DK64286A - Dihydropyridinderivater - Google Patents

Dihydropyridinderivater Download PDF

Info

Publication number
DK64286A
DK64286A DK64286A DK64286A DK64286A DK 64286 A DK64286 A DK 64286A DK 64286 A DK64286 A DK 64286A DK 64286 A DK64286 A DK 64286A DK 64286 A DK64286 A DK 64286A
Authority
DK
Denmark
Prior art keywords
dihydropyridine derivatives
dihydropyridine
derivatives
Prior art date
Application number
DK64286A
Other languages
English (en)
Other versions
DK64286D0 (da
Inventor
Robin Douglas Clark
Moysey Michael Povzhitkov
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/700,439 external-priority patent/US4595690A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK64286D0 publication Critical patent/DK64286D0/da
Publication of DK64286A publication Critical patent/DK64286A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20Free hydroxyl or mercaptan
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK64286A 1985-02-11 1986-02-10 Dihydropyridinderivater DK64286A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/700,439 US4595690A (en) 1985-02-11 1985-02-11 Antihypertensive dihydropyridine derivatives
US06/808,401 US4672071A (en) 1985-02-11 1985-12-12 Antihypertensive dihydropyridine compositions, optical isomers and intermediates

Publications (2)

Publication Number Publication Date
DK64286D0 DK64286D0 (da) 1986-02-10
DK64286A true DK64286A (da) 1986-08-12

Family

ID=27106619

Family Applications (1)

Application Number Title Priority Date Filing Date
DK64286A DK64286A (da) 1985-02-11 1986-02-10 Dihydropyridinderivater

Country Status (15)

Country Link
US (1) US4672071A (da)
EP (1) EP0191448A3 (da)
JP (1) JPS61210071A (da)
KR (1) KR860006442A (da)
AU (1) AU591093B2 (da)
DK (1) DK64286A (da)
ES (2) ES8708130A1 (da)
FI (1) FI860584A (da)
GR (1) GR860384B (da)
HU (2) HU198019B (da)
IL (1) IL77843A (da)
NO (1) NO860458L (da)
PH (1) PH22806A (da)
PL (1) PL257890A1 (da)
PT (1) PT81987B (da)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2576843A (en) * 1944-12-30 1951-11-27 Rosenblads Patenter Ab Heat exchange apparatus
US2788065A (en) * 1950-08-14 1957-04-09 Rosenblads Patenter Ab Surface type evaporator employing channel switching for cleaning purposes

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814455A (en) * 1986-04-16 1989-03-21 Bristol-Myers Company Dihydro-3,5-dicarboxylates
US4886819A (en) * 1986-08-27 1989-12-12 The Green Cross Corporation Dihydropyridine derivatives and pharmaceutical composition thereof
JPH0686429B2 (ja) * 1986-08-27 1994-11-02 株式会社ミドリ十字 ジヒドロピリジン誘導体
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
US5576439A (en) * 1994-10-28 1996-11-19 Ciba-Geigy Corporation Dihydropyridinecarboxylic acid anhydrides
SE9801990D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl propionic acid derivatives and analogs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
CH583702A5 (en) * 1973-02-13 1977-01-14 Science Union & Cie Anti-hypertensive dihydropyridines - 4-aryl 2,5-dihydropyridine 3,5-dicarboxylic esters
US3985758A (en) * 1973-02-20 1976-10-12 Yamanouchi Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2639498A1 (de) * 1976-09-02 1978-03-09 Bayer Ag Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
US4595690A (en) * 1985-02-11 1986-06-17 Syntex (U.S.A.) Inc. Antihypertensive dihydropyridine derivatives
GB8503426D0 (en) * 1985-02-11 1985-03-13 Ici Plc Pyridine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2576843A (en) * 1944-12-30 1951-11-27 Rosenblads Patenter Ab Heat exchange apparatus
US2788065A (en) * 1950-08-14 1957-04-09 Rosenblads Patenter Ab Surface type evaporator employing channel switching for cleaning purposes

Also Published As

Publication number Publication date
GR860384B (en) 1986-05-09
EP0191448A3 (en) 1987-08-19
ES8708130A1 (es) 1987-10-16
HU198478B (en) 1989-10-30
FI860584A (fi) 1986-08-12
ES557628A0 (es) 1988-07-01
HU198019B (en) 1989-07-28
EP0191448A2 (en) 1986-08-20
US4672071A (en) 1987-06-09
DK64286D0 (da) 1986-02-10
PT81987A (en) 1986-03-01
KR860006442A (ko) 1986-09-11
HUT44501A (en) 1988-03-28
PL257890A1 (en) 1988-07-21
ES551809A0 (es) 1987-10-16
PH22806A (en) 1988-12-27
ES8802449A1 (es) 1988-07-01
JPS61210071A (ja) 1986-09-18
HUT41732A (en) 1987-05-28
AU5336386A (en) 1986-08-14
FI860584A0 (fi) 1986-02-10
PT81987B (en) 1987-08-13
IL77843A (en) 1989-07-31
NO860458L (no) 1986-08-12
AU591093B2 (en) 1989-11-30

Similar Documents

Publication Publication Date Title
DK190986D0 (da) Imidazoquinolinonderivater
DK263587A (da) Imidazoquinolinyletherderivater
ATA312487A (de) Tetrahydrocarbazolonderivate
DK64386D0 (da) Piperidinforbindelser
DK693587A (da) Alkansulfonanilidderivater
DK300887A (da) Dihydropyridinderivater
DK109186D0 (da) Dihydropyridazinonderivater
DK15686A (da) Dihydropyridinderivater
DK691287D0 (da) 5-floururacilderivater
DK64286A (da) Dihydropyridinderivater
DK17386D0 (da) Aminderivater
DK491786A (da) Dichloranilinderivater
BR8606663A (pt) Derivados de triazolil-quinolina
DK79986A (da) Pyridinderivater
DK444687A (da) Alfa-substituerede ketonitron-derivater
DK556386D0 (da) Quinilinderivater
DK224786A (da) Dihydropyridinderivater
DK261284D0 (da) Dihydropyridinderivater
DK303886A (da) Secocanthinderivater
DK440687D0 (da) Bicyclooctanderivater
DK229887A (da) Alkenamidderivater
DK619187A (da) Isoindolderivater
DE3662889D1 (de) Tetrahydrofurancarboxylic-acid derivatives
KR880700821A (ko) 데--데옥시테이코플라닌 유도체
DK435087D0 (da) Isoprenderivater

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment