EA004180B1 - Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз - Google Patents

Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз Download PDF

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Publication number
EA004180B1
EA004180B1 EA200000578A EA200000578A EA004180B1 EA 004180 B1 EA004180 B1 EA 004180B1 EA 200000578 A EA200000578 A EA 200000578A EA 200000578 A EA200000578 A EA 200000578A EA 004180 B1 EA004180 B1 EA 004180B1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
amino
aminocarbonylmethyl
pyridinone
guanidinooxyethyl
Prior art date
Application number
EA200000578A
Other languages
English (en)
Russian (ru)
Other versions
EA200000578A1 (ru
Inventor
Тианбао Лу
Томас П. Маркоутэн
Коллин Сайедем
Брюс Э. Томкзук
Original Assignee
3-Дименшенл Фамэсьютикэлс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3-Дименшенл Фамэсьютикэлс, Инк. filed Critical 3-Дименшенл Фамэсьютикэлс, Инк.
Publication of EA200000578A1 publication Critical patent/EA200000578A1/ru
Publication of EA004180B1 publication Critical patent/EA004180B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
EA200000578A 1997-11-26 1998-11-25 Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз EA004180B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6647597P 1997-11-26 1997-11-26
US6732497P 1997-12-05 1997-12-05
US7910798P 1998-03-23 1998-03-23
PCT/US1998/025185 WO1999026926A1 (en) 1997-11-26 1998-11-25 Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Publications (2)

Publication Number Publication Date
EA200000578A1 EA200000578A1 (ru) 2001-02-26
EA004180B1 true EA004180B1 (ru) 2004-02-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000578A EA004180B1 (ru) 1997-11-26 1998-11-25 Гетероарильные производные аминогуанидинов и алкоксигуанидинов (варианты), способ их получения и их применение в качестве ингибиторов протеаз

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US (8) US6037356A (US06566379-20030520-C00036.png)
EP (1) EP1036063B1 (US06566379-20030520-C00036.png)
JP (1) JP2001524467A (US06566379-20030520-C00036.png)
AR (1) AR016702A1 (US06566379-20030520-C00036.png)
AT (1) ATE344246T1 (US06566379-20030520-C00036.png)
AU (1) AU751412B2 (US06566379-20030520-C00036.png)
BR (1) BR9815325A (US06566379-20030520-C00036.png)
CA (1) CA2311969A1 (US06566379-20030520-C00036.png)
DE (1) DE69836346T2 (US06566379-20030520-C00036.png)
EA (1) EA004180B1 (US06566379-20030520-C00036.png)
ES (1) ES2274587T3 (US06566379-20030520-C00036.png)
PL (1) PL340560A1 (US06566379-20030520-C00036.png)
TW (1) TWI222441B (US06566379-20030520-C00036.png)
WO (1) WO1999026926A1 (US06566379-20030520-C00036.png)

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Also Published As

Publication number Publication date
AR016702A1 (es) 2001-07-25
US6472399B2 (en) 2002-10-29
US6350764B2 (en) 2002-02-26
EA200000578A1 (ru) 2001-02-26
JP2001524467A (ja) 2001-12-04
US20030225115A1 (en) 2003-12-04
DE69836346D1 (de) 2006-12-14
US20030087921A1 (en) 2003-05-08
BR9815325A (pt) 2001-12-26
US20020007070A1 (en) 2002-01-17
AU1799199A (en) 1999-06-15
CA2311969A1 (en) 1999-06-03
US20020086872A1 (en) 2002-07-04
TWI222441B (en) 2004-10-21
AU751412B2 (en) 2002-08-15
US6245763B1 (en) 2001-06-12
US6037356A (en) 2000-03-14
WO1999026926A1 (en) 1999-06-03
ATE344246T1 (de) 2006-11-15
EP1036063B1 (en) 2006-11-02
EP1036063A1 (en) 2000-09-20
US20060211719A1 (en) 2006-09-21
US7402586B2 (en) 2008-07-22
US7029654B2 (en) 2006-04-18
DE69836346T2 (de) 2007-05-24
US6566379B1 (en) 2003-05-20
US20040106633A1 (en) 2004-06-03
ES2274587T3 (es) 2007-05-16
US6706021B2 (en) 2004-03-16
PL340560A1 (en) 2001-02-12

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