EA201171229A1 - Терапевтическое применение производных хиназолиндиона при сердечно-сосудистых заболеваниях - Google Patents

Терапевтическое применение производных хиназолиндиона при сердечно-сосудистых заболеваниях

Info

Publication number
EA201171229A1
EA201171229A1 EA201171229A EA201171229A EA201171229A1 EA 201171229 A1 EA201171229 A1 EA 201171229A1 EA 201171229 A EA201171229 A EA 201171229A EA 201171229 A EA201171229 A EA 201171229A EA 201171229 A1 EA201171229 A1 EA 201171229A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hinazolindion
derivatives
cardiovascular diseases
therapeutic application
cardiovascular
Prior art date
Application number
EA201171229A
Other languages
English (en)
Other versions
EA020984B1 (ru
Inventor
Филип Жаниак
Жильбер Марсиньяк
Жан-Франсуа Нав
Фабрис Вивьяни
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of EA201171229A1 publication Critical patent/EA201171229A1/ru
Publication of EA020984B1 publication Critical patent/EA020984B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к применению соединений формулы (I) в виде основания, гидрата, сольвата или их смесей в качестве лекарственных средств или для получения лекарственных средств, предназначенных для лечения по меньшей мере одного сердечно-сосудистого заболевания и/или профилактики появления по меньшей мере одного сердечно-сосудистого заболевания.
EA201171229A 2009-04-09 2010-04-07 Терапевтическое применение производных хиназолиндиона при сердечно-сосудистых заболеваниях EA020984B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901755A FR2944206B1 (fr) 2009-04-09 2009-04-09 Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
PCT/FR2010/050672 WO2010116090A1 (fr) 2009-04-09 2010-04-07 Applications thérapeutiques dans le domaine cardiovasculaire de dérivés de quinazolinedione

Publications (2)

Publication Number Publication Date
EA201171229A1 true EA201171229A1 (ru) 2012-12-28
EA020984B1 EA020984B1 (ru) 2015-03-31

Family

ID=41181038

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171229A EA020984B1 (ru) 2009-04-09 2010-04-07 Терапевтическое применение производных хиназолиндиона при сердечно-сосудистых заболеваниях

Country Status (35)

Country Link
US (1) US8846654B2 (ru)
EP (1) EP2416777B1 (ru)
JP (1) JP5685578B2 (ru)
KR (1) KR101686267B1 (ru)
CN (1) CN102458409B (ru)
AR (1) AR076232A1 (ru)
AU (1) AU2010233596B2 (ru)
BR (1) BRPI1010256A2 (ru)
CA (1) CA2758234A1 (ru)
CL (1) CL2011002525A1 (ru)
CO (1) CO6440577A2 (ru)
CR (1) CR20110527A (ru)
CY (1) CY1115987T1 (ru)
DK (1) DK2416777T3 (ru)
DO (1) DOP2011000306A (ru)
EA (1) EA020984B1 (ru)
EC (1) ECSP11011377A (ru)
ES (1) ES2528633T3 (ru)
FR (1) FR2944206B1 (ru)
HK (1) HK1165997A1 (ru)
HR (1) HRP20150106T1 (ru)
HU (1) HUE024161T2 (ru)
IL (1) IL215610A (ru)
MA (1) MA33254B1 (ru)
MX (1) MX2011010645A (ru)
NI (1) NI201100180A (ru)
NZ (1) NZ595660A (ru)
PL (1) PL2416777T3 (ru)
PT (1) PT2416777E (ru)
SG (2) SG10201400420PA (ru)
SI (1) SI2416777T1 (ru)
TN (1) TN2011000506A1 (ru)
TW (1) TWI457330B (ru)
UY (1) UY32555A (ru)
WO (1) WO2010116090A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2944282B1 (fr) * 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
WO2013184806A1 (en) 2012-06-05 2013-12-12 University Of Kansas Inhibitors of respiratory syncytial virus
WO2014102589A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Quinazolin-4(3h)-one-type piperidine compounds and uses thereof
WO2024038090A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879393A (en) * 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
JPS56164172A (en) * 1980-05-22 1981-12-17 Masayuki Ishikawa Novel 2,4 1h,3h -quinazolinedione derivative
DE3172006D1 (en) * 1980-05-22 1985-10-03 Masayuki Ishikawa Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
EP0638567A4 (en) 1993-02-18 1995-05-10 Kyowa Hakko Kogyo Kk ADENOSINE INHIBITORS.
BR9909781A (pt) 1998-04-20 2000-12-19 Fujisawa Pharmaceutical Co Composto de formula (i), processo para sua preparação, composição farmacêutica compreendendo dito composto, seu uso e método.
WO2001044228A2 (fr) 1999-12-14 2001-06-21 Sanofi-Synthelabo Derives de quinazolinedione et phtalimide, leurs preparations et leurs applications en therapeutique
WO2006092692A1 (en) 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
US20090111837A1 (en) 2005-03-01 2009-04-30 Peter Cox Use of pde7 inhibitors for the treatment of neuropathic pain
WO2007067946A2 (en) 2005-12-07 2007-06-14 The Regents Of The University Of California Diagnosis and treatment of chronic lymphocytic leukemia (cll)
WO2008119057A2 (en) 2007-03-27 2008-10-02 Omeros Corporation The use of pde7 inhibitors for the treatment of movement disorders
JPWO2008133155A1 (ja) 2007-04-19 2010-07-22 アステラス製薬株式会社 二環式ヘテロ環化合物
FR2921926B1 (fr) * 2007-10-03 2009-12-04 Sanofi Aventis Derives de quinazolinedione,leur preparation et leurs applications therapeutiques.
FR2943673B1 (fr) * 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione

Also Published As

Publication number Publication date
SG175131A1 (en) 2011-11-28
DK2416777T3 (en) 2015-02-09
AU2010233596B2 (en) 2016-06-23
HRP20150106T1 (hr) 2015-05-08
NI201100180A (es) 2012-01-11
CR20110527A (es) 2014-05-12
US20120184522A1 (en) 2012-07-19
KR101686267B1 (ko) 2016-12-13
CL2011002525A1 (es) 2012-02-17
CY1115987T1 (el) 2017-01-25
ECSP11011377A (es) 2011-11-30
AR076232A1 (es) 2011-05-26
HUE024161T2 (hu) 2016-02-29
MA33254B1 (fr) 2012-05-02
EP2416777A1 (fr) 2012-02-15
MX2011010645A (es) 2012-01-19
TW201040155A (en) 2010-11-16
WO2010116090A1 (fr) 2010-10-14
EP2416777B1 (fr) 2014-11-12
IL215610A0 (en) 2011-12-29
CN102458409B (zh) 2014-06-18
TWI457330B (zh) 2014-10-21
JP5685578B2 (ja) 2015-03-18
BRPI1010256A2 (pt) 2016-03-22
KR20120005499A (ko) 2012-01-16
NZ595660A (en) 2013-03-28
SG10201400420PA (en) 2014-05-29
ES2528633T3 (es) 2015-02-11
AU2010233596A1 (en) 2011-11-03
FR2944206B1 (fr) 2012-12-28
PL2416777T3 (pl) 2015-05-29
IL215610A (en) 2013-07-31
SI2416777T1 (sl) 2015-02-27
CN102458409A (zh) 2012-05-16
DOP2011000306A (es) 2011-10-31
TN2011000506A1 (fr) 2013-05-24
HK1165997A1 (en) 2012-10-19
CO6440577A2 (es) 2012-05-15
US8846654B2 (en) 2014-09-30
FR2944206A1 (fr) 2010-10-15
EA020984B1 (ru) 2015-03-31
CA2758234A1 (fr) 2010-10-14
UY32555A (es) 2010-11-30
PT2416777E (pt) 2015-02-04
JP2012523398A (ja) 2012-10-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU