DOP2011000306A - Aplicaciones terapeuticas en el dominio cardiovascular de derivados de quinazolinadiona - Google Patents

Aplicaciones terapeuticas en el dominio cardiovascular de derivados de quinazolinadiona

Info

Publication number
DOP2011000306A
DOP2011000306A DO2011000306A DO2011000306A DOP2011000306A DO P2011000306 A DOP2011000306 A DO P2011000306A DO 2011000306 A DO2011000306 A DO 2011000306A DO 2011000306 A DO2011000306 A DO 2011000306A DO P2011000306 A DOP2011000306 A DO P2011000306A
Authority
DO
Dominican Republic
Prior art keywords
quinazolinadiona
derivatives
therapeutic applications
cardiovascular
domain
Prior art date
Application number
DO2011000306A
Other languages
English (en)
Inventor
Gilbert Marciniak
Philip Janiak
Jean-Francois Nave
Fabrice Viviani
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DOP2011000306A publication Critical patent/DOP2011000306A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención tiene por objeto la utilización de compuestos de la fórmula (l) en estado de base, de hidrato, de solvato, o de sus mezclas como medicamentos o para la preparación de medicamentos destinados al tratamiento de al menos una enfermedad cardiovascular yio a prevenir la aparición de al menos una enfermedad cardiovascular.
DO2011000306A 2009-04-09 2011-10-06 Aplicaciones terapeuticas en el dominio cardiovascular de derivados de quinazolinadiona DOP2011000306A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901755A FR2944206B1 (fr) 2009-04-09 2009-04-09 Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione

Publications (1)

Publication Number Publication Date
DOP2011000306A true DOP2011000306A (es) 2011-10-31

Family

ID=41181038

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000306A DOP2011000306A (es) 2009-04-09 2011-10-06 Aplicaciones terapeuticas en el dominio cardiovascular de derivados de quinazolinadiona

Country Status (35)

Country Link
US (1) US8846654B2 (es)
EP (1) EP2416777B1 (es)
JP (1) JP5685578B2 (es)
KR (1) KR101686267B1 (es)
CN (1) CN102458409B (es)
AR (1) AR076232A1 (es)
AU (1) AU2010233596B2 (es)
BR (1) BRPI1010256A2 (es)
CA (1) CA2758234A1 (es)
CL (1) CL2011002525A1 (es)
CO (1) CO6440577A2 (es)
CR (1) CR20110527A (es)
CY (1) CY1115987T1 (es)
DK (1) DK2416777T3 (es)
DO (1) DOP2011000306A (es)
EA (1) EA020984B1 (es)
EC (1) ECSP11011377A (es)
ES (1) ES2528633T3 (es)
FR (1) FR2944206B1 (es)
HK (1) HK1165997A1 (es)
HR (1) HRP20150106T1 (es)
HU (1) HUE024161T2 (es)
IL (1) IL215610A (es)
MA (1) MA33254B1 (es)
MX (1) MX2011010645A (es)
NI (1) NI201100180A (es)
NZ (1) NZ595660A (es)
PL (1) PL2416777T3 (es)
PT (1) PT2416777E (es)
SG (2) SG175131A1 (es)
SI (1) SI2416777T1 (es)
TN (1) TN2011000506A1 (es)
TW (1) TWI457330B (es)
UY (1) UY32555A (es)
WO (1) WO2010116090A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2944282B1 (fr) * 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
US9499496B2 (en) 2012-06-05 2016-11-22 University Of Kansas Inhibitors of respiratory syncytial virus
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
WO2024038089A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879393A (en) * 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
JPS56164172A (en) * 1980-05-22 1981-12-17 Masayuki Ishikawa Novel 2,4 1h,3h -quinazolinedione derivative
EP0040793B1 (en) * 1980-05-22 1985-08-28 Masayuki Ishikawa Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
US5624926A (en) 1993-02-18 1997-04-29 Kyowa Hakko Kogyo Co., Ltd. Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors
US6384080B1 (en) 1998-04-20 2002-05-07 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
AU2525701A (en) 1999-12-14 2001-06-25 Sanofi-Synthelabo Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses
WO2006092692A1 (en) 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
CA2599662A1 (en) 2005-03-01 2006-09-08 Pfizer Limited Use of pde7 inhibitors for the treatment of neuropathic pain
US7846664B2 (en) 2005-12-07 2010-12-07 The Regents Of The University Of California Diagnosis and treatment of chronic lymphocytic leukemia (CLL)
CN104758291B (zh) 2007-03-27 2020-03-03 奥默罗斯公司 用于治疗运动障碍的pde7抑制剂的用途
EP2138482A4 (en) 2007-04-19 2011-06-15 Astellas Pharma Inc BICYCLIC HETEROCYCLIC COMPOUND
FR2921926B1 (fr) * 2007-10-03 2009-12-04 Sanofi Aventis Derives de quinazolinedione,leur preparation et leurs applications therapeutiques.
FR2943673B1 (fr) * 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione

Also Published As

Publication number Publication date
FR2944206A1 (fr) 2010-10-15
CA2758234A1 (fr) 2010-10-14
CY1115987T1 (el) 2017-01-25
PL2416777T3 (pl) 2015-05-29
EA201171229A1 (ru) 2012-12-28
CO6440577A2 (es) 2012-05-15
EP2416777A1 (fr) 2012-02-15
NI201100180A (es) 2012-01-11
SI2416777T1 (sl) 2015-02-27
US8846654B2 (en) 2014-09-30
JP2012523398A (ja) 2012-10-04
JP5685578B2 (ja) 2015-03-18
CL2011002525A1 (es) 2012-02-17
FR2944206B1 (fr) 2012-12-28
AU2010233596B2 (en) 2016-06-23
AR076232A1 (es) 2011-05-26
DK2416777T3 (en) 2015-02-09
KR20120005499A (ko) 2012-01-16
AU2010233596A1 (en) 2011-11-03
HUE024161T2 (hu) 2016-02-29
TWI457330B (zh) 2014-10-21
MA33254B1 (fr) 2012-05-02
BRPI1010256A2 (pt) 2016-03-22
TN2011000506A1 (fr) 2013-05-24
CN102458409A (zh) 2012-05-16
TW201040155A (en) 2010-11-16
IL215610A0 (en) 2011-12-29
SG175131A1 (en) 2011-11-28
CN102458409B (zh) 2014-06-18
PT2416777E (pt) 2015-02-04
ES2528633T3 (es) 2015-02-11
EA020984B1 (ru) 2015-03-31
IL215610A (en) 2013-07-31
UY32555A (es) 2010-11-30
WO2010116090A1 (fr) 2010-10-14
HK1165997A1 (en) 2012-10-19
NZ595660A (en) 2013-03-28
SG10201400420PA (en) 2014-05-29
EP2416777B1 (fr) 2014-11-12
HRP20150106T1 (hr) 2015-05-08
CR20110527A (es) 2014-05-12
ECSP11011377A (es) 2011-11-30
US20120184522A1 (en) 2012-07-19
MX2011010645A (es) 2012-01-19
KR101686267B1 (ko) 2016-12-13

Similar Documents

Publication Publication Date Title
CY1120318T1 (el) Υποκατεστημενες βενζυλινδαζολες για χρηση ως αναστολεις κινασης bub1 στη θεραπευτικη αντιμετωπιση υπερπολλαπλασιαστικων ασθενειων
ECSP19078196A (es) Composiciones terapéuticas que comprenden rilpivirina hcl y tenofovir disoproxil fumarato
MX2014012695A (es) Derivados de isoindolona.
UY29876A1 (es) Derivados de acidos dicarboxilicos y su uso
GT200900230A (es) 4-aril-1,4-dihidro-1,6-naftiridinamidas sustituidas y uso
DOP2010000013A (es) Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas
CL2011003350A1 (es) Compuestos derivados de heterociclo nitrogenados, moduladores pkm2; composicion farmaceutica que los comprende; y su uso en el tratamiento del cancer.
CO6440531A2 (es) 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso
HN2012000023A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
CR11684A (es) Dihidropirazolonas sustituidas de hif-propil-4- como inhibidores hidroxilasa
ECSP10010058A (es) Derivados de quinazolinadiona, su preparación y sus aplicaciones terapéuticas
CL2015001374A1 (es) Compuestos derivados de 2-(metilamino)-n-(2-oxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3il)propanamida; composicion farmaceutica; y su uso en el tratamiento terapeutico o profilactico del cancer.
CO6430429A2 (es) Aplicaciones terapéuticas de derivados de quinazolinodiona
CU20110088A7 (es) Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibidores de quinasas dependientes de ciclina (cdk), producción y uso de los mismos como productos medicinales
GB201209587D0 (en) Therapeutic compounds
ECSP11011021A (es) Antagonistas de la via hedgehog de ftalazina disustituida
ECSP11011101A (es) Compuestos cicloundecadepsipéptidos y el uso de dichos compuestos como un medicamento
CL2014001959A1 (es) Compuestos derivados de fenil-1h-imidazo[1,2-b]pirazol sustituidos; procedimiento de preparacion; composicion farmaceutica; y el uso en el tratamiento del cancer.
HN2010000330A (es) DERIVADOS DE INDOL-2-ONA DISUSTITUIDOS EN 3 y SU PREPARACION
DOP2011000306A (es) Aplicaciones terapeuticas en el dominio cardiovascular de derivados de quinazolinadiona
CL2011000168A1 (es) Compuestos derivados de narciclasina y pancratistatina; procedimiento de preparación; composición farmacéutica; combinación farmacéutica; y su uso para el tratamiento del cáncer.
MA32461B1 (fr) Dronedarone pour la prevention de cardioversion
GT200800066A (es) Derivados de 9-cloro-15-deoxiprostaglandina, procedimiento para su preparacion y su uso como medicamento.
SV2009003315A (es) Nueva utilizacion para el tratamiento de las leucemias
UY32447A (es) Derivados de 3-benzofuranilindol-2-ona sustituidos en 3, su preparacion y su aplicacion en terapia