PT81987B - Process for preparing antihypertensive dihydropiridine derivatives - Google Patents
Process for preparing antihypertensive dihydropiridine derivativesInfo
- Publication number
- PT81987B PT81987B PT81987A PT8198786A PT81987B PT 81987 B PT81987 B PT 81987B PT 81987 A PT81987 A PT 81987A PT 8198786 A PT8198786 A PT 8198786A PT 81987 B PT81987 B PT 81987B
- Authority
- PT
- Portugal
- Prior art keywords
- dihydropiridine
- derivatives
- preparing antihypertensive
- antihypertensive
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/700,439 US4595690A (en) | 1985-02-11 | 1985-02-11 | Antihypertensive dihydropyridine derivatives |
US06/808,401 US4672071A (en) | 1985-02-11 | 1985-12-12 | Antihypertensive dihydropyridine compositions, optical isomers and intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
PT81987A PT81987A (en) | 1986-03-01 |
PT81987B true PT81987B (en) | 1987-08-13 |
Family
ID=27106619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT81987A PT81987B (en) | 1985-02-11 | 1986-02-07 | Process for preparing antihypertensive dihydropiridine derivatives |
Country Status (15)
Country | Link |
---|---|
US (1) | US4672071A (pt) |
EP (1) | EP0191448A3 (pt) |
JP (1) | JPS61210071A (pt) |
KR (1) | KR860006442A (pt) |
AU (1) | AU591093B2 (pt) |
DK (1) | DK64286A (pt) |
ES (2) | ES8708130A1 (pt) |
FI (1) | FI860584A (pt) |
GR (1) | GR860384B (pt) |
HU (2) | HU198019B (pt) |
IL (1) | IL77843A (pt) |
NO (1) | NO860458L (pt) |
PH (1) | PH22806A (pt) |
PL (1) | PL257890A1 (pt) |
PT (1) | PT81987B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2576843A (en) * | 1944-12-30 | 1951-11-27 | Rosenblads Patenter Ab | Heat exchange apparatus |
US2788065A (en) * | 1950-08-14 | 1957-04-09 | Rosenblads Patenter Ab | Surface type evaporator employing channel switching for cleaning purposes |
US4814455A (en) * | 1986-04-16 | 1989-03-21 | Bristol-Myers Company | Dihydro-3,5-dicarboxylates |
JPH0686429B2 (ja) * | 1986-08-27 | 1994-11-02 | 株式会社ミドリ十字 | ジヒドロピリジン誘導体 |
US4886819A (en) * | 1986-08-27 | 1989-12-12 | The Green Cross Corporation | Dihydropyridine derivatives and pharmaceutical composition thereof |
DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
US5576439A (en) * | 1994-10-28 | 1996-11-19 | Ciba-Geigy Corporation | Dihydropyridinecarboxylic acid anhydrides |
SE9801990D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4031104A (en) * | 1972-04-18 | 1977-06-21 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
CH583702A5 (en) * | 1973-02-13 | 1977-01-14 | Science Union & Cie | Anti-hypertensive dihydropyridines - 4-aryl 2,5-dihydropyridine 3,5-dicarboxylic esters |
US3985758A (en) * | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
DE2639498A1 (de) * | 1976-09-02 | 1978-03-09 | Bayer Ag | Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
US4595690A (en) * | 1985-02-11 | 1986-06-17 | Syntex (U.S.A.) Inc. | Antihypertensive dihydropyridine derivatives |
GB8503426D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Pyridine derivatives |
-
1985
- 1985-02-10 IL IL77843A patent/IL77843A/xx unknown
- 1985-12-12 US US06/808,401 patent/US4672071A/en not_active Expired - Fee Related
-
1986
- 1986-02-07 PT PT81987A patent/PT81987B/pt unknown
- 1986-02-10 HU HU86541A patent/HU198019B/hu not_active IP Right Cessation
- 1986-02-10 FI FI860584A patent/FI860584A/fi not_active Application Discontinuation
- 1986-02-10 PL PL25789086A patent/PL257890A1/xx unknown
- 1986-02-10 HU HU861987A patent/HU198478B/hu unknown
- 1986-02-10 EP EP86101674A patent/EP0191448A3/en not_active Ceased
- 1986-02-10 JP JP61027735A patent/JPS61210071A/ja active Pending
- 1986-02-10 AU AU53363/86A patent/AU591093B2/en not_active Ceased
- 1986-02-10 DK DK64286A patent/DK64286A/da not_active Application Discontinuation
- 1986-02-10 NO NO860458A patent/NO860458L/no unknown
- 1986-02-10 ES ES551809A patent/ES8708130A1/es not_active Expired
- 1986-02-10 KR KR1019860000900A patent/KR860006442A/ko not_active Application Discontinuation
- 1986-02-10 PH PH33402A patent/PH22806A/en unknown
- 1986-02-11 GR GR860384A patent/GR860384B/el unknown
-
1987
- 1987-07-16 ES ES557628A patent/ES8802449A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
PT81987A (en) | 1986-03-01 |
AU591093B2 (en) | 1989-11-30 |
EP0191448A2 (en) | 1986-08-20 |
ES8802449A1 (es) | 1988-07-01 |
JPS61210071A (ja) | 1986-09-18 |
DK64286D0 (da) | 1986-02-10 |
PH22806A (en) | 1988-12-27 |
NO860458L (no) | 1986-08-12 |
PL257890A1 (en) | 1988-07-21 |
FI860584A (fi) | 1986-08-12 |
HU198019B (en) | 1989-07-28 |
FI860584A0 (fi) | 1986-02-10 |
EP0191448A3 (en) | 1987-08-19 |
ES8708130A1 (es) | 1987-10-16 |
HUT44501A (en) | 1988-03-28 |
KR860006442A (ko) | 1986-09-11 |
US4672071A (en) | 1987-06-09 |
ES557628A0 (es) | 1988-07-01 |
IL77843A (en) | 1989-07-31 |
ES551809A0 (es) | 1987-10-16 |
HU198478B (en) | 1989-10-30 |
GR860384B (en) | 1986-05-09 |
HUT41732A (en) | 1987-05-28 |
AU5336386A (en) | 1986-08-14 |
DK64286A (da) | 1986-08-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU116787A (en) | Process for obtaining imidazochynolinic derivatives | |
HUT35639A (en) | Process for preparing 3-chloro-1-formyl-4-phenyl-pyrrole derivatives | |
HUT40454A (en) | Process for preparing 4-substituted androstene-dione derivatives | |
YU183586A (en) | Process for obtaining chynoline derivatives | |
PT82850B (en) | Process for preparing furanone derivatives | |
HUT38941A (en) | Process for preparing triazolo-quinazoline derivatives | |
HUT38093A (en) | Process for preparing benzene-sulphonamide derivatives | |
HUT38317A (en) | Process for preparing ethylene-diamino-monoamide derivatives | |
HUT42441A (en) | Process for preparing indolyl- and indazolyl-carboxamide derivatives | |
EG18109A (en) | Process for preparing flavone derivatives | |
YU45469B (en) | Process for obtaining imidazolylalkylguanidinic derivatives | |
HUT42082A (en) | Process for preparing quinolone derivatives | |
HUT42500A (en) | New process for preparing sphyngosine derivatives | |
HUT38604A (en) | Process for preparing fluoro-alkyl-amine derivatives | |
PT81987B (en) | Process for preparing antihypertensive dihydropiridine derivatives | |
HUT38333A (en) | Process for preparing 1-piperidino-2-phenyl-quinoline derivatives | |
HUT40114A (en) | Process for preparing flavolignane derivatives | |
HUT37757A (en) | Process for preparing 2-substituted-5-methyl-pyridina derivatives | |
RO93563B (ro) | Procedeu de preparare a unor derivati de 3-fenoxifenil-propen-1-il-ciclopropan | |
PT81988A (en) | Process for preparing novel alkylamino-furanone derivatives | |
HUT42432A (en) | Process for preparing substituted phenyl-carbamide derivatives | |
GB2157287B (en) | Process for preparing 3-exomethylenecepham derivatives | |
HUT40412A (en) | Process for preparing dihydropyridine derivatives | |
GR862191B (en) | Method for preparing novel hydropyridin derivatives | |
PT80643A (en) | Process for preparing nitroethenamina derivatives |