EA005406B1 - Фармацевтические препараты на основе бибапцитида для визуализации и лечения тромбов - Google Patents

Фармацевтические препараты на основе бибапцитида для визуализации и лечения тромбов Download PDF

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Publication number
EA005406B1
EA005406B1 EA200000820A EA200000820A EA005406B1 EA 005406 B1 EA005406 B1 EA 005406B1 EA 200000820 A EA200000820 A EA 200000820A EA 200000820 A EA200000820 A EA 200000820A EA 005406 B1 EA005406 B1 EA 005406B1
Authority
EA
Eurasian Patent Office
Prior art keywords
bibapcytide
monocarboxylate
dicarboxylate
bibapcitide
imaging
Prior art date
Application number
EA200000820A
Other languages
English (en)
Russian (ru)
Other versions
EA200000820A1 (ru
Inventor
Ричард Т. Дин
Джон Листер-Джеймс
Original Assignee
Дайэтайд, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9802681A external-priority patent/GB9802681D0/en
Application filed by Дайэтайд, Инк. filed Critical Дайэтайд, Инк.
Publication of EA200000820A1 publication Critical patent/EA200000820A1/ru
Publication of EA005406B1 publication Critical patent/EA005406B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA200000820A 1998-02-06 1999-02-05 Фармацевтические препараты на основе бибапцитида для визуализации и лечения тромбов EA005406B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/020,086 US6028056A (en) 1998-02-06 1998-02-06 Pharmaceutical compositions for imaging and treating thrombi
GB9802681A GB9802681D0 (en) 1998-02-06 1998-02-06 Pharmaceutical compoations for imaging and treating thrombi
PCT/US1999/002583 WO1999039747A1 (en) 1998-02-06 1999-02-05 Bipapcitide-based pharmaceutical compositions for imaging and treating thrombi

Publications (2)

Publication Number Publication Date
EA200000820A1 EA200000820A1 (ru) 2001-02-26
EA005406B1 true EA005406B1 (ru) 2005-02-24

Family

ID=26313082

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000820A EA005406B1 (ru) 1998-02-06 1999-02-05 Фармацевтические препараты на основе бибапцитида для визуализации и лечения тромбов

Country Status (26)

Country Link
US (1) US6028056A (zh)
EP (1) EP1053027B1 (zh)
JP (1) JP2003532617A (zh)
KR (1) KR100452390B1 (zh)
CN (1) CN1103606C (zh)
AR (1) AR018546A1 (zh)
AT (1) ATE279214T1 (zh)
AU (1) AU761778B2 (zh)
BR (1) BR9908352A (zh)
CA (1) CA2319544C (zh)
DE (1) DE69921096T2 (zh)
DK (1) DK1053027T3 (zh)
EA (1) EA005406B1 (zh)
ES (1) ES2229681T3 (zh)
HK (1) HK1032198A1 (zh)
HU (1) HUP0100887A3 (zh)
IL (1) IL137076A (zh)
NO (1) NO20003881L (zh)
NZ (1) NZ505085A (zh)
PE (1) PE20000250A1 (zh)
PL (1) PL342253A1 (zh)
PT (1) PT1053027E (zh)
SI (1) SI1053027T1 (zh)
SK (1) SK284463B6 (zh)
TW (1) TWI246425B (zh)
WO (1) WO1999039747A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX352546B (es) 2011-08-17 2017-11-29 Piramal Imaging Sa Compuesto para la union de glicoproteina iib/iiia especifica a plaquetas y su uso para la formacion de imagenes de un trombo.
CN105189521A (zh) 2013-02-12 2015-12-23 拜耳医药股份公司 结合至血小板特异性糖蛋白IIb/IIIa的金属螯合化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023085A1 (en) * 1992-05-21 1993-11-25 Diatech, Inc. TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING
WO1995033496A1 (en) * 1994-06-03 1995-12-14 Diatech, Inc. Radiolabeled compounds for thrombus imaging

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023085A1 (en) * 1992-05-21 1993-11-25 Diatech, Inc. TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING
WO1995033496A1 (en) * 1994-06-03 1995-12-14 Diatech, Inc. Radiolabeled compounds for thrombus imaging

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D. A. PEARSON ET AL.: "Thrombus imaging using technetium-99m-labeled high-potency GPIIb/IIIa receptor antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1 January 1996, pages 1372-1382, XP002080979, see page 1377, see paragraph RESULTS AND DISCUSSION, see paragraph CONCLUSION *
KNIGHT L. C. ET AL.: "THROMBUS IMAGING WITH TECHNETIUM-99M SYNTHETIC PEPTIDES BASED UPON THE BINDING DOMAIN OF A MONOCLONAL ANTIBODY TO ACTIVATED PLATELETS", JOURNAL OF NUCLEAR MEDICINE, vol. 35, no. 2, 1 February 1994, pages 282-288, XP000677312, see the whole document *
LASTORIA S. ET AL.: "IMAGING DELLA TROMBOEMBOLIA MEDIANTE SCINTIGRAFIA CON PEPTIDE SINTETICO P280 MARCATO CON 99m-TECNEZIO", RADIOLOGIA MEDICA, VOL. 90, NO. 6, PAGE(S) 812-819,1995, XP002105310, IT, see abstract, see page 813, right-hand column - page 814, left-hand column, see figure 1, see paragraph CONCLUSIONI *
LISTER-JAMES J.: "A structure-activity-relationship (SAR) study of GPIIb/IIIa receptor-binding peptides radiolabeled with Tc-99m for imaging thromboembolism", JOURNAL OF NUCLEAR MEDICINE, 1994, VOL. 35, PAGE(S) 257P, ABSTRACT NO. 1056, May 1994, XP002105312, see abstract & 41ST ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, ORLANDO, FLORIDA, USA, 5-8 June 1994 *
MUTO P. ET AL.: "Detecting deep venous thrombosis with technetium-99m-labeled synthetic peptide P280.", J NUCL MED, AUG 1995, VOL. 36, NO. 8, PAGE(S) 1384-91, XP002105311, see abstract, see figures 1, 3, see page 1389 - page 1390 *
PHAM H. L. ET AL.: "The detection of venous thrombosis (VT) with Tc-99m P280 labeled synthetic peptide", JOURNAL OF NUCLEAR MEDICINE, 1995, VOL. 36, PAGE(S) 89P, ABSTRACT NO. 361, May 1995, XP002105313, see abstract & 42ND ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, MINNEAPOLIS, MINNESOTA, USA, 12-15 June 1995 *

Also Published As

Publication number Publication date
TWI246425B (en) 2006-01-01
PL342253A1 (en) 2001-06-04
NO20003881D0 (no) 2000-07-28
BR9908352A (pt) 2000-11-28
IL137076A0 (en) 2001-06-14
EP1053027B1 (en) 2004-10-13
PT1053027E (pt) 2005-01-31
NO20003881L (no) 2000-07-28
CA2319544C (en) 2006-07-04
AU2660499A (en) 1999-08-23
ES2229681T3 (es) 2005-04-16
AU761778B2 (en) 2003-06-12
SK284463B6 (sk) 2005-04-01
SI1053027T1 (en) 2005-04-30
NZ505085A (en) 2002-10-25
PE20000250A1 (es) 2000-06-02
CA2319544A1 (en) 1999-08-12
HUP0100887A3 (en) 2003-08-28
ATE279214T1 (de) 2004-10-15
DK1053027T3 (da) 2005-01-17
KR20010040676A (ko) 2001-05-15
DE69921096D1 (de) 2004-11-18
EP1053027A1 (en) 2000-11-22
CN1103606C (zh) 2003-03-26
KR100452390B1 (ko) 2004-10-08
WO1999039747A1 (en) 1999-08-12
JP2003532617A (ja) 2003-11-05
HK1032198A1 (en) 2001-07-13
SK11392000A3 (sk) 2001-03-12
US6028056A (en) 2000-02-22
AR018546A1 (es) 2001-11-28
DE69921096T2 (de) 2006-02-02
IL137076A (en) 2004-08-31
HUP0100887A2 (hu) 2001-06-28
EA200000820A1 (ru) 2001-02-26
CN1290179A (zh) 2001-04-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU