DOP2012000017A - Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodo-fenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos - Google Patents

Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodo-fenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos

Info

Publication number
DOP2012000017A
DOP2012000017A DO2012000017A DO2012000017A DOP2012000017A DO P2012000017 A DOP2012000017 A DO P2012000017A DO 2012000017 A DO2012000017 A DO 2012000017A DO 2012000017 A DO2012000017 A DO 2012000017A DO P2012000017 A DOP2012000017 A DO P2012000017A
Authority
DO
Dominican Republic
Prior art keywords
sulfonamide
difluoro
fluoro
preparation
dihydroxipropil
Prior art date
Application number
DO2012000017A
Other languages
English (en)
Inventor
Andreas Maderna
Jean-Michel Vernier
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2012000017(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of DOP2012000017A publication Critical patent/DOP2012000017A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se relaciona con la preparación de (R)-N-(3,4-difluoro- 2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)- 1 -(2,3 -dihidroxipropil)ciclopropan- 1 - sulfonamida y (S)-N-(3 ,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)- 1 - (2,3 -dihidroxipropil)ciclopropan- 1 -sulfonamida.
DO2012000017A 2009-07-24 2012-01-24 Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodo-fenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos DOP2012000017A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22850909P 2009-07-24 2009-07-24
US22850109P 2009-07-24 2009-07-24

Publications (1)

Publication Number Publication Date
DOP2012000017A true DOP2012000017A (es) 2012-05-15

Family

ID=42830488

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2012000017A DOP2012000017A (es) 2009-07-24 2012-01-24 Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodo-fenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y derivados protegidos de los mismos

Country Status (32)

Country Link
US (3) US8513443B2 (es)
EP (1) EP2462111B1 (es)
JP (1) JP5776115B2 (es)
KR (1) KR101763437B1 (es)
CN (2) CN102471246B (es)
AR (1) AR079183A1 (es)
AU (1) AU2010275780B2 (es)
BR (1) BR112012001592A2 (es)
CA (2) CA2990097A1 (es)
CL (1) CL2012000192A1 (es)
CO (1) CO6491075A2 (es)
CR (1) CR20120044A (es)
CU (1) CU24113B1 (es)
DO (1) DOP2012000017A (es)
EA (1) EA023623B1 (es)
EC (1) ECSP12011621A (es)
GT (1) GT201200017A (es)
HK (2) HK1171218A1 (es)
HN (1) HN2012000142A (es)
IL (1) IL217312A (es)
IN (1) IN2012DN00696A (es)
MA (1) MA33452B1 (es)
MX (2) MX2012001063A (es)
MY (1) MY160421A (es)
NZ (1) NZ597738A (es)
PE (1) PE20120573A1 (es)
PH (1) PH12014500158A1 (es)
SG (1) SG177535A1 (es)
TN (1) TN2012000027A1 (es)
TW (1) TWI524890B (es)
UY (1) UY32800A (es)
WO (1) WO2011009541A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI524890B (zh) 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
MX362823B (es) * 2011-05-27 2019-02-18 Ardea Biosciences Inc Star Sintesis quiral de n-{3,4-difluoro-2-[(2-fluoro-4-yodofenil)amino] -6-metoxifenil}-1-[2,3-dihidroxi-propil]ciclopropanosulfonamidas.
JPWO2013094546A1 (ja) * 2011-12-19 2015-04-27 住友化学株式会社 スルホン酸塩の製造方法
EP2848246A1 (en) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
SI1912636T1 (sl) * 2005-07-21 2014-08-29 Ardea Biosciences, Inc. N-(arilamino)-sulfonamidni inhibitorji MEK
WO2007121269A2 (en) * 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors
ATE483463T1 (de) * 2006-04-18 2010-10-15 Ardea Biosciences Inc Pyridonsulfonamide und pyridonsulfamide als mek- hemmer
UA99731C2 (ru) * 2007-07-30 2012-09-25 Ардеа Биосайенсис, Инк Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение
CA2720671A1 (en) * 2008-04-14 2009-10-22 Ardea Biosciences, Inc. Compositions and methods for preparing and using same
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
US20130261320A1 (en) 2013-10-03
CO6491075A2 (es) 2012-07-31
AU2010275780A1 (en) 2012-02-02
MX2012001063A (es) 2012-03-26
AR079183A1 (es) 2012-01-04
CN103848808A (zh) 2014-06-11
US20120178946A1 (en) 2012-07-12
HK1198364A1 (zh) 2015-04-10
CU20120014A7 (es) 2012-06-21
HK1171218A1 (en) 2013-03-22
MA33452B1 (fr) 2012-07-03
KR20120032536A (ko) 2012-04-05
UY32800A (es) 2011-01-31
IL217312A0 (en) 2012-02-29
US20150274651A1 (en) 2015-10-01
CN102471246A (zh) 2012-05-23
PH12014500158B1 (en) 2015-09-07
CN102471246B (zh) 2015-08-26
CA2768788C (en) 2018-01-09
CL2012000192A1 (es) 2012-10-05
CA2768788A1 (en) 2011-01-27
GT201200017A (es) 2013-12-19
EP2462111A1 (en) 2012-06-13
TN2012000027A1 (en) 2013-09-19
JP2013500242A (ja) 2013-01-07
PH12014500158A1 (en) 2015-09-07
TW201113017A (en) 2011-04-16
KR101763437B1 (ko) 2017-07-31
IN2012DN00696A (es) 2015-06-19
JP5776115B2 (ja) 2015-09-09
CU24113B1 (es) 2015-08-27
US8513443B2 (en) 2013-08-20
CN103848808B (zh) 2016-02-10
BR112012001592A2 (pt) 2016-03-08
MY160421A (en) 2017-03-15
EA023623B1 (ru) 2016-06-30
NZ597738A (en) 2014-03-28
HN2012000142A (es) 2015-06-08
ECSP12011621A (es) 2012-02-29
WO2011009541A1 (en) 2011-01-27
CA2990097A1 (en) 2011-01-27
EP2462111B1 (en) 2016-03-30
US8884058B2 (en) 2014-11-11
SG177535A1 (en) 2012-03-29
US9296686B2 (en) 2016-03-29
TWI524890B (zh) 2016-03-11
AU2010275780B2 (en) 2015-10-22
MX344965B (es) 2017-01-12
CR20120044A (es) 2012-03-12
EA201200175A1 (ru) 2012-12-28
PE20120573A1 (es) 2012-05-17
IL217312A (en) 2017-02-28

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