EA011439B1 - Конденсированные производные пиримидина и их композиции, применимые в качестве модуляторов cxcr3 рецепторов для профилактики и лечения воспалительных и иммунорегуляторных расстройств и заболеваний - Google Patents
Конденсированные производные пиримидина и их композиции, применимые в качестве модуляторов cxcr3 рецепторов для профилактики и лечения воспалительных и иммунорегуляторных расстройств и заболеваний Download PDFInfo
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- EA011439B1 EA011439B1 EA200700169A EA200700169A EA011439B1 EA 011439 B1 EA011439 B1 EA 011439B1 EA 200700169 A EA200700169 A EA 200700169A EA 200700169 A EA200700169 A EA 200700169A EA 011439 B1 EA011439 B1 EA 011439B1
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| Application Number | Priority Date | Filing Date | Title |
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| US58390104P | 2004-06-28 | 2004-06-28 | |
| PCT/US2005/023251 WO2006004915A1 (en) | 2004-06-28 | 2005-06-28 | Fused pyrimidine derivatives and compositions thereof as cxcr3 receptor modulators, useful in prevention and treatment of inflammatory and immunoregulatory disorders and diseases |
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| EA200700169A1 EA200700169A1 (ru) | 2007-08-31 |
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| US7939538B2 (en) | 2004-06-28 | 2011-05-10 | Amgen Inc. | Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases |
| TW200714610A (en) * | 2005-02-16 | 2007-04-16 | Univ Maryland | CXCR3 is a gliadin receptor |
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| DK1999129T3 (da) * | 2005-10-11 | 2011-02-07 | Intermune Inc | Forbindelser og fremgangsmåder til inhibering af replikationen af hepatitis C-virus |
| KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
| EP2079739A2 (en) * | 2006-10-04 | 2009-07-22 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| EP2160392A2 (en) * | 2007-05-03 | 2010-03-10 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| BRPI0811447A2 (pt) | 2007-05-10 | 2014-10-29 | Intermune Inc | Compostos, composição farmacêutica e métodos de inibição da atividade da protease ns3/ns4, de tratamento da fibrose hepática e de intensificação da função hepática num indivíduo tendo infecção de vírus da hepatite c. |
| WO2009094168A1 (en) * | 2008-01-22 | 2009-07-30 | Amgen Inc. | Cxcr3 antagonists |
| WO2009142842A2 (en) * | 2008-04-15 | 2009-11-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| JP2013505952A (ja) * | 2009-09-28 | 2013-02-21 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新しい大環状阻害剤 |
| JPWO2012011591A1 (ja) * | 2010-07-23 | 2013-09-09 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP2935246B1 (en) | 2012-12-21 | 2018-07-25 | Gilead Calistoga LLC | Isoquinolinone or quinazolinone phosphatidylinositol 3-kinase inhibitors |
| AU2013364068B2 (en) | 2012-12-21 | 2016-10-20 | Gilead Calistoga Llc | Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors |
| AR096621A1 (es) | 2013-06-14 | 2016-01-20 | Gilead Sciences Inc | Inhibidores de isómeros de la fosfatidilinositol 3-quinasa (pi3k) |
| UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
| PE20160685A1 (es) | 2013-10-04 | 2016-07-23 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN113620958A (zh) | 2014-03-19 | 2021-11-09 | 无限药品股份有限公司 | 用于治疗PI3K-γ介导的障碍的杂环化合物 |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| PH12018500554B1 (en) | 2015-09-14 | 2024-01-24 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
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| US5756502A (en) | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
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-
2005
- 2005-06-27 US US11/168,005 patent/US7939538B2/en not_active Expired - Fee Related
- 2005-06-28 BR BRPI0512703-3A patent/BRPI0512703A/pt not_active IP Right Cessation
- 2005-06-28 AR ARP050102670A patent/AR049558A1/es not_active Application Discontinuation
- 2005-06-28 AU AU2005260620A patent/AU2005260620A1/en not_active Abandoned
- 2005-06-28 ZA ZA200700752A patent/ZA200700752B/xx unknown
- 2005-06-28 WO PCT/US2005/023251 patent/WO2006004915A1/en not_active Ceased
- 2005-06-28 MX MX2007000051A patent/MX2007000051A/es not_active Application Discontinuation
- 2005-06-28 KR KR1020077002012A patent/KR20070045203A/ko not_active Withdrawn
- 2005-06-28 EA EA200700169A patent/EA011439B1/ru not_active IP Right Cessation
- 2005-06-28 CA CA002572083A patent/CA2572083A1/en not_active Abandoned
- 2005-06-28 CN CNA2005800277780A patent/CN101006088A/zh active Pending
- 2005-06-28 EP EP05789126A patent/EP1771447A1/en not_active Withdrawn
- 2005-06-28 TW TW094121708A patent/TW200611699A/zh unknown
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2007
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- 2007-01-29 EC EC2007007212A patent/ECSP077212A/es unknown
- 2007-01-29 MA MA29639A patent/MA28755B1/fr unknown
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| WO2001016114A2 (en) * | 1999-08-27 | 2001-03-08 | Chemocentryx, Inc. | Heterocyclic compounds and methods for modulating cxcr3 function |
| WO2001098278A1 (en) * | 2000-06-21 | 2001-12-27 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| WO2002083143A1 (en) * | 2000-12-11 | 2002-10-24 | Tularik Inc. | Cxcr3 antagonists |
| US20030055054A1 (en) * | 2000-12-11 | 2003-03-20 | Tularik, Inc. | CXCR3 antagonists |
| WO2004075863A2 (en) * | 2003-02-27 | 2004-09-10 | Amgen Sf, Llc | Cxcr3 antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070045203A (ko) | 2007-05-02 |
| JP2008504301A (ja) | 2008-02-14 |
| NO20070484L (no) | 2007-03-26 |
| TW200611699A (en) | 2006-04-16 |
| IL180327A0 (en) | 2007-07-04 |
| EA200700169A1 (ru) | 2007-08-31 |
| CA2572083A1 (en) | 2006-01-12 |
| MA28755B1 (fr) | 2007-07-02 |
| EP1771447A1 (en) | 2007-04-11 |
| ECSP077212A (es) | 2007-03-29 |
| US20060069099A1 (en) | 2006-03-30 |
| WO2006004915A1 (en) | 2006-01-12 |
| AU2005260620A1 (en) | 2006-01-12 |
| BRPI0512703A (pt) | 2008-04-01 |
| US7939538B2 (en) | 2011-05-10 |
| TNSN06430A1 (en) | 2008-02-22 |
| AR049558A1 (es) | 2006-08-16 |
| MX2007000051A (es) | 2007-05-11 |
| ZA200700752B (en) | 2008-09-25 |
| CN101006088A (zh) | 2007-07-25 |
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