NZ529966A - Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands - Google Patents
Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligandsInfo
- Publication number
- NZ529966A NZ529966A NZ529966A NZ52996602A NZ529966A NZ 529966 A NZ529966 A NZ 529966A NZ 529966 A NZ529966 A NZ 529966A NZ 52996602 A NZ52996602 A NZ 52996602A NZ 529966 A NZ529966 A NZ 529966A
- Authority
- NZ
- New Zealand
- Prior art keywords
- group
- branched
- straight
- general formula
- stands
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title claims abstract description 9
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title claims description 32
- 239000002126 C01EB10 - Adenosine Substances 0.000 title claims description 18
- 229960005305 adenosine Drugs 0.000 title claims description 18
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 25
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 23
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
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- RBVFCHLFDTUSCP-UHFFFAOYSA-N n-[3-cyano-4-(thiophen-2-ylmethylamino)quinolin-2-yl]thiophene-3-carboxamide Chemical compound C1=CSC=C1C(=O)NC(C=1C#N)=NC2=CC=CC=C2C=1NCC1=CC=CS1 RBVFCHLFDTUSCP-UHFFFAOYSA-N 0.000 claims description 2
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0102279A HUP0102279A3 (en) | 2001-05-31 | 2001-05-31 | A3 antagonist amino-quinoline-derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
| HU0200774A HUP0200774A2 (hu) | 2002-03-01 | 2002-03-01 | Amino-piridin és amino-kinolin származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| PCT/HU2002/000048 WO2002096879A1 (en) | 2001-05-31 | 2002-05-29 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands |
Publications (1)
| Publication Number | Publication Date |
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| NZ529966A true NZ529966A (en) | 2004-11-26 |
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| NZ529966A NZ529966A (en) | 2001-05-31 | 2002-05-29 | Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands |
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| HUP0203976A3 (en) * | 2002-11-15 | 2004-08-30 | Sanofi Aventis | Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| CA2508165C (en) | 2002-12-06 | 2014-05-06 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| JP2007500689A (ja) * | 2003-07-31 | 2007-01-18 | サノフイ−アベンテイス | アミノキノリン誘導体およびアデノシンａ３リガンドとしてのそれらの使用 |
| RU2317290C2 (ru) * | 2003-07-31 | 2008-02-20 | Санофи-Авентис | Производные аминохинолина и их применение в качестве лигандов аденозина а3 |
| HUP0400812A2 (en) * | 2004-04-19 | 2006-02-28 | Sanofi Aventis | Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them |
| WO2006040645A1 (en) * | 2004-10-11 | 2006-04-20 | Ranbaxy Laboratories Limited | N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma |
| HUP0402371A2 (en) * | 2004-11-15 | 2006-09-28 | Sanofi Aventis | Novel 125-i-labeled amino-quinoline derivatives |
| KR100788161B1 (ko) * | 2006-01-06 | 2007-12-21 | (주)아모레퍼시픽 | 벤즈이미다졸 아민 유도체 또는 아미노퀴놀린 유도체를 함유하는 피부 미백용 조성물 |
| HUP0700395A2 (en) * | 2007-06-07 | 2009-03-02 | Sanofi Aventis | Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates |
| KR101106050B1 (ko) * | 2009-03-25 | 2012-01-18 | 한국과학기술연구원 | 아미노퀴놀린 화합물, 이의 제조 방법 및 이를 함유하는 의약 조성물 |
| WO2012030918A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Adenosine a3 receptor modulating compounds and methods of use thereof |
| WO2012166654A1 (en) * | 2011-05-27 | 2012-12-06 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
| CA2754237A1 (en) | 2011-05-27 | 2012-11-27 | The Regents Of The University Of California | Cyanoquinoline compounds having activity in correcting mutant-cftr processing and increasing ion transport and uses thereof |
| ES2578363B1 (es) | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
| CN108137547B (zh) | 2015-08-03 | 2021-11-12 | 百时美施贵宝公司 | 可用作TNFα调节剂的杂环化合物 |
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| DE265143C (enExample) | ||||
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| JPH01180518A (ja) * | 1988-01-12 | 1989-07-18 | Nissan Chem Ind Ltd | 配向処理剤 |
| IL111266A (en) * | 1993-10-22 | 2002-03-10 | Zeneca Ltd | 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| IL146105A (en) * | 1999-04-23 | 2005-09-25 | Tadeda Pharmaceutical Company | 5-pyridyl-1, 3-azole compounds, process for producing the same and use therefor |
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2002
- 2002-05-29 EP EP02732985A patent/EP1390349B1/en not_active Expired - Lifetime
- 2002-05-29 SK SK1414-2003A patent/SK14142003A3/sk unknown
- 2002-05-29 RS YUP-950/03A patent/RS95003A/sr unknown
- 2002-05-29 CZ CZ20033510A patent/CZ20033510A3/cs unknown
- 2002-05-29 MX MXPA03010870A patent/MXPA03010870A/es active IP Right Grant
- 2002-05-29 EA EA200301317A patent/EA006854B1/ru not_active IP Right Cessation
- 2002-05-29 US US10/478,721 patent/US6969723B2/en not_active Expired - Fee Related
- 2002-05-29 WO PCT/HU2002/000048 patent/WO2002096879A1/en not_active Ceased
- 2002-05-29 CN CNB02810840XA patent/CN1257160C/zh not_active Expired - Fee Related
- 2002-05-29 HR HRP20031091AA patent/HRP20031091B1/xx not_active IP Right Cessation
- 2002-05-29 RU RU2003137836/04A patent/RU2278112C2/ru not_active IP Right Cessation
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- 2002-05-29 NZ NZ529966A patent/NZ529966A/en not_active IP Right Cessation
- 2002-05-29 AU AU2002304358A patent/AU2002304358B2/en not_active Ceased
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- 2002-05-29 JP JP2003500059A patent/JP4409935B2/ja not_active Expired - Fee Related
- 2002-05-29 CA CA2448561A patent/CA2448561C/en not_active Expired - Fee Related
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- 2002-05-29 PL PL02366516A patent/PL366516A1/xx not_active Application Discontinuation
- 2002-05-31 AR ARP020102036A patent/AR036074A1/es unknown
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2003
- 2003-07-08 TN TNPCT/HU2002/000048A patent/TNSN03117A1/en unknown
- 2003-11-10 MA MA27388A patent/MA26236A1/fr unknown
- 2003-11-26 IS IS7052A patent/IS2773B/is unknown
- 2003-11-28 NO NO20035300A patent/NO327710B1/no not_active IP Right Cessation
- 2003-12-05 CO CO03107462A patent/CO5550457A2/es not_active Application Discontinuation
- 2003-12-19 BG BG108477A patent/BG108477A/bg unknown
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