AR079183A1 - Preparacion de (r)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (s) -n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida - Google Patents

Preparacion de (r)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (s) -n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida

Info

Publication number
AR079183A1
AR079183A1 ARP100102678A ARP100102678A AR079183A1 AR 079183 A1 AR079183 A1 AR 079183A1 AR P100102678 A ARP100102678 A AR P100102678A AR P100102678 A ARP100102678 A AR P100102678A AR 079183 A1 AR079183 A1 AR 079183A1
Authority
AR
Argentina
Prior art keywords
difluoro
fluoro
sulfonamide
dihydroxipropil
ciclopropan
Prior art date
Application number
ARP100102678A
Other languages
English (en)
Inventor
Jean Michel Vernier
Andreas Maderna
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR079183(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of AR079183A1 publication Critical patent/AR079183A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Preparacion de (R)-N-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (S)-N-(3,4-difluoro-2-(2-fluoro-4 -yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil) ciclopropan-1-sulfonamida. Reivindicacion 1: Un proceso para preparar un compuesto de formula (1) caracterizado porque comprende poner en contacto 5,6-difluoro-N1- (2-fluoro-4-yodofenil)-3-metoxibencen-1,2-diamina con un compuesto de formula (2) donde R1 es H o un grupo protector de alcohol; R2 es H o un grupo protector de alcohol; o R1 y R2 junto con los átomos de carbono a los cuales se encuentran unidos forman un grupo protector cíclico de 1,2-diol.
ARP100102678A 2009-07-24 2010-07-23 Preparacion de (r)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (s) -n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida AR079183A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22850909P 2009-07-24 2009-07-24
US22850109P 2009-07-24 2009-07-24

Publications (1)

Publication Number Publication Date
AR079183A1 true AR079183A1 (es) 2012-01-04

Family

ID=42830488

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102678A AR079183A1 (es) 2009-07-24 2010-07-23 Preparacion de (r)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (s) -n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida

Country Status (32)

Country Link
US (3) US8513443B2 (es)
EP (1) EP2462111B1 (es)
JP (1) JP5776115B2 (es)
KR (1) KR101763437B1 (es)
CN (2) CN103848808B (es)
AR (1) AR079183A1 (es)
AU (1) AU2010275780B2 (es)
BR (1) BR112012001592A2 (es)
CA (2) CA2990097A1 (es)
CL (1) CL2012000192A1 (es)
CO (1) CO6491075A2 (es)
CR (1) CR20120044A (es)
CU (1) CU24113B1 (es)
DO (1) DOP2012000017A (es)
EA (1) EA023623B1 (es)
EC (1) ECSP12011621A (es)
GT (1) GT201200017A (es)
HK (2) HK1171218A1 (es)
HN (1) HN2012000142A (es)
IL (1) IL217312A (es)
IN (1) IN2012DN00696A (es)
MA (1) MA33452B1 (es)
MX (2) MX2012001063A (es)
MY (1) MY160421A (es)
NZ (1) NZ597738A (es)
PE (1) PE20120573A1 (es)
PH (1) PH12014500158A1 (es)
SG (1) SG177535A1 (es)
TN (1) TN2012000027A1 (es)
TW (1) TWI524890B (es)
UY (1) UY32800A (es)
WO (1) WO2011009541A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI524890B (zh) 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
MY186875A (en) * 2011-05-27 2021-08-26 Bayer Ip Gmbh Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
JPWO2013094546A1 (ja) * 2011-12-19 2015-04-27 住友化学株式会社 スルホン酸塩の製造方法
EP2848246A1 (en) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
CN101495118B (zh) * 2005-07-21 2012-09-05 阿迪亚生命科学公司 Mek的n-(芳基氨基)磺酰胺抑制剂
US7842836B2 (en) 2006-04-11 2010-11-30 Ardea Biosciences N-aryl-N'alkyl sulfamides as MEK inhibitors
CN101454004B (zh) 2006-04-18 2013-12-04 阿迪亚生命科学公司 作为mek抑制剂的吡啶酮磺酰胺类和吡啶酮硫酰胺类
UA99731C2 (ru) * 2007-07-30 2012-09-25 Ардеа Биосайенсис, Инк Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение
JP2011518786A (ja) * 2008-04-14 2011-06-30 アルデア バイオサイエンシズ，インコーポレイティド 調製及び使用のための組成物及び方法
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
UY32800A (es) 2011-01-31
AU2010275780B2 (en) 2015-10-22
TWI524890B (zh) 2016-03-11
KR101763437B1 (ko) 2017-07-31
CA2768788C (en) 2018-01-09
CU20120014A7 (es) 2012-06-21
CN103848808B (zh) 2016-02-10
PH12014500158B1 (en) 2015-09-07
ECSP12011621A (es) 2012-02-29
US20150274651A1 (en) 2015-10-01
JP2013500242A (ja) 2013-01-07
SG177535A1 (en) 2012-03-29
CO6491075A2 (es) 2012-07-31
IL217312A0 (en) 2012-02-29
US9296686B2 (en) 2016-03-29
KR20120032536A (ko) 2012-04-05
CU24113B1 (es) 2015-08-27
EA023623B1 (ru) 2016-06-30
JP5776115B2 (ja) 2015-09-09
US8513443B2 (en) 2013-08-20
CN103848808A (zh) 2014-06-11
CN102471246B (zh) 2015-08-26
IL217312A (en) 2017-02-28
EA201200175A1 (ru) 2012-12-28
PH12014500158A1 (en) 2015-09-07
CN102471246A (zh) 2012-05-23
HK1198364A1 (zh) 2015-04-10
HK1171218A1 (en) 2013-03-22
MX344965B (es) 2017-01-12
MX2012001063A (es) 2012-03-26
GT201200017A (es) 2013-12-19
MY160421A (en) 2017-03-15
CA2768788A1 (en) 2011-01-27
HN2012000142A (es) 2015-06-08
EP2462111B1 (en) 2016-03-30
WO2011009541A1 (en) 2011-01-27
TW201113017A (en) 2011-04-16
US8884058B2 (en) 2014-11-11
CL2012000192A1 (es) 2012-10-05
AU2010275780A1 (en) 2012-02-02
US20120178946A1 (en) 2012-07-12
NZ597738A (en) 2014-03-28
BR112012001592A2 (pt) 2016-03-08
US20130261320A1 (en) 2013-10-03
CA2990097A1 (en) 2011-01-27
DOP2012000017A (es) 2012-05-15
IN2012DN00696A (es) 2015-06-19
TN2012000027A1 (en) 2013-09-19
PE20120573A1 (es) 2012-05-17
MA33452B1 (fr) 2012-07-03
CR20120044A (es) 2012-03-12
EP2462111A1 (en) 2012-06-13

Similar Documents

Publication Publication Date Title
AR064842A1 (es) Pirrolidin-2-onas, y su uso en la preparacion de inhibidores de nep
PE20142394A1 (es) Procedimiento para la absorcion de co2 a partir de una mezcla gaseosa
CO7111275A2 (es) Inhibidores de dgat1 de éter cíclico de cabeza de puente
EA201290872A1 (ru) Способ получения бензоксаборолов
RS54526B1 (en) USE OF PIRAZOLOSPIROKETONE DERIVATIVES AS ACETYL-COA CARBOXYLASE INHIBITORS
EA201492140A1 (ru) Диметилбензойные кислоты
HN2009001436A (es) Nuevo procedimiento de sintesis de la agometatina
AR079183A1 (es) Preparacion de (r)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (s) -n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida
UA113615C2 (xx) Спосіб отримання 2-аміно-n-(2,2,2-трифторетил)ацетаміду
EA201400058A1 (ru) Соединения и композиции на основе амидопиридиловых эфиров и их применение против паразитов
CU24290B1 (es) Composición de bitumen/polímero y el método de preparación de una composición bitumen/polímero
EA201591498A1 (ru) Азетидинилоксифенилпирролидиновые соединения
BR112013015604A2 (pt) novo derivado de isoquinolina substituído
ES2521017T3 (es) Aminas enantioméricamente puras
EP3722277A3 (en) 3'end caps for rna-interferring agents for use in rna
EA201200498A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201490383A1 (ru) Способ получения ситаглиптина и его фармацевтически приемлемых солей
UY33177A (es) Derivados de ácido carboxílico que comprenden un anillo de oxazolopirimidina 2, 5, 7-sustituido
EA201270390A1 (ru) 1,2,4-триазин, который может быть использован в качестве ускорителя вулканизации, и способ его получения
AR067534A1 (es) Proceso para la preparacion de trifluoroalquil - fenil sulfonamidas y de sulfonamidas heterociclicas
EA201401277A1 (ru) Соединения метантиона, обладающие противовирусной активностью
EA201300794A1 (ru) Новый способ синтеза агомелатина
EA201592167A1 (ru) Способ получения производных пирролидин-2-карбоновой кислоты
BR112013009176A8 (pt) processo para a síntese de álcoois propargílicos quirais
BR112014000613A2 (pt) método para a preparação de ácido ciclo-hexanocarboxílico

Legal Events

Date Code Title Description
FB Suspension of granting procedure