EA019202B1 - Способ проведения аллерген-специфической иммунотерапии для профилактики или лечения аллергии - Google Patents
Способ проведения аллерген-специфической иммунотерапии для профилактики или лечения аллергии Download PDFInfo
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- EA019202B1 EA019202B1 EA201071182A EA201071182A EA019202B1 EA 019202 B1 EA019202 B1 EA 019202B1 EA 201071182 A EA201071182 A EA 201071182A EA 201071182 A EA201071182 A EA 201071182A EA 019202 B1 EA019202 B1 EA 019202B1
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- Eurasian Patent Office
- Prior art keywords
- allergen
- administration
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- seasonal
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4440108P | 2008-04-11 | 2008-04-11 | |
| DKPA200800533 | 2008-04-11 | ||
| PCT/EP2009/054186 WO2009124954A1 (en) | 2008-04-11 | 2009-04-08 | Mucosomal allergen-specific immunotherapy with initial dosing after start of pollen season |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201071182A1 EA201071182A1 (ru) | 2011-06-30 |
| EA019202B1 true EA019202B1 (ru) | 2014-01-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| EA201071182A EA019202B1 (ru) | 2008-04-11 | 2009-04-08 | Способ проведения аллерген-специфической иммунотерапии для профилактики или лечения аллергии |
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| Country | Link |
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| US (2) | US9248097B2 (enExample) |
| EP (1) | EP2265285B1 (enExample) |
| JP (2) | JP5618981B2 (enExample) |
| CN (1) | CN102014954A (enExample) |
| AU (1) | AU2009235490B2 (enExample) |
| BR (1) | BRPI0911433A2 (enExample) |
| CA (1) | CA2720455A1 (enExample) |
| DE (1) | DE202008006598U1 (enExample) |
| EA (1) | EA019202B1 (enExample) |
| ES (1) | ES2406391T3 (enExample) |
| MX (1) | MX2010011012A (enExample) |
| WO (1) | WO2009124954A1 (enExample) |
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| WO2004047793A1 (en) * | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| DE202008006598U1 (de) * | 2008-04-11 | 2008-10-02 | Alk-Abelló A/S | Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung |
| EP2627354B1 (en) * | 2010-10-15 | 2015-07-15 | ALK-Abelló A/S | Suppression of a type 1 hypersensitivity immune response with an unrelated antigen |
| US20120100164A1 (en) | 2010-10-15 | 2012-04-26 | Alk-Abello A/S | Suppression of a hypersensitivity immune response with unrelated antigen derived from allergen source material |
| WO2012148549A1 (en) | 2011-02-25 | 2012-11-01 | Benaroya Research Institute | Detection of an immune response |
| JP2012240975A (ja) * | 2011-05-20 | 2012-12-10 | Nitto Denko Corp | 医薬組成物及びゼリー状製剤 |
| JP2012240978A (ja) * | 2011-05-20 | 2012-12-10 | Nitto Denko Corp | 医薬組成物及びゼリー状製剤 |
| SG10201605350UA (en) | 2012-01-16 | 2016-08-30 | Mckenna Elizabeth | Compositions and Methods for the Treatment of Hepatic Diseases and Disorders |
| US12268718B2 (en) | 2012-01-16 | 2025-04-08 | Labyrinth Holdings Llc | Control of cellular redox levels |
| KR102307248B1 (ko) | 2012-08-21 | 2021-10-01 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| NZ630178A (en) | 2012-09-07 | 2017-06-30 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| WO2014047588A1 (en) | 2012-09-21 | 2014-03-27 | Elizabeth Mckenna | Naturally occurring cpg oligonucleotide compositions and therapeutic applications thereof |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| KR20160120735A (ko) | 2014-02-28 | 2016-10-18 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제의 투여에 의한 피부 감염의 치료 방법 |
| CA2967602C (en) | 2014-11-14 | 2024-09-24 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATMENT OF CHRONIC SINUSITIS WITH NASAL POLYPOSIS BY ADMINISTRATION OF AN IL-4R ANTAGONIST |
| US11771743B2 (en) | 2016-09-01 | 2023-10-03 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an IL-4R antagonist |
| US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| TWI857389B (zh) | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| EP4344706A3 (en) | 2017-10-30 | 2024-05-22 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| CN120227453A (zh) | 2018-05-13 | 2025-07-01 | 瑞泽恩制药公司 | 用于通过施用il-4r抑制剂治疗特应性皮炎的方法 |
| KR20210143246A (ko) | 2019-03-21 | 2021-11-26 | 리제너론 파아마슈티컬스, 인크. | 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용 |
| BR112022000740A2 (pt) | 2019-07-16 | 2022-07-05 | Sanofi Biotechnology | Métodos para tratamento ou prevenção de asma por administração de um antagonista de il-4r |
| EP4010373A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| KR20220042217A (ko) | 2019-08-05 | 2022-04-04 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 알레르기를 치료하고 알레르겐-특이적 면역치료요법을 증진시키기 위한 방법 |
| EP4513185A1 (en) * | 2023-08-22 | 2025-02-26 | Luxembourg Institute of Health (LIH) | Early response biomarkers for allergen immunotherapy |
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| WO2005083385A2 (en) * | 2004-02-26 | 2005-09-09 | Alk-Abelló A/S | Method of evaluating the therapeutic potential of a vaccine for mucosal administration |
| WO2007051476A1 (en) * | 2005-11-04 | 2007-05-10 | Alk-Abelló A/S | Use of a liquid allergy vaccine formulation for oromucosal administration |
| DE202007004567U1 (de) * | 2007-03-28 | 2007-10-11 | Alk-Abelló A/S | Verwendung einer adjuvierten Allergievakzinformulierung zur parenteralen Verabreichung |
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| DK137992D0 (da) | 1992-11-13 | 1992-11-13 | Alk Lab As | Fremgangsmaade til paavisning af et immunologisk aktivt stof i en proeve under anvendelse af et maerkningsstof |
| JPH0959179A (ja) * | 1995-08-28 | 1997-03-04 | Japan Tobacco Inc | スギ花粉症予防性を有する口腔衛生剤 |
| DK1062341T3 (da) | 1998-03-16 | 2008-11-03 | Alk Abello As | Muterede rekombinante allergener |
| FR2778244B1 (fr) | 1998-04-30 | 2000-07-13 | Univ Joseph Fourier | Procede d'excitation d'une cavite optique pour la detection de gaz a l'etat de traces |
| DE60136653D1 (de) | 2000-11-16 | 2009-01-02 | Alk Abello As | Mutante allergene |
| EP1504089A2 (en) | 2002-05-16 | 2005-02-09 | Alk Abell A/S | Allergen mutants |
| WO2004047793A1 (en) * | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| WO2005077410A1 (en) | 2004-02-06 | 2005-08-25 | Greer Laboratories, Inc. | Methods and compositions for dosing of allergens |
| US20060115499A1 (en) | 2004-09-27 | 2006-06-01 | Alk-Abello A/S | Liquid allergy vaccine formulation for oromucosal administration |
| JP5628473B2 (ja) | 2004-11-10 | 2014-11-19 | アルク−アベッロ エイ／エスＡｌｋ−Ａｂｅｌｌｏ Ａ／Ｓ | アレルギーワクチンの粘膜投与によるアレルギーの予防治療方法 |
| DK1812059T3 (da) | 2004-11-10 | 2010-09-13 | Alk Abello As | Fremgangsmåde til forebyggende behandling af allergi ved mukosaadministration af en allergivaccine |
| CN101098711A (zh) * | 2005-01-07 | 2008-01-02 | 阿尔克-阿贝洛有限公司 | 通过口粘膜施用变态反应疫苗预防性治疗变态反应的方法 |
| US20060210590A1 (en) * | 2005-02-03 | 2006-09-21 | Alk-Abello A/S | Minor allergen control to increase safety of immunotherapy |
| AU2006299310A1 (en) | 2005-10-04 | 2007-04-12 | Alk-Abello A/S | Solid vaccine formulation |
| EP1974746B1 (en) * | 2007-03-28 | 2012-01-11 | Alk-Abelló A/S | Use of an adjuvanted allergy vaccine formulation for parenteral administration |
| DE202008006598U1 (de) * | 2008-04-11 | 2008-10-02 | Alk-Abelló A/S | Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung |
-
2008
- 2008-05-15 DE DE202008006598U patent/DE202008006598U1/de not_active Expired - Lifetime
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2009
- 2009-04-08 ES ES09730293T patent/ES2406391T3/es active Active
- 2009-04-08 WO PCT/EP2009/054186 patent/WO2009124954A1/en not_active Ceased
- 2009-04-08 CN CN2009801154343A patent/CN102014954A/zh active Pending
- 2009-04-08 CA CA2720455A patent/CA2720455A1/en not_active Abandoned
- 2009-04-08 EA EA201071182A patent/EA019202B1/ru not_active IP Right Cessation
- 2009-04-08 JP JP2011503429A patent/JP5618981B2/ja not_active Expired - Fee Related
- 2009-04-08 EP EP09730293A patent/EP2265285B1/en not_active Revoked
- 2009-04-08 US US12/988,513 patent/US9248097B2/en active Active
- 2009-04-08 AU AU2009235490A patent/AU2009235490B2/en not_active Ceased
- 2009-04-08 MX MX2010011012A patent/MX2010011012A/es active IP Right Grant
- 2009-04-08 BR BRPI0911433A patent/BRPI0911433A2/pt not_active IP Right Cessation
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2014
- 2014-01-10 US US14/152,753 patent/US20140127298A1/en not_active Abandoned
- 2014-09-16 JP JP2014187908A patent/JP2015013891A/ja active Pending
Patent Citations (3)
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| WO2005083385A2 (en) * | 2004-02-26 | 2005-09-09 | Alk-Abelló A/S | Method of evaluating the therapeutic potential of a vaccine for mucosal administration |
| WO2007051476A1 (en) * | 2005-11-04 | 2007-05-10 | Alk-Abelló A/S | Use of a liquid allergy vaccine formulation for oromucosal administration |
| DE202007004567U1 (de) * | 2007-03-28 | 2007-10-11 | Alk-Abelló A/S | Verwendung einer adjuvierten Allergievakzinformulierung zur parenteralen Verabreichung |
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| DAHL RONALD ET AL.: "Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years" JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 121, no. 2, February 2008 (2008-02), pages 512-518, XP002505159 ISSN: 0091-6749 the whole document * |
| FRATI FRANCO ET AL.: "Mucosal immunization application to allergic disease: sublingual immunotherapy." ALLERGY AND ASTHMA PROCEEDINGS : THE OFFICIAL JOURNAL OF REGIONAL AND STATE ALLERGY SOCIETIES 2007 JAN-FEB, vol. 28, no. 1, January 2007 (2007-01), pages 35-39, XP009109006 ISSN: 1088-5412 * |
| KLEINE-TEBBE J. ET AL.: "Safety of a SQ-standardised grass allergen tablet for sublingual immunotherapy: a randomized, placebo-controlled trial" ALLERGY, MUNSKGAARD, COPENHAGEN, vol. 61, no. 2, 1 February 2006 (2006-02-01), pages 181-184, XP002392406 ISSN: 0105-4538 * |
| KOPP М.V. ЕТ AL.: "Administration schedules of specific immunotherapy" ALLER60 JOURNAL 200712 DE, vol. 16, no. 8, December 2007 (2007-12), pages 570-575, XP009108997 ISSN: 0941-8849 page 574, left-hand column - page 575; table 2 * |
| NIGGEMANN В. ET AL.: "Five-year follow-up on the PAT study: specific Immunotherapy and long-term prevention of asthma in children" ALLERGY, MUNSKGAARD, COPENHAGEN, vol. 61, no. 7, 1 July 2006 (2006-07-01), pages 855-859, XP002437350 ISSN: 0105-4538 * |
| NOVEMBRE E. ET AL.: "Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis" JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 114, no. 4, 1 October 2004 (2004-10-01), pages 851-857, XP004631432 ISSN: 0091-6749 the whole document * |
| ON BEHALF OF THE UK IMMUNOTHERAPY STUDY GROUP FREW ET AL.: "Efficacy and safety of specific Immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis" JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 117, no. 2, 1 February 2006 (2006-02-01), pages 319-325, XP005275416 ISSN: 0091-6749 * |
| OTT H. ET AL.: "ECRIT-study: efficacy and safety of coseasonal SLIT in patients with grass pollen allergy over a 3 years period" ALLERGY (OXFORD), vol. 62, no. Suppl. 83, June 2007 (2007-06), page 72, XP002505158 & 26TH CONGRESS OF THE EUROPEAN-ACADEMY-OF-ALLERGOLOGY-AND-CLINIC AL-IMM UNOLOGY; GOTEBORG, SWEDEN; JUNE 09-13, 2007 ISSN: 0105-4538 abstract * |
| SEIDENBERG J. ET AL.: "EVALUATION OF THE SAFETY OF A SEASONAL ULTRA RUSH HIGH-DOSE SUBLINGUAL IMMUNOTHERAPY IN CHILDREN WITH ALLERGIC RHINITIS TO TREE POLLEN AND GRASS POLLEN" CLINICAL AND EXPERIMENTAL ALLERGY, BLACKWELL SCIENTIFIC PUBLICATIONS, LONDON, GB, vol. 36, no. 9, 1 September 2006 (2006-09-01), pages 1205-1206, XP009085031 ISSN: 0954-7894 cited in the application abstract * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011516521A (ja) | 2011-05-26 |
| CN102014954A (zh) | 2011-04-13 |
| EP2265285B1 (en) | 2013-03-20 |
| US9248097B2 (en) | 2016-02-02 |
| DE202008006598U1 (de) | 2008-10-02 |
| WO2009124954A1 (en) | 2009-10-15 |
| JP2015013891A (ja) | 2015-01-22 |
| EP2265285A1 (en) | 2010-12-29 |
| CA2720455A1 (en) | 2009-10-15 |
| US20110142934A1 (en) | 2011-06-16 |
| US20140127298A1 (en) | 2014-05-08 |
| HK1147946A1 (en) | 2011-08-26 |
| ES2406391T3 (es) | 2013-06-06 |
| EA201071182A1 (ru) | 2011-06-30 |
| AU2009235490A1 (en) | 2009-10-15 |
| BRPI0911433A2 (pt) | 2016-07-26 |
| JP5618981B2 (ja) | 2014-11-05 |
| AU2009235490B2 (en) | 2013-10-24 |
| MX2010011012A (es) | 2010-11-12 |
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