EA016885B1 - Применение индазолметоксиалкановой кислоты для лечения заболевания, связанного с уровнями триглицерида, холестерина и/или глюкозы и способ лечения указанных заболеваний - Google Patents

Применение индазолметоксиалкановой кислоты для лечения заболевания, связанного с уровнями триглицерида, холестерина и/или глюкозы и способ лечения указанных заболеваний Download PDF

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Publication number
EA016885B1
EA016885B1 EA200970506A EA200970506A EA016885B1 EA 016885 B1 EA016885 B1 EA 016885B1 EA 200970506 A EA200970506 A EA 200970506A EA 200970506 A EA200970506 A EA 200970506A EA 016885 B1 EA016885 B1 EA 016885B1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
cholesterol
treating
triglyceride
alkyl
Prior art date
Application number
EA200970506A
Other languages
English (en)
Russian (ru)
Other versions
EA200970506A1 (ru
Inventor
Анджело Гульельмотти
Джузеппе Бьонди
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А.
Publication of EA200970506A1 publication Critical patent/EA200970506A1/ru
Publication of EA016885B1 publication Critical patent/EA016885B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
EA200970506A 2006-11-24 2007-11-13 Применение индазолметоксиалкановой кислоты для лечения заболевания, связанного с уровнями триглицерида, холестерина и/или глюкозы и способ лечения указанных заболеваний EA016885B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002254A ITMI20062254A1 (it) 2006-11-24 2006-11-24 Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
PCT/EP2007/009908 WO2008061671A2 (en) 2006-11-24 2007-11-13 Use of an indazolemethoxyalkanoic acid for reducing triglyceride, cholesterol and glucose levels

Publications (2)

Publication Number Publication Date
EA200970506A1 EA200970506A1 (ru) 2009-10-30
EA016885B1 true EA016885B1 (ru) 2012-08-30

Family

ID=38198404

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970506A EA016885B1 (ru) 2006-11-24 2007-11-13 Применение индазолметоксиалкановой кислоты для лечения заболевания, связанного с уровнями триглицерида, холестерина и/или глюкозы и способ лечения указанных заболеваний

Country Status (23)

Country Link
US (2) US8198310B2 (enExample)
EP (2) EP2409698B1 (enExample)
JP (1) JP5192490B2 (enExample)
KR (1) KR101413616B1 (enExample)
CN (1) CN101541323B (enExample)
AR (1) AR063894A1 (enExample)
AU (1) AU2007323351B2 (enExample)
BR (1) BRPI0718522A2 (enExample)
CA (1) CA2666371C (enExample)
CY (1) CY1116664T1 (enExample)
DK (2) DK2097080T3 (enExample)
EA (1) EA016885B1 (enExample)
ES (2) ES2530623T3 (enExample)
GE (1) GEP20125570B (enExample)
IL (1) IL198286A (enExample)
IT (1) ITMI20062254A1 (enExample)
MX (1) MX2009004295A (enExample)
PL (2) PL2097080T3 (enExample)
PT (2) PT2097080E (enExample)
SG (1) SG176508A1 (enExample)
SI (2) SI2409698T1 (enExample)
UA (1) UA97123C2 (enExample)
WO (1) WO2008061671A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
CN102471282A (zh) 2009-08-03 2012-05-23 方济各安吉利克化学联合股份有限公司 1-苄基-3-羟甲基-1h-吲唑及其衍生物以及所需镁中间体的制备方法
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
WO2015173786A1 (en) * 2014-05-15 2015-11-19 Boyd Shelley Romayne Compositions and methods for treating and diagnosing ocular disorders
CA3144861A1 (en) 2019-06-25 2020-12-30 Translatum Medicus, Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
WO2021263246A1 (en) 2020-06-27 2021-12-30 Crescenta Biosciences Novel cell metabolism modulating compounds and uses thereof
US12138243B2 (en) 2021-12-31 2024-11-12 Crescenta Biosciences Antiviral use of FABP4 modulating compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510748A1 (en) * 1991-04-22 1992-10-28 ANGELINI RICERCHE S.p.A. SOCIETA' CONSORTILE Use of a methoxy alkanoic acid of indazole for the manufacture of a medicament for the treatment of autoimmune diseases
WO1997016185A2 (en) * 1995-10-31 1997-05-09 Angelini Ricerche S.P.A. Societa' Consortile A pharmaceutical composition for the treatment of autoimmune diseases
WO1999004770A2 (en) * 1997-07-28 1999-02-04 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (Trading also as ACRAF S.P.A.) A pharmaceutical composition active in reducing production of mcp-1 protein
WO2006117316A1 (en) * 2005-04-29 2006-11-09 Nycomed Gmbh Mutual prodrug compounds for use us antiinflammatory agents with gastrointestinal protective activity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1131779B (it) * 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1230441B (it) * 1989-02-07 1991-10-23 Acraf Eteri della serie dell'indazolo
US6077539A (en) * 1996-11-12 2000-06-20 Pozen, Inc. Treatment of migraine headache
IT1293794B1 (it) 1997-07-28 1999-03-10 Acraf Farmaco attivo nel ridurre la produzione di proteina mcp-1
AU766219B2 (en) * 1998-02-02 2003-10-09 1149336 Ontario Inc. Method of regulating glucose metabolism, and reagents related thereto
DE19821625C1 (de) * 1998-05-15 2000-01-05 Merck Patent Gmbh Pharmazeutische Zubereitung
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
ITFI20010230A1 (it) * 2001-11-29 2003-05-29 Menarini Int Operations Lu Sa Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
JP5368801B2 (ja) * 2005-12-01 2013-12-18 フリンダーズ パートナーズ ピーティワイ リミテッド 膵炎を予防および/または治療するための方法および組成物
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510748A1 (en) * 1991-04-22 1992-10-28 ANGELINI RICERCHE S.p.A. SOCIETA' CONSORTILE Use of a methoxy alkanoic acid of indazole for the manufacture of a medicament for the treatment of autoimmune diseases
WO1997016185A2 (en) * 1995-10-31 1997-05-09 Angelini Ricerche S.P.A. Societa' Consortile A pharmaceutical composition for the treatment of autoimmune diseases
WO1999004770A2 (en) * 1997-07-28 1999-02-04 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (Trading also as ACRAF S.P.A.) A pharmaceutical composition active in reducing production of mcp-1 protein
WO2006117316A1 (en) * 2005-04-29 2006-11-09 Nycomed Gmbh Mutual prodrug compounds for use us antiinflammatory agents with gastrointestinal protective activity

Also Published As

Publication number Publication date
EP2097080A2 (en) 2009-09-09
EP2409698A1 (en) 2012-01-25
PT2409698E (pt) 2015-02-10
AR063894A1 (es) 2009-02-25
SI2409698T1 (sl) 2015-04-30
SI2097080T1 (sl) 2013-05-31
SG176508A1 (en) 2011-12-29
ES2403584T3 (es) 2013-05-20
IL198286A (en) 2016-03-31
HK1165275A1 (en) 2012-10-05
IL198286A0 (en) 2010-02-17
GEP20125570B (en) 2012-07-10
CY1116664T1 (el) 2017-03-15
WO2008061671A3 (en) 2008-11-27
EP2097080B1 (en) 2013-02-20
WO2008061671A2 (en) 2008-05-29
HK1129071A1 (en) 2009-11-20
US20100069456A1 (en) 2010-03-18
JP2010510263A (ja) 2010-04-02
CA2666371A1 (en) 2008-05-29
US8846745B2 (en) 2014-09-30
US20120283307A1 (en) 2012-11-08
MX2009004295A (es) 2009-05-05
ES2530623T3 (es) 2015-03-04
CN101541323B (zh) 2012-01-04
EA200970506A1 (ru) 2009-10-30
PL2097080T3 (pl) 2013-07-31
PL2409698T3 (pl) 2015-06-30
KR101413616B1 (ko) 2014-07-01
AU2007323351B2 (en) 2013-05-02
DK2409698T3 (en) 2015-04-27
EP2409698B1 (en) 2015-01-21
CN101541323A (zh) 2009-09-23
AU2007323351A1 (en) 2008-05-29
CA2666371C (en) 2014-05-06
US8198310B2 (en) 2012-06-12
UA97123C2 (uk) 2012-01-10
DK2097080T3 (da) 2013-05-21
JP5192490B2 (ja) 2013-05-08
BRPI0718522A2 (pt) 2013-11-12
ITMI20062254A1 (it) 2008-05-25
KR20090081410A (ko) 2009-07-28
PT2097080E (pt) 2013-04-01

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU