DK723488A - Fremgangsmaade til rekombinant udtrykkelse af zymogene former af humant protein c samt vektorer, dna-forbindelser og transformanter til brug ved fremgangsmaaden - Google Patents

Fremgangsmaade til rekombinant udtrykkelse af zymogene former af humant protein c samt vektorer, dna-forbindelser og transformanter til brug ved fremgangsmaaden

Info

Publication number
DK723488A
DK723488A DK723488A DK723488A DK723488A DK 723488 A DK723488 A DK 723488A DK 723488 A DK723488 A DK 723488A DK 723488 A DK723488 A DK 723488A DK 723488 A DK723488 A DK 723488A
Authority
DK
Denmark
Prior art keywords
procedure
humant
transformers
vectors
protein
Prior art date
Application number
DK723488A
Other languages
Danish (da)
English (en)
Other versions
DK723488D0 (da
Inventor
Nils Ulrik Bang
Hartmut Josef Ehrlich
Brian William Grinnell
Sau-Chi Betty Yan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK723488D0 publication Critical patent/DK723488D0/da
Publication of DK723488A publication Critical patent/DK723488A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
DK723488A 1987-12-28 1988-12-27 Fremgangsmaade til rekombinant udtrykkelse af zymogene former af humant protein c samt vektorer, dna-forbindelser og transformanter til brug ved fremgangsmaaden DK723488A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13800987A 1987-12-28 1987-12-28

Publications (2)

Publication Number Publication Date
DK723488D0 DK723488D0 (da) 1988-12-27
DK723488A true DK723488A (da) 1989-06-29

Family

ID=22480037

Family Applications (1)

Application Number Title Priority Date Filing Date
DK723488A DK723488A (da) 1987-12-28 1988-12-27 Fremgangsmaade til rekombinant udtrykkelse af zymogene former af humant protein c samt vektorer, dna-forbindelser og transformanter til brug ved fremgangsmaaden

Country Status (21)

Country Link
EP (1) EP0323149B1 (ja)
JP (1) JP2851287B2 (ja)
KR (1) KR890010202A (ja)
CN (1) CN1035526A (ja)
AR (1) AR244804A1 (ja)
AT (1) ATE116368T1 (ja)
AU (1) AU609919B2 (ja)
CA (1) CA1340111C (ja)
DE (1) DE3852625T2 (ja)
DK (1) DK723488A (ja)
ES (1) ES2065341T3 (ja)
GR (1) GR3015609T3 (ja)
HU (1) HU210863B (ja)
IE (1) IE66337B1 (ja)
IL (1) IL88758A (ja)
MX (1) MX14312A (ja)
NZ (1) NZ227434A (ja)
PT (1) PT89285B (ja)
RU (1) RU2018535C1 (ja)
SU (1) SU1739854A3 (ja)
ZA (1) ZA889497B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012685A1 (en) * 1987-05-18 1989-12-28 Integrated Genetics, Inc. Improved protein c molecules and method for making and activating same
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
EP0506821B1 (en) * 1989-12-29 1998-02-04 Zymogenetics, Inc. Hybrid protein c
US5270178A (en) * 1990-02-23 1993-12-14 Eli Lilly And Company Vectors and compounds for expression of zymogen forms of human protein C
IL97311A0 (en) * 1990-02-23 1992-05-25 Lilly Co Eli Vectors and compounds for expression of glycosylation mutants of human protein c
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives
US5618714A (en) * 1993-12-15 1997-04-08 Eli Lilly And Company Methods for producing protein C
AU1751801A (en) * 1999-11-19 2001-05-30 Eli Lilly And Company Protein c derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C

Also Published As

Publication number Publication date
IE883849L (en) 1989-06-28
DE3852625T2 (de) 1995-05-24
KR890010202A (ko) 1989-08-07
HU210863B (en) 1995-08-28
DE3852625D1 (de) 1995-02-09
IL88758A (en) 1994-02-27
CA1340111C (en) 1998-11-03
PT89285A (pt) 1989-12-29
AR244804A1 (es) 1993-11-30
MX14312A (es) 1994-01-31
NZ227434A (en) 1991-03-26
JPH022376A (ja) 1990-01-08
ES2065341T3 (es) 1995-02-16
EP0323149B1 (en) 1994-12-28
AU609919B2 (en) 1991-05-09
ZA889497B (en) 1990-08-29
DK723488D0 (da) 1988-12-27
EP0323149A3 (en) 1990-06-13
CN1035526A (zh) 1989-09-13
IE66337B1 (en) 1995-12-27
AU2732988A (en) 1989-06-29
SU1739854A3 (ru) 1992-06-07
IL88758A0 (en) 1989-07-31
HUT50499A (en) 1990-02-28
EP0323149A2 (en) 1989-07-05
JP2851287B2 (ja) 1999-01-27
PT89285B (pt) 1993-08-31
ATE116368T1 (de) 1995-01-15
GR3015609T3 (en) 1995-06-30
RU2018535C1 (ru) 1994-08-30

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