ES551809A0 - Procedimiento para la preparacion de derivados de dihidropiridina antihipertensores - Google Patents
Procedimiento para la preparacion de derivados de dihidropiridina antihipertensoresInfo
- Publication number
- ES551809A0 ES551809A0 ES551809A ES551809A ES551809A0 ES 551809 A0 ES551809 A0 ES 551809A0 ES 551809 A ES551809 A ES 551809A ES 551809 A ES551809 A ES 551809A ES 551809 A0 ES551809 A0 ES 551809A0
- Authority
- ES
- Spain
- Prior art keywords
- hypertensive
- procedure
- preparation
- dihydropyridine derivatives
- dihydropyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/700,439 US4595690A (en) | 1985-02-11 | 1985-02-11 | Antihypertensive dihydropyridine derivatives |
| US06/808,401 US4672071A (en) | 1985-02-11 | 1985-12-12 | Antihypertensive dihydropyridine compositions, optical isomers and intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES551809A0 true ES551809A0 (es) | 1987-10-16 |
| ES8708130A1 ES8708130A1 (es) | 1987-10-16 |
Family
ID=27106619
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551809A Expired ES8708130A1 (es) | 1985-02-11 | 1986-02-10 | Procedimiento para la preparacion de derivados de dihidropiridina antihipertensores |
| ES557628A Expired ES8802449A1 (es) | 1985-02-11 | 1987-07-16 | Procedimiento para la preparacion de derivados de dihidropiridina antihipertensores |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557628A Expired ES8802449A1 (es) | 1985-02-11 | 1987-07-16 | Procedimiento para la preparacion de derivados de dihidropiridina antihipertensores |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4672071A (es) |
| EP (1) | EP0191448A3 (es) |
| JP (1) | JPS61210071A (es) |
| KR (1) | KR860006442A (es) |
| AU (1) | AU591093B2 (es) |
| DK (1) | DK64286A (es) |
| ES (2) | ES8708130A1 (es) |
| FI (1) | FI860584A (es) |
| GR (1) | GR860384B (es) |
| HU (2) | HU198019B (es) |
| IL (1) | IL77843A (es) |
| NO (1) | NO860458L (es) |
| PH (1) | PH22806A (es) |
| PL (1) | PL257890A1 (es) |
| PT (1) | PT81987B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2576843A (en) * | 1944-12-30 | 1951-11-27 | Rosenblads Patenter Ab | Heat exchange apparatus |
| US2788065A (en) * | 1950-08-14 | 1957-04-09 | Rosenblads Patenter Ab | Surface type evaporator employing channel switching for cleaning purposes |
| US4814455A (en) * | 1986-04-16 | 1989-03-21 | Bristol-Myers Company | Dihydro-3,5-dicarboxylates |
| JPH0686429B2 (ja) * | 1986-08-27 | 1994-11-02 | 株式会社ミドリ十字 | ジヒドロピリジン誘導体 |
| US4886819A (en) * | 1986-08-27 | 1989-12-12 | The Green Cross Corporation | Dihydropyridine derivatives and pharmaceutical composition thereof |
| DE3633496A1 (de) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln |
| US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
| US5576439A (en) * | 1994-10-28 | 1996-11-19 | Ciba-Geigy Corporation | Dihydropyridinecarboxylic acid anhydrides |
| SE9801990D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031104A (en) * | 1972-04-18 | 1977-06-21 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
| CH583702A5 (en) * | 1973-02-13 | 1977-01-14 | Science Union & Cie | Anti-hypertensive dihydropyridines - 4-aryl 2,5-dihydropyridine 3,5-dicarboxylic esters |
| US3985758A (en) * | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| DE2639498A1 (de) * | 1976-09-02 | 1978-03-09 | Bayer Ag | Neue schwefelhaltige amino-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
| JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
| GB8503426D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Pyridine derivatives |
| US4595690A (en) * | 1985-02-11 | 1986-06-17 | Syntex (U.S.A.) Inc. | Antihypertensive dihydropyridine derivatives |
-
1985
- 1985-02-10 IL IL77843A patent/IL77843A/xx unknown
- 1985-12-12 US US06/808,401 patent/US4672071A/en not_active Expired - Fee Related
-
1986
- 1986-02-07 PT PT81987A patent/PT81987B/pt unknown
- 1986-02-10 NO NO860458A patent/NO860458L/no unknown
- 1986-02-10 FI FI860584A patent/FI860584A/fi not_active Application Discontinuation
- 1986-02-10 AU AU53363/86A patent/AU591093B2/en not_active Ceased
- 1986-02-10 HU HU86541A patent/HU198019B/hu not_active IP Right Cessation
- 1986-02-10 PL PL25789086A patent/PL257890A1/xx unknown
- 1986-02-10 EP EP86101674A patent/EP0191448A3/en not_active Ceased
- 1986-02-10 ES ES551809A patent/ES8708130A1/es not_active Expired
- 1986-02-10 PH PH33402A patent/PH22806A/en unknown
- 1986-02-10 DK DK64286A patent/DK64286A/da not_active Application Discontinuation
- 1986-02-10 KR KR1019860000900A patent/KR860006442A/ko not_active Application Discontinuation
- 1986-02-10 HU HU861987A patent/HU198478B/hu unknown
- 1986-02-10 JP JP61027735A patent/JPS61210071A/ja active Pending
- 1986-02-11 GR GR860384A patent/GR860384B/el unknown
-
1987
- 1987-07-16 ES ES557628A patent/ES8802449A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES557628A0 (es) | 1988-07-01 |
| EP0191448A3 (en) | 1987-08-19 |
| AU591093B2 (en) | 1989-11-30 |
| HUT41732A (en) | 1987-05-28 |
| HUT44501A (en) | 1988-03-28 |
| DK64286D0 (da) | 1986-02-10 |
| HU198019B (en) | 1989-07-28 |
| IL77843A (en) | 1989-07-31 |
| HU198478B (en) | 1989-10-30 |
| FI860584A0 (fi) | 1986-02-10 |
| PT81987A (en) | 1986-03-01 |
| AU5336386A (en) | 1986-08-14 |
| PH22806A (en) | 1988-12-27 |
| ES8802449A1 (es) | 1988-07-01 |
| PL257890A1 (en) | 1988-07-21 |
| US4672071A (en) | 1987-06-09 |
| JPS61210071A (ja) | 1986-09-18 |
| EP0191448A2 (en) | 1986-08-20 |
| PT81987B (en) | 1987-08-13 |
| KR860006442A (ko) | 1986-09-11 |
| ES8708130A1 (es) | 1987-10-16 |
| FI860584A (fi) | 1986-08-12 |
| DK64286A (da) | 1986-08-12 |
| NO860458L (no) | 1986-08-12 |
| GR860384B (en) | 1986-05-09 |
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