EA006854B1 - Производные аминохинолина и его применение в качестве лигандов аденозина a - Google Patents
Производные аминохинолина и его применение в качестве лигандов аденозина a Download PDFInfo
- Publication number
- EA006854B1 EA006854B1 EA200301317A EA200301317A EA006854B1 EA 006854 B1 EA006854 B1 EA 006854B1 EA 200301317 A EA200301317 A EA 200301317A EA 200301317 A EA200301317 A EA 200301317A EA 006854 B1 EA006854 B1 EA 006854B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- branched
- straight
- cyanoquinolin
- compounds
- Prior art date
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0102279A HUP0102279A3 (en) | 2001-05-31 | 2001-05-31 | A3 antagonist amino-quinoline-derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
| HU0200774A HUP0200774A2 (hu) | 2002-03-01 | 2002-03-01 | Amino-piridin és amino-kinolin származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| PCT/HU2002/000048 WO2002096879A1 (en) | 2001-05-31 | 2002-05-29 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200301317A1 EA200301317A1 (ru) | 2004-06-24 |
| EA006854B1 true EA006854B1 (ru) | 2006-04-28 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200301317A EA006854B1 (ru) | 2001-05-31 | 2002-05-29 | Производные аминохинолина и его применение в качестве лигандов аденозина a |
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| EP (1) | EP1390349B1 (enExample) |
| JP (1) | JP4409935B2 (enExample) |
| KR (1) | KR100745307B1 (enExample) |
| CN (1) | CN1257160C (enExample) |
| AR (1) | AR036074A1 (enExample) |
| AU (1) | AU2002304358B2 (enExample) |
| BG (1) | BG108477A (enExample) |
| BR (1) | BR0209719A (enExample) |
| CA (1) | CA2448561C (enExample) |
| CO (1) | CO5550457A2 (enExample) |
| CZ (1) | CZ20033510A3 (enExample) |
| EA (1) | EA006854B1 (enExample) |
| EE (1) | EE05304B1 (enExample) |
| HR (1) | HRP20031091B1 (enExample) |
| IL (1) | IL158854A0 (enExample) |
| IS (1) | IS2773B (enExample) |
| MA (1) | MA26236A1 (enExample) |
| MX (1) | MXPA03010870A (enExample) |
| NO (1) | NO327710B1 (enExample) |
| NZ (1) | NZ529966A (enExample) |
| PL (1) | PL366516A1 (enExample) |
| RS (1) | RS95003A (enExample) |
| RU (1) | RU2278112C2 (enExample) |
| SK (1) | SK14142003A3 (enExample) |
| TN (1) | TNSN03117A1 (enExample) |
| WO (1) | WO2002096879A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| HUP0203976A3 (en) * | 2002-11-15 | 2004-08-30 | Sanofi Aventis | Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| WO2004052291A2 (en) | 2002-12-06 | 2004-06-24 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| MEP19108A (en) * | 2003-07-31 | 2010-06-10 | Sanofi Aventis | Aminoquinoline derivatives and their use as adenosine a3 ligands |
| RU2317290C2 (ru) * | 2003-07-31 | 2008-02-20 | Санофи-Авентис | Производные аминохинолина и их применение в качестве лигандов аденозина а3 |
| HUP0400812A2 (en) * | 2004-04-19 | 2006-02-28 | Sanofi Aventis | Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them |
| WO2006040645A1 (en) * | 2004-10-11 | 2006-04-20 | Ranbaxy Laboratories Limited | N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma |
| HUP0402371A2 (en) * | 2004-11-15 | 2006-09-28 | Sanofi Aventis | Novel 125-i-labeled amino-quinoline derivatives |
| KR100788161B1 (ko) * | 2006-01-06 | 2007-12-21 | (주)아모레퍼시픽 | 벤즈이미다졸 아민 유도체 또는 아미노퀴놀린 유도체를 함유하는 피부 미백용 조성물 |
| HUP0700395A2 (en) * | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
| KR101106050B1 (ko) * | 2009-03-25 | 2012-01-18 | 한국과학기술연구원 | 아미노퀴놀린 화합물, 이의 제조 방법 및 이를 함유하는 의약 조성물 |
| WO2012030918A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Adenosine a3 receptor modulating compounds and methods of use thereof |
| WO2012166654A1 (en) * | 2011-05-27 | 2012-12-06 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
| CA2754237A1 (en) | 2011-05-27 | 2012-11-27 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
| ES2578363B1 (es) | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
| MA43512A (fr) * | 2015-08-03 | 2018-11-07 | Bristol Myers Squibb Co | Composés hétérocycliques utiles en tant que modulateurs du tnf alpha |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE265143C (enExample) | ||||
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| JPH01180518A (ja) * | 1988-01-12 | 1989-07-18 | Nissan Chem Ind Ltd | 配向処理剤 |
| IL111266A (en) * | 1993-10-22 | 2002-03-10 | Zeneca Ltd | 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| WO2000064894A1 (en) | 1999-04-23 | 2000-11-02 | Takeda Chemical Industries, Ltd. | 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof |
-
2002
- 2002-05-29 EA EA200301317A patent/EA006854B1/ru not_active IP Right Cessation
- 2002-05-29 BR BR0209719-2A patent/BR0209719A/pt not_active IP Right Cessation
- 2002-05-29 CZ CZ20033510A patent/CZ20033510A3/cs unknown
- 2002-05-29 CN CNB02810840XA patent/CN1257160C/zh not_active Expired - Fee Related
- 2002-05-29 SK SK1414-2003A patent/SK14142003A3/sk unknown
- 2002-05-29 RS YUP-950/03A patent/RS95003A/sr unknown
- 2002-05-29 MX MXPA03010870A patent/MXPA03010870A/es active IP Right Grant
- 2002-05-29 WO PCT/HU2002/000048 patent/WO2002096879A1/en not_active Ceased
- 2002-05-29 AU AU2002304358A patent/AU2002304358B2/en not_active Ceased
- 2002-05-29 JP JP2003500059A patent/JP4409935B2/ja not_active Expired - Fee Related
- 2002-05-29 RU RU2003137836/04A patent/RU2278112C2/ru not_active IP Right Cessation
- 2002-05-29 EP EP02732985A patent/EP1390349B1/en not_active Expired - Lifetime
- 2002-05-29 PL PL02366516A patent/PL366516A1/xx not_active Application Discontinuation
- 2002-05-29 NZ NZ529966A patent/NZ529966A/en not_active IP Right Cessation
- 2002-05-29 KR KR1020037015646A patent/KR100745307B1/ko not_active Expired - Fee Related
- 2002-05-29 IL IL15885402A patent/IL158854A0/xx not_active IP Right Cessation
- 2002-05-29 CA CA2448561A patent/CA2448561C/en not_active Expired - Fee Related
- 2002-05-29 HR HRP20031091AA patent/HRP20031091B1/xx not_active IP Right Cessation
- 2002-05-29 US US10/478,721 patent/US6969723B2/en not_active Expired - Fee Related
- 2002-05-29 EE EEP200300574A patent/EE05304B1/xx not_active IP Right Cessation
- 2002-05-31 AR ARP020102036A patent/AR036074A1/es unknown
-
2003
- 2003-07-08 TN TNPCT/HU2002/000048A patent/TNSN03117A1/en unknown
- 2003-11-10 MA MA27388A patent/MA26236A1/fr unknown
- 2003-11-26 IS IS7052A patent/IS2773B/is unknown
- 2003-11-28 NO NO20035300A patent/NO327710B1/no not_active IP Right Cessation
- 2003-12-05 CO CO03107462A patent/CO5550457A2/es not_active Application Discontinuation
- 2003-12-19 BG BG108477A patent/BG108477A/bg unknown
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| HC1A | Change in name of an applicant in a eurasian application | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |