ES2528633T3

ES2528633T3 - Aplicaciones terapéuticas en el campo cardiovascular de derivados de quinazolindiona

Info

Publication number: ES2528633T3
Application number: ES10723222.5T
Authority: ES
Inventors: Philip Janiak; Gilbert Marciniak; Jean-François Nave; Fabrice Viviani
Original assignee: Sanofi SA
Current assignee: Sanofi SA
Priority date: 2009-04-09
Filing date: 2010-04-07
Publication date: 2015-02-11
Anticipated expiration: 2030-04-07
Also published as: IL215610A; AU2010233596A1; US20120184522A1; CY1115987T1; FR2944206A1; DK2416777T3; HUE024161T2; HK1165997A1; PL2416777T3; EA020984B1; SG175131A1; JP5685578B2; MX2011010645A; EA201171229A1; TN2011000506A1; CN102458409B; CN102458409A; SG10201400420PA; DOP2011000306A; ECSP11011377A

Abstract

Un compuesto que responde a la fórmula general (I):**Fórmula** en la que: - A representa un grupo arilo o un grupo heteroarilo; - R1 representa: - un átomo de hidrógeno, - -C(O)R en el que R es un átomo de hidrógeno, un grupo alcoxi (C1-C6), un grupo arilo, un grupo cicloalquilo (C3- C6), o un grupo alquilo (C1-C6), estando dicho alquilo opcionalmente sustituido con: . uno o varios grupos hidroxi, . un grupo benciloxi, - un grupo alcoxi (C1-C6), opcionalmente sustituido con un arilo, o . un grupo cicloalquilo (C3-C6), - un grupo alquilo (C1-C6) opcionalmente sustituido; - R2 representa: - un átomo de hidrógeno, - un átomo de halógeno, - un grupo ciano, - un grupo nitro, - un grupo alquilo (C1-C6) opcionalmente sustituido con un -NH2, o bien con un grupo -NHC(O)Rb, siendo Rb tal como se define más adelante, - un grupo -ORa en el que Ra representa: . un átomo de hidrógeno, . un grupo alquilo (C1-C6) opcionalmente sustituido con uno o varios átomos de halógeno, con uno o varios grupos hidroxi, con un grupo arilo y/o con uno o varios grupos ciano, . un grupo alquinilo (C2-C6), . un grupo arilo; - R3 representa: - un átomo de hidrógeno, - un átomo de halógeno, - un grupo hidroxi. un grupo ciano, - un grupo -SCF3, - un grupo nitro, - un grupo -S(O)0-2-alquilo, un grupo -S(O)0-2-heterocicloalquilo, un grupo -O- SO2-arilo opcionalmente sustituido con uno o varios átomos de halógeno; - un grupo -alquil-amino-alquilo o -cicloalquil-amino-alquilo, cada uno de ellos opcionalmente sustituido sobre el alquilo terminal, - un grupo sulfonamida opcionalmente sustituido, - un grupo arilo o un grupo heteroarilo, siendo dicho grupo monocíclico o policíclico y estando además opcionalmente sustituido con un grupo alquilo (C1-C6), con uno o varios átomos de halógeno, o con un grupo alcoxi (C1-C6), - un grupo heterocicloalquilo opcionalmente sustituido con un grupo alquilo (C1-C6), - un grupo alquilo (C1-C6) opcionalmente sustituido con: - uno o varios átomos de halógeno, - un grupo arilo que puede estar sustituido con uno o varios átomos de halógeno, o con uno o varios grupos hidroxi, - un grupo heteroarilo.

Description

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Compuesto N°: ESTRUCTURA NOMENCLATURA RMN o MASAS

1: imagen33 2-{[3-(3,4-dimetoxibencil)-1-(1formilpiperidin-4-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6il]oxi}propanonitrilo 1H RMN (500 MHz, DMSO-d6) δ ppm 1,71(d, 3H) 1,79(brdd, 2H) 2,41(dq, 1H) 2,53(dq, 1H) 2,80(td, 1H) 3,25(t, 1H) 3,70(s, 3H) 3,71(s, 3H) 3,80(d, 1H) 4,31(d, 1H) 4,77(brs, 1H) 5,03(s, 2H) 5,60(q, 1H) 6,83(dd, 1H) 6,85 (d, 1H) 6,98(s, 1H) 7,51(dd, 1H) 7,74(d, 1H) 7,84(d, 1H) 8,03(s, 1H)

2: imagen34 1-(1-acetilpiperidin-4-il)-3-(3,4dimetoxibencil)-6-hidroxiquinazolina2,4(1H,3H)-diona 1H RMN (500 MHz, DMSO-d6) δ ppm 1,69(d, 1H) 1,74(d, 1H) 2,05(s, 3H) 2,42(dq, 1H) 2,57(dq, 1H) 2,70(t, 1H) 3,24(t, 1H) 3,70(br s, 3H) 3,71(s, 3H) 3,92(d, 1H) 4,51(d, 1H) 4,69(brs, 1H) 5,02(s, 2H) 6,81(dd, 1H) 6,86(d, 1H) 6,97(d, 1H) 7,21(dd, 1H) 7,44(d, 1H) 7,65(d, 1H) 9,88(brs, 1H)

3: imagen35 {[1-(1-acetilpiperidin-4-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]oxi}acetonitrilo 1H NMR (500 MHz, DMSO-d6) δ ppm 1,71 (d, 1H) 1,76 (d, 1H) 2,04 (s, 3H) 2,41 (dq, 1H) 2,56 (dq, 1H) 2,70 (t, 1H) 3,24 (t, 1H) 3,70 (s, 3H) 3,71 (s, 3H) 3,92 (d, 1H) 4,51 (d, 1H) 4,73 (brs,1H) 5,04(s, 2H) 5,29 (s, 2H) 6,82 (dd, 1H) 6,85 (d, 1H) 6,98 (d, 1H) 7,50 (dd, 1H) 7,70 (d, 1H) 7,83 (d, 1H)

4: imagen36 2-{[1-(1-acetilpiperidin-4-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6il]oxi}propanonitrilo 1H RMN (500 MHz, DMSO-d6) δ ppm 1,71(d, 3H) 1,72(d, 2H) 1,77(d, 1H) 2,04(s, 3H) 2,41(qd, 1H) 2,56(dq, 1H) 2,70(d, 1H) 3,24(t, 1H) 3,70(s, 3H) 3,71(s, 3H) 3,92(d, 1H) 4,51(d, 1H) 4,73(brs, 1H) 5,03(s, 2H) 5,60(q, 1H) 6,83(d, 1H) 6,85(m, 1H) 6,98(d, 1H) 7,51(dd, 1H) 7,74(d, 1H) 7,83(d, 1H)

5: imagen37 4-[3-(3,4-Dimetoxibencil)-6-hidroxi-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,75(d, 1H) 1,78(d, 1H) 2,41(qd, 1H) 2,53(qd, 1H) 2,79(td, 1H) 3,25(td, 1H) 3,70(s, 3H) 3,71(s, 3H) 3,80(d, 1H) 4,31(d, 1H)4,72 (brs, 1H) 5,02(s, 2H) 6,82(dd, 1H) 6,86(d, 1H) 6,97(d, 1H) 7,21(dd, 1H) 7,44(d, 1H) 7,66(d, 1H) 8,03(s, 1H) 9,85(brs, 1H)

6: imagen38 {[3-(3,4-dimetoxibencil)-1-(1formilpiperidin-4-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]oxi}acetonitrilo 1H RMN (500 MHz, DMSO-d6) δ ppm 1,78(d, 1H) 1,81(d, 1H) 2,42(qd, 1H) 2,54(dt, 1H) 2,81(td, 4H) 3,26(dt, 1H) 3,71(s, 3H) 3,72(s, 3H) 3,81(d, 1H) 4,32(d, 1H) 4,77(brs, 1H) 5,05(s, 2H) 5,30(s, 2H) 6,84(dd, 1H) 6,87(d, 1H) 6,99(d, 1H) 7,51(dd, 1H) 7,71(d, 1H) 7,85(d, 1H) 8,04(s, 1H)

7: imagen39 2-{[3-(3,4-dimetoxibencil)-2,4-dioxo-1piperidin-4-il-1,2,3,4tetrahidroquinazolin-6il]oxi}propanonitrilo 1H RMN (500 MHz, DMSO-d6) δ ppm 1,69(d, 3H) 1,75(d, 2H) 2,65(td, 2H) 2,87(t, 2H) 3,21(d, 2H) 3,69(s, 3H) 3,70(s, 3H) 4,68(brs, 1H) 5,04(s, 2H) 5,59(q, 1H) 6,84(m, 2H) 6,98(d, 1H) 7,50(dd, 1H) 7,73(d, 1H) 7,80(d, 1H)

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8: imagen41 {[3-(3,4-dimetoxibencil)-2,4-dioxo-1piperidin-4-il-1,2,3,4tetrahidroquinazolin-6-il]oxi}acetonitrilo 1H RMN (600 MHz, DMSO-d6) δ ppm 1,77(d, 2H) 2,67(dt, 2H) 2,89(t, 2H) 3,23(d, 2H) 3,69(s, 3H) 3,70(s, 3H) 4,69(brs, 1H) 5,05(s, 2H) 5,28(s, 2H) 6,84(m, 2H) 6,99(s, 1H) 7,49(dd, 1H) 7,70(d, 1H) 7,80(d, 1H)

9: imagen42 2-{[3-(3,4-dimetoxibencil)-1-(1metilpiperidin-4-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6il]oxi}propanonitrilo 1H RMN (500 MHz, DMSO-d6) δ ppm 1,59(d, 2H) 1,66(d, 3H) 2,04(t, 2H) 2,16(s, 3H) 2,62(dt, 2H) 2,82(d, 2H) 3,66(s, 3H) 3,67(s, 3H) 4,43(brs, 1H) 5,01(s, 2H) 5,54(q, 1H) 6,79(m, 1H) 6,82(d, 1H) 6,95(d, 1H) 7,45(dd, 1H) 7,68(d, 1H) 7,70(d, 1H)

10: imagen43 3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-1-piperidin-4ilquinazolina-2,4(1H,3H)-diona 1H RMN (500 MHz, DMSO-d6) δ ppm 1,85(d, 2H) 2,78(td, 2H) 3,04(t, 2H) 3,33(d, 2H) 3,71(s, 6H) 4,61-4,82(m, 4H) 5,04(brt, 1H ) 5,05(s, 2H) 6,86(m, 2H) 6,99(s, 1H) 7,49(dd, 1H) 7,68(d, 1H) 7,76(d, 1H) 8,05(brs, 1H)

11: imagen44 4-[3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,76(d, 1H) 1,80(d, 1H) 2,41(qd, 1H) 2,53(qd, 1H) 2,80(td, 1H) 3,25(dt, 1H) 3,70(s, 6H) 3,80(d, 1H) 4,31(d, 1H) 4,61-4,83(m, 5H) 5,02(m, 1H) 5,03(s, 2H) 6,83(dd, 1H) 6,85(d, 1H) 6,97(d, 1H) 7,47(dd, 1H) 7,67(d, 1H) 7,77(d, 1H) 8,03(s, 1H)

12: imagen45 1-(1-acetilpiperidin-4-il)-3-(3,4dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona 1H RMN (500 MHz, DMSO-d6) δ ppm 1,70(d, 1H) 1,76(d, 1H) 2,04(s, 3H) 2,41(dq, 1H) 2,56(dq, 1H) 2,70(t, 1H) 3,25(t, 1H) 3,70(s, 3H) 3,71(s, 3H) 3,92(d, 1H) 4,51(d, 1H) 4,61-4,83(m, 5H) 5,02(m, 1H) 5,03(s, 2H) 6,82(dd, 1H) 6,85(m, 1H) 6,97(d, 1H) 7,47(dd, 1H) 7,67(d, 1H) 7,77(d, 1H)

13: imagen46 4-[3-(3,4-dimetoxibencil)-2,4-dioxo-6(2,22-trifluoroetoxi)-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,75(d, 1H) 1,79(d, 1H) 2,40(dq, 1H)) 2,52(dq, 1H) 2,79(td, 1H) 3,25(td, 1H) 3,69(s, 6H) 3,79(d, 1H) 4,30(d, 1H) 4,75(brs, 1H) 4,88(q, 2H) 5,02(s, 2H) 6,82(d, 1H) 6,85(d, 1H) 6,97(s, 1H) 7,49(dd, 1H) 7,66(d, 1H) 7,79(d, 1H) 8,02(s, 1H)

14: imagen47 1-(1-acetilpiperidin-4-il)-6-(2,2difluoroetoxi)-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona 1H RMN (500 MHz, DMSO-d6) δ ppm 1,70(d, 1H) 1,74(d, 1H) 2,04(s, 3H) 2,41(qd, 1H) 2,56(qd, 1H) 2,70(t, 1H) 3,24(t, 1H) 3,70(s, 3H) 3,70(s, 3H) 3,91(d, 1H) 4,43(td, 2H) 4,50(d, 1H) 4,73(brs,1H) 5,03 (s, 2H) 6,41(tt, 1H) 6,82(dd, 1H) 6,85(d, 1H) 6,97(d, 1H) 7,46(dd, 1H) 7,60(d, 1H) 7,79(d, 1H)

15: imagen48 6-(2,2-difluoroetoxi)-3-(3,4dimetoxibencil)-1-piperidin-4ilquinazolina-2,4(1H,3H)-diona 1H RMN (500 MHz, DMSO-d6) δ ppm 1,83(d, 2H) 2,75(td, 2H) 3,00(t, 2H) 3,30(d, 2H) 3,71(s, 6H) 4,44(td, 2H) 4,75(b, s, 1H) 5,06(s, 2H) 6,42(tt, 1H) 6,83-6,89(m, 2H) 7,00(s, 1H) 7,48(dd, 1H) 7,62(d, 1H) 7,78(d, 1H)

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ppm 1,89(d, 2H) 2,83-2,92(m, 2H) 4,97(m, 1H) 7,99(m, 2H) 8,24(s, 1H)

2,45(m,, 1H) 3,29(m, 1H) 3,70(s, 1H) 3,71(s,

(s,

1H) 8,16(s, 1H) 8,62(t, 1H)

24: imagen52 N-{[1-(1-acetilpiperidin-4-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}formamida 1H RMN (500 MHz, DMSO-d6) δ ppm 1,67-1,78(m, 2H) 2,05(s, 3H) 2,352,48(m, 1H) 2,53-2,62(m, 1H) 2,72(t, 1H) 3,25(t, 1H) 3,70(s, 3H) 3,71(s, 3H) 3,93(d, 1H) 4,37(d, 2H) 4,52(d, 1H) 4,75(brs, 1H) 5,04(s, 2H) 6,82(dd, 1H) 6,86(d, 1H) 6,98(d, 1H) 7,67(dd,1 H) 7,78(d,1 H) 7,99(d, 1H) 8,16(s, 1H) 8,63(t, 1H)

25: imagen53 N-{[1-(1-acetilpiperidin-4-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}acetamida 1H RMN (500 MHz, DMSO-d6) δ ppm 1,63-1,81(m, 2H) 1,87(s, 3H) 2,05(s, 3H) 2,32-2,42(m, 1H) 2,54-2,63(m, 1H) 2,71(dt, 1H) 3,25(dt, 1H) 3,70(s, 3H) 3,71(s, 3H) 3,93(d, 1H) 4,30(d, 2H) 4,52(d, 1H) 4,76(brs, 1H) 5,04(s, 2H) 6,81(dd 1H) 6,86(d, 1H) 6,97(d, 1H) 7,65(dd, 1H) 7,76(d, 1H) 7,97(d, 1H) 8,47(t, 1H)

26: imagen54 hidrocloruro de 6-(2,2-difluoroetoxi)-3(3,4-dimetoxibencil)-1-piperidin-3ilquinazolina-2,4(1H,3H)-diona 1H RMN (600 MHz, DMSO-d6) δ ppm 1,86-1,97(m, 3H) 2,54-2,62(m, 1H) 2,85-2,92(m, 1H) 3,31-3,35(m, 1H) 3,37-3,42(m, 1H) 3,71(s, 3H) 3,72(s, 3H) 3,73-3,78(m,1H) 3,76(t, 1H) 4,45(td, 2H) 4,87(br s, 1H) 5,05(s, 2H) 6,41(tt, 1H) 6,83-6,88(m, 2H) 6,99(s, 1H) 7,52(dd, 1H) 7,63(d, 1H) 7,72(d, 1H) 8,95(brs, 1H)

27: imagen55 hidrocloruro de 6-(2,2-difluoroetoxi)-3(3,4-dimetoxibencil)-1-pirrolidin-3ilquinazolina-2,4(1H,3H)-diona 1H RMN (500 MHz, DMSO-d6) δ ppm 2,25-2,32(m, 1H) 2,42-2,48(m, 1H) 3,11-3,19(m, 1H) 3,38-3,45(m, 1H) 3,58-3,64(m, 1H) 3,65-3,72(m, 1H) 3,73(s, 3H) 3,71(s, 3H) 4,45(td, 2H) 5,05-5,12(m, 2H) 5,47-5,54(m, 1H) 6,42(tt, 1H) 6,82-6,88(m, 2H) 7,01(s, 1H) 7,55(dd, 1H) 7,62(d, 1H) 7,71(d, 1H) 8,87(brs, 1H)

28: imagen56 3-[6-(2,2-difluoroetoxi)-3-(3,4dimetoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (600 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,521,62(m, 0,5H) 1,64-1,73(m, 0,5H) 1,75-1,84(m, 1H) 1,84-1,90(m, 1H) 2,542,67(m, 1,5H) 3,05(t, 0,5H) 3,59(t, 0,5H) 3,70(s, 3,5H) 3,70(s, 3H) 3,77(dd, 0,5H) 4,06(t, 0,5H) 4,17-4,27(m, 1H) 4,31(brs, 0,5H) 4,42(td, 2H) 4,44(brs, 0,5H) 5,04(s, 2H) 6,38(tt, 1H) 6,80-6,84(m, 1H) 6,84-6,88(m, 1H) 6,98(brs, 1H) 7,43(td, 1H) 7,60(brs, 1H) 7,62(d, 0,5H) 7,79(d, 0,5H) 7,99(s, 0,5H) 8,09(s, 0,5H)

29: imagen57 1-(1-acetilpiperidin-3-il)-6-(2,2difluoroetoxi)-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,551,65(m, 0,5H) 1,67-1,89(m, 2,5H) 1,99(s, 1,5H) 2,06(s, 1,5H) 2,52-2,65(m, 1H) 3,06(t, 0,5H) 3,30-3,37(m, 0,5H) 3,52(t, 0,5H) 3,70(s, 3H) 3,71(s, 3H) 3,52(t, 0,5H) 3,84(d, 0,5H) 3,91(d, 0,5H) 4,09(t, 0,5H) 4,28(brs, 0,5H) 4,394,48(m, 3H) 4,49(brs, 0,5H) 5,05(d, 2H) 6,41(tt, 1H) 6,81-6,89(m, 2H) 6,99(d, 1H) 7,44-7,48(m, 1H) 7,59-7,62(m, 1H) 7,64(d, 0,5H) 7,82(d, 0,5H)

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30: imagen59 3-[6-(2,2-difluoroetoxi)-3-(3,4dimetoxibencil)-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]pirrolidin-1carbaldehído 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 2,182,27(m, 1H) 2,36-2,46(m, 1H) 3,41-3,48(m, 0,5H) 3,53-3,60(m, 0,5H) 3,633,73(m, 1,5H) 3,85-3,95(m, 1,5H) 4,43(td, 2H) 5,06(s, 2H) 5,38-5,45(m, 0,5H) 5,46-5,54(m, 0,5H) 6,41(tt, 1H) 6,82-6,88(m, 2H) 7,00(s, 1H) 7,46 -7,51(m, 1H) 7,61(d, 1H) 7,66(d, 0,5H) 7,72(d, 0,5H) 8,16(s, 0,5H) 8,20(s, 0,5H)

31: imagen60 1-(1-acetilpirrolidin-3-il)-6-(2,2difluoroetoxi)-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,98(s, 1,5H) 2,04(s, 1,5H) 2,17-2,25(m, 0,5H) 2,27-2,35(m, 0,5H ) 2,57-2,66(m, 1H) 3,40-3,45(m, 0,5H) 3 56-3,61(m, 0,5H) 3,70-3,78(m, 7,5H) 3,823,95(m, 1,5H) 4,48(td, 2H) 5,10(d, 2H) 5,45-5,58(m, 1H) 6,46(tt, 1H) 6,876,92(m, 2H) 7,05(dd, 1H) 7,53(td, 1H) 7,66(t, 1H) 7,72 (dd, 1H)

32: imagen61 4-[6-(2,2-difluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,72-1,82(m, 2H) 2,35-2,44(m, 1H) 2,47-2,55(m, 1H) 2,79(td, 1H) 3,25(td, 1H) 3,80(d, 1H) 4,32(d, 1H) 4,42(td, 2H) 4,71(brs, 1H) 6,40(tt, 1H) 7,43(dd, 1H) 7,55(d, 1H) 7,74(d, 1H) 8,03(s, 1H)

33: imagen62 4-[3-(3,4-diclorobencil)-6-(2,2difluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,80(dd, 2H) 2,32-2,43(m, 1H) 2,442,52(m, 1H) 2,80(td, 1H) 3,26(dt, 1H) 3,80(brd, 1H) 4,31(br d, 1H) 4,44(td, 2H) 4,78(brs, 1H) 5,09(s, 2H) 6,41(tt, 1H) 7,30(dd, 1H) 7,49(dd, 1H) 7,58(d, 1H) 7,60(d, 1H) 7,62(d, 1H) 7,81(d, 1H) 8,03(s, 1H)

34: imagen63 4-[3-(4-clorobencil)-6-(2,2-difluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,72-1,83(m, 2H) 2,32-2,44(m, 1H) 2,45-2,53(m, 1H) 2,80(dt, 1H) 3,25-3,30(dt, 1H) 3,80 (d, 1 H) 4,30 (d,1 H) 4,44 (td, 2H) 4,78(brs, 1H) 5,09(s, 2H) 6,42 (tt, 1H) 7,32-7,40(m, 4H) 7,48(dd, 1H) 7,61(d, 1H) 7,81(d, 1H) 8,03(s, 1H)

35: imagen64 4-{[6-(2,2-difluoroetoxi)-1-(1formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il]metil}benzoato de metilo 1H RMN (500 MHz, DMSO-d6) δ ppm 1,78(dd, 1H) 2,33-2,42(m, 1H) 2,442,52(m, 1H) 2,80(dt, 1H) 3,26(dt, 1H) 3,79(brd, 1H) 3,84(s, 3H) 4,30(brd, 1H) 4,45(td, 2H) 4,79(brs, 1H) 5,18(s, 2 H) 6,42(tt, 1H) 7,43(d, 2H) 7,49(dd, 1H) 7,62(d, 1H) 7,83(d, 1H) 7,91(d, 2H) 8,02(s, 1H)

36: imagen65 ácido 4-{[6-(2,2-difluoroetoxi)-1-(1formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il]metil}benzoico 1H RMN (500 MHz, DMSO-d6) δ ppm 1,79(dd, 2H) 2,38(qd, 1H) 2,49(qd, 1H) 2,80(dt, 1H) 3,26(dt, 1H) 3,79(d, 1H) 4,31(d, 1H) 4,45(td, 2H) 4,79(brs, 1H) 5,17(s, 2H) 6,42(tt, 1H) 7,40(d, 2H) 7,49(dd, 1H) 7,62(d, 1H) 7,83(d, 1H) 7,88(d, 2H) 8,02(s, 1H) 12,94(brs, 1H)

imagen66

37: imagen67 4-{[6-(2,2-difluoroetoxi)-1-(1formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)-il]metil}-N-(2metoxietil)benzamida 1H RMN (500 MHz, DMSO-d6) δ ppm 1,72-1,82(m, 2H) 2,32-2,42(m, 1H) 2,44-2,54(m, 1H) 2,75-2,83(m, 1H) 3,21-3,29(m, 4H) 3,37-3,45(m, 4H) 3,77(br,d,, 1H) 4,29(br,d,, 1H) 4,44(td, 2H) 4,78(br,s,, 1H) 5,14(s, 2H) 6,41(tt , 1H) 7,35(m, 2H) 7,48(dd, 1H) 7,61(d, 1H) 7,77(m, 2H) 7,81(d, 1H) 8,01(s, 1H) 8,47(t, 1H)

38: imagen68 4-[3-(3,4-dimetoxibencil)-6-metil-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,76(dd, 2H) 2,37(s, 3H) 2,392,42(m, 1H) 2,50-2,54(m, 1H) 2,77-2,82(m, 1H) 3,19-3,30(m, 1H) 3,70(s, 6H) 3,79(d, 1H) 4,30(d, 1H) 4,76(brs, 1H) 5,02(s, 2H) 6,82(dd, 1H) 6,85(d, 1H) 6,97(d, 1H) 7,60(dd, 1H) 7,71(d, 1H) 7,89(s, 1H) 8,03(s, 1H)

39: imagen69 4-[6-(2,2-difluoroetoxi)-3-(3-hidroxi-4metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,70-1,80(m, 2H) 2,35-1,45(m, 1H) 2,47-2,56(m, 1H) 2,80(dt, 1H) 3,25(dt, 1H) 3,70(s, 3H) 3,79(brd, 1H) 4,30(brd, 1H) 4,43(td, 2H) 4,77(brs, 1H) 4,96(s, 2H) 6,41(tt, 1H) 6,73(d, 1H) 6,78-6,82(m, 2H) 7,46(dd, 1H) 7,60(d, 1H) 7,79(d, 1H) 8,03(s, 1H) 8,95 (s, 1 H)

40: imagen70 4-[6-(2,2-difluoroetoxi)-3-[3-(2hidroxietoxi)-4-metoxibencil]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,76(dd, 2H) 2,35-2,45(m, 1H) 2,50-2,54(m, 1H) 2,79(dt, 1H) 3,25(dt, 1H) 3,68(dt, 2H) 3,70(s, 3H) 3,79(brd, 1H) 3,90(t, 2H) 4,30(brd, 1H) 4,42(td, 2H) 4,75(brs, 1H) 4,77(t, 1H) 5,01(s, 2H) 6,39(tt, 1H) 6,85(m, 2H) 6,97(s, 1H) 7,45(dd, 1H) 7,60(d, 1H) 7,77(d, 1H) 8,02(s, 1H)

41: imagen71 4-[6-(2,2-difluoroetoxi)-3-(3-etoxi-4metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,29(t, 3H) 1,76(dd, 2H) 2,33-2,45(m, 1H) 2,50-2,56(m, 1H) 2,76-2,82(m, 1H) 3,21-3,31(m, 1H) 3,70(s, 3H) 3,79(brd, 1H) 3,94(q, 2H) 4,30(brd,1 H) 4,41(dt, 2H) 4,75(brs, 1H) 5,01(s, 2H) 6,39(tt, 1H) 6,81-6,86(m, 2H) 6,96(s, 1H) 7,45(dd, 1H) 7,60(d, 1H) 7,77(d, 1H) 8,02(s, 1H)

42: imagen72 4-[6-(2,2-difluoroetoxi)-3-[4-metoxi-3-(2metoxietoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,69-1,82(m, 2H) 2,35-2,45(m, 1H) 2,45-2,55(m, 1H) 2,78(t, 1H) 3,21-3,28(m, 1H) 3,61(brs, 2H) 3,70(s, 3H) 3,78(d, 1H) 4,00(brs, 2H) 4,30(d, 1H) 4,42(t, 2H) 4,75(brs, 1H) 5,01(s, 2H) 6,39(t, 1H) 6,82- 6,88(m, 2H) 6,97(s, 1H) 7,45(d, 1H) 7,59(s, 1H) 7,77(d, 1H) 8,02(s, 1H)

43: imagen73 4-[6-(2,2-difluoroetoxi)-3-(3,4dimetoxibencil)-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]azepan-1carbaldehído 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,721,81(m, 1H) 1,85(brd, 1H) 1,86-2,03(m, 2H) 2,47(brs, 2H) 3,30-3,40(m, 1H) 3,42-3,52(m, 1H) 3,58-3,64(m, 2H) 3,70(s, 3H) 3,71(s, 3H) 4,42(td, 2H) 4,45(brs, 0,5H) 5,04(brs, 2H) 5,21(brs, 0,5H) 6,40(tt, 1H) 6,78-6,83(m, 1H) 6,86(d, 1H) 6,98(s, 1H) 7,38-7,48(m, 1H) 7,59(brs, 1H) 7,64-7,74(m, 1H) 8,08(brs, 0,5H) 8,12(s, 0,5H)

imagen74

44: imagen75 3-(3,4-dimetoxibencil)-2,4-dioxo-1pirrolidin-3-il-1,2,3,4tetrahidroquinazolina-6-carbonitrilo 1H RMN (600 MHz, DMSO-d6) δ ppm 1,96-2,09(m, 2H) 2,78-2,84(m, 1H) 3,05-3,12(m, 2H) 3,18-3,27(m, 1H) 3,70(s, 3H) 3,71(s, 3H) 5,04(s, 2H) 5,47-5,53(m, 1H) 6,83(brs, 2H) 6,99(s, 1H) 8,15(dd, 1H) 8,20(d, 1H) 8,47(d, 1H)

45: imagen76 1-(1-acetilpirrolidin-3-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-6-carbonitrilo 1H RMN (600 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,91(s, 1,5H) 1,98(s, 1,5H) 2,14-2,22(m, 0,5H) 2,25-2,32(m, 0,5H) 2,43-2,50(m, 0,5H) 2,52-2,58(m, 0,5H) 3,31-3,39(m, 0,5H) 3,50-3,55(m, 0,5H) 3,633,73(m, 7,5H) 3,79-3,87(m, 1,5H) 5,00-5,06(m, 2H) 5,43-5,55(m, 1H) 6,826,90(m, 2H) 6,98(d, 1H) 7,84(dd, 1H) 8,17(dt, 1H) 8,43(dd, 1H)

46: imagen77 3-(3,4-dimetoxibencil)-1-(1formilpirrolidin-3-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-6-carbonitrilo 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 2,192,27(m, 1H) 2,36-2,43(m, 1H) 3,43-3,47(m, 0,4H) 3,53-3,59(m, 0,6 ) 3,623,73(m, 1,6H) 3,70(s, 3H) 3,71(s, 3H) 3,84-3,94(m, 1,4H) 5,04(s, 2H) 5,425,49(m, 0,4H) 5,50-5,56(m, 0,6H) 6,86(s, 2H) 6,99(s, 1H) 7,85(d, 0,6H) 7,90(d, 0,4H) 8,15-8,22(m, 2H) 8,45(s, 1H)

47: imagen78 4-[6-(2,2-difluoroetoxi)-3-[3-(3hidroxipropoxi)-4-metoxibencil]-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,72-1,79(m, 2H) 1,82(q, 2H) 2,362,44(m, 1H) 2,49-2,55(m, 1H) 2,78(td, 1H) 3,25(td, 1H) 3,51-3,54(m, 2H) 3,70(s, 3H) 3,76-3,80(m, 1H) 3,95(t, 2H) 4,28-4,32(m, 1H) 4,41(td, 2H) 4,47(t, 1H) 4,75(s, 1H) 5,01(s, 2H) 6,39(tt, 1H) 6,81-6,86(m, 2H) 6,966,97(m, 1H) 7,45(dd, 1H) 7,59(d, 1H) 7,77(d, 1H) 8,02(s, 1H)

48: imagen79 4-[5-cloro-3-(3,4-dimetoxibencil)-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,78-1,88(m, 2H) 2,34-2,44(m, 1H) 2,46-2,56(m, 1H) 2,80(t, 1H) 3,25(t, 1H) 3,71(s, 6H) 3,80(d, 1H) 4,31(d, 1H) 4,71(brs, 1H) 5,00(s, 2H) 6,83(d, 1H) 6,87(d, 1H) 6,97(s, 1H) 7,37(d, 1H) 7,69(dd, 1H) 7,77(d, 1H) 8,03(s, 1H)

49: imagen80 4-{3-[3-(ciclopentiloxi)-4-metoxibencil]-6(2,2-difluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 1H RMN (500 MHz, DMSO-d6) δ ppm 1,5-1,6(m, 2H) 1,63-1,71(m, 3H) 1,68-1,78(m, 1H) 1,78-1,98(m, 3H) 2,35-2,46(m, 1H) 2,47-2,57(m, 1H) 2,79(dt, 1H) 3,26(dt, 1H) 3,69(s, 3H) 3,79(br,d,, 1H) 4,30(br,d,, 1H) 4,43(td, 2H) 4,66-4,70(m, 1H) 4,76(br,s,, 1H) 5,01(s, 2H) 6,41(tt, 1H) 6,82 – 6,86(m, 2H) 6,96(s, 1H) 7,46(dd, 1H) 7,6(d, 1H) 7,80(d, 1H) 8,03(s, 1H)

50: imagen81 2-(5-{[6-(2,2-difluoroetoxi)-1-(1formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il]metil}metoxifenoxi)acetamida 1H RMN (500 MHz, DMSO-d6) δ ppm 1,72-1,82(m, 2H) 2,35-2,45(m, 1H) 2,46-2,56(m, 1H) 2,79(td, 1H) 3,25(td, 1H) 3,74(s, 3H) 3,79(d, 1H) 4,31(d, 1H) 4,35(s, 2H) 4,43(td, 2H) 4,76(brs, 1H) 5,00(s, 2H) 6,41(tt, 1H) 6,886,95(m, 3H) 7,31(brs, 1H) 7,37(brs, 1H) 7,46(dd, 1H) 7,59(d, 1H) 7,79(d, 1H) 8,02(s, 1H)

imagen82

51: imagen83 4-[6-(2,2-difluoroetoxi)-3-(3,4dimetoxibencil)-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]-3metilpiperidin-1-carbaldehído 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 0,92(t, 3H) 1,72-1,82(m, 1H) 2,23(brs, 1H) 2,70-2,77(m, 0,5H) 3,00-3,10(m, 0,5H) 3,12-3,20(m, 1,5H) 3,44(d, 0,5H) 3,63(dd, 0,5H) 3,69(s, 6H) 3,80(d, 0,5H) 4,04(d, 0,5H) 4,29(d, 0,5H) 4,43(td, 2H) 4,62-4,70(m, 1H) 5,03(s, 2H) 6,41(tt, 1H) 6,80(dd, 1H) 6,85(d, 1H) 6,97(d, 1H) 7,46(dd, 1H) 7,60(d, 1H) 7,64(dd, 1H) 7,97(s, 0,5H) 8,11(s, 0,5H)

52: imagen84 3-[6-(2,2-difluoroetoxi)-3-(3,4dimetoxibencil)-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]-8azabiciclo[3.2.1]octano-8-carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,85-1,95(m, 4H) 2,18(t, 2H) 2,272,33(m, 1H) 2,34-2,41(m, 1H) 3,70(s, 1H) 3,71(s, 1H) 4,25-4,29(m, 1H) 4,40(td, 2H) 4,50-4,54(m, 1H) 4,55(br,s,, 1H) 5,05(s, 2H) 6,38(tt, H) 6,80(d, 1H) 6,85(d, 1H) 6,98(s, 1H) 7,45(dd, 1H) 7,56(d, 1H) 7,58(d, 1H) 8,12(s, 1H)

53: imagen85 3-(3,4-dimetoxibencil)-1-(1formilpiperidin-3-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-6-carbonitrilo 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,521,63(m, 0,5H) 1,65-1,73(m, 0,5H) 1,74-1,83(m, 1H) 1,87-1,93(m, 1H) 2,542,64(m, 1,5H) 3,06(dt, 0,5H) 3,57(t, 0,5H) 3,70(s, 3H) 3,71(s, 3H) 3,79(dd, 0,5H) 4,03(t, 0,5H) 4,20(d, 0,5H) 4,30(d, 0,5H) 4,38(brs, 0,5H) 4,53(brs, 0,5H) 4,99-5,07(m, 2H) 6,84-6,88(m, 2H) 6,98(s, 1H) 7,86(d, 0,5H) 8,01(d, 0,5H) 7,98(s, 0,5H) 8,08(s, 0,5H) 8,14-8,18(m, 1H) 8,44(s, 1H)

54: imagen86 1-(1-acetilpiperidin-3-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-6-carbonitrilo 1H RMN (500 MHz, DMSO-d6) mezcla de dos isómeros δ ppm 1,561,66(m, 0,5H) 1,70-1,82(m, 1,5H) 1,87(brd, 1H) 1,97(s, 1,5H) 2,05(s, 1,5H) 2,54(dd, 1H) 3,05(brt, 0,5H) 3,48(t, 0,5H) 3,70-3,72(m, 6H) 3,83(d, 0,5H) 3,94(brd, 0,5H) 4,04(t, 0,5H) 4,33(brs, 0,5H) 4,45(dd, 1H) 4,53(brs, 0,5H) 4,99-5,07(m, 2H) 6,83-6,87(m, 2H) 6,98(d, 1H) 7,84(d, 0,5H) 8,02(d, 0,5H) 8,16(dt, 1H) 8,44(dd, 1H)

55: imagen87 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 1H RMN (600 MHz, DMSO-d6) δ ppm 1,73-1,82(m, 2H) 2,36-2,44(m, 1H) 2,44-2,55(m, 1H) 2,79(td, 1H) 3,25(td, 1H) 3,80(brd, 1H) 4,32(brd, 1H) 4,62-4,67(m, 1H) 4,68-4,76(m, 3H) 4,76-4,82(m, 1H) 4,96-5,06(m, 1H) 7,44(dd, 1H) 7,61(d, 1H) 7,73(d, 1H) 8,03(s, 1H) 11,46(brs, 1H)

56: imagen88 4-{3-[4-(ciclopentiloxi)-3-metoxibencil]-6[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il}piperidin1-carbaldehído LCMS m/z [MH]+ 572

57: imagen89 4-[3-(3-clorobencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 492

imagen90

58: imagen91 4-[3-(4-clorobencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 492

59: imagen92 4-{3-[3-(ciclopentiloxi)-4-metoxibencil]-6[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il}piperidin1-carbaldehído LCMS m/z [MH]+ 572

60: imagen93 6-bromo-3-(3,4-dimetoxibencil)-1-[1(hidroxiacetil)piperidin-3-il]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 532

61: imagen94 1-(1-acetilpiperidin-3-il)-6-bromo-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 516

62: imagen95 3-(3,4-dimetoxibencil)-1-[1(hidroxiacetil)piperidin-3-il]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 454

63: imagen96 6-bromo-3-(3,4-dimetoxibencil)-1[piperidin-3-il]quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 474

64: imagen97 N-{[1-(1-acetilpirrolidin-3-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}acetamida LCMS m/z [MH]+ 495

65: imagen98 3-[6-bromo-3-(3,4-dimetoxibencil)-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído LCMS m/z [MH]+ 502

imagen99

66: imagen100 6-bromo-1-[1(ciclopropilcarbonil)piperidin-3-il]-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 542

67: imagen101 1-{1-[(benciloxi)acetil]piperidin-3-il}-6bromo-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 622

68: imagen102 1-{1-[(benciloxi)acetil]piperidin-3-il}-3(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 638

69: imagen103 3-[3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 518

70: imagen104 3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-1-[1(hidroxiacetil)piperidin-3-il]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 548

71: imagen105 3-[3-(3,4-dimetoxibencil)-6-(2hidroxietoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 484

72: imagen106 4-[3-(3,4-dimetoxibencil)-6-(2hidroxietoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+484

73: imagen107 1-[1-(ciclopropilcarbonil)piperidin-3-il]-3(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 558

imagen108

74: imagen109 4-[3-(3,4-diclorobencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 526

75: imagen110 3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-1-piperidin-3ilquinazolina-2,4(1H,3H)-diona LCMS m/z [MH]+ 490

76: imagen111 4-{3-[(6-cloropiridin-3-il)metil]-6-[2-fluoro1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído LCMS m/z [MH]+ 493

77: imagen112 N-{[3-(3,4-dimetoxibencil)-1-(1formilpirrolidin-3-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}acetamida LCMS m/z [MH]+ 481

78: imagen113 4-[3-(3-cloro-4-metoxibencil)-6-[2-fluoro1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 522

79: imagen114 4-[3-(3,4-dimetoxibencil)-6-(2fluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 486

80: imagen115 6-bromo-3-(3,4-dimetoxibencil)-1[pirrolidin-3-il]quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 460

81: imagen116 6-bromo-1-[1(ciclopropilcarbonil)pirrolidin-3-il]-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 528

imagen117

82: imagen118 1-(1-acetilpirrolidin-3-il)-6-bromo-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 502

83: imagen119 3-[6-bromo-3-(3,4-dimetoxibencil)-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]pirrolidina-1-carbaldehído LCMS m/z [MH]+ 488

84: imagen120 1-[1-(ciclopropilcarbonil)piperidin-3-il]-3(3,4-dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-6-carbonitrilo LCMS m/z [MH]+ 489

85: imagen121 3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-1-pirrolidin-3ilquinazolina-2,4(1H,3H)-diona LCMS m/z [MH]+ 476

86: imagen122 3-(3,4-dimetoxibencil)-1-[1(hidroxiacetil)piperidin-3-il]-2,4-dioxo1,2,3,4-tetrahidroquinazolina-6carbonitrilo LCMS m/z [MH]+ 479

87: imagen123 1-[1-(ciclopropilcarbonil)pirrolidin-3-il]-3(3,4-dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-6-carbonitrilo LCMS m/z [MH]+ 475

88: imagen124 1-{1-[(benciloxi)acetil]pirrolidin-3-il}-6bromo-3-(3,4dimetoxibencil)quinazolina-2,4(1H,3H)diona LCMS m/z [MH]+ 608

89: imagen125 2-[5-({6-[2-fluoro-1-(fluorometil)etoxi]-1(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)-2metoxifenoxi]acetamida LCMS m/z [MH]+ 561

imagen126

90: imagen127 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3hidroxi-4-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído LCMS m/z [MH]+ 504

91: imagen128 4-[3-(3,4-dimetoxibencil)-6-etoxi-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído LCMS m/z [MH]+ 468

92: imagen129 1-[1-(ciclopropilcarbonil)pirrolidin-3-il]-3(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 544

93: imagen130 1-{1-[(benciloxi)acetil]pirrolidin-3-il}-3(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 624

94: imagen131 3-[3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]pirrolidina-1carbaldehído LCMS m/z [MH]+ 504

95: imagen132 N-({1-[1-(ciclopropilcarbonil)pirrolidin-3il]-3-(3,4-dimetoxibencil)-2,4-dioxo1,2,3,4-tetrahidroquinazolin-6il}metil)acetamida LCMS m/z [MH]+ 521

96: imagen133 3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-1-[1(hidroxiacetil)pirrolidin-3-il]quinazolina2,4(1H,3H)-diona LCMS m/z [M+Na]+ 534

97: imagen134 4-[5,7-dicloro-3-(3,4-dimetoxibencil)-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído LCMS m/z [MH]+ 492

imagen135

98: imagen136 3-{6-[(acetilamino)metil]-3-(3,4dimetoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carboxilato de 1,1-dimetiletilo LCMS m/z [M+Na]+ 589

99: imagen137 N-{[3-(3,4-dimetoxibencil)-1-(1formilpiperidin-3-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}acetamida LCMS m/z [MH]+ 495

100: imagen138 N-{[1-(1-acetilpiperidin-3-il)-3-(3,4dimetoxibencil)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}acetamida LCMS m/z [MH]+ 509

101: imagen139 N-({1-[1-(ciclopropilcarbonil)piperidin-3il]-3-(3,4-dimetoxibencil)-2,4-dioxo1,2,3,4-tetrahidroquinazolin-6il}metil)acetamida LCMS m/z [MH]+ 535

102: imagen140 4-[7-cloro-3-(3,4-dimetoxibencil)-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído LCMS m/z [MH]+ 458

103: imagen141 N-({3-(3,4-dimetoxibencil)-1-[1(hidroxiacetil)piperidin-3-il]-2,4-dioxo1,2,3,4-tetrahidroquinazolin-6il}metil)acetamida LCMS m/z [MH]+ 525

104: imagen142 3-(3,4-dimetoxibencil)-1-[1(hidroxiacetil)pirrolidin-3-il]-2,4-dioxo1,2,3,4-tetrahidroquinazolina-6carbonitrilo LCMS m/z [MH]+ 465

105: imagen143 6-bromo-3-(3,4-dimetoxibencil)-1-[1(hidroxiacetil)pirrolidin-3-il]quinazolina2,4(1H,3H)-diona LCMS m/z [MH]+ 518

imagen144

106: imagen145 3-[3-(3,4-dimetoxibencil)-6-metil-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]pirrolidina-1-carbaldehído LCMS m/z [MH]+ 424

107: imagen146 N-{[3-(3,4-dimetoxibencil)-1-(1formilpirrolidin-3-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolin-6-il]metil}formamida LCMS m/z [MH]+ 467

108: imagen147 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3fluoro-4-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído LCMS m/z [MH]+ 506

109: imagen148 4-[6-(Benciloxi)-3-(3,4-dimetoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído LCMS m/z [MH]+ 530

110: imagen149 3-[6-(benciloxi)-3-(3,4-dimetoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]azetidina-1-carboxilato de 1,1dimetiletilo LCMS m/z [MH]+ 574

111: imagen150 4-[6-(difluorometoxi)-3-(3,4dimetoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 490

112: imagen151 4-[3-(3,4-dimetoxibencil)-6-(1-metiletoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído LCMS m/z [MH]+ 482

113: imagen152 3-[3-(3,4-dimetoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]azetidina-1carboxilato de 1,1-dimetiletilo LCMS m/z [MH]+ 562

imagen153

114: imagen154 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4metoxi-3-(1-metiletoxi)bencil]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il}piperidin1-carbaldehído LCMS m/z [MH]+ 546

115: imagen155 3-[3-(3,4-dimetoxibencil)-6-hidroxi-2,4dioxo-3,4-dihidroquinazolin-1(2H)il]azetidina-1-carboxilato de 1,1dimetiletilo LCMS m/z [MH]+ 484

116: imagen156 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído LCMS m/z [MH]+ 488

117: imagen157 4-{3-[3,5-bis(trifluorometil)bencil]-6-[2fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído LCMS m/z [MH]+ 564

118: imagen158 4-[3-(3-etoxibencil)-6-[2-fluoro-1(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído LCMS m/z [MH]+ 502

imagen159

Compuesto No: ESTRUCTURA NOMENCLATURA MASAS LC/UV/MS MH+

119: imagen160 4-[3-(3,4-dimetoxibencil)-6-hidroxi-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 440

120: imagen161 3-({4-(benciloxi)-2-[(3,4-dimetoxibencil)carbamoil]fenil}amino)azetidina-1-carboxilato de 1,1-dimetiletilo 548

121: imagen162 4-{3-[3-cloro-4-(ciclopentiloxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 576

122: imagen163 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-fluoro-4-metilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 490

123: imagen164 4-[3-(3,5-difluorobencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 494

124: imagen165 4-{3-[3-cloro-4-(2-metoxietoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 566

125: imagen166 4-{3-[(2-cloropiridin-4-il)metil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 493

imagen167

126: imagen168 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(trifluorometoxi)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 542

127: imagen169 4-[3-(3,5-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 518

128: imagen170 4-[3-(3-fluorobencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 476

129: imagen171 4-[3-(4-fluorobencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 476

130: imagen172 4-[3-(3,4-dietoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 546

131: imagen173 4-[3-(4-etoxi-3-metoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 532

132: imagen174 4-[3-(2,3-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 518

133: imagen175 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-metoxi-3-metilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 502

imagen176

134: imagen177 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(trifluorometil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 526

135: imagen178 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(3-fenoxibencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 550

136: imagen179 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(3-fluoropropoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 534

137: imagen180 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-nitrobencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 503

138: imagen181 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-nitrobencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 503

139: imagen182 1-(1-acetilazetidin-3-il)-3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]quinazolina-2,4(1H,3H)-diona 504

140: imagen183 4-[3-(2,5-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 518

141: imagen184 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 488

imagen185

142: imagen186 4-{3-[3-(benciloxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 564

143: imagen187 4-{3-[4-(benciloxi)-3-metoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 594

144: imagen188 4-[3-(3,5-diclorobencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 526

145: imagen189 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-nitrobencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 533

146: imagen190 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-{4-[(trifluorometil)sulfanyl]bencil}-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 558

147: imagen191 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(pirrolidin-1-ilmetil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 541

148: imagen192 1-[1-(ciclopropilcarbonil)azetidin-3-il]-3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona 530

149: imagen193 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(piperidin-1-ilmetil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 555

imagen194

150: imagen195 3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-1-[1-(hidroxiacetil)azetidin-3-il]quinazolina2,4(1H,3H)-diona 520

151: imagen196 4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)benzonitrilo 483

152: imagen197 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(trifluorometil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 526

153: imagen198 3-[3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]azetidina1-carbaldehído 490

154: imagen199 1-{1-[(benciloxi)acetil]azetidin-3-il}-3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona 610

155: imagen200 4-[3-(4-etoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 502

156: imagen201 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(piperidin-1-ilmetil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 555

157: imagen202 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-(morfolin-4-ilmetil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 557

imagen203

158: imagen204 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(morfolin-4-ilmetil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 557

159: imagen205 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-(2-morfolin-4-iletoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 587

160: imagen206 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-morfolin-4-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin1-carbaldehído 543

161: imagen207 4-[3-(1-benzofur-6-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin1-carbaldehído 498

162: imagen208 4-[4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)bencil]piperazina-1-carboxilato de 1,1-dimetiletilo 656

163: imagen209 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(6-metoxipiridin-3-il)metil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 489

164: imagen210 4-{3-[3-cloro-4-(1-metiletoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 550

165: imagen211 4-[3-(bifenil-4-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 534

imagen212

166: imagen213 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(metilsulfanyl)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 504

167: imagen214 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-piridin-3-ilbencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 535

168: imagen215 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(3-pirrolidin-1-ilbencil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 527

169: imagen216 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-fluoro-3-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 506

170: imagen217 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-metilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 502

171: imagen218 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-metil-3-(trifluorometil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 540

172: imagen219 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-{4-[(4-metilpiperazin-1-il)metil]bencil}-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 570

173: imagen220 4-[3-{4-(ciclopentiloxi)-3-[2-fluoro-1-(fluorometil)etoxi]bencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 636

imagen221

174: imagen222 3-[3,4-bis(ciclopentiloxi)bencil]-1-(1-etenilpiperidin-4-il)-6-[2-fluoro-1-(fluorometil)etoxi]quinazolina2,4(1H,3H)-diona 626

175: imagen223 2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]acetamida 615

176: imagen224 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-(5-metil-1,2,4-oxadiazol-3-il)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 540

177: imagen225 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(metilsulfonil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 536

178: imagen226 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-propoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 546

179: imagen227 4-[3-(3-cloro-4-etoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 536

180: imagen228 4-{3-[4-(1,1-dimetiletoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 530

181: imagen229 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(trifluorometoxi)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 542

imagen230

182: imagen231 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-fluoro-4-(trifluorometil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 544

183: imagen232 2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]-N-metilacetamida 629

184: imagen233 2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]-N,N-dimetilacetamida 643

185: imagen234 2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]-N-metoxi-N-metilacetamida 659

186: imagen235 4-{3-[4-(ciclopentiloxi)-3-etoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 586

187: imagen236 4-{3-[3-(ciclobutilmetoxi)-4-(ciclopentiloxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 626

188: imagen237 4-{3-[4-(ciclopentiloxi)-3-(1-metiletoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 600

189: imagen238 4-{3-[4-(ciclopentiloxi)-3-propoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 600

imagen239

190: imagen240 4-{3-[4-(ciclopentiloxi)-3-hidroxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 558

191: imagen241 4-{3-[4-(ciclopentiloxi)-3-(2-metilpropoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 614

192: imagen242 4-[3-(1,3-benzodioxol-5-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 502

193: imagen243 4-{3-[4-(difluorometoxi)-3-metoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 554

194: imagen244 4-{3-[4-(difluorometoxi)-3-etoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 568

195: imagen245 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-hidroxi-3-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 504

196: imagen246 4-[3-(3,4-dihidro-2H-1,5-benzodiozepin-7-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 530

197: imagen247 4-[3-(2,3-dihidro-1-benzofur-5-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 500

imagen248

198: imagen249 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-fluoro-5-(trifluorometil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 544

199: imagen250 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-1H-benzotriazol-5-il)metil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 513

200: imagen251 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-tiofen-3-ilbencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 540

201: imagen252 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-piridin-4-ilbencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 535

202: imagen253 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(piperazin-1-ilmetil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 555

203: imagen254 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-11H-indol-6-il)metil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 511

204: imagen255 4-{3-[3-cloro-4-(difluorometoxi)-5-metoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 588

205: imagen256 4-{3-[2-(difluorometoxi)-3-etoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 568

imagen257

206: imagen258 4-{3-[4-(ciclopropilmetoxi)-3-metoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 558

207: imagen259 2-[4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)-2-metoxifenoxi]-N-metilacetamida 575

208: imagen260 4-[3-(bifenil-3-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 534

209: imagen261 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-{3-[(4-metilpiperazin-1-il)metil]bencil}-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 570

210: imagen262 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(1H-1,2,4-triazol-1-il)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 525

211: imagen263 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(2-morfolin-4-iletoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 587

212: imagen264 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(1H-pirazol-1-il)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 524

213: imagen265 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-piridin-2-ilbencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 535

imagen266

214: imagen267 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(3-piperidin-1-ilbencil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 541

215: imagen268 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-tiofen-2-ilbencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 540

216: imagen269 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(quinolein-7-ilmetil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 509

217: imagen270 4-{3-[4-(difluorometoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 524

218: imagen271 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(6-metoxinaftalen-2-il)metil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 538

219: imagen272 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(1H-pirazol-1-il)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 524

220: imagen273 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-morfolin-4-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin1-carbaldehído 543

221: imagen274 4-[3-{4-[2-(dimetilamino)etoxi]bencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 545

imagen275

222: imagen276 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-(2-metil-1,3-tiazol-4-il)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 555

223: imagen277 4-{3-[4-(1H-bencimidazol-1-il)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 574

224: imagen278 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(2-metilpropoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 560

225: imagen279 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-piperidin-1-ilbencil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 541

226: imagen280 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(tetrahidrofuran-3-iloxi)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 574

227: imagen281 4-{3-[4-(4-etilpiperazin-1-il)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 570

228: imagen282 4-[3-{4-[(1-bencilpirrolidin-3-il)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 663

229: imagen283 carbonato de 4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin3(2H)-il}metil)-2-metoxifenilo y de 1-metiletilo 590

imagen284

230: imagen285 4-[3-(1-benzotiofen-5-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 514

231: imagen286 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(pirrolidin-3-iloxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 573

232: imagen287 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(1-metiletoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 546

233: imagen288 4-[3-(3,4-dimetoxibencil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 536

234: imagen289 4-[3-{4-[(1-acetilpirrolidin-3-il)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 615

235: imagen290 4-{3-[3-cloro-4-(ciclopropilmetoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 562

236: imagen291 4-{3-[3-cloro-4-(ciclobutilmetoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 576

237: imagen292 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-(morfolin-4-ilsulfonil)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 607

imagen293

238: imagen294 4-[3-(3,4-dietoxibencil)-6-(difluorometoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 518

239: imagen295 4-[3-{4-[(4-fluorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 612

240: imagen296 4-[3-{4-[(4-clorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 628

241: imagen297 4-[3-(1,3-benzotiazol-6-ilmetil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 515

242: imagen298 4-[3-{4-[(3-clorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 628

243: imagen299 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(3-tiofen-3-ilbencil)-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 540

244: imagen300 4-[3-(3,4-dietoxibencil)-6-(2,2-difluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 532

245: imagen301 4-[3-(4-etoxi-3-metoxibencil)-6-(2-hidroxietoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 498

imagen302

246: imagen303 4-[3-{4-[2-(2,3-dihidro-1H-indol-1-il)-2-oxoetoxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 663

247: imagen304 4-[6-(2,2-difluoroetoxi)-3-(4-etoxi-3-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 518

248: imagen305 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-piridin-3-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 565

249: imagen306 4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)benzoato de metilo 516

250: imagen307 4-[3-{4-[(3,4-diclorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 662

251: imagen308 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(2-oxo-2-piperidin-1-iletoxi)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 629

252: imagen309 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-pirimidin-5-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 566

253: imagen310 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(4'-fluoro-2-metoxibifenil-4-il)metil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 582

imagen311

254: imagen312 4-{3-[3-etoxi-4-(tiofen-2-ilmetoxi)bencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 614

255: imagen313 4-[3-(3,4-dietoxibencil)-6-(2-fluoroetoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 514

256: imagen314 4-[3-(3,4-dimetoxibencil)-6-(3-fluoro-2-hidroxipropoxi)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1carbaldehído 516

257: imagen315 4-({4-[2-fluoro-1-(fluorometil)etoxi]-2-(metoxicarbonil)fenil}amino)piperidin-1-carboxilato de 1,1-dimetiletilo 429

258: imagen316 4-[3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(hidroximetil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin1-carbaldehído 516

259: imagen317 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(1H-pirazol-1-ilmetil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 538

260: imagen318 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-tiofen-2-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 570

261: imagen319 ácido 4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)benzoico 502

imagen320

262: imagen321 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[3-(1H-1,2,4-triazol-1-ilmetil)bencil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 539

263: imagen322 ácido (2R)-2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]propanoico 630

264: imagen323 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-3-tiofen-2-il-1H-pirazol-5-il)metil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 544

265: imagen324 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(1H-1,2,4-triazol-1-ilmetil)bencil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 539

266: imagen325 4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)-il}metil)-N(2-morfolin-4-iletil)benzamida 614

267: imagen326 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(5-tiofen-3-il-1,2,4-oxadiazol-3-il)metil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 532

268: imagen327 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(4-metil-2-fenilpirimidin-5-il)metil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 550

269: imagen328 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(5-tiofen-2-il-1,2,4-oxadiazol-3-il)metil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 532

imagen329

270: imagen330 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(5-metil-1,2,4-oxadiazol-3-il)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 540

271: imagen331 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(2-tiofen-2-il-1,3-tiazol-4-il)metil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 547

272: imagen332 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(2-fluoro-4-tiofen-2-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 558

273: imagen333 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-5-tiofen-2-il-1H-pirazol-3-il)metil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 544

274: imagen334 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(3-tiofen-2-il-1,2,4-oxadiazol-5-il)metil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 532

275: imagen335 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-pirimidin-5-ilbencil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 536

276: imagen336 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-3-fenil-1H-pirazol-5-il)metil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 538

277: imagen337 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(5-fenil-1,2,4-oxadiazol-3-il)metil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 526

imagen338

278: imagen339 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-{[6-(1H-pirazol-1-il)piridin-3-il]metil}-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 525

279: imagen340 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(2-tiofen-2-ilpirimidin-5-il)metil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 542

280: imagen341 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(1-metil-1H-pirazol-3-il)bencil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 538

281: imagen342 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(imidazo[1,2-a]piridin-7-ilmetil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 598

282: imagen343 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(3-metil-1,2,4-oxadiazol-5-il)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 540

283: imagen344 ácido [2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]acético 616

284: imagen345 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(5-tiofen-2-ilisoxazol-3-il)metil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 531

285: imagen346 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(tieno[2,3-b]piridin-2-ilmetil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 514

imagen347

286: imagen348 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(6-fenilpiridin-3-il)metil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 535

287: imagen349 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(6-morfolin-4-ilpiridin-3-il)metil]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 544

288: imagen350 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(2-fenil-1,3-tiazol-4-il)metil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 541

289: imagen351 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(6-tiofen-2-ilpiridin-3-il)metil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 541

290: imagen352 4-{6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(2-tiofen-2-il-1,3-oxazol-4-il)metil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 531

291: imagen353 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-{[5-(4-metoxifenil)-1,2,4-oxadiazol-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 556

292: imagen354 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-5-fenil-1H-pirazol-3-il)metil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 538

293: imagen355 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-{[5-(2-metoxifenil)-1,2,4-oxadiazol-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 556

imagen356

294: imagen357 4-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)bifenil-2-carbonitrilo 559

295: imagen358 (2R)-2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]-N-metilpropanamida 643

296: imagen359 (2R)-2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]-N-fenilpropanamida 705

297: imagen360 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-tiofen-2-ilbencil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 558

298: imagen361 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(morfolin-4-ilmetil)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 587

299: imagen362 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(piperidin-1-ilmetil)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 585

300: imagen363 4-[3-{4-[(3,4-diclorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

301: imagen364 2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]-N-etilacetamida 643

imagen365

302: imagen366 ácido (2S)-2-[2-(ciclopentiloxi)-5-({6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)fenoxi]propanoico 630

303: imagen367 4-[3-(3-fluoro-4,5-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 536

304: imagen368 4-[3-(2-fluoro-4,5-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 536

305: imagen369 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-{[(3R)-2-oxo-1-fenilpirrolidin-3-il]oxi}bencil)-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 663

306: imagen370 4-{3-[4-(ciclobutilmetoxi)-3-metoxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 572

307: imagen371 4-{3-[4-(benciloxi)-3-metoxibencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 612

308: imagen372 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-hidroxi-3-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 522

309: imagen373 4-{3-[4-(ciclopropilmetoxi)-3-metoxibencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 576

imagen374

310: imagen375 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4(2-metilpropoxi)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 578

311: imagen376 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4(1-metiletoxi)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 564

312: imagen377 4-[3-(4-etoxi-3-metoxibencil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 550

313: imagen378 3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-1-(6-oxopiperidin-3-il)quinazolina-2,4(1H,3H)-diona 504

314: imagen379 4-{6-[2-fluoro-1-(fluorometil)etoxi]-3-[(5-metoxi-1-metil-4-oxo-1,4-dihidropiridin-2-il)metil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 519

315: imagen380 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-{[6-(3-metoxifenil)piridin-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 583

316: imagen381 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-{[6-(2-fluorofenil)piridin-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 571

317: imagen382 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-{[6-(4-fluorofenil)piridin-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 571

imagen383

318: imagen384 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-{[6-(4-metoxifenil)piridin-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 583

319: imagen385 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[(6-tiofen-2-ilpiridin-3-il)metil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 559

320: imagen386 4-{3-[3-etoxi-4-(tiofen-2-ilmetoxi)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 632

321: imagen387 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(1-metil-1H-pirazol-3-il)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 556

322: imagen388 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-(4-pirimidin-5-ilbencil)-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 554

323: imagen389 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[(1-metil-3-tiofen-2-il-1H-pirazol-5-il)metil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 562

324: imagen390 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(2-oxo-2-piperidin-1-iletoxi)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 647

325: imagen391 4-[3-{4-[2-(2,3-dihidro-1H-indol-1-il)-2-oxoetoxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 681

imagen392

326: imagen393 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(5-metil-1,2,4-oxadiazol-3-il)bencil]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 558

327: imagen394 4-[3-{4-[(3-clorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 646

328: imagen395 4-[3-{[6-(3,5-diclorofenil)piridin-3-il]metil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 603

329: imagen396 4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)bifenil-2-carbonitrilo 577

330: imagen397 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(1H-pirazol-1-il)bencil]-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 542

331: imagen398 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-{[6-(3-fluorofenil)piridin-3-il]metil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 571

332: imagen399 3-[5-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin3(2H)-il}metil)piridin-2-il]benzonitrilo 578

333: imagen400 4-[3-(3,4-dietoxibencil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 564

imagen401

334: imagen402 4-[3-{4-[(4-clorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 646

335: imagen403 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(morfolin-4-ilmetil)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 575

336: imagen404 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-{[6-(1H-pirazol-1-il)piridin-3-il]metil}-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 543

337: imagen405 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-morfolin-4-ilbencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 561

338: imagen406 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-propoxibencil)-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 564

339: imagen407 4-{3-[4-(1H-bencimidazol-1-il)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 592

340: imagen408 5-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin-3(2H)il}metil)-2-metoxibenzonitrilo 531

341: imagen409 3-(3,4-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,2,3,4tetrahidroquinazolina-7-carbonitrilo 543

imagen410

342: imagen411 4-[3-(4-bromobencil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 554

343: imagen412 4-[3-{4-[(3,4-diclorobencil)oxi]-3-(2-metoxietoxi)bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 724

344: imagen413 4-{3-[4-(benciloxi)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 582

345: imagen414 4-[3-{4-[(3,4-diclorobencil)oxi]-3-etoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 694

346: imagen415 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-hidroxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 492

347: imagen416 4-[3-{4-[(3,4-diclorobencil)oxi]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 650

348: imagen417 4-{7-fluoro-3-[3-(2-fluoroetoxi)-4-hidroxibencil]-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 554

349: imagen418 4-[3-{4-[(3,4-diclorobencil)oxi]-3-(2-fluoroetoxi)bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 712

imagen419

350: imagen420 4-[3-{4-[(2-cloro-4-fluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 664

351: imagen421 4-[3-{4-[(2,4-diclorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

352: imagen422 4-[3-{4-[(2-cloro-6-fluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 664

353: imagen423 4-[3-{4-[(2,6-diclorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

354: imagen424 4-[3-{4-[(2-clorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 646

355: imagen425 4-[7-fluoro-3-{4-[(2-fluorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 630

356: imagen426 4-[3-{3-[(3,4-diclorobencil)oxi]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 650

357: imagen427 2-[(3,4-diclorobencil)oxi]-5-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)benzonitrilo 675

imagen428

358: imagen429 4-[3-{4-[(3,4-diclorofenoxi)metil]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

359: imagen430 4-{3-bencil-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1carbaldehído 476

360: imagen431 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3-[4-(2-feniletil)bencil]-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 580

361: imagen432 4-[3-(2-cloro-4,5-dimetoxibencil)-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il]piperidin-1-carbaldehído 552

362: imagen433 4-[3-{4-[(4,5-dicloro-2-fluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 698

363: imagen434 4-[3-{3-[(3,4-diclorobencil)oxi]-4-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

364: imagen435 4-[3-(4-bromo-3-metoxibencil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 584

365: imagen436 4-[3-{4-[(3,4-diclorophenoxi)metil]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 650

imagen437

366: imagen438 4-[3-{4-[(4-clorofenoxi)metil]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 616

367: imagen439 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[3-metoxi-4-(2-feniletil)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 610

368: imagen440 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxibencil)-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 506

369: imagen441 4-[3-{4-[(4-clorofenoxi)metil]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 646

370: imagen442 4-{3-[4-(benciloxi)-3-clorobencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 616

371: imagen443 4-[3-{3-cloro-4-[(4-clorobencil)oxi]-5-etoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 694

372: imagen444 4-[3-{4-[(2,4-diclorobencil)oxi]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 650

373: imagen445 4-[3-{3-cloro-4-[(2,4-diclorobencil)oxi]-5-etoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 728

374: imagen446 4-{3-[4-(benciloxi)-3-cloro-5-etoxibencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 660

imagen447

375: imagen448 4-[7-fluoro-3-{4-[(4-fluorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 630

376: imagen449 4-[3-{4-[(3,5-diclorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

377: imagen450 4-[3-(4-{[4-cloro-3-(trifluorometil)bencil]oxi}-3-metoxibencil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4dioxo-3,4-dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 714

378: imagen451 4-[3-{4-[(3-clorofenoxi)metil]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 616

379: imagen452 4-[3-{4-[(3-clorofenoxi)metil]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 646

380: imagen453 4-[3-{4-[(3,5-difluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 648

381: imagen454 4-{3-[4-(benciloxi)-3-metoxibencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 680

382: imagen455 4-[3-{4-[(3-cloro-5-fluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 664

imagen456

383: imagen457 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(3-metoxi-4-{[4-(trifluorometil)bencil]oxi}bencil)-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 680

384: imagen458 4-[3-{4-[(2,5-diclorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 680

385: imagen459 4-{[4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin3(2H)-il}metil)-2-metoxifenoxi]metil}benzonitrilo 637

386: imagen460 3-{[4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4-dihidroquinazolin3(2H)-il}metil)-2-metoxifenoxi]metil}benzonitrilo 637

387: imagen461 4-[3-{4-[(4-cloro-2-fluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 664

388: imagen462 4-[3-{4-[1-(3,4-diclorofenil)etoxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 694

389: imagen463 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-{4-[(3-hidroxibencil)oxi]-3-metoxibencil}-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 696

390: imagen464 4-[7-fluoro-3-{4-[(3-fluorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 630

imagen465

391: imagen466 4-[3-{4-[(3,4-difluorobencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 648

392: imagen467 4-{3-[4-(5,6-dicloro-1H-bencimidazol-1-il)-3-metoxibencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo3,4-dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 660

393: imagen468 3,4-diclorobencenosulfonato de 4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4dioxo-1,4-dihidroquinazolin-3(2H)-il}metil)fenilo 700

394: imagen469 3,4-diclorobencenosulfonato de 4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4dioxo-1,4-dihidroquinazolin-3(2H)-il}metil)-2-metoxifenilo 730

395: imagen470 4-{3-[4-(3,4-diclorofenoxi)-3-metoxibencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 666

396: imagen471 N-(3,4-diclorofenil)-4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)benzamida 645

397: imagen472 N-(3,4-diclorobencil)-4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)benzamida 659

398: imagen473 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-(4-{[3-fluoro-4-(trifluorometil)bencil]oxi}-3-metoxibencil)-2,4dioxo-3,4-dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 698

399: imagen474 carbonato de 4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)-2-metoxifenilo y de 1-metiletilo 608

imagen475

400: imagen476 4-{3-[4-(4-clorofenoxi)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 602

401: imagen477 4-{3-[4-(3-clorofenoxi)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin-1(2H)il}piperidin-1-carbaldehído 602

402: imagen478 4-[3-{[1-(3,4-diclorobencil)-1H-pirazol-4-il]metil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 624

403: imagen479 3,4-dicloro-N-[4-({7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4-dioxo-1,4dihidroquinazolin-3(2H)-il}metil)-2-metoxifenil]benzamida 693

404: imagen480 4-[3-{4-[(4-clorobencil)oxi]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 616

405: imagen481 4-{7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-3-[4-(4-fluorofenoxi)bencil]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 586

406: imagen482 4-{3-[4-(3,4-diclorofenoxi)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il}piperidin-1-carbaldehído 636

407: imagen483 4-[3-({6-[(3,4-diclorobencil)oxi]piridin-3-il}metil)-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 651

imagen484

408: imagen485 4-[3-{4-[(2-clorobencil)oxi]bencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4-dihidroquinazolin1(2H)-il]piperidin-1-carbaldehído 616

409: imagen486 4-[3-{[1-(3,4-diclorobencil)-1H-pirazol-3-il]metil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 624

410: imagen487 4-[3-{[1-(3,4-diclorobencil)-1H-indol-5-il]metil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 673

411: imagen488 3-{4-[(3,4-diclorobencil)oxi]-3-metoxibencil}-6-[2-fluoro-1-(fluorometil)etoxi]-1-(1-formilpiperidin-4-il)-2,4dioxo-1,2,3,4-tetrahidroquinazolina-7-carbonitrilo 687

412: imagen489 4-{3-[4-(5-cloro-6-fluoro-1H-bencimidazol-1-il)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 644

413: imagen490 4-{3-[4-(5-cloro-1H-bencimidazol-1-il)bencil]-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il}piperidin-1-carbaldehído 626

414: imagen491 4-[3-{4-[(4-cloro-2-metoxibencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 676

415: imagen492 4-[3-{4-[(3-cloro-4-hidroxibencil)oxi]-3-metoxibencil}-7-fluoro-6-[2-fluoro-1-(fluorometil)etoxi]-2,4-dioxo-3,4dihidroquinazolin-1(2H)-il]piperidin-1-carbaldehído 730

imagen493

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imagen497

Claims

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