BR112012001592A2 - preparação de (r) e (s) -n- (3,4-difluoro-2-(2-fluoro-4-iodofe-nilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopro-pano-1-sulfonamida e derivados protegidos dos mesmos. - Google Patents
preparação de (r) e (s) -n- (3,4-difluoro-2-(2-fluoro-4-iodofe-nilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopro-pano-1-sulfonamida e derivados protegidos dos mesmos.Info
- Publication number
- BR112012001592A2 BR112012001592A2 BR112012001592A BR112012001592A BR112012001592A2 BR 112012001592 A2 BR112012001592 A2 BR 112012001592A2 BR 112012001592 A BR112012001592 A BR 112012001592A BR 112012001592 A BR112012001592 A BR 112012001592A BR 112012001592 A2 BR112012001592 A2 BR 112012001592A2
- Authority
- BR
- Brazil
- Prior art keywords
- iodophenylamino
- dihydroxypropyl
- cyclopropane
- sulfonamide
- difluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22850109P | 2009-07-24 | 2009-07-24 | |
| US22850909P | 2009-07-24 | 2009-07-24 | |
| PCT/EP2010/004222 WO2011009541A1 (en) | 2009-07-24 | 2010-07-10 | Preparation of (r)- and (s)-n-(3, 4-difluoro-2-(2-fluoro-4-iodophenylamino)--6-methoxyphenyl) -1- (2, 3-dihydroxypropyl)cyclopropane-1-sulfonamide and protected derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012001592A2 true BR112012001592A2 (pt) | 2016-03-08 |
Family
ID=42830488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012001592A BR112012001592A2 (pt) | 2009-07-24 | 2010-07-10 | preparação de (r) e (s) -n- (3,4-difluoro-2-(2-fluoro-4-iodofe-nilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopro-pano-1-sulfonamida e derivados protegidos dos mesmos. |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US8513443B2 (pt) |
| EP (1) | EP2462111B1 (pt) |
| JP (1) | JP5776115B2 (pt) |
| KR (1) | KR101763437B1 (pt) |
| CN (2) | CN102471246B (pt) |
| AR (1) | AR079183A1 (pt) |
| AU (1) | AU2010275780B2 (pt) |
| BR (1) | BR112012001592A2 (pt) |
| CA (2) | CA2768788C (pt) |
| CL (1) | CL2012000192A1 (pt) |
| CO (1) | CO6491075A2 (pt) |
| CR (1) | CR20120044A (pt) |
| CU (1) | CU24113B1 (pt) |
| DO (1) | DOP2012000017A (pt) |
| EA (1) | EA023623B1 (pt) |
| EC (1) | ECSP12011621A (pt) |
| GT (1) | GT201200017A (pt) |
| HK (2) | HK1171218A1 (pt) |
| HN (1) | HN2012000142A (pt) |
| IL (1) | IL217312A (pt) |
| IN (1) | IN2012DN00696A (pt) |
| MA (1) | MA33452B1 (pt) |
| MX (2) | MX2012001063A (pt) |
| MY (1) | MY160421A (pt) |
| NZ (1) | NZ597738A (pt) |
| PE (1) | PE20120573A1 (pt) |
| PH (1) | PH12014500158A1 (pt) |
| SG (1) | SG177535A1 (pt) |
| TN (1) | TN2012000027A1 (pt) |
| TW (1) | TWI524890B (pt) |
| UY (1) | UY32800A (pt) |
| WO (1) | WO2011009541A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI524890B (zh) * | 2009-07-24 | 2016-03-11 | 亞德生化公司 | （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備 |
| KR101939682B1 (ko) * | 2011-05-27 | 2019-01-17 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | Ｎ-｛3,4-디플루오로-2-〔(2-플루오로-4-요오도페닐)아미노〕-6-메톡시페닐｝-1-[2,3-디하이드록시프로필]사이클로프로판설폰아미드의 키랄 합성 |
| EP2796455A4 (en) * | 2011-12-19 | 2015-08-19 | Sumitomo Chemical Co | PROCESS FOR PRODUCING SULFONATE |
| EP2848246A1 (en) | 2013-09-13 | 2015-03-18 | Bayer Pharma Aktiengesellschaft | Pharmaceutical compositions containing refametinib |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495118B (zh) * | 2005-07-21 | 2012-09-05 | 阿迪亚生命科学公司 | Mek的n-(芳基氨基)磺酰胺抑制剂 |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| WO2009018238A1 (en) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof |
| US7842836B2 (en) | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
| CA2649122C (en) | 2006-04-18 | 2015-06-30 | Ardea Biosciences, Inc. | Pyridone sulfonamides and pyridone sulfamides as mek inhibitors |
| SG189784A1 (en) * | 2008-04-14 | 2013-05-31 | Ardea Biosciences Inc | Compositions and methods for preparing and using same |
| TWI524890B (zh) * | 2009-07-24 | 2016-03-11 | 亞德生化公司 | （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備 |
-
2010
- 2010-07-09 TW TW099122740A patent/TWI524890B/zh not_active IP Right Cessation
- 2010-07-10 CA CA2768788A patent/CA2768788C/en not_active Expired - Fee Related
- 2010-07-10 CU CUP2012000014A patent/CU24113B1/es active IP Right Grant
- 2010-07-10 US US13/386,519 patent/US8513443B2/en not_active Expired - Fee Related
- 2010-07-10 IN IN696DEN2012 patent/IN2012DN00696A/en unknown
- 2010-07-10 NZ NZ597738A patent/NZ597738A/en not_active IP Right Cessation
- 2010-07-10 AU AU2010275780A patent/AU2010275780B2/en not_active Ceased
- 2010-07-10 EA EA201200175A patent/EA023623B1/ru not_active IP Right Cessation
- 2010-07-10 WO PCT/EP2010/004222 patent/WO2011009541A1/en active Application Filing
- 2010-07-10 BR BR112012001592A patent/BR112012001592A2/pt not_active Application Discontinuation
- 2010-07-10 CN CN201080031572.6A patent/CN102471246B/zh not_active Expired - Fee Related
- 2010-07-10 MY MYPI2012000099A patent/MY160421A/en unknown
- 2010-07-10 MA MA34562A patent/MA33452B1/fr unknown
- 2010-07-10 CA CA2990097A patent/CA2990097A1/en not_active Abandoned
- 2010-07-10 PE PE2012000092A patent/PE20120573A1/es not_active Application Discontinuation
- 2010-07-10 JP JP2012520927A patent/JP5776115B2/ja not_active Expired - Fee Related
- 2010-07-10 MX MX2012001063A patent/MX2012001063A/es active IP Right Grant
- 2010-07-10 KR KR1020127001737A patent/KR101763437B1/ko active IP Right Grant
- 2010-07-10 SG SG2012000964A patent/SG177535A1/en unknown
- 2010-07-10 EP EP10734043.2A patent/EP2462111B1/en active Active
- 2010-07-10 CN CN201310670649.XA patent/CN103848808B/zh not_active Expired - Fee Related
- 2010-07-22 UY UY0001032800A patent/UY32800A/es not_active Application Discontinuation
- 2010-07-23 AR ARP100102678A patent/AR079183A1/es unknown
-
2012
- 2012-01-01 IL IL217312A patent/IL217312A/en not_active IP Right Cessation
- 2012-01-19 TN TNP2012000027A patent/TN2012000027A1/en unknown
- 2012-01-23 CR CR20120044A patent/CR20120044A/es unknown
- 2012-01-24 GT GT201200017A patent/GT201200017A/es unknown
- 2012-01-24 MX MX2014000732A patent/MX344965B/es unknown
- 2012-01-24 HN HN2012000142A patent/HN2012000142A/es unknown
- 2012-01-24 CO CO12010431A patent/CO6491075A2/es active IP Right Grant
- 2012-01-24 EC EC2012011621A patent/ECSP12011621A/es unknown
- 2012-01-24 DO DO2012000017A patent/DOP2012000017A/es unknown
- 2012-01-24 CL CL2012000192A patent/CL2012000192A1/es unknown
- 2012-11-23 HK HK12112020.5A patent/HK1171218A1/xx not_active IP Right Cessation
-
2013
- 2013-04-23 US US13/868,621 patent/US8884058B2/en not_active Expired - Fee Related
-
2014
- 2014-01-16 PH PH12014500158A patent/PH12014500158A1/en unknown
- 2014-08-25 US US14/467,424 patent/US9296686B2/en not_active Expired - Fee Related
- 2014-11-24 HK HK14111856A patent/HK1198364A1/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: ARDEA BIOSCIENCES, INC. (US) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |