MX344965B - Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilam ino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonam ida y derivados protegidos de los mismos. - Google Patents

Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilam ino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonam ida y derivados protegidos de los mismos.

Info

Publication number
MX344965B
MX344965B MX2014000732A MX2014000732A MX344965B MX 344965 B MX344965 B MX 344965B MX 2014000732 A MX2014000732 A MX 2014000732A MX 2014000732 A MX2014000732 A MX 2014000732A MX 344965 B MX344965 B MX 344965B
Authority
MX
Mexico
Prior art keywords
dihydroxypropyl
sulfonamide
difluoro
fluoro
preparation
Prior art date
Application number
MX2014000732A
Other languages
English (en)
Inventor
Vernier Jean-Michel
Maderna Andreas
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42830488&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344965(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of MX344965B publication Critical patent/MX344965B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se relaciona con la preparación de (R)-N-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)- 1-(2,3-dihidroxipropil)ciclopropan-1-sulfonamida y (S)-N-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)- 1-(2,3-dihidroxipropil)ciclopropan-1-suIfonamida.
MX2014000732A 2009-07-24 2012-01-24 Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilam ino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonam ida y derivados protegidos de los mismos. MX344965B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22850909P 2009-07-24 2009-07-24
US22850109P 2009-07-24 2009-07-24

Publications (1)

Publication Number Publication Date
MX344965B true MX344965B (es) 2017-01-12

Family

ID=42830488

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012001063A MX2012001063A (es) 2009-07-24 2010-07-10 Preparacion de (r) y (s)-n-(3,4-difluoro-2(2-fluoro-4-yodofenilami no)-6-metoxifenil)-1-(2,3-dihidroxipropil) ciclopropan-1-sulfonami da y derivados protegidos de los mismos.
MX2014000732A MX344965B (es) 2009-07-24 2012-01-24 Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilam ino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonam ida y derivados protegidos de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012001063A MX2012001063A (es) 2009-07-24 2010-07-10 Preparacion de (r) y (s)-n-(3,4-difluoro-2(2-fluoro-4-yodofenilami no)-6-metoxifenil)-1-(2,3-dihidroxipropil) ciclopropan-1-sulfonami da y derivados protegidos de los mismos.

Country Status (32)

Country Link
US (3) US8513443B2 (es)
EP (1) EP2462111B1 (es)
JP (1) JP5776115B2 (es)
KR (1) KR101763437B1 (es)
CN (2) CN102471246B (es)
AR (1) AR079183A1 (es)
AU (1) AU2010275780B2 (es)
BR (1) BR112012001592A2 (es)
CA (2) CA2990097A1 (es)
CL (1) CL2012000192A1 (es)
CO (1) CO6491075A2 (es)
CR (1) CR20120044A (es)
CU (1) CU24113B1 (es)
DO (1) DOP2012000017A (es)
EA (1) EA023623B1 (es)
EC (1) ECSP12011621A (es)
GT (1) GT201200017A (es)
HK (2) HK1171218A1 (es)
HN (1) HN2012000142A (es)
IL (1) IL217312A (es)
IN (1) IN2012DN00696A (es)
MA (1) MA33452B1 (es)
MX (2) MX2012001063A (es)
MY (1) MY160421A (es)
NZ (1) NZ597738A (es)
PE (1) PE20120573A1 (es)
PH (1) PH12014500158A1 (es)
SG (1) SG177535A1 (es)
TN (1) TN2012000027A1 (es)
TW (1) TWI524890B (es)
UY (1) UY32800A (es)
WO (1) WO2011009541A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI524890B (zh) 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備
PE20140580A1 (es) * 2011-05-27 2014-06-01 Bayer Ip Gmbh Sintesis quiral de n-{3,4-difluoro-2-[(2-fluoro-4-yodofenil)amino]-6-metoxifenil}-1-[2,3-dihidroxi-propil]ciclopropanosulfonamidas
CN104011039A (zh) * 2011-12-19 2014-08-27 住友化学株式会社 磺酸盐的制造方法
EP2848246A1 (en) 2013-09-13 2015-03-18 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1912636T1 (sl) * 2005-07-21 2014-08-29 Ardea Biosciences, Inc. N-(arilamino)-sulfonamidni inhibitorji MEK
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
WO2007121269A2 (en) * 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors
EP2012786B1 (en) * 2006-04-18 2010-10-06 Ardea Biosciences, Inc. Pyridone sulfonamides and pyridone sulfamides as mek inhibitors
UA99731C2 (ru) * 2007-07-30 2012-09-25 Ардеа Биосайенсис, Инк Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение
EA201001639A1 (ru) * 2008-04-14 2011-06-30 Арди Байосайенсиз, Инк. Композиции и способы их получения и применения
TWI524890B (zh) * 2009-07-24 2016-03-11 亞德生化公司 （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備

Also Published As

Publication number Publication date
SG177535A1 (en) 2012-03-29
CA2990097A1 (en) 2011-01-27
CN102471246A (zh) 2012-05-23
WO2011009541A1 (en) 2011-01-27
CA2768788C (en) 2018-01-09
TN2012000027A1 (en) 2013-09-19
CU20120014A7 (es) 2012-06-21
US8884058B2 (en) 2014-11-11
HK1171218A1 (en) 2013-03-22
TW201113017A (en) 2011-04-16
GT201200017A (es) 2013-12-19
HN2012000142A (es) 2015-06-08
US8513443B2 (en) 2013-08-20
AU2010275780A1 (en) 2012-02-02
AU2010275780B2 (en) 2015-10-22
CL2012000192A1 (es) 2012-10-05
CA2768788A1 (en) 2011-01-27
KR20120032536A (ko) 2012-04-05
US20150274651A1 (en) 2015-10-01
CU24113B1 (es) 2015-08-27
MA33452B1 (fr) 2012-07-03
TWI524890B (zh) 2016-03-11
EA201200175A1 (ru) 2012-12-28
CN103848808A (zh) 2014-06-11
NZ597738A (en) 2014-03-28
ECSP12011621A (es) 2012-02-29
PH12014500158B1 (en) 2015-09-07
MX2012001063A (es) 2012-03-26
IL217312A (en) 2017-02-28
IN2012DN00696A (es) 2015-06-19
CR20120044A (es) 2012-03-12
IL217312A0 (en) 2012-02-29
PE20120573A1 (es) 2012-05-17
AR079183A1 (es) 2012-01-04
MY160421A (en) 2017-03-15
US20120178946A1 (en) 2012-07-12
JP2013500242A (ja) 2013-01-07
BR112012001592A2 (pt) 2016-03-08
HK1198364A1 (zh) 2015-04-10
EP2462111B1 (en) 2016-03-30
EA023623B1 (ru) 2016-06-30
CN103848808B (zh) 2016-02-10
UY32800A (es) 2011-01-31
US9296686B2 (en) 2016-03-29
DOP2012000017A (es) 2012-05-15
JP5776115B2 (ja) 2015-09-09
US20130261320A1 (en) 2013-10-03
EP2462111A1 (en) 2012-06-13
CN102471246B (zh) 2015-08-26
CO6491075A2 (es) 2012-07-31
KR101763437B1 (ko) 2017-07-31
PH12014500158A1 (en) 2015-09-07

Similar Documents

Publication Publication Date Title
MY151986A (en) Adamantyl diamide derivatives and uses of same
WO2012030927A3 (en) Modified-release dosage forms of 5-ht2c agonists useful for weight management
WO2012072424A3 (en) Anti-dandruff shampoo
UA104885C2 (uk) Ізотіазолілоксифеніламідини та їх застосування як фунгіцидів
UA108645C2 (uk) Композиція для боротьби з хворобами рослин і її застосування
MX2012007161A (es) Derivados fenolicos y su uso farmaceutico o cosmetico.
MX2014004858A (es) Compuestos de 3,4-diamino-3-ciclobuten-1,2-diona disustituidos utiles en el tratamiento de patologias mediadas por quimiocinas.
WO2011039735A3 (en) Compounds with ddx3 inhibitory activity and uses thereof
WO2010118291A3 (en) Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
WO2013061004A8 (fr) Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines
MY159776A (en) Pesticidal composition and its use
MX2013006492A (es) Nueva forma de administracion de inhibidor de encefalinasa.
PH12014502512A1 (en) Topical pharmaceutical compositions comprising terbinafine and urea
UA107495C2 (uk) Пестицидна композиція і її застосування
WO2010052071A3 (en) Concentrated shampoo composition
WO2011011420A3 (en) 3, 4-methylenedioxyphenyl inhibitors of gaba aminotransferase and/or gaba reuptake transporter inhibitor
MX344965B (es) Preparacion de (r) y (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilam ino)-6-metoxifenil)-1-(2,3-dihidroxipropil)ciclopropan-1-sulfonam ida y derivados protegidos de los mismos.
MX2012011382A (es) Nuevo polimero.
WO2010077730A3 (en) Indanone inhibitors of acetylcholinesterase
MX338441B (es) Uso de 2,3-dihidroxipropil dodecanoato para tratar seborrea.
MX2009011207A (es) Eteres de amidas de acido naftalen-carboxilico como cura para el cancer.
UA106762C2 (uk) Спосіб одержання (r)- та (s)-n-(3,4-дифтор-2-(2-фтор-4-йодфеніламіно)-6-метоксифеніл)-1-(2,3-дигідроксипропіл)циклопропан-1-сульфанаміду та його захищених похідних
MX2012007097A (es) Derivados fenolicos y su uso farmaceutico o cosmetico.
UA91166C2 (en) use of ethyl ether N-[(2-oxoindolylinylydene-3)-2-oxyacetyl]-aminoacetic acid of the general formula as nootropic and anxyolytic agent
WO2010065889A3 (en) Cyclobutanemethanamine inhibitors of monomine reuptake