EA017564B1 - Способ ингибирования клостридиум диффициле введением оритаванцина - Google Patents
Способ ингибирования клостридиум диффициле введением оритаванцина Download PDFInfo
- Publication number
- EA017564B1 EA017564B1 EA201000383A EA201000383A EA017564B1 EA 017564 B1 EA017564 B1 EA 017564B1 EA 201000383 A EA201000383 A EA 201000383A EA 201000383 A EA201000383 A EA 201000383A EA 017564 B1 EA017564 B1 EA 017564B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- clostridium difficile
- oritavancin
- spores
- glycopeptide antibiotic
- vancomycin
- Prior art date
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- VILMUCRZVVVJCA-UHFFFAOYSA-M sodium glycolate Chemical compound [Na+].OCC([O-])=O VILMUCRZVVVJCA-UHFFFAOYSA-M 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical class [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- YVOFSHPIJOYKSH-NLYBMVFSSA-M sodium rifomycin sv Chemical compound [Na+].OC1=C(C(O)=C2C)C3=C([O-])C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O YVOFSHPIJOYKSH-NLYBMVFSSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
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- 239000008227 sterile water for injection Substances 0.000 description 1
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- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
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- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 230000009469 supplementation Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 108010089019 telavancin Proteins 0.000 description 1
- 229960005240 telavancin Drugs 0.000 description 1
- ONUMZHGUFYIKPM-MXNFEBESSA-N telavancin Chemical compound O1[C@@H](C)[C@@H](O)[C@](NCCNCCCCCCCCCC)(C)C[C@@H]1O[C@H]1[C@H](OC=2C3=CC=4[C@H](C(N[C@H]5C(=O)N[C@H](C(N[C@@H](C6=CC(O)=C(CNCP(O)(O)=O)C(O)=C6C=6C(O)=CC=C5C=6)C(O)=O)=O)[C@H](O)C5=CC=C(C(=C5)Cl)O3)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC)[C@H](O)C3=CC=C(C(=C3)Cl)OC=2C=4)O[C@H](CO)[C@@H](O)[C@@H]1O ONUMZHGUFYIKPM-MXNFEBESSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
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- 238000002604 ultrasonography Methods 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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- 229940046009 vitamin E Drugs 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
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- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- KGPGQDLTDHGEGT-JCIKCJKQSA-N zeven Chemical compound C=1C([C@@H]2C(=O)N[C@H](C(N[C@H](C3=CC(O)=C4)C(=O)NCCCN(C)C)=O)[C@H](O)C5=CC=C(C(=C5)Cl)OC=5C=C6C=C(C=5O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@H](O5)C(O)=O)NC(=O)CCCCCCCCC(C)C)OC5=CC=C(C=C5)C[C@@H]5C(=O)N[C@H](C(N[C@H]6C(=O)N2)=O)C=2C(Cl)=C(O)C=C(C=2)OC=2C(O)=CC=C(C=2)[C@H](C(N5)=O)NC)=CC=C(O)C=1C3=C4O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O KGPGQDLTDHGEGT-JCIKCJKQSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97176607P | 2007-09-12 | 2007-09-12 | |
| PCT/US2008/075949 WO2009036121A1 (en) | 2007-09-12 | 2008-09-11 | Method of inhibiting clostridium difficile by administration of oritavancin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201000383A1 EA201000383A1 (ru) | 2010-10-29 |
| EA017564B1 true EA017564B1 (ru) | 2013-01-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201000383A EA017564B1 (ru) | 2007-09-12 | 2008-09-11 | Способ ингибирования клостридиум диффициле введением оритаванцина |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8518873B2 (enExample) |
| EP (1) | EP2195004B1 (enExample) |
| JP (1) | JP5591112B2 (enExample) |
| CN (1) | CN102316885A (enExample) |
| AU (1) | AU2008298987B2 (enExample) |
| CA (1) | CA2699550C (enExample) |
| EA (1) | EA017564B1 (enExample) |
| ES (1) | ES2535928T3 (enExample) |
| WO (1) | WO2009036121A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518873B2 (en) * | 2007-09-12 | 2013-08-27 | The Medicines Company | Method of inhibiting clostridium difficile by administration of oritavancin |
| ES2884673T3 (es) * | 2008-04-08 | 2021-12-10 | Melinta Therapeutics Inc | Oritavancina para inhibir y tratar biopelículas |
| PT2424559T (pt) * | 2009-04-28 | 2024-04-30 | Melinta Therapeutics Llc | Métodos de tratamento de infeções bacterianas utilizando oritavancina |
| JP5986416B2 (ja) * | 2012-04-11 | 2016-09-06 | 花王株式会社 | 皮膚外用剤 |
| MX2015006491A (es) | 2012-11-23 | 2015-12-03 | Seres Health Inc | Composiciones bacterianas sinergicas y metodos de produccion y uso de las mismas. |
| EP2951283A4 (en) | 2013-02-04 | 2017-01-25 | Seres Therapeutics, Inc. | Compositions and methods |
| MX369877B (es) * | 2013-02-04 | 2019-11-25 | Seres Therapeutics Inc | Composiciones y metodos. |
| JP2016519664A (ja) | 2013-03-15 | 2016-07-07 | セレス セラピューティクス インコーポレイテッド | ネットワークを基にした微生物組成物及び方法 |
| MX367109B (es) | 2013-11-25 | 2019-08-05 | Seres Therapeutics Inc | Composiciones bacterianas sinergicas y sus metodos de produccion y usos. |
| US9956282B2 (en) | 2013-12-16 | 2018-05-01 | Seres Therapeutics, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
| JP6553074B2 (ja) * | 2014-10-14 | 2019-07-31 | アーゼッド・エレクトロニック・マテリアルズ（ルクセンブルグ）ソシエテ・ア・レスポンサビリテ・リミテ | レジストパターン処理用組成物およびそれを用いたパターン形成方法 |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| CA3014294A1 (en) | 2016-02-18 | 2017-08-24 | Melinta Therapeutics, Inc. | Oritavancin formulations |
| CN107325159A (zh) * | 2016-04-29 | 2017-11-07 | 中国科学院上海药物研究所 | 一类万古霉素衍生物、其制备方法、药物组合物和用途 |
| MX388732B (es) | 2016-05-09 | 2025-03-20 | Xellia Pharmaceuticals Aps | Formulaciones de antibioticos glicopeptidicos estabilizados |
| BR112020002992A2 (pt) | 2017-08-14 | 2020-08-18 | Seres Therapeutics, Inc. | composições e métodos para tratamento de doença colestática |
| JP2021501185A (ja) | 2017-10-30 | 2021-01-14 | セレス セラピューティクス インコーポレイテッド | 抗生物質耐性を処置するための組成物及び方法 |
| CA3109900A1 (en) * | 2018-08-17 | 2020-02-20 | Universidad Andres Bello | Method and pharmacological composition for the prevention of recurrent infections caused by clostridium difficile |
| KR102444119B1 (ko) * | 2020-04-22 | 2022-09-16 | 주식회사 인트론바이오테크놀로지 | 클로스트리디오이데스 디피실리 균에 대하여 용균 활성을 갖는 항균단백질 cdl200 |
Citations (2)
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|---|---|---|---|---|
| US20050197333A1 (en) * | 2003-12-23 | 2005-09-08 | Van Duzer John H. | Rifamycin analogs and uses thereof |
| US20070014849A1 (en) * | 2002-06-06 | 2007-01-18 | Daniela Jabes | Use of ramoplanin to treat diseases associated with the use of antibiotics |
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|---|---|---|---|---|
| JP2961184B2 (ja) * | 1990-05-07 | 1999-10-12 | ミヤリサン株式会社 | クロストリジウム・ディフィシル下痢症および偽膜性大腸炎の予防ならびに治療用医薬組成物 |
| GB0212622D0 (en) * | 2002-05-31 | 2002-07-10 | Natural Technologies Group Ltd | Bacterial transforming agent |
| ATE448775T1 (de) * | 2002-08-29 | 2009-12-15 | Activbiotics Pharma Llc | Rifalazil zur behandlung von infektionen mit clostridium difficile |
| WO2007092582A2 (en) * | 2006-02-08 | 2007-08-16 | Biosynexus Incorporated | Neutralization of bacterial spores |
| GB0714030D0 (en) * | 2007-07-18 | 2007-08-29 | Novacta Biosystems Ltd | The use of type-B lantibiotic-based compounds having antimicrobial activity |
| US8518873B2 (en) * | 2007-09-12 | 2013-08-27 | The Medicines Company | Method of inhibiting clostridium difficile by administration of oritavancin |
-
2008
- 2008-09-11 US US12/676,420 patent/US8518873B2/en active Active
- 2008-09-11 EP EP08830916.6A patent/EP2195004B1/en active Active
- 2008-09-11 EA EA201000383A patent/EA017564B1/ru unknown
- 2008-09-11 AU AU2008298987A patent/AU2008298987B2/en not_active Ceased
- 2008-09-11 CN CN2008801102448A patent/CN102316885A/zh active Pending
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2013
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070014849A1 (en) * | 2002-06-06 | 2007-01-18 | Daniela Jabes | Use of ramoplanin to treat diseases associated with the use of antibiotics |
| US20050197333A1 (en) * | 2003-12-23 | 2005-09-08 | Van Duzer John H. | Rifamycin analogs and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201000383A1 (ru) | 2010-10-29 |
| EP2195004A1 (en) | 2010-06-16 |
| CA2699550C (en) | 2020-08-18 |
| US8518873B2 (en) | 2013-08-27 |
| BRPI0816662A2 (pt) | 2017-06-13 |
| US20140100157A1 (en) | 2014-04-10 |
| US8629100B2 (en) | 2014-01-14 |
| US20130310308A1 (en) | 2013-11-21 |
| EP2195004B1 (en) | 2015-04-01 |
| EP2195004A4 (en) | 2011-12-28 |
| AU2008298987B2 (en) | 2013-12-05 |
| CA2699550A1 (en) | 2009-03-19 |
| JP2010539179A (ja) | 2010-12-16 |
| US20100311646A1 (en) | 2010-12-09 |
| WO2009036121A1 (en) | 2009-03-19 |
| JP5591112B2 (ja) | 2014-09-17 |
| ES2535928T3 (es) | 2015-05-19 |
| CN102316885A (zh) | 2012-01-11 |
| AU2008298987A1 (en) | 2009-03-19 |
| US9220749B2 (en) | 2015-12-29 |
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Legal Events
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| PC4A | Registration of transfer of a eurasian patent by assignment |