EA009441B1 - Пиразолпиридины и способы их получения и применения - Google Patents
Пиразолпиридины и способы их получения и применения Download PDFInfo
- Publication number
- EA009441B1 EA009441B1 EA200500450A EA200500450A EA009441B1 EA 009441 B1 EA009441 B1 EA 009441B1 EA 200500450 A EA200500450 A EA 200500450A EA 200500450 A EA200500450 A EA 200500450A EA 009441 B1 EA009441 B1 EA 009441B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- compound according
- group
- cycloalkyl
- heterocycloalkyl
- Prior art date
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| PCT/US2003/027722 WO2004022054A1 (en) | 2002-09-06 | 2003-09-05 | Pyrazolopyridines and methods of making and using the same |
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| EA200500450A1 EA200500450A1 (ru) | 2005-08-25 |
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| WO2006004194A1 (ja) * | 2004-07-02 | 2006-01-12 | Nishimoto, Tomo | TGFβ2を標的としたアルツハイマー病治療薬のスクリーニング法 |
| JP2008516962A (ja) * | 2004-10-15 | 2008-05-22 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 血管傷害を治療する方法 |
| US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| JP2009507032A (ja) | 2005-09-02 | 2009-02-19 | アボット・ラボラトリーズ | 新規なイミダゾ系複素環 |
| EP1873157A1 (en) * | 2006-06-21 | 2008-01-02 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| DK2918288T3 (da) | 2006-10-03 | 2017-11-27 | Genzyme Corp | Anvendelse af TGF-beta-antagonister til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
| US20090082354A1 (en) * | 2007-09-20 | 2009-03-26 | Wyeth | Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation and use thereof |
| MX2010010073A (es) * | 2008-03-14 | 2010-10-04 | Otsuka Pharma Co Ltd | Inhibidor de la metaloproteasa de matriz-2 y/o de la metaloproteasa de matriz-9. |
| CN101544634B (zh) * | 2008-03-27 | 2011-08-10 | 天津药物研究院 | 2-苯基-3-取代吡唑并[1,5-a]吡啶类衍生物及其制备方法和用途 |
| EP2402335A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
| EP2402344A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole fused bicyclic compounds |
| US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| WO2013014262A1 (en) | 2011-07-27 | 2013-01-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating myhre syndrome |
| BR112014009789A2 (pt) | 2011-10-26 | 2017-04-25 | Seattle Children's Res Inst | cisteamina no tratamento da doença fibrótica |
| DK2970205T3 (da) | 2013-03-14 | 2019-07-29 | Tolero Pharmaceuticals Inc | JAK2- og ALK2-inhibitorer og fremgangsmåder til anvendelse deraf |
| AU2014308616B2 (en) | 2013-08-23 | 2018-12-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP3087069B1 (en) | 2013-12-23 | 2019-01-30 | Norgine B.V. | Compounds useful as ccr9 modulators |
| ES2686747T3 (es) * | 2014-03-27 | 2018-10-19 | Janssen Pharmaceutica Nv | Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirimidina y derivados de 2,3-dihidro-1H-imidazo[1,2-b]pirazol sustituidos como inhibidores de ROS1 |
| EP4006035B1 (en) * | 2016-08-15 | 2023-11-22 | Neupharma, Inc. | Quinazoline derivatives as tyrosine kinase inhibitors for the treatment of cancer |
| CN112512597A (zh) | 2018-07-26 | 2021-03-16 | 大日本住友制药肿瘤公司 | 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂 |
| US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| SG11202111327XA (en) * | 2019-05-13 | 2021-11-29 | Relay Therapeutics Inc | Fgfr inhibitors and methods of use thereof |
| WO2021142086A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| CN112707902B (zh) * | 2020-03-23 | 2022-04-15 | 杭州阿诺生物医药科技有限公司 | TGF-β受体抑制剂 |
| CN114380818A (zh) * | 2020-10-16 | 2022-04-22 | 四川科伦博泰生物医药股份有限公司 | 吡唑并吡啶类化合物，及其药物组合物、制备方法和用途 |
| WO2024258967A1 (en) | 2023-06-13 | 2024-12-19 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
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| US6096766A (en) * | 1995-12-11 | 2000-08-01 | Merck Sharp & Dohme Ltd. | 3-benzylaminopiperidines as tachykinin receptor antagonists |
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2003
- 2003-05-09 UA UAA200503095A patent/UA80295C2/uk unknown
- 2003-09-05 PL PL03375699A patent/PL375699A1/xx not_active Application Discontinuation
- 2003-09-05 US US10/526,839 patent/US7691865B2/en not_active Expired - Fee Related
- 2003-09-05 CN CNA038248670A patent/CN1694698A/zh active Pending
- 2003-09-05 AU AU2003268447A patent/AU2003268447B2/en not_active Ceased
- 2003-09-05 MX MXPA05002443A patent/MXPA05002443A/es active IP Right Grant
- 2003-09-05 EP EP03749412A patent/EP1551398A4/en not_active Withdrawn
- 2003-09-05 JP JP2004534571A patent/JP2006502165A/ja active Pending
- 2003-09-05 BR BR0314053-9A patent/BR0314053A/pt not_active IP Right Cessation
- 2003-09-05 NZ NZ539069A patent/NZ539069A/en unknown
- 2003-09-05 EA EA200500450A patent/EA009441B1/ru not_active IP Right Cessation
- 2003-09-05 GE GEAP20038727A patent/GEP20074125B/en unknown
- 2003-09-05 CA CA002497970A patent/CA2497970A1/en not_active Abandoned
- 2003-09-05 KR KR1020057003874A patent/KR20050057235A/ko not_active Withdrawn
- 2003-09-05 WO PCT/US2003/027722 patent/WO2004022054A1/en not_active Ceased
- 2003-09-05 RS YUP-2005/0200A patent/RS20050200A/sr unknown
- 2003-09-08 AR ARP030103250A patent/AR041207A1/es unknown
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2005
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- 2005-03-04 IS IS7725A patent/IS7725A/is unknown
- 2005-03-04 IS IS7726A patent/IS7726A/is unknown
- 2005-03-21 NO NO20051503A patent/NO20051503D0/no not_active Application Discontinuation
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Also Published As
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|---|---|
| IS7726A (is) | 2005-03-04 |
| RS20050200A (sr) | 2007-08-03 |
| EA200500450A1 (ru) | 2005-08-25 |
| EP1551398A4 (en) | 2006-06-07 |
| AU2003268447A1 (en) | 2004-03-29 |
| GEP20074125B (en) | 2007-06-11 |
| US20060106033A1 (en) | 2006-05-18 |
| NZ539069A (en) | 2007-03-30 |
| PL375699A1 (en) | 2005-12-12 |
| NO20051503L (no) | 2005-03-21 |
| CA2497970A1 (en) | 2004-03-18 |
| BR0314053A (pt) | 2005-07-19 |
| WO2004022054A1 (en) | 2004-03-18 |
| UA80295C2 (en) | 2007-09-10 |
| CN1694698A (zh) | 2005-11-09 |
| IS7725A (is) | 2005-03-04 |
| KR20050057235A (ko) | 2005-06-16 |
| US7691865B2 (en) | 2010-04-06 |
| NO20051503D0 (no) | 2005-03-21 |
| ZA200501856B (en) | 2006-04-26 |
| MXPA05002443A (es) | 2005-09-30 |
| AU2003268447B2 (en) | 2008-07-24 |
| EP1551398A1 (en) | 2005-07-13 |
| JP2006502165A (ja) | 2006-01-19 |
| AR041207A1 (es) | 2005-05-11 |
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