IL88758A - Vectors and compounds for expressing zymogenic forms of human protein C - Google Patents

Vectors and compounds for expressing zymogenic forms of human protein C

Info

Publication number
IL88758A
IL88758A IL8875888A IL8875888A IL88758A IL 88758 A IL88758 A IL 88758A IL 8875888 A IL8875888 A IL 8875888A IL 8875888 A IL8875888 A IL 8875888A IL 88758 A IL88758 A IL 88758A
Authority
IL
Israel
Prior art keywords
leu
gly
ser
glu
val
Prior art date
Application number
IL8875888A
Other languages
English (en)
Hebrew (he)
Other versions
IL88758A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL88758A0 publication Critical patent/IL88758A0/xx
Publication of IL88758A publication Critical patent/IL88758A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL8875888A 1987-12-28 1988-12-21 Vectors and compounds for expressing zymogenic forms of human protein C IL88758A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13800987A 1987-12-28 1987-12-28

Publications (2)

Publication Number Publication Date
IL88758A0 IL88758A0 (en) 1989-07-31
IL88758A true IL88758A (en) 1994-02-27

Family

ID=22480037

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8875888A IL88758A (en) 1987-12-28 1988-12-21 Vectors and compounds for expressing zymogenic forms of human protein C

Country Status (21)

Country Link
EP (1) EP0323149B1 (ja)
JP (1) JP2851287B2 (ja)
KR (1) KR890010202A (ja)
CN (1) CN1035526A (ja)
AR (1) AR244804A1 (ja)
AT (1) ATE116368T1 (ja)
AU (1) AU609919B2 (ja)
CA (1) CA1340111C (ja)
DE (1) DE3852625T2 (ja)
DK (1) DK723488A (ja)
ES (1) ES2065341T3 (ja)
GR (1) GR3015609T3 (ja)
HU (1) HU210863B (ja)
IE (1) IE66337B1 (ja)
IL (1) IL88758A (ja)
MX (1) MX14312A (ja)
NZ (1) NZ227434A (ja)
PT (1) PT89285B (ja)
RU (1) RU2018535C1 (ja)
SU (1) SU1739854A3 (ja)
ZA (1) ZA889497B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012685A1 (en) * 1987-05-18 1989-12-28 Integrated Genetics, Inc. Improved protein c molecules and method for making and activating same
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
ATE163048T1 (de) * 1989-12-29 1998-02-15 Zymogenetics Inc Hybrides protein c
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
US5270178A (en) * 1990-02-23 1993-12-14 Eli Lilly And Company Vectors and compounds for expression of zymogen forms of human protein C
IL97311A0 (en) * 1990-02-23 1992-05-25 Lilly Co Eli Vectors and compounds for expression of glycosylation mutants of human protein c
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives
US5618714A (en) * 1993-12-15 1997-04-08 Eli Lilly And Company Methods for producing protein C
CA2391651A1 (en) * 1999-11-19 2001-05-25 Eli Lilly And Company Protein c derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C

Also Published As

Publication number Publication date
IE66337B1 (en) 1995-12-27
KR890010202A (ko) 1989-08-07
HU210863B (en) 1995-08-28
AU609919B2 (en) 1991-05-09
IL88758A0 (en) 1989-07-31
EP0323149B1 (en) 1994-12-28
IE883849L (en) 1989-06-28
AR244804A1 (es) 1993-11-30
ZA889497B (en) 1990-08-29
CN1035526A (zh) 1989-09-13
EP0323149A2 (en) 1989-07-05
JP2851287B2 (ja) 1999-01-27
DK723488D0 (da) 1988-12-27
JPH022376A (ja) 1990-01-08
SU1739854A3 (ru) 1992-06-07
RU2018535C1 (ru) 1994-08-30
CA1340111C (en) 1998-11-03
DK723488A (da) 1989-06-29
ATE116368T1 (de) 1995-01-15
PT89285B (pt) 1993-08-31
NZ227434A (en) 1991-03-26
DE3852625T2 (de) 1995-05-24
AU2732988A (en) 1989-06-29
PT89285A (pt) 1989-12-29
HUT50499A (en) 1990-02-28
MX14312A (es) 1994-01-31
GR3015609T3 (en) 1995-06-30
ES2065341T3 (es) 1995-02-16
EP0323149A3 (en) 1990-06-13
DE3852625D1 (de) 1995-02-09

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Publication Publication Date Title
US4992373A (en) Vectors and compounds for direct expression of activated human protein C
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US4784950A (en) Expression of factor VII activity in mammalian cells
US5270178A (en) Vectors and compounds for expression of zymogen forms of human protein C
US5358932A (en) Hybrid protein C
US5196322A (en) Vectors and compounds for expression of zymogen forms of human protein C
CA2036894C (en) Vectors and compounds for expression of glycosylation mutants of human protein c
US5766921A (en) Hybrid protein C
EP0323149B1 (en) Vectors and compounds for expression of zymogen forms of human protein C
EP0493037A2 (en) Method of treating thromboembolic disorders
WO1991012320A1 (en) Activated protein c with truncated light chain
WO1991009951A2 (en) Recombinant protein c with truncated light chain

Legal Events

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