EA014907B1 - ИНГИБИТОРЫ Mnk2 НА ОСНОВЕ 8-ГЕТЕРОАРИЛПУРИНА ДЛЯ ЛЕЧЕНИЯ МЕТАБОЛИЧЕСКИХ НАРУШЕНИЙ - Google Patents
ИНГИБИТОРЫ Mnk2 НА ОСНОВЕ 8-ГЕТЕРОАРИЛПУРИНА ДЛЯ ЛЕЧЕНИЯ МЕТАБОЛИЧЕСКИХ НАРУШЕНИЙ Download PDFInfo
- Publication number
- EA014907B1 EA014907B1 EA200801897A EA200801897A EA014907B1 EA 014907 B1 EA014907 B1 EA 014907B1 EA 200801897 A EA200801897 A EA 200801897A EA 200801897 A EA200801897 A EA 200801897A EA 014907 B1 EA014907 B1 EA 014907B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amine
- purin
- ethyl
- pyridin
- phenyl
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78080006P | 2006-03-09 | 2006-03-09 | |
| PCT/US2007/063699 WO2007104053A2 (en) | 2006-03-09 | 2007-03-09 | 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200801897A1 EA200801897A1 (ru) | 2009-02-27 |
| EA014907B1 true EA014907B1 (ru) | 2011-02-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200801897A EA014907B1 (ru) | 2006-03-09 | 2007-03-09 | ИНГИБИТОРЫ Mnk2 НА ОСНОВЕ 8-ГЕТЕРОАРИЛПУРИНА ДЛЯ ЛЕЧЕНИЯ МЕТАБОЛИЧЕСКИХ НАРУШЕНИЙ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7951803B2 (enExample) |
| EP (1) | EP1991547A2 (enExample) |
| JP (1) | JP2009529541A (enExample) |
| KR (1) | KR20080107466A (enExample) |
| CN (1) | CN101454325A (enExample) |
| AU (1) | AU2007222982A1 (enExample) |
| BR (1) | BRPI0709007A2 (enExample) |
| CA (1) | CA2646429A1 (enExample) |
| EA (1) | EA014907B1 (enExample) |
| MX (1) | MX2008011525A (enExample) |
| WO (1) | WO2007104053A2 (enExample) |
| ZA (1) | ZA200807715B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070225304A1 (en) * | 2005-09-06 | 2007-09-27 | Pharmacopeia Drug Discovery, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
| TWI398252B (zh) | 2006-05-26 | 2013-06-11 | Novartis Ag | 吡咯并嘧啶化合物及其用途 |
| AU2007309167A1 (en) * | 2006-10-20 | 2008-05-02 | N.V. Organon | Purines as PKC-theta inhibitors |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| NZ591176A (en) | 2008-08-22 | 2012-11-30 | Novartis Ag | Pyrrolopyrimidine compounds as cdk inhibitors |
| EP2536720A1 (en) * | 2010-02-18 | 2012-12-26 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Triazolo [4, 5 - b]pyridin derivatives |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| JP5575274B2 (ja) * | 2010-02-26 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| GB201205669D0 (en) * | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
| US10280168B2 (en) | 2012-03-30 | 2019-05-07 | Agency For Science, Technology And Research | Bicyclic heteroaryl derivatives as MNK1 and MNK2 modulators and uses thereof |
| WO2014072244A1 (en) | 2012-11-09 | 2014-05-15 | Boehringer Ingelheim International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| US20150051208A1 (en) * | 2013-08-14 | 2015-02-19 | Boehringer Ingelheim International Gmbh | Pyridinones |
| ES2693520T3 (es) | 2013-12-04 | 2018-12-12 | Evotec International Gmbh | Quinazolinas sustituidas con sulfoximina para composiciones farmacéuticas |
| WO2015091156A1 (en) | 2013-12-17 | 2015-06-25 | Boehringer Ingelheim International Gmbh | Sulfoximine substituted pyrrolotriazines for pharmaceutical compositions |
| EP3140300B1 (en) | 2014-05-07 | 2019-08-14 | Evotec International GmbH | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| CN105001096B (zh) * | 2015-07-21 | 2017-07-21 | 沈阳化工研究院有限公司 | 一种制备4‑氨基‑n‑烷基苄胺的方法 |
| CN106008506B (zh) * | 2016-06-27 | 2018-02-13 | 山东大学 | 取代嘌呤类衍生物及其制备方法与应用 |
| FI3984523T3 (fi) | 2018-12-07 | 2025-10-21 | Neurocrine Biosciences Inc | Crf1-reseptorin antagonisti, lääkeformulaatioita ja niiden kiinteitä muotoja synnynnäisen lisämunuaisten liikakasvun hoitoon |
| CA3152590A1 (en) | 2019-09-27 | 2021-04-01 | Evan Smith | Crf receptor antagonists and methods of use |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
Citations (2)
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| WO2003006465A1 (en) * | 2001-07-13 | 2003-01-23 | Cv Therapeutics, Inc. | Partial and full agonist of a adenosine receptors |
| WO2007030438A2 (en) * | 2005-09-06 | 2007-03-15 | Pharmacopeia, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
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|---|---|---|---|---|
| US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
| NZ304859A (en) | 1995-04-03 | 2000-01-28 | Novartis Ag | 4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives, medicaments and processes for the preparation thereof |
| ZA9810490B (en) * | 1997-12-03 | 1999-05-20 | Dainippon Pharmaceutical Co | 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor |
| SE0102147D0 (sv) | 2001-06-18 | 2001-06-18 | Pharmacia Ab | New methods |
| DE60238929D1 (de) | 2001-10-29 | 2011-02-24 | Boehringer Ingelheim Int | Mnk-kinase-homologe proteine, die an der regulierung der energiehomöostase und dem organellen metabolismus beteiligt sind |
| US7105526B2 (en) * | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US20090054358A1 (en) * | 2004-07-19 | 2009-02-26 | The John Hopkins University | Flt3 inhibitors for immune suppression |
| WO2006045828A1 (en) * | 2004-10-29 | 2006-05-04 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting bicyclic pyrimidine derivatives |
| US7884109B2 (en) * | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
| AU2006232105A1 (en) * | 2005-04-05 | 2006-10-12 | Pharmacopeia, Inc. | Purine and imidazopyridine derivatives for immunosuppression |
| US20090023723A1 (en) * | 2005-09-21 | 2009-01-22 | Pharmacopeia Drug Discovery, Inc. | Purinone derivatives for treating neurodegenerative diseases |
| EP1951234A2 (en) * | 2005-10-18 | 2008-08-06 | Janssen Pharmaceutica N.V. | Method of inhibiting flt3 kinase |
| US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| TW200831104A (en) * | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| AU2007309167A1 (en) * | 2006-10-20 | 2008-05-02 | N.V. Organon | Purines as PKC-theta inhibitors |
| US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
| US20080220256A1 (en) * | 2007-03-09 | 2008-09-11 | Ues, Inc. | Methods of coating carbon/carbon composite structures |
-
2007
- 2007-03-09 MX MX2008011525A patent/MX2008011525A/es unknown
- 2007-03-09 CA CA002646429A patent/CA2646429A1/en not_active Abandoned
- 2007-03-09 AU AU2007222982A patent/AU2007222982A1/en not_active Abandoned
- 2007-03-09 US US11/684,262 patent/US7951803B2/en not_active Expired - Fee Related
- 2007-03-09 KR KR1020087024592A patent/KR20080107466A/ko not_active Withdrawn
- 2007-03-09 JP JP2008558554A patent/JP2009529541A/ja active Pending
- 2007-03-09 CN CNA2007800157773A patent/CN101454325A/zh active Pending
- 2007-03-09 BR BRPI0709007-2A patent/BRPI0709007A2/pt not_active IP Right Cessation
- 2007-03-09 EA EA200801897A patent/EA014907B1/ru not_active IP Right Cessation
- 2007-03-09 ZA ZA200807715A patent/ZA200807715B/xx unknown
- 2007-03-09 EP EP07758270A patent/EP1991547A2/en not_active Withdrawn
- 2007-03-09 WO PCT/US2007/063699 patent/WO2007104053A2/en not_active Ceased
-
2011
- 2011-05-27 US US13/118,166 patent/US20110230480A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003006465A1 (en) * | 2001-07-13 | 2003-01-23 | Cv Therapeutics, Inc. | Partial and full agonist of a adenosine receptors |
| WO2007030438A2 (en) * | 2005-09-06 | 2007-03-15 | Pharmacopeia, Inc. | Aminopurine derivatives for treating neurodegenerative diseases |
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| KNAUF U. ET AL.: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1and 2", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 21, no. 16, August 2001 (2001-08), pages 5500-5511, XP002310601, ISSN 0270-7306, abstract, fig. 6 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110230480A1 (en) | 2011-09-22 |
| AU2007222982A1 (en) | 2007-09-13 |
| BRPI0709007A2 (pt) | 2011-06-21 |
| EP1991547A2 (en) | 2008-11-19 |
| US7951803B2 (en) | 2011-05-31 |
| WO2007104053A2 (en) | 2007-09-13 |
| CN101454325A (zh) | 2009-06-10 |
| ZA200807715B (en) | 2009-11-25 |
| CA2646429A1 (en) | 2007-09-13 |
| EA200801897A1 (ru) | 2009-02-27 |
| US20080032971A1 (en) | 2008-02-07 |
| WO2007104053A3 (en) | 2007-11-01 |
| MX2008011525A (es) | 2008-09-18 |
| KR20080107466A (ko) | 2008-12-10 |
| JP2009529541A (ja) | 2009-08-20 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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