CL2012000192A1 - Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado. - Google Patents

Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado.

Info

Publication number
CL2012000192A1
CL2012000192A1 CL2012000192A CL2012000192A CL2012000192A1 CL 2012000192 A1 CL2012000192 A1 CL 2012000192A1 CL 2012000192 A CL2012000192 A CL 2012000192A CL 2012000192 A CL2012000192 A CL 2012000192A CL 2012000192 A1 CL2012000192 A1 CL 2012000192A1
Authority
CL
Chile
Prior art keywords
cyclopropan
sulfonamide
sulfonamides
diamine
obtaining
Prior art date
Application number
CL2012000192A
Other languages
English (en)
Inventor
Andreas Vernier Jean Michael Maderna
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000192(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of CL2012000192A1 publication Critical patent/CL2012000192A1/es
Priority to CL2015001030A priority Critical patent/CL2015001030A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Proceso para preparar (R) y (S)-N-(3,4-difluoro-2 (2-fluoro-4 yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y compuestos intermediarios.
CL2012000192A 2009-07-24 2012-01-24 Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado. CL2012000192A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CL2015001030A CL2015001030A1 (es) 2009-07-24 2015-04-22 Proceso para preparar (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil) ciclopropan-1-sulfonamida y compuestos intermediarios (div. sol. 192-12).

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22850109P 2009-07-24 2009-07-24
US22850909P 2009-07-24 2009-07-24

Publications (1)

Publication Number Publication Date
CL2012000192A1 true CL2012000192A1 (es) 2012-10-05

Family

ID=42830488

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000192A CL2012000192A1 (es) 2009-07-24 2012-01-24 Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado.

Country Status (32)

Country Link
US (3) US8513443B2 (es)
EP (1) EP2462111B1 (es)
JP (1) JP5776115B2 (es)
KR (1) KR101763437B1 (es)
CN (2) CN103848808B (es)
AR (1) AR079183A1 (es)
AU (1) AU2010275780B2 (es)
BR (1) BR112012001592A2 (es)
CA (2) CA2990097A1 (es)
CL (1) CL2012000192A1 (es)
CO (1) CO6491075A2 (es)
CR (1) CR20120044A (es)
CU (1) CU24113B1 (es)
DO (1) DOP2012000017A (es)
EA (1) EA023623B1 (es)
EC (1) ECSP12011621A (es)
GT (1) GT201200017A (es)
HK (2) HK1171218A1 (es)
HN (1) HN2012000142A (es)
IL (1) IL217312A (es)
IN (1) IN2012DN00696A (es)
MA (1) MA33452B1 (es)
MX (2) MX2012001063A (es)
MY (1) MY160421A (es)
NZ (1) NZ597738A (es)
PE (1) PE20120573A1 (es)
PH (1) PH12014500158A1 (es)
SG (1) SG177535A1 (es)
TN (1) TN2012000027A1 (es)
TW (1) TWI524890B (es)
UY (1) UY32800A (es)
WO (1) WO2011009541A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI524890B (zh) 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
KR101939682B1 (ko) * 2011-05-27 2019-01-17 바이엘 인텔렉쳐 프로퍼티 게엠베하 Ｎ-｛3,4-디플루오로-2-〔(2-플루오로-4-요오도페닐)아미노〕-6-메톡시페닐｝-1-[2,3-디하이드록시프로필]사이클로프로판설폰아미드의 키랄 합성
EP2796455A4 (en) * 2011-12-19 2015-08-19 Sumitomo Chemical Co PROCESS FOR PRODUCING SULFONATE
EP2848246A1 (en) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
CN101495118B (zh) * 2005-07-21 2012-09-05 阿迪亚生命科学公司 Mek的n-(芳基氨基)磺酰胺抑制剂
WO2007121269A2 (en) * 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors
CA2649122C (en) 2006-04-18 2015-06-30 Ardea Biosciences, Inc. Pyridone sulfonamides and pyridone sulfamides as mek inhibitors
CA2694646C (en) * 2007-07-30 2017-09-05 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
JP2011518786A (ja) * 2008-04-14 2011-06-30 アルデア バイオサイエンシズ，インコーポレイティド 調製及び使用のための組成物及び方法
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
TWI524890B (zh) 2016-03-11
US20120178946A1 (en) 2012-07-12
US9296686B2 (en) 2016-03-29
NZ597738A (en) 2014-03-28
EA201200175A1 (ru) 2012-12-28
EP2462111B1 (en) 2016-03-30
US20130261320A1 (en) 2013-10-03
AU2010275780A1 (en) 2012-02-02
MX2012001063A (es) 2012-03-26
TW201113017A (en) 2011-04-16
CA2768788C (en) 2018-01-09
CN102471246A (zh) 2012-05-23
US8513443B2 (en) 2013-08-20
PH12014500158B1 (en) 2015-09-07
MA33452B1 (fr) 2012-07-03
KR101763437B1 (ko) 2017-07-31
IL217312A0 (en) 2012-02-29
MY160421A (en) 2017-03-15
CO6491075A2 (es) 2012-07-31
ECSP12011621A (es) 2012-02-29
AR079183A1 (es) 2012-01-04
AU2010275780B2 (en) 2015-10-22
HK1171218A1 (en) 2013-03-22
PH12014500158A1 (en) 2015-09-07
BR112012001592A2 (pt) 2016-03-08
JP5776115B2 (ja) 2015-09-09
DOP2012000017A (es) 2012-05-15
HK1198364A1 (zh) 2015-04-10
IN2012DN00696A (es) 2015-06-19
CN103848808B (zh) 2016-02-10
CN102471246B (zh) 2015-08-26
EA023623B1 (ru) 2016-06-30
US8884058B2 (en) 2014-11-11
US20150274651A1 (en) 2015-10-01
CU20120014A7 (es) 2012-06-21
CA2990097A1 (en) 2011-01-27
JP2013500242A (ja) 2013-01-07
WO2011009541A1 (en) 2011-01-27
IL217312A (en) 2017-02-28
HN2012000142A (es) 2015-06-08
CN103848808A (zh) 2014-06-11
SG177535A1 (en) 2012-03-29
EP2462111A1 (en) 2012-06-13
GT201200017A (es) 2013-12-19
PE20120573A1 (es) 2012-05-17
KR20120032536A (ko) 2012-04-05
CU24113B1 (es) 2015-08-27
MX344965B (es) 2017-01-12
TN2012000027A1 (en) 2013-09-19
UY32800A (es) 2011-01-31
CR20120044A (es) 2012-03-12
CA2768788A1 (en) 2011-01-27

Similar Documents

Publication Publication Date Title
CY1124873T1 (el) Διεργασια για την παρασκευη (1r,2r)-3-(3-διμεθυλαμινο-1-αιθυλο-2-μεθυλο-προπυλο)-φαινολης
BRPI0615705A2 (pt) processo para preparar um composto, e, composto
CY1112467T1 (el) Παραγωγα 1-θειο-d-γλυκιτολης
PE20142372A1 (es) Combinacion farmaceutica de 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol y un antiepileptico
IL185107A0 (en) Process for preparing cinacalcet hydrochloride
EA201101060A1 (ru) Новые гербициды
SI2516433T1 (sl) Substituirane N-(1 H-indazol-4-il)imidazo(1,2-a)piridin-3-karboksamidne spojine kot cFMS inhibitorji
EA201101099A1 (ru) Гербициды, полученные из циклопентадиона
EA201101148A1 (ru) Новые гербициды
TW200736195A (en) Methods for preparing sulfonamide substituted alcohols and intermediates thereof
NI200900151A (es) Nuevo procedimiento de síntesis de la agomelatina.
GEP20125512B (en) Process for synthesis of agomelatin
MX2011007932A (es) Herbicidas nuevos.
CL2012000192A1 (es) Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado.
CL2013000589A1 (es) Metodo para preparar derivados del acido 3-amino-4-(3,4,5,5-tetrasustituido)-2-oxo-piperidin-1-il)-4-butirico por reaccion entre un acido 3,4-diaminobutanoico y un acido 5-hidroxipentanoico.
UA106195C2 (ru) Способ синтеза агомелатина
CL2010000254A1 (es) Procedimiento de sintesis de ivabradina por formacion de una imina; y los compuestos intermediarios considerados en el procedimiento.
UY34170A (es) Formas cristalinas de 2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorofenil)indazol-5-il]oxi-1-(3-metoxifenil)propan-2-il]acetamida
ES2525528T3 (es) Amicolamicina, método para su producción y su utilización
CL2013001882A1 (es) Procedimiento de sintesis industrial del compuesto de formula (i) agomelatina, a partir de cianuro de alilo; compuestos intermediarios.
BR112012008332A2 (pt) processo para preparação de cinacalcet
MX2017012960A (es) Metodo para producir acilsulfamoilbenzamidas.
ITMI20060488A1 (it) Procedimento per la preparazione di 3,4-bis trifluoronetil-n-metilbenzilammina
CL2009001008A1 (es) Metodo de preparacion de derivados de tiofeno por reaccion entre un fenil acrilonitrilo y una acetamida.
CL2011000120A1 (es) Proceso de preparacion de compuestos 2-amino-tiazolonas sustituidas.