ATE537178T1 - Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten - Google Patents

Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten

Info

Publication number
ATE537178T1
ATE537178T1 AT09742523T AT09742523T ATE537178T1 AT E537178 T1 ATE537178 T1 AT E537178T1 AT 09742523 T AT09742523 T AT 09742523T AT 09742523 T AT09742523 T AT 09742523T AT E537178 T1 ATE537178 T1 AT E537178T1
Authority
AT
Austria
Prior art keywords
piperidines
spiro
treatment
neurodegenerative diseases
new class
Prior art date
Application number
AT09742523T
Other languages
German (de)
English (en)
Inventor
Michael Brodney
Christopher HELAL
Brian O'neill
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE537178T1 publication Critical patent/ATE537178T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT09742523T 2008-05-05 2009-05-04 Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten ATE537178T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5042308P 2008-05-05 2008-05-05
PCT/IB2009/051815 WO2009136350A1 (en) 2008-05-05 2009-05-04 Novel class of spiro piperidines for the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
ATE537178T1 true ATE537178T1 (de) 2011-12-15

Family

ID=40902870

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09742523T ATE537178T1 (de) 2008-05-05 2009-05-04 Neue klasse von spiro-piperidinen zur behandlung neurodegenerativer krankheiten

Country Status (22)

Country Link
US (1) US20110046160A1 (https=)
EP (1) EP2300484B1 (https=)
JP (1) JP2011519913A (https=)
KR (1) KR20110000749A (https=)
CN (1) CN102083841A (https=)
AP (1) AP2010005456A0 (https=)
AT (1) ATE537178T1 (https=)
AU (1) AU2009245322B2 (https=)
BR (1) BRPI0912433A2 (https=)
CA (1) CA2721786A1 (https=)
CO (1) CO6321280A2 (https=)
CR (1) CR11759A (https=)
DO (1) DOP2010000317A (https=)
EA (1) EA201001566A1 (https=)
EC (1) ECSP10010597A (https=)
ES (1) ES2375913T3 (https=)
IL (1) IL208793A0 (https=)
MA (1) MA32290B1 (https=)
MX (1) MX2010012066A (https=)
NZ (1) NZ588589A (https=)
SV (1) SV2010003725A (https=)
WO (1) WO2009136350A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
EP2556076A2 (en) * 2010-04-09 2013-02-13 Pfizer Inc. Novel sultam compounds
EP2694489B1 (en) 2011-04-07 2017-09-06 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2694521B1 (en) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
RU2014111055A (ru) 2011-08-22 2015-09-27 Мерк Шарп И Доум Корп. 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004031560D1 (de) * 2004-01-08 2011-04-07 Hoffmann La Roche Diazaspiropiperidinderivate
JP2006044497A (ja) * 2004-08-05 2006-02-16 Toyota Motor Corp 車輪情報処理装置
WO2006044497A2 (en) * 2004-10-13 2006-04-27 Merck & Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer’s disease
US8211904B2 (en) * 2005-07-18 2012-07-03 Merck, Sharp & Dohme Corp. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
AU2007293416A1 (en) * 2006-09-07 2008-03-13 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
AU2007342368A1 (en) * 2007-01-04 2008-07-17 Merck & Co., Inc. Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease

Also Published As

Publication number Publication date
BRPI0912433A2 (pt) 2015-12-22
EA201001566A1 (ru) 2011-04-29
CO6321280A2 (es) 2011-09-20
EP2300484A1 (en) 2011-03-30
CR11759A (es) 2010-11-22
ES2375913T3 (es) 2012-03-07
US20110046160A1 (en) 2011-02-24
JP2011519913A (ja) 2011-07-14
MA32290B1 (fr) 2011-05-02
SV2010003725A (es) 2011-07-05
KR20110000749A (ko) 2011-01-05
DOP2010000317A (es) 2010-11-15
AU2009245322A1 (en) 2009-11-12
AP2010005456A0 (en) 2010-12-31
WO2009136350A1 (en) 2009-11-12
CA2721786A1 (en) 2009-11-12
IL208793A0 (en) 2010-12-30
CN102083841A (zh) 2011-06-01
NZ588589A (en) 2012-07-27
ECSP10010597A (es) 2010-12-30
MX2010012066A (es) 2010-12-06
AU2009245322B2 (en) 2011-07-14
EP2300484B1 (en) 2011-12-14

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