DOP2010000317A - Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas - Google Patents
Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativasInfo
- Publication number
- DOP2010000317A DOP2010000317A DO2010000317A DO2010000317A DOP2010000317A DO P2010000317 A DOP2010000317 A DO P2010000317A DO 2010000317 A DO2010000317 A DO 2010000317A DO 2010000317 A DO2010000317 A DO 2010000317A DO P2010000317 A DOP2010000317 A DO P2010000317A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- treatment
- espiro
- piperidines
- neurodegenerative diseases
- new class
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5042308P | 2008-05-05 | 2008-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2010000317A true DOP2010000317A (es) | 2010-11-15 |
Family
ID=40902870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2010000317A DOP2010000317A (es) | 2008-05-05 | 2010-10-21 | Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20110046160A1 (https=) |
| EP (1) | EP2300484B1 (https=) |
| JP (1) | JP2011519913A (https=) |
| KR (1) | KR20110000749A (https=) |
| CN (1) | CN102083841A (https=) |
| AP (1) | AP2010005456A0 (https=) |
| AT (1) | ATE537178T1 (https=) |
| AU (1) | AU2009245322B2 (https=) |
| BR (1) | BRPI0912433A2 (https=) |
| CA (1) | CA2721786A1 (https=) |
| CO (1) | CO6321280A2 (https=) |
| CR (1) | CR11759A (https=) |
| DO (1) | DOP2010000317A (https=) |
| EA (1) | EA201001566A1 (https=) |
| EC (1) | ECSP10010597A (https=) |
| ES (1) | ES2375913T3 (https=) |
| IL (1) | IL208793A0 (https=) |
| MA (1) | MA32290B1 (https=) |
| MX (1) | MX2010012066A (https=) |
| NZ (1) | NZ588589A (https=) |
| SV (1) | SV2010003725A (https=) |
| WO (1) | WO2009136350A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| EP2556076A2 (en) * | 2010-04-09 | 2013-02-13 | Pfizer Inc. | Novel sultam compounds |
| EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| EP2694521B1 (en) | 2011-04-07 | 2015-11-25 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| RU2014111055A (ru) | 2011-08-22 | 2015-09-27 | Мерк Шарп И Доум Корп. | 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение |
| US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004031560D1 (de) * | 2004-01-08 | 2011-04-07 | Hoffmann La Roche | Diazaspiropiperidinderivate |
| JP2006044497A (ja) * | 2004-08-05 | 2006-02-16 | Toyota Motor Corp | 車輪情報処理装置 |
| WO2006044497A2 (en) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer’s disease |
| US8211904B2 (en) * | 2005-07-18 | 2012-07-03 | Merck, Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| AU2007293416A1 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| AU2007342368A1 (en) * | 2007-01-04 | 2008-07-17 | Merck & Co., Inc. | Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
-
2009
- 2009-05-04 US US12/990,739 patent/US20110046160A1/en not_active Abandoned
- 2009-05-04 KR KR1020107024794A patent/KR20110000749A/ko not_active Ceased
- 2009-05-04 WO PCT/IB2009/051815 patent/WO2009136350A1/en not_active Ceased
- 2009-05-04 ES ES09742523T patent/ES2375913T3/es active Active
- 2009-05-04 CA CA2721786A patent/CA2721786A1/en not_active Abandoned
- 2009-05-04 EA EA201001566A patent/EA201001566A1/ru unknown
- 2009-05-04 AT AT09742523T patent/ATE537178T1/de active
- 2009-05-04 EP EP09742523A patent/EP2300484B1/en active Active
- 2009-05-04 AU AU2009245322A patent/AU2009245322B2/en not_active Ceased
- 2009-05-04 JP JP2011508035A patent/JP2011519913A/ja not_active Withdrawn
- 2009-05-04 NZ NZ588589A patent/NZ588589A/en not_active IP Right Cessation
- 2009-05-04 BR BRPI0912433A patent/BRPI0912433A2/pt not_active Application Discontinuation
- 2009-05-04 CN CN2009801261947A patent/CN102083841A/zh active Pending
- 2009-05-04 MX MX2010012066A patent/MX2010012066A/es not_active Application Discontinuation
- 2009-05-04 AP AP2010005456A patent/AP2010005456A0/xx unknown
-
2010
- 2010-10-18 IL IL208793A patent/IL208793A0/en unknown
- 2010-10-21 DO DO2010000317A patent/DOP2010000317A/es unknown
- 2010-10-26 CR CR11759A patent/CR11759A/es not_active Application Discontinuation
- 2010-11-05 SV SV2010003725A patent/SV2010003725A/es not_active Application Discontinuation
- 2010-11-05 MA MA33328A patent/MA32290B1/fr unknown
- 2010-11-09 EC EC2010010597A patent/ECSP10010597A/es unknown
- 2010-11-11 CO CO10141834A patent/CO6321280A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0912433A2 (pt) | 2015-12-22 |
| EA201001566A1 (ru) | 2011-04-29 |
| CO6321280A2 (es) | 2011-09-20 |
| EP2300484A1 (en) | 2011-03-30 |
| CR11759A (es) | 2010-11-22 |
| ES2375913T3 (es) | 2012-03-07 |
| ATE537178T1 (de) | 2011-12-15 |
| US20110046160A1 (en) | 2011-02-24 |
| JP2011519913A (ja) | 2011-07-14 |
| MA32290B1 (fr) | 2011-05-02 |
| SV2010003725A (es) | 2011-07-05 |
| KR20110000749A (ko) | 2011-01-05 |
| AU2009245322A1 (en) | 2009-11-12 |
| AP2010005456A0 (en) | 2010-12-31 |
| WO2009136350A1 (en) | 2009-11-12 |
| CA2721786A1 (en) | 2009-11-12 |
| IL208793A0 (en) | 2010-12-30 |
| CN102083841A (zh) | 2011-06-01 |
| NZ588589A (en) | 2012-07-27 |
| ECSP10010597A (es) | 2010-12-30 |
| MX2010012066A (es) | 2010-12-06 |
| AU2009245322B2 (en) | 2011-07-14 |
| EP2300484B1 (en) | 2011-12-14 |
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