DK59077A - Fremgangsmade til fremstilling af hidtil ukendte carboxyalkylacylaminosyrer - Google Patents

Fremgangsmade til fremstilling af hidtil ukendte carboxyalkylacylaminosyrer

Info

Publication number
DK59077A
DK59077A DK59077A DK59077A DK59077A DK 59077 A DK59077 A DK 59077A DK 59077 A DK59077 A DK 59077A DK 59077 A DK59077 A DK 59077A DK 59077 A DK59077 A DK 59077A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
present
carboxyalkylacylamino
acids
Prior art date
Application number
DK59077A
Other languages
Danish (da)
English (en)
Inventor
D W Cushman
M A Ondetti
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DK59077A publication Critical patent/DK59077A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
DK59077A 1976-02-13 1977-02-11 Fremgangsmade til fremstilling af hidtil ukendte carboxyalkylacylaminosyrer DK59077A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/657,793 US4052511A (en) 1976-02-13 1976-02-13 Carboxyacylproline derivatives

Publications (1)

Publication Number Publication Date
DK59077A true DK59077A (da) 1977-08-14

Family

ID=24638684

Family Applications (1)

Application Number Title Priority Date Filing Date
DK59077A DK59077A (da) 1976-02-13 1977-02-11 Fremgangsmade til fremstilling af hidtil ukendte carboxyalkylacylaminosyrer

Country Status (23)

Country Link
US (3) US4052511A (ja)
JP (1) JPS6058751B2 (ja)
AT (1) AT366030B (ja)
BE (1) BE851363A (ja)
CA (1) CA1104059A (ja)
CH (1) CH602633A5 (ja)
CS (1) CS197285B2 (ja)
DD (1) DD129651A5 (ja)
DE (1) DE2704985A1 (ja)
DK (1) DK59077A (ja)
FR (1) FR2340933A1 (ja)
GB (1) GB1570921A (ja)
HU (1) HU177144B (ja)
IE (1) IE45086B1 (ja)
NL (1) NL167688C (ja)
NO (1) NO145915C (ja)
NZ (1) NZ183222A (ja)
PH (1) PH12066A (ja)
PL (1) PL106416B1 (ja)
SE (1) SE426169B (ja)
SU (1) SU694070A3 (ja)
YU (1) YU33277A (ja)
ZA (1) ZA77564B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242869A (en) * 1964-07-15 1966-03-29 Walter D Komhyr Rectangular-piston pump

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US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
US4179568A (en) * 1978-07-31 1979-12-18 E. R. Squibb & Sons, Inc. (N-lower alkyl-3,5-dioxo-3-pyrrolidinyl)thioalkanoylpyrrolidine-and piperidine-carboxylic acid compounds
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US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids
JPS5531022A (en) * 1978-08-24 1980-03-05 Yoshitomi Pharmaceut Ind Ltd Hydroxamic acid derivative and its preparation
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
US4226775A (en) * 1979-06-01 1980-10-07 American Cyanamid Company Substituted thio-substituted benzyl-propionyl-L-prolines
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4217359A (en) * 1979-01-15 1980-08-12 E. R. Squibb & Sons, Inc. Carbamate derivatives of mercaptoacyl hydroxy prolines
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US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4499102A (en) * 1979-12-13 1985-02-12 Santen Pharmaceutical Co., Ltd. Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
PT70158A1 (en) * 1980-03-03 1982-03-01 Univ Miami Process for preparing anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
US4629787A (en) * 1980-08-18 1986-12-16 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4587050A (en) * 1980-08-18 1986-05-06 Merck & Co., Inc. Substituted enantholactam derivatives as antihypertensives
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4390700A (en) * 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
EP0053017B1 (en) * 1980-11-24 1985-02-20 Imperial Chemical Industries Plc Amide derivatives
US4321383A (en) * 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
US4401818A (en) * 1980-12-24 1983-08-30 Ciba-Geigy Corporation 1-Carboxyalkanoyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4402969A (en) * 1981-03-23 1983-09-06 Merck & Co., Inc. Antihypertensive proline derivatives
US4587238A (en) * 1981-07-06 1986-05-06 Merck & Co., Inc. Substituted caprylolactam derivatives as anti-hypertensives
US4866087A (en) * 1982-01-21 1989-09-12 Merck & Co., Inc. Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives
US4483850A (en) * 1982-05-10 1984-11-20 Merck & Co., Inc. N-Terminal substituted oligopeptide converting enzyme inhibitors
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4472384A (en) * 1983-06-15 1984-09-18 Merck & Co., Inc. Antihypertensive composition
US4617301A (en) * 1983-06-22 1986-10-14 Merck & Co., Inc. Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
US4558037A (en) * 1984-06-04 1985-12-10 Merck & Co., Inc. Cardiovascular composition
US5096925A (en) * 1984-06-08 1992-03-17 Ciba-Geigy Corporation N-substituted butyramide derivatives
US4939261A (en) * 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
US4678800A (en) * 1984-06-15 1987-07-07 Ciba-Geigy Corporation Gamma-r-glutamoyl derivatives
US4568489A (en) * 1984-06-29 1986-02-04 E. R. Squibb & Sons, Inc. N-Acyl-γ-glutamyl imino and amino acids and esters
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
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US5187183A (en) * 1988-06-15 1993-02-16 Brigham & Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
US5025001A (en) * 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5002964A (en) * 1988-06-15 1991-03-26 Brigham & Women's Hospital S-nitrosocaptopril compounds and the use thereof
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
ATE360014T1 (de) * 2001-06-15 2007-05-15 Vicuron Pharm Inc Bicyclische pyrrolidinverbindungen
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
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US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
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US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
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US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
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US2627487A (en) * 1949-01-11 1953-02-03 Nathan L Drake Insect repellents
US3335145A (en) * 1963-03-07 1967-08-08 Reilly Tar & Chem Corp N-carboxyacyl- and n-carboxyaroylcarboxy piperidines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242869A (en) * 1964-07-15 1966-03-29 Walter D Komhyr Rectangular-piston pump

Also Published As

Publication number Publication date
US4086338A (en) 1978-04-25
NL167688C (nl) 1982-01-18
GB1570921A (en) 1980-07-09
NZ183222A (en) 1979-07-11
YU33277A (en) 1982-08-31
NO145915B (no) 1982-03-15
NO770465L (no) 1977-08-16
CH602633A5 (ja) 1978-07-31
JPS6058751B2 (ja) 1985-12-21
SE7701562L (sv) 1977-09-23
NL167688B (nl) 1981-08-17
SU694070A3 (ru) 1979-10-25
PH12066A (en) 1978-10-18
CS197285B2 (en) 1980-04-30
IE45086L (en) 1977-08-13
FR2340933A1 (fr) 1977-09-09
PL106416B1 (pl) 1979-12-31
ZA77564B (en) 1977-12-28
US4128653A (en) 1978-12-05
FR2340933B1 (ja) 1980-04-11
DD129651A5 (de) 1978-02-01
IE45086B1 (en) 1982-06-16
CA1104059A (en) 1981-06-30
SE426169B (sv) 1982-12-13
PL195997A1 (pl) 1978-02-27
DE2704985A1 (de) 1977-08-18
US4052511A (en) 1977-10-04
AT366030B (de) 1982-03-10
ATA96977A (de) 1981-07-15
AU2189877A (en) 1978-08-10
BE851363A (fr) 1977-08-11
JPS52100461A (en) 1977-08-23
HU177144B (en) 1981-07-28
NO145915C (no) 1982-06-23
NL7701463A (nl) 1977-08-16

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