JPS56164172A - Novel 2,4 1h,3h -quinazolinedione derivative - Google Patents

Novel 2,4 1h,3h -quinazolinedione derivative

Info

Publication number
JPS56164172A
JPS56164172A JP6708580A JP6708580A JPS56164172A JP S56164172 A JPS56164172 A JP S56164172A JP 6708580 A JP6708580 A JP 6708580A JP 6708580 A JP6708580 A JP 6708580A JP S56164172 A JPS56164172 A JP S56164172A
Authority
JP
Japan
Prior art keywords
alkyl
formula
quinazolinedione
agent
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6708580A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Fujinori Sasaki
Masao Eguchi
Akiko Sugimoto
Katsuhiko Goto
Soyao Moriguchi
Hisashi Ebisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP6708580A priority Critical patent/JPS56164172A/en
Priority to CA000377591A priority patent/CA1161036A/en
Priority to AU70625/81A priority patent/AU547554B2/en
Priority to US06/263,898 priority patent/US4405623A/en
Priority to DE8181103838T priority patent/DE3172006D1/en
Priority to EP19810103838 priority patent/EP0040793B1/en
Publication of JPS56164172A publication Critical patent/JPS56164172A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:A 2,4(1H,3H)-quinazolinedione derivative expressed by formula I [R1 and R3 are alkyl; R2 is alkoxycarbonyl, and R1, R2 and R3 are linked to the 5-, 6- and 7-positions or the 6-, 7- and 8-positions of the quinazoline nucleus; R4 is alkyl, carboxyalkyl, alkoxycarobonylalkyl or formula II (R6 and R7 are alkyl; X is alkylene); R5 is H, halogen, alkyl, CF3 or nitro].
EXAMPLE: 6- Ethoxycarbonyl-5, 7-diemethyl-1-[ 3-( N,N-dimethylamino )propyl]-3- (o-chlorophenyl)-2,4(1H,3H)-quinazolinedione.
USE: A vasodilator agent, an ameliorant of blood flow, hypotensive agent or antiarteriosclerotic agent.
PROCESS: A compound of formula III is reacted with a compound expressed by the formula Z-R4 (Z is halogen) in the presence of an alkali metallic hydride, etc. to give a reaction product, which is then hydrolyzed if desired.
COPYRIGHT: (C)1981,JPO&Japio
JP6708580A 1980-05-15 1980-05-22 Novel 2,4 1h,3h -quinazolinedione derivative Pending JPS56164172A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP6708580A JPS56164172A (en) 1980-05-22 1980-05-22 Novel 2,4 1h,3h -quinazolinedione derivative
CA000377591A CA1161036A (en) 1980-05-15 1981-05-14 Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
AU70625/81A AU547554B2 (en) 1980-05-15 1981-05-15 2,4(1h,3h)-quinazoline diones
US06/263,898 US4405623A (en) 1980-05-15 1981-05-15 Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof
DE8181103838T DE3172006D1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
EP19810103838 EP0040793B1 (en) 1980-05-22 1981-05-19 Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6708580A JPS56164172A (en) 1980-05-22 1980-05-22 Novel 2,4 1h,3h -quinazolinedione derivative

Publications (1)

Publication Number Publication Date
JPS56164172A true JPS56164172A (en) 1981-12-17

Family

ID=13334681

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6708580A Pending JPS56164172A (en) 1980-05-15 1980-05-22 Novel 2,4 1h,3h -quinazolinedione derivative

Country Status (1)

Country Link
JP (1) JPS56164172A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523398A (en) * 2009-04-09 2012-10-04 サノフイ Therapeutic application of quinazolinedione derivatives in the cardiovascular field

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523398A (en) * 2009-04-09 2012-10-04 サノフイ Therapeutic application of quinazolinedione derivatives in the cardiovascular field

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