JPS56164172A - Novel 2,4 1h,3h -quinazolinedione derivative - Google Patents
Novel 2,4 1h,3h -quinazolinedione derivativeInfo
- Publication number
- JPS56164172A JPS56164172A JP6708580A JP6708580A JPS56164172A JP S56164172 A JPS56164172 A JP S56164172A JP 6708580 A JP6708580 A JP 6708580A JP 6708580 A JP6708580 A JP 6708580A JP S56164172 A JPS56164172 A JP S56164172A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- quinazolinedione
- agent
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2,4(1H,3H)-quinazolinedione derivative expressed by formula I [R1 and R3 are alkyl; R2 is alkoxycarbonyl, and R1, R2 and R3 are linked to the 5-, 6- and 7-positions or the 6-, 7- and 8-positions of the quinazoline nucleus; R4 is alkyl, carboxyalkyl, alkoxycarobonylalkyl or formula II (R6 and R7 are alkyl; X is alkylene); R5 is H, halogen, alkyl, CF3 or nitro].
EXAMPLE: 6- Ethoxycarbonyl-5, 7-diemethyl-1-[ 3-( N,N-dimethylamino )propyl]-3- (o-chlorophenyl)-2,4(1H,3H)-quinazolinedione.
USE: A vasodilator agent, an ameliorant of blood flow, hypotensive agent or antiarteriosclerotic agent.
PROCESS: A compound of formula III is reacted with a compound expressed by the formula Z-R4 (Z is halogen) in the presence of an alkali metallic hydride, etc. to give a reaction product, which is then hydrolyzed if desired.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6708580A JPS56164172A (en) | 1980-05-22 | 1980-05-22 | Novel 2,4 1h,3h -quinazolinedione derivative |
CA000377591A CA1161036A (en) | 1980-05-15 | 1981-05-14 | Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
AU70625/81A AU547554B2 (en) | 1980-05-15 | 1981-05-15 | 2,4(1h,3h)-quinazoline diones |
US06/263,898 US4405623A (en) | 1980-05-15 | 1981-05-15 | Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof |
DE8181103838T DE3172006D1 (en) | 1980-05-22 | 1981-05-19 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
EP19810103838 EP0040793B1 (en) | 1980-05-22 | 1981-05-19 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6708580A JPS56164172A (en) | 1980-05-22 | 1980-05-22 | Novel 2,4 1h,3h -quinazolinedione derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56164172A true JPS56164172A (en) | 1981-12-17 |
Family
ID=13334681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6708580A Pending JPS56164172A (en) | 1980-05-15 | 1980-05-22 | Novel 2,4 1h,3h -quinazolinedione derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56164172A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012523398A (en) * | 2009-04-09 | 2012-10-04 | サノフイ | Therapeutic application of quinazolinedione derivatives in the cardiovascular field |
-
1980
- 1980-05-22 JP JP6708580A patent/JPS56164172A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012523398A (en) * | 2009-04-09 | 2012-10-04 | サノフイ | Therapeutic application of quinazolinedione derivatives in the cardiovascular field |
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