pharmaceutically acceptable
group
couple
Prior art date
Application number
EA201070603A
Other languages
English (en)
Russian (ru)
Other versions
EA201070603A1 (ru
Inventor
Мария Алессандра Ализи
Никола Каццолла
Гвидо Фурлотти
Анджело Гульельмотти
Лоренцо Поленцани
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо A.К.P.A.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо A.К.P.A.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо A.К.P.A.Ф. С.П.А.
Publication of EA201070603A1 publication Critical patent/EA201070603A1/ru
Publication of EA019405B1 publication Critical patent/EA019405B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201070603A 2007-11-12 2008-11-06 Лекарственное средство, активное в отношении невропатической боли EA019405B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07425709 2007-11-12
PCT/EP2008/065081 WO2009062883A1 (en) 2007-11-12 2008-11-06 Drug active in neuropathic pain

Publications (2)

Publication Number Publication Date
EA201070603A1 EA201070603A1 (ru) 2010-10-29
EA019405B1 true EA019405B1 (ru) 2014-03-31

Family

ID=39312937

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070603A EA019405B1 (ru) 2007-11-12 2008-11-06 Лекарственное средство, активное в отношении невропатической боли

Country Status (25)

Country Link
US (1) US8455519B2 (zh)
EP (1) EP2207776B9 (zh)
JP (1) JP5443372B2 (zh)
KR (1) KR101555626B1 (zh)
CN (1) CN101855220B (zh)
AR (1) AR069249A1 (zh)
AU (1) AU2008323026B2 (zh)
CA (1) CA2702874C (zh)
CY (1) CY1118131T1 (zh)
DK (1) DK2207776T3 (zh)
EA (1) EA019405B1 (zh)
ES (1) ES2601250T3 (zh)
GE (1) GEP20125526B (zh)
HK (1) HK1142884A1 (zh)
HR (1) HRP20161497T1 (zh)
HU (1) HUE031676T2 (zh)
IL (1) IL205309A (zh)
LT (1) LT2207776T (zh)
MX (1) MX2010005267A (zh)
PL (1) PL2207776T3 (zh)
PT (1) PT2207776T (zh)
SG (1) SG185982A1 (zh)
SI (1) SI2207776T1 (zh)
UA (1) UA99927C2 (zh)
WO (1) WO2009062883A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS54539B1 (en) 2012-02-21 2016-06-30 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. USE OF 1H-INDASOL-3-CARBOXAMIDE COMPOUNDS AS A 3-BETA GLYCOGEN SYNTHETASE KINASE INHIBITOR
ES2564961T3 (es) 2012-02-21 2016-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta
TW202019876A (zh) * 2018-07-31 2020-06-01 日商小野藥品工業股份有限公司 苯衍生物
JP7384179B2 (ja) * 2020-01-29 2023-11-21 小野薬品工業株式会社 ベンゼン誘導体を含有する医薬組成物
WO2021153690A1 (ja) * 2020-01-29 2021-08-05 小野薬品工業株式会社 ベンゼン誘導体の新規結晶形
KR102374820B1 (ko) 2020-11-04 2022-03-16 전남대학교병원 프레가발린 및 티아넵틴을 포함하는 신경병성 통증 치료용 약학적 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046589A2 (en) * 1997-04-15 1998-10-22 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Indazole amide compounds as serotoninergic agents
EP1182193A1 (en) * 1999-04-09 2002-02-27 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
WO2004101548A1 (en) * 2003-05-15 2004-11-25 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Indazole having analgesic activity ,
WO2005013989A1 (en) * 2003-07-18 2005-02-17 Aziende Chimiche Riunite Angelini Francesco A.C.R..A.F. S.P.A. Use of indazole derivatives for the treatment of neuropathic pain

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945434A (en) * 1995-05-31 1999-08-31 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
US7834010B2 (en) * 2003-12-23 2010-11-16 Serodus As Modulators of peripheral 5-HT receptors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046589A2 (en) * 1997-04-15 1998-10-22 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Indazole amide compounds as serotoninergic agents
EP1182193A1 (en) * 1999-04-09 2002-02-27 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
WO2004101548A1 (en) * 2003-05-15 2004-11-25 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Indazole having analgesic activity ,
WO2005013989A1 (en) * 2003-07-18 2005-02-17 Aziende Chimiche Riunite Angelini Francesco A.C.R..A.F. S.P.A. Use of indazole derivatives for the treatment of neuropathic pain

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.G. WERMUTH, THE PRACTICE OF MEDICINAL CHEMISTRY, pages 203-237, 1996, ACADEMIC PRESS LTD., LONDON UK, XP002190259, page 216, tab. 13.8 *

Also Published As

Publication number Publication date
US8455519B2 (en) 2013-06-04
CY1118131T1 (el) 2017-06-28
DK2207776T3 (en) 2016-10-31
KR101555626B1 (ko) 2015-09-24
AU2008323026A1 (en) 2009-05-22
PT2207776T (pt) 2016-11-08
GEP20125526B (en) 2012-05-25
KR20100082359A (ko) 2010-07-16
AR069249A1 (es) 2010-01-06
CA2702874A1 (en) 2009-05-22
IL205309A0 (en) 2010-12-30
LT2207776T (lt) 2016-11-10
SI2207776T1 (sl) 2016-11-30
PL2207776T3 (pl) 2017-01-31
JP5443372B2 (ja) 2014-03-19
CN101855220B (zh) 2014-07-30
IL205309A (en) 2015-04-30
US20100215742A1 (en) 2010-08-26
HRP20161497T1 (hr) 2016-12-16
JP2011503030A (ja) 2011-01-27
HUE031676T2 (en) 2017-07-28
EP2207776A1 (en) 2010-07-21
MX2010005267A (es) 2010-05-24
EP2207776B9 (en) 2016-12-21
SG185982A1 (en) 2012-12-28
ES2601250T3 (es) 2017-02-14
UA99927C2 (uk) 2012-10-25
CN101855220A (zh) 2010-10-06
HK1142884A1 (zh) 2010-12-17
AU2008323026B2 (en) 2014-06-19
EA201070603A1 (ru) 2010-10-29
EP2207776B1 (en) 2016-08-17
CA2702874C (en) 2015-12-29
WO2009062883A1 (en) 2009-05-22

Similar Documents

Publication Publication Date Title
JPH08176145A (ja) アロイル−ピペリジン誘導体
KR100878416B1 (ko) 피페라진 화합물
CA2747427C (en) Method for producing diamine derivative
JP3054677B2 (ja) 第三級アルキル官能基化ピペラジン誘導体
EA019405B1 (ru) Лекарственное средство, активное в отношении невропатической боли
US20100317618A1 (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1
JPH0673038A (ja) ビフェニル誘導体、これらの化合物を含む医薬組成物及びそれらの調製法
JP4564713B2 (ja) 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法
KR20130027005A (ko) 마니디핀의 다형 형태
KR20100081349A (ko) 브라디키닌 ｂ１ 길항제인 신규 비펩티드 유도체
EP2867215B1 (en) Tetrazole derivatives and their use as potassium channel modulators
JP6298172B2 (ja) Ｇｐｒ１４２アゴニスト化合物
JP6843845B2 (ja) １，４−ジ−（４−メチルチオフェニル）−３−フタロイルアゼチジン−２−オンおよびその誘導体
JP2020524708A (ja) Ｒｏｃｋを阻害する化合物及びその使用
KR20210126975A (ko) 신규한 우레아 유도체 및 이의 용도
WO2014182673A1 (en) Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
JP5921555B2 (ja) 新規メチルシクロヘキサン誘導体およびその使用
JP2004513096A (ja) 新規なニューロキニンアンタゴニストとしての（４−アシルアミノピペリジン−１−イル）アセトアミド
JP5060133B2 (ja) エステル誘導体及びその医薬用途
US20020115666A1 (en) Neurokinin antagonists
WO2012161173A1 (ja) 置換アミド化合物
JPH08208640A (ja) ベンズイミダゾール誘導体およびそれを含有する心不全治療薬
JP2010083760A (ja) ヒスタミンｈ２受容体拮抗作用を有する２−フェニルインドール化合物
WO2012165314A1 (ja) アミド化合物

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU