EA007618B1 - Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе - Google Patents
Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе Download PDFInfo
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- EA007618B1 EA007618B1 EA200301115A EA200301115A EA007618B1 EA 007618 B1 EA007618 B1 EA 007618B1 EA 200301115 A EA200301115 A EA 200301115A EA 200301115 A EA200301115 A EA 200301115A EA 007618 B1 EA007618 B1 EA 007618B1
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- Prior art keywords
- azithromycin
- ppm
- crystalline
- peaks
- water
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Classifications
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- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29256501P | 2001-05-22 | 2001-05-22 | |
| US29774101P | 2001-06-12 | 2001-06-12 | |
| US34304101P | 2001-12-21 | 2001-12-21 | |
| PCT/IB2002/001570 WO2002094843A1 (en) | 2001-05-22 | 2002-05-01 | Crystal forms of azithromycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200301115A1 EA200301115A1 (ru) | 2004-04-29 |
| EA007618B1 true EA007618B1 (ru) | 2006-12-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| EA200301115A EA007618B1 (ru) | 2001-05-22 | 2002-05-01 | Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе |
| EA200500630A EA009611B1 (ru) | 2001-05-22 | 2002-05-01 | Кристаллическая форма азитромицина |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA200500630A EA009611B1 (ru) | 2001-05-22 | 2002-05-01 | Кристаллическая форма азитромицина |
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| EP (1) | EP1390377B1 (https=) |
| JP (3) | JP2004530703A (https=) |
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| AR (1) | AR036022A1 (https=) |
| AT (2) | ATE404575T1 (https=) |
| AU (1) | AU2002256846B2 (https=) |
| BG (1) | BG108370A (https=) |
| BR (1) | BR0209918A (https=) |
| CA (1) | CA2391659C (https=) |
| CR (1) | CR7159A (https=) |
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| DE (2) | DE60228345D1 (https=) |
| DK (1) | DK1390377T3 (https=) |
| EA (2) | EA007618B1 (https=) |
| EE (1) | EE200300575A (https=) |
| ES (2) | ES2258142T3 (https=) |
| GE (1) | GEP20084399B (https=) |
| HU (1) | HUP0400446A2 (https=) |
| IL (1) | IL158591A0 (https=) |
| IS (1) | IS7007A (https=) |
| MA (1) | MA27023A1 (https=) |
| MX (1) | MXPA03010028A (https=) |
| MY (1) | MY129319A (https=) |
| NO (2) | NO321894B1 (https=) |
| NZ (2) | NZ529118A (https=) |
| PA (1) | PA8545701A1 (https=) |
| PE (1) | PE20021064A1 (https=) |
| PL (1) | PL367091A1 (https=) |
| PT (1) | PT1390377E (https=) |
| SK (1) | SK14402003A3 (https=) |
| TN (1) | TNSN03121A1 (https=) |
| WO (1) | WO2002094843A1 (https=) |
| YU (1) | YU91603A (https=) |
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| HRP20020231A2 (en) | 2002-03-18 | 2003-12-31 | Pliva D D | ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A |
| SI20639A (sl) * | 1998-11-30 | 2002-02-28 | Teva Pharmaceutical Industries Ltd. | Etanolat azitromicina, postopek za njegovo pripravo in njegovi farmacevtski sestavki |
| JP2004506664A (ja) * | 2000-08-23 | 2004-03-04 | ウォックハート・リミテッド | 無水アジトロマイシンの製造法 |
| KR100431431B1 (ko) * | 2001-04-25 | 2004-05-14 | 한미약품 주식회사 | 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물 |
| ES2258142T3 (es) * | 2001-05-22 | 2006-08-16 | Pfizer Products Inc. | Nueva forma cristalina. |
| ITMI20011762A1 (it) | 2001-08-10 | 2003-02-10 | Cosmo Spa | Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione |
| NZ532063A (en) * | 2001-12-21 | 2006-03-31 | Pfizer Prod Inc | Methods for wet granulating azithromycin |
| PL371259A1 (pl) | 2001-12-21 | 2005-06-13 | Pfizer Products Inc. | Bezpośrednio sprasowywalne preparaty azytromycyny |
| RU2283092C2 (ru) | 2002-02-01 | 2006-09-10 | Пфайзер Продактс Инк. | Сухие гранулированные композиции азитромицина |
| HRP20020614A2 (en) | 2002-07-22 | 2004-06-30 | PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. | Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a |
| CA2422972A1 (en) * | 2003-03-21 | 2004-09-21 | Apotex Inc. | Isopropanolate of azithromycin and method of manufacturing |
| US20050013835A1 (en) * | 2003-07-15 | 2005-01-20 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| EP1878432A1 (en) * | 2003-07-24 | 2008-01-16 | Pliva - Research and Development Ltd. | Single dose fast dissolving azithromycin |
| ATE421882T1 (de) * | 2003-07-24 | 2009-02-15 | Pliva Hrvatska D O O | Schnellösliches azithromycin in einzeldosisform |
| EP1687308B1 (en) * | 2003-11-17 | 2019-06-12 | Merck & Cie | Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms |
| US7943585B2 (en) | 2003-12-22 | 2011-05-17 | Sandoz, Inc. | Extended release antibiotic composition |
| US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
| US20050250714A1 (en) * | 2004-05-06 | 2005-11-10 | Lin Kangwen L | Crystalline forms of 9-(S)-erythromycylamine |
| WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
| US7683162B2 (en) | 2004-08-30 | 2010-03-23 | Taro Pharmaceutical Industries Limited | Process of preparing a crystalline azithromycin monohydrate |
| US8495244B2 (en) * | 2005-06-29 | 2013-07-23 | Jumpstart Wireless Corporation | System and method for dynamic automatic communication path selection, distributed device synchronization and task delegation |
| WO2007004230A2 (en) * | 2005-07-05 | 2007-01-11 | Hetero Drugs Limited | A novel process for the preparation of didanosine using novel intermediates |
| JP2009501206A (ja) * | 2005-07-14 | 2009-01-15 | ファイザー・プロダクツ・インク | 非晶質アジスロマイシン粒子の生成方法 |
| BRPI0616040A2 (pt) * | 2005-09-21 | 2011-06-07 | Nycomed Gmbh | cloridrato de sulfonilpirról como inibidor de histona desacetilases |
| EP2404911A1 (en) * | 2005-10-31 | 2012-01-11 | Janssen Pharmaceutica NV | Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives |
| US8558765B2 (en) * | 2005-11-07 | 2013-10-15 | Global Oled Technology Llc | Method and apparatus for uniformity and brightness correction in an electroluminescent display |
| CA2656057C (en) * | 2006-06-16 | 2012-10-02 | H. Lundbeck A/S | Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
| US7919598B2 (en) * | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
| CA2667345C (en) * | 2006-10-27 | 2016-03-22 | Signal Pharmaceuticals, Llc | Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol, compositions thereof, and uses therewith |
| CA2570949A1 (en) * | 2006-12-12 | 2008-06-12 | Apotex Pharmachem Inc. | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof |
| US7834195B2 (en) | 2007-01-24 | 2010-11-16 | Apotex Pharmachem Inc. | Atorvastatin calcium propylene glycol solvates |
| ITMI20071616A1 (it) | 2007-08-03 | 2009-02-04 | Cosmo Spa | Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati. |
| US7919676B2 (en) | 2007-08-03 | 2011-04-05 | Pioneer Hi-Bred International, Inc. | Msca1 nucleotide sequences impacting plant male fertility and method of using same |
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| US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
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| US20100158821A1 (en) * | 2008-12-22 | 2010-06-24 | Eastman Chemical Company | Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products |
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