EA017549B1 - Стабильные жидкие композиции антител против вируса бешенства - Google Patents
Стабильные жидкие композиции антител против вируса бешенства Download PDFInfo
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- EA017549B1 EA017549B1 EA200970533A EA200970533A EA017549B1 EA 017549 B1 EA017549 B1 EA 017549B1 EA 200970533 A EA200970533 A EA 200970533A EA 200970533 A EA200970533 A EA 200970533A EA 017549 B1 EA017549 B1 EA 017549B1
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- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229940099511 polysorbate 65 Drugs 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87289206P | 2006-12-05 | 2006-12-05 | |
| EP06125400 | 2006-12-05 | ||
| PCT/EP2007/063244 WO2008068246A1 (en) | 2006-12-05 | 2007-12-04 | Liquid anti-rabies antibody formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200970533A1 EA200970533A1 (ru) | 2009-10-30 |
| EA017549B1 true EA017549B1 (ru) | 2013-01-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970533A EA017549B1 (ru) | 2006-12-05 | 2007-12-04 | Стабильные жидкие композиции антител против вируса бешенства |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7959922B2 (enExample) |
| EP (1) | EP2088997B1 (enExample) |
| JP (1) | JP5410985B2 (enExample) |
| KR (1) | KR101522036B1 (enExample) |
| CN (1) | CN101557799B (enExample) |
| AU (1) | AU2007328960B2 (enExample) |
| CA (1) | CA2668947C (enExample) |
| CU (1) | CU23795A3 (enExample) |
| EA (1) | EA017549B1 (enExample) |
| IL (1) | IL199004A (enExample) |
| MX (1) | MX2009005414A (enExample) |
| WO (1) | WO2008068246A1 (enExample) |
| ZA (1) | ZA200902772B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ543635A (en) | 2003-06-25 | 2008-05-30 | Crucell Holland Bv | Human C-type lectin: a suitable target molecule for binding molecules, particularly immunoconjugates, in the diagnosis, prevention and/or treatment of myeloid neoplastic diseases such as AML and CML |
| CN102139106B (zh) * | 2004-05-27 | 2014-10-08 | 克鲁塞尔荷兰公司 | 能中和狂犬病病毒的结合分子及其应用 |
| EP3018142A1 (en) | 2006-06-06 | 2016-05-11 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
| MX2009005414A (es) | 2006-12-05 | 2009-06-01 | Crucell Holland Bv | Formulaciones liquidas de anticuerpo antirrabico. |
| JP2010085126A (ja) * | 2008-09-29 | 2010-04-15 | Adtec Kk | 狂犬病ウイルス中和抗体価判定具および狂犬病ウイルス中和抗体価の測定方法 |
| US8821879B2 (en) | 2009-09-04 | 2014-09-02 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
| IN2014CN03555A (enExample) | 2011-10-25 | 2015-07-03 | Onclave Therapeutics Ltd | |
| WO2013134052A1 (en) * | 2012-03-07 | 2013-09-12 | Eli Lilly And Company | Il-17 antibody formulation |
| KR20140119396A (ko) | 2013-03-29 | 2014-10-10 | 삼성전자주식회사 | 단백질 약물의 액상 제형 |
| CA3060581A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| JP7159642B2 (ja) * | 2018-06-26 | 2022-10-25 | 東ソー株式会社 | カラムの抗体に対する保持力の測定方法 |
| BR112021008873A8 (pt) | 2018-11-07 | 2023-04-11 | Merck Sharp & Dohme | Formulação |
| TWI878554B (zh) | 2020-06-12 | 2025-04-01 | 大陸商南京維立志博生物科技股份有限公司 | 結合ｔｎｆｒ２的抗體及其用途 |
| CN119405798A (zh) * | 2022-04-02 | 2025-02-11 | 重庆智翔金泰生物制药股份有限公司 | 一种治疗狂犬病的抗体药物组合物及其制备方法 |
| CN117771365B (zh) * | 2023-12-07 | 2025-07-04 | 兰州生物制品研究所有限责任公司 | 一种抗狂犬病病毒组合单克隆抗体制剂 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005118644A2 (en) * | 2004-05-27 | 2005-12-15 | Crucell Holland B.V. | Binding molecules capable of neutralizing rabies virus and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69005908T2 (de) | 1989-06-08 | 1994-04-28 | Wistar Inst Philadelphia | Monoklonale Antikörper zur Behandlung nach einem Kontakt mit Tollwutvirus. |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| CA2267139A1 (en) | 1996-10-08 | 1998-04-16 | Ton Logtenberg | Methods and means for selecting peptides and proteins having specific affinity for a target |
| US20040013672A1 (en) * | 2000-05-16 | 2004-01-22 | Thomas Jefferson University | Recombinant antibodies, and compositions and methods for making and using the same |
| WO2003016501A2 (en) | 2001-08-21 | 2003-02-27 | Thomas Jefferson University | Recombinant antibodies, and compositions and methods for making and using the same |
| SI1523496T1 (sl) | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| WO2005023849A2 (en) | 2003-09-04 | 2005-03-17 | Crucell Holland B.V. | Antigenic peptides of rabies virus and uses thereof |
| JP4762717B2 (ja) * | 2003-10-09 | 2011-08-31 | 中外製薬株式会社 | ＩｇＭ高濃度安定化溶液 |
| EP1686137A4 (en) * | 2003-10-09 | 2009-10-28 | Chugai Pharmaceutical Co Ltd | PROCESS FOR STABILIZING PROTEIN SOLUTIONS |
| WO2005063291A1 (ja) * | 2003-12-25 | 2005-07-14 | Kirin Beer Kabushiki Kaisha | 抗体を含有する安定な水性医薬製剤 |
| AU2005330672B2 (en) * | 2005-04-18 | 2011-07-28 | Yeda Research And Development Company Limited | Stabilized anti-hepatitis B (HBV) antibody formulations |
| MX2009005414A (es) | 2006-12-05 | 2009-06-01 | Crucell Holland Bv | Formulaciones liquidas de anticuerpo antirrabico. |
-
2007
- 2007-12-04 MX MX2009005414A patent/MX2009005414A/es active IP Right Grant
- 2007-12-04 WO PCT/EP2007/063244 patent/WO2008068246A1/en not_active Ceased
- 2007-12-04 AU AU2007328960A patent/AU2007328960B2/en not_active Ceased
- 2007-12-04 JP JP2009539730A patent/JP5410985B2/ja not_active Expired - Fee Related
- 2007-12-04 US US12/312,967 patent/US7959922B2/en not_active Expired - Fee Related
- 2007-12-04 CN CN2007800448444A patent/CN101557799B/zh not_active Expired - Fee Related
- 2007-12-04 CA CA2668947A patent/CA2668947C/en active Active
- 2007-12-04 EP EP07847749.4A patent/EP2088997B1/en active Active
- 2007-12-04 KR KR1020097013012A patent/KR101522036B1/ko not_active Expired - Fee Related
- 2007-12-04 EA EA200970533A patent/EA017549B1/ru unknown
-
2009
- 2009-04-21 ZA ZA2009/02772A patent/ZA200902772B/en unknown
- 2009-05-27 IL IL199004A patent/IL199004A/en active IP Right Grant
- 2009-06-04 CU CU20090099A patent/CU23795A3/es not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005118644A2 (en) * | 2004-05-27 | 2005-12-15 | Crucell Holland B.V. | Binding molecules capable of neutralizing rabies virus and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5410985B2 (ja) | 2014-02-05 |
| IL199004A (en) | 2015-10-29 |
| WO2008068246A1 (en) | 2008-06-12 |
| CA2668947A1 (en) | 2008-06-12 |
| MX2009005414A (es) | 2009-06-01 |
| AU2007328960B2 (en) | 2013-01-17 |
| ZA200902772B (en) | 2012-09-26 |
| EA200970533A1 (ru) | 2009-10-30 |
| EP2088997B1 (en) | 2016-08-24 |
| CN101557799B (zh) | 2012-08-22 |
| CN101557799A (zh) | 2009-10-14 |
| CU23795A3 (es) | 2012-03-15 |
| KR20090089881A (ko) | 2009-08-24 |
| KR101522036B1 (ko) | 2015-05-20 |
| US7959922B2 (en) | 2011-06-14 |
| CA2668947C (en) | 2017-02-07 |
| AU2007328960A1 (en) | 2008-06-12 |
| US20100034829A1 (en) | 2010-02-11 |
| EP2088997A1 (en) | 2009-08-19 |
| JP2010511665A (ja) | 2010-04-15 |
| IL199004A0 (en) | 2010-02-17 |
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