DOP2020000189A - Proceso para la hidrólisis de ésteres carboxílicos de quinolona - Google Patents

Proceso para la hidrólisis de ésteres carboxílicos de quinolona

Info

Publication number
DOP2020000189A
DOP2020000189A DO2020000189A DO2020000189A DOP2020000189A DO P2020000189 A DOP2020000189 A DO P2020000189A DO 2020000189 A DO2020000189 A DO 2020000189A DO 2020000189 A DO2020000189 A DO 2020000189A DO P2020000189 A DOP2020000189 A DO P2020000189A
Authority
DO
Dominican Republic
Prior art keywords
quinolone
hydrolysis
mole
formula
carboxyl esters
Prior art date
Application number
DO2020000189A
Other languages
English (en)
Inventor
Fey Peter
Berwe Mathias
Wischnat Ralf
Longerich Markus
Dietzel Antje
Wirths Jörg
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of DOP2020000189A publication Critical patent/DOP2020000189A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Chemistry (AREA)

Abstract

Los ésteres del ácido carboxílico de quinolona la fórmula general (II) se hidrolizan para dar ácidos quinoloncarboxílicos la fórmula general (I): (II) (I) El procedimiento comprende la etapa A): A) Reacción de compuestos de fórmula (II) con una mezcla que contiene ácido acético, ácido sulfúrico y agua En la etapa A) se utilizan por mol compuestos de la fórmula (II) = 30 a = 40 mol de ácido acético, = 0.3 a = 1 mol de ácido sulfúrico y = 0,9 a = 2.5 mol de agua. El procedimiento es particularmente adecuado para la síntesis del intermedio (I) en la síntesis de pradofloxacina.
DO2020000189A 2018-04-25 2020-10-21 Proceso para la hidrólisis de ésteres carboxílicos de quinolona DOP2020000189A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18169170 2018-04-25
PCT/EP2019/060072 WO2019206798A1 (de) 2018-04-25 2019-04-18 Verfahren zur hydrolyse von chinoloncarbonsäureestern

Publications (1)

Publication Number Publication Date
DOP2020000189A true DOP2020000189A (es) 2020-11-30

Family

ID=62063375

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2020000189A DOP2020000189A (es) 2018-04-25 2020-10-21 Proceso para la hidrólisis de ésteres carboxílicos de quinolona

Country Status (23)

Country Link
US (1) US11332444B2 (es)
EP (1) EP3784656B1 (es)
JP (1) JP7410050B2 (es)
KR (1) KR20210005079A (es)
CN (1) CN111989314B (es)
AU (1) AU2019260015B2 (es)
BR (1) BR112020021635A2 (es)
CA (1) CA3098060A1 (es)
CL (1) CL2020002735A1 (es)
CO (1) CO2020013343A2 (es)
CR (1) CR20200502A (es)
DK (1) DK3784656T3 (es)
DO (1) DOP2020000189A (es)
ES (1) ES2956316T3 (es)
IL (1) IL278175A (es)
MX (1) MX2020011280A (es)
PE (1) PE20201257A1 (es)
PH (1) PH12020551750A1 (es)
PT (1) PT3784656T (es)
SG (1) SG11202010544TA (es)
TW (1) TW202003470A (es)
UY (1) UY38201A (es)
WO (1) WO2019206798A1 (es)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3420798A1 (de) 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3702393A1 (de) 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
CZ291251B6 (cs) 1996-02-23 2003-01-15 Bayer Aktiengesellschaft Popřípadě substituované 8-kyan-1-cyklopropyl-7-(2,8-diazabicyklo-[4,3,0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolinkarboxylové kyseliny a jejich deriváty, způsob jejich výroby, léčiva tyto látka obsahující a jejich pouľití
DE19652239A1 (de) 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
CN1338455A (zh) * 2000-08-16 2002-03-06 大连绿源实业有限公司 新的喹诺酮羧酸的制备方法
DE10108750A1 (de) * 2001-02-23 2002-09-05 Bayer Ag Verbessertes Verfahren zur Herstellung von Fluorchinoloncarbonsäuren
DE10134719A1 (de) 2001-07-17 2003-02-06 Bayer Ag Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze
DE10224086A1 (de) 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DE10312346A1 (de) 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10337191A1 (de) 2003-08-13 2005-03-17 Bayer Healthcare Ag Neue Verwendung von Chinolon-Antibiotika
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
CN105622632B (zh) * 2014-10-29 2018-06-29 浙江海森药业股份有限公司 一种喹诺酮类化合物及其制备方法

Also Published As

Publication number Publication date
ES2956316T3 (es) 2023-12-19
IL278175A (en) 2020-11-30
AU2019260015A1 (en) 2020-12-17
EP3784656B1 (de) 2023-06-28
WO2019206798A1 (de) 2019-10-31
UY38201A (es) 2019-11-29
PE20201257A1 (es) 2020-11-16
AU2019260015B2 (en) 2024-07-11
CR20200502A (es) 2020-12-22
CA3098060A1 (en) 2019-10-31
JP7410050B2 (ja) 2024-01-09
US20210078950A1 (en) 2021-03-18
CN111989314A (zh) 2020-11-24
PT3784656T (pt) 2023-09-22
JP2021521238A (ja) 2021-08-26
US11332444B2 (en) 2022-05-17
CL2020002735A1 (es) 2021-02-26
EP3784656A1 (de) 2021-03-03
BR112020021635A2 (pt) 2021-01-26
TW202003470A (zh) 2020-01-16
MX2020011280A (es) 2020-11-13
PH12020551750A1 (en) 2021-07-26
KR20210005079A (ko) 2021-01-13
CN111989314B (zh) 2024-04-30
DK3784656T3 (da) 2023-09-18
CO2020013343A2 (es) 2020-10-30
SG11202010544TA (en) 2020-11-27

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