EA200900897A1 - Способ производства 6-[3-(1-адамантил)-4-метоксифенил]-2-нафтойной кислоты - Google Patents
Способ производства 6-[3-(1-адамантил)-4-метоксифенил]-2-нафтойной кислотыInfo
- Publication number
- EA200900897A1 EA200900897A1 EA200900897A EA200900897A EA200900897A1 EA 200900897 A1 EA200900897 A1 EA 200900897A1 EA 200900897 A EA200900897 A EA 200900897A EA 200900897 A EA200900897 A EA 200900897A EA 200900897 A1 EA200900897 A1 EA 200900897A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- adamantyl
- methoxyphenyl
- naptoic
- manufacture
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Способ получения 6-[3-(1-адамантил)-4-метоксифенил]-2-нафтойной кислоты на основе однореакторного ("one pot") процесса синтеза, включающий прямой синтез производного борной кислоты из 2-(1-адамантил)-4-броманизола и циклоборанов с последующим сочетанием Suzuki-Miyaura с 6-галогеннафтенатами и щелочной гидролиз продукта реакции в этиленгликоле или 1,2-пропандиоле.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LVP-06-149A LV13736B (en) | 2006-12-28 | 2006-12-28 | Method for manufacturing 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid |
PCT/EP2007/064643 WO2008086942A2 (en) | 2006-12-28 | 2007-12-28 | A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200900897A1 true EA200900897A1 (ru) | 2010-02-26 |
Family
ID=39636414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200900897A EA200900897A1 (ru) | 2006-12-28 | 2007-12-28 | Способ производства 6-[3-(1-адамантил)-4-метоксифенил]-2-нафтойной кислоты |
Country Status (7)
Country | Link |
---|---|
US (1) | US8119835B2 (ru) |
EP (1) | EP2139839B1 (ru) |
AT (1) | ATE551316T1 (ru) |
EA (1) | EA200900897A1 (ru) |
LV (1) | LV13736B (ru) |
UA (1) | UA97509C2 (ru) |
WO (1) | WO2008086942A2 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013004814A1 (en) * | 2011-07-07 | 2013-01-10 | Universite Catholique De Louvain | Method of carrying out cc-coupling reactions using oxide supported pd-catalysts |
US9963439B2 (en) | 2013-08-20 | 2018-05-08 | University Of Washington Through Its Center For Commercialization | Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase |
WO2018213609A1 (en) * | 2017-05-17 | 2018-11-22 | Ausubel Frederick M | Antibiotic compounds |
CN111333496B (zh) * | 2020-05-02 | 2023-10-13 | 武汉诺安药业有限公司 | 一种阿达帕林的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU744173B2 (en) * | 1997-08-28 | 2002-02-14 | Advanced Life Sciences Inc. | Robustaflavone, intermediates and analogues and method for preparation thereof |
JP2979139B2 (ja) * | 1998-03-11 | 1999-11-15 | 東北大学長 | L−パラボロノフェニルアラニンの製造方法 |
AR037714A1 (es) * | 2001-12-06 | 2004-12-01 | Maxia Pharmaceuticals Inc | Derivados de tiazolidinona y oxazolidinona 2-sustituidos para la inhibicion de fosfatasas y el tratamiento de cancer |
WO2005108338A1 (en) * | 2004-05-03 | 2005-11-17 | Auspex Pharmaceuticals | Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
ITMI20050550A1 (it) * | 2005-04-01 | 2006-10-02 | Dipharma Spa | Procedimento per la preparazione di adapalene |
-
2006
- 2006-12-28 LV LVP-06-149A patent/LV13736B/lv unknown
-
2007
- 2007-12-28 US US12/448,672 patent/US8119835B2/en not_active Expired - Fee Related
- 2007-12-28 UA UAA200907981A patent/UA97509C2/ru unknown
- 2007-12-28 EA EA200900897A patent/EA200900897A1/ru unknown
- 2007-12-28 AT AT07870214T patent/ATE551316T1/de active
- 2007-12-28 WO PCT/EP2007/064643 patent/WO2008086942A2/en active Application Filing
- 2007-12-28 EP EP07870214A patent/EP2139839B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20100076219A1 (en) | 2010-03-25 |
LV13736B (en) | 2008-09-20 |
WO2008086942A3 (en) | 2008-11-06 |
EP2139839B1 (en) | 2012-03-28 |
US8119835B2 (en) | 2012-02-21 |
WO2008086942A2 (en) | 2008-07-24 |
UA97509C2 (ru) | 2012-02-27 |
ATE551316T1 (de) | 2012-04-15 |
EP2139839A2 (en) | 2010-01-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1124753T1 (el) | Συνθεση ενωσεων βορονικων εστερων και οξεων | |
EP1995228A4 (en) | POLYFLUORALKYL ALCOHOL BZW. (METH) ACRYLIC ACID DERIVATIVE AND MANUFACTURING METHOD | |
BRPI0609496C8 (pt) | derivado do éster do ácido propiônico | |
EA200900897A1 (ru) | Способ производства 6-[3-(1-адамантил)-4-метоксифенил]-2-нафтойной кислоты | |
EA200901563A1 (ru) | Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой | |
MY153851A (en) | Carbonylation process for the production of methyl acetate | |
CY1115623T1 (el) | Μεθοδος για την συνθεση 7,8-διμεθοξυ-1,3-διϋδρο-2η-3-βενζαζεπιν-2-ονης και εφαρμογη αυτης στη συνθεση της ιβαμπραδινης καθως επισης αλατων προσθηκης αυτης με ενα φαρμακευτικως αποδεκτο οξυ | |
ATE449098T1 (de) | Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole | |
TW200704752A (en) | Synthesis process | |
CY1111242T1 (el) | Νεα μεθοδος παρασκευης 6-[3-(1-αδαμαντυλο)-4-μεθοξυφαινυλ0]-2-ναφθοϊκου οξεος | |
CY1113779T1 (el) | Διαδικασια παραγωγης bepromoline | |
ATE407931T1 (de) | Verbessertes verfahren zur herstellung von moxonidine | |
WO2012025935A3 (en) | Process for preparing 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one and its use for preparing deferasirox | |
TN2012000361A1 (en) | Process for the preparation of 2-(cyclohexylmethyl)-n-{2- [(2s)-1-methylpyrrolidin-2-yl]ethyl}-1, 2, 3, 4- tetrahydroisoquinoline-7-sulfonamide | |
BR112013002990A2 (pt) | métodos de produção de 6-hidroxiexanofenona e ácido 5-benzoilpentanoico e mono ou diésteres dos mesmos | |
WO2008150487A3 (en) | Synthesis of half esters | |
ATE353868T1 (de) | Herstellungsverfahren für optisch reine 2-(4- hydroxyphenoxy)-propionsäureverbindungen | |
ITMI20041271A1 (it) | Processo di preparazione di gabapentina | |
FR2912131B1 (fr) | Procede pour l'obtention d'acide propionique | |
EA200900898A1 (ru) | Способ получения 6-[3-(1-адамантил)-4-метоксифенил]-2-нафтойной кислоты | |
WO2009116075A3 (en) | Process for preparation of tazarotene | |
ATE479649T1 (de) | Zwischenprodukte und verfahren zur herstellung aromatischer derivate von 1-adamantan | |
CO2020013343A2 (es) | Proceso para la hidrólisis de ésteres carboxílicos de quinolona | |
DE602006011167D1 (de) | Verfahren zur herstellung von 3,4-dioxosubstituierten aromatischen aldehyden | |
RU2010148895A (ru) | Способ получения гидроксипроизводных стирилхинолинов |