CO2020013343A2 - Proceso para la hidrólisis de ésteres carboxílicos de quinolona - Google Patents

Proceso para la hidrólisis de ésteres carboxílicos de quinolona

Info

Publication number
CO2020013343A2
CO2020013343A2 CONC2020/0013343A CO2020013343A CO2020013343A2 CO 2020013343 A2 CO2020013343 A2 CO 2020013343A2 CO 2020013343 A CO2020013343 A CO 2020013343A CO 2020013343 A2 CO2020013343 A2 CO 2020013343A2
Authority
CO
Colombia
Prior art keywords
mol
quinolone carboxylic
hydrolysis
carboxylic esters
formula
Prior art date
Application number
CONC2020/0013343A
Other languages
English (en)
Inventor
Peter Fey
Mathias Berwe
Jörg Wirths
Ralf Wischnat
Markus Longerich
Antje Dietzel
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of CO2020013343A2 publication Critical patent/CO2020013343A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

Los ésteres del ácido carboxílico de quinolona la fórmula general (II) se hidrolizan para dar ácidos quinoloncarboxílicos la fórmula general (I): (II) (I) El procedimiento comprende la etapa A): A) Reacción de compuestos de fórmula (II) con una mezcla que contiene ácido acético, ácido sulfúrico y agua En la etapa A) se utilizan por mol compuestos de la fórmula (II) ≥ 30 a ≤ 40 mol de ácido acético, ≥ 0.3 a ≤ 1 mol de ácido sulfúrico y ≥ 0,9 a ≤ 2.5 mol de agua. El procedimiento es particularmente adecuado para la síntesis del intermedio (I) en la síntesis de pradofloxacina.
CONC2020/0013343A 2018-04-25 2020-10-23 Proceso para la hidrólisis de ésteres carboxílicos de quinolona CO2020013343A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18169170 2018-04-25
PCT/EP2019/060072 WO2019206798A1 (de) 2018-04-25 2019-04-18 Verfahren zur hydrolyse von chinoloncarbonsäureestern

Publications (1)

Publication Number Publication Date
CO2020013343A2 true CO2020013343A2 (es) 2020-10-30

Family

ID=62063375

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0013343A CO2020013343A2 (es) 2018-04-25 2020-10-23 Proceso para la hidrólisis de ésteres carboxílicos de quinolona

Country Status (23)

Country Link
US (1) US11332444B2 (es)
EP (1) EP3784656B1 (es)
JP (1) JP7410050B2 (es)
KR (1) KR20210005079A (es)
CN (1) CN111989314B (es)
AU (1) AU2019260015B2 (es)
BR (1) BR112020021635A2 (es)
CA (1) CA3098060A1 (es)
CL (1) CL2020002735A1 (es)
CO (1) CO2020013343A2 (es)
CR (1) CR20200502A (es)
DK (1) DK3784656T3 (es)
DO (1) DOP2020000189A (es)
ES (1) ES2956316T3 (es)
IL (1) IL278175A (es)
MX (1) MX2020011280A (es)
PE (1) PE20201257A1 (es)
PH (1) PH12020551750A1 (es)
PT (1) PT3784656T (es)
SG (1) SG11202010544TA (es)
TW (1) TW202003470A (es)
UY (1) UY38201A (es)
WO (1) WO2019206798A1 (es)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3702393A1 (de) 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
ATE228130T1 (de) 1996-02-23 2002-12-15 Bayer Ag Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo- 4.3.0)-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3- hinolincarbonsäuren und ihre derivate
DE19652239A1 (de) 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
CN1338455A (zh) * 2000-08-16 2002-03-06 大连绿源实业有限公司 新的喹诺酮羧酸的制备方法
DE10108750A1 (de) 2001-02-23 2002-09-05 Bayer Ag Verbessertes Verfahren zur Herstellung von Fluorchinoloncarbonsäuren
DE10134719A1 (de) 2001-07-17 2003-02-06 Bayer Ag Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze
DE10224086A1 (de) 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DE10312346A1 (de) 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10337191A1 (de) 2003-08-13 2005-03-17 Bayer Healthcare Ag Neue Verwendung von Chinolon-Antibiotika
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
CN105622632B (zh) * 2014-10-29 2018-06-29 浙江海森药业股份有限公司 一种喹诺酮类化合物及其制备方法

Also Published As

Publication number Publication date
JP2021521238A (ja) 2021-08-26
CA3098060A1 (en) 2019-10-31
DOP2020000189A (es) 2020-11-30
PE20201257A1 (es) 2020-11-16
SG11202010544TA (en) 2020-11-27
MX2020011280A (es) 2020-11-13
JP7410050B2 (ja) 2024-01-09
KR20210005079A (ko) 2021-01-13
IL278175A (en) 2020-11-30
TW202003470A (zh) 2020-01-16
CL2020002735A1 (es) 2021-02-26
AU2019260015B2 (en) 2024-07-11
UY38201A (es) 2019-11-29
CN111989314B (zh) 2024-04-30
EP3784656B1 (de) 2023-06-28
PT3784656T (pt) 2023-09-22
CN111989314A (zh) 2020-11-24
US20210078950A1 (en) 2021-03-18
EP3784656A1 (de) 2021-03-03
DK3784656T3 (da) 2023-09-18
BR112020021635A2 (pt) 2021-01-26
US11332444B2 (en) 2022-05-17
ES2956316T3 (es) 2023-12-19
AU2019260015A1 (en) 2020-12-17
PH12020551750A1 (en) 2021-07-26
WO2019206798A1 (de) 2019-10-31
CR20200502A (es) 2020-12-22

Similar Documents

Publication Publication Date Title
AR046567A1 (es) Procesos de preparacion de esteres de acidos mono, di o policarboxilicos
AR092278A1 (es) Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
ECSP10010405A (es) Procesos e intermediarios para la preparacion de derivados de acido 5-bifenil-4-il-2-metilpentanoico
BR0103890A (pt) Processo para preparação de ésteres de ácido carboxìlico
NZ595817A (en) Processes and intermediates for the preparation of protease inhibitors
PA8503801A1 (es) Procedimiento para la obtencion de 1, 2, 3, 4-tetrahidroquinolinas 4-carboxiamino-2-sustituidas
PH12019502041A1 (en) Novel ester compounds, method for the production thereof and use thereof
DK1506159T3 (da) Fremgangsmåde til fremstilling af 2-(4-N,N-diethylamino-2-hydroxybenzoyl)benzoesyre-n-hexyl-ester
MX2012003914A (es) Metodo para la fabricacion de acidos aminohidroxi difosfonicos.
CO2020013343A2 (es) Proceso para la hidrólisis de ésteres carboxílicos de quinolona
AR084037A1 (es) Proceso para la preparacion del nebivolol
AR084344A1 (es) Procedimiento para la produccion de esteres alquilicos de bendamustina, bendamustina, y derivados del mismo
IN2014MN01086A (es)
DE602007007824D1 (de) Verfahren zur herstellung von abacavir
ATE551316T1 (de) Verfahren zur herstellung von 6-ä3-(1-adamantyl)- 4-methoxyphenylü-2-naphtoesäure
PE20030929A1 (es) Acidos 3-(imidazolil)-2-alcoxipropanoicos
MX2020005544A (es) Metodo para preparar acetato de salicilamina.
MX2012000278A (es) Procedimiento para la preparacion de acidos (2,4-dimetilbifenil-3- il)aceticos, sus esteres, asi como compuestos intermedios.
FR2974084B1 (fr) Procede de fabrication de phtalate de dialkyle
GB397212A (en) Improvements in the manufacture of optically active menthols
HUP0200692A2 (hu) Javított eljárás fluor-kinolon-karbonsavak előállítására
PL419800A1 (pl) Kwas (4-tert-butylo-1-etenylocykloheks-1-ylo)octowy i sposób jego wytwarzania
HUP0303170A2 (hu) Eljárás 2-kumaron és szubsztituált 2-kumaronok előállítására
MX2024007336A (es) Inhibidores de dhodh que contienen un bioester de acido carboxilico.
MX2022010709A (es) Proceso para la preparacion de amidas y carboxilatos del acido 5-cloro-3-alquilsulfanilo-piridina-2-carboxilico.