PL195997A1 - Sposob wytwarzania nowych pochodnych karboksyalkiloacyloaminokwasow - Google Patents

Sposob wytwarzania nowych pochodnych karboksyalkiloacyloaminokwasow

Info

Publication number
PL195997A1
PL195997A1 PL19599777A PL19599777A PL195997A1 PL 195997 A1 PL195997 A1 PL 195997A1 PL 19599777 A PL19599777 A PL 19599777A PL 19599777 A PL19599777 A PL 19599777A PL 195997 A1 PL195997 A1 PL 195997A1
Authority
PL
Poland
Prior art keywords
carboxyalkyloacyloamino
acid derivatives
making new
making
new
Prior art date
Application number
PL19599777A
Other languages
English (en)
Other versions
PL106416B1 (pl
Inventor
David W Cushman
Miguel A Ondetti
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of PL195997A1 publication Critical patent/PL195997A1/pl
Publication of PL106416B1 publication Critical patent/PL106416B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
PL1977195997A 1976-02-13 1977-02-14 Sposob wytwarzania nowych pochodnych karboksyalkiloacyloaminokwasow PL106416B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/657,793 US4052511A (en) 1976-02-13 1976-02-13 Carboxyacylproline derivatives

Publications (2)

Publication Number Publication Date
PL195997A1 true PL195997A1 (pl) 1978-02-27
PL106416B1 PL106416B1 (pl) 1979-12-31

Family

ID=24638684

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1977195997A PL106416B1 (pl) 1976-02-13 1977-02-14 Sposob wytwarzania nowych pochodnych karboksyalkiloacyloaminokwasow

Country Status (23)

Country Link
US (3) US4052511A (pl)
JP (1) JPS6058751B2 (pl)
AT (1) AT366030B (pl)
BE (1) BE851363A (pl)
CA (1) CA1104059A (pl)
CH (1) CH602633A5 (pl)
CS (1) CS197285B2 (pl)
DD (1) DD129651A5 (pl)
DE (1) DE2704985A1 (pl)
DK (1) DK59077A (pl)
FR (1) FR2340933A1 (pl)
GB (1) GB1570921A (pl)
HU (1) HU177144B (pl)
IE (1) IE45086B1 (pl)
NL (1) NL167688C (pl)
NO (1) NO145915C (pl)
NZ (1) NZ183222A (pl)
PH (1) PH12066A (pl)
PL (1) PL106416B1 (pl)
SE (1) SE426169B (pl)
SU (1) SU694070A3 (pl)
YU (1) YU33277A (pl)
ZA (1) ZA77564B (pl)

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JPS584711B2 (ja) * 1978-08-02 1983-01-27 参天製薬株式会社 ピロリジン誘導体
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids
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US4226775A (en) * 1979-06-01 1980-10-07 American Cyanamid Company Substituted thio-substituted benzyl-propionyl-L-prolines
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US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
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US4629787A (en) * 1980-08-18 1986-12-16 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
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US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
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US4390700A (en) * 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
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US4321383A (en) * 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
US4401818A (en) * 1980-12-24 1983-08-30 Ciba-Geigy Corporation 1-Carboxyalkanoyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
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US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4402969A (en) * 1981-03-23 1983-09-06 Merck & Co., Inc. Antihypertensive proline derivatives
US4587238A (en) * 1981-07-06 1986-05-06 Merck & Co., Inc. Substituted caprylolactam derivatives as anti-hypertensives
US4866087A (en) * 1982-01-21 1989-09-12 Merck & Co., Inc. Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives
US4483850A (en) * 1982-05-10 1984-11-20 Merck & Co., Inc. N-Terminal substituted oligopeptide converting enzyme inhibitors
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
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US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4472384A (en) * 1983-06-15 1984-09-18 Merck & Co., Inc. Antihypertensive composition
US4617301A (en) * 1983-06-22 1986-10-14 Merck & Co., Inc. Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
US4558037A (en) * 1984-06-04 1985-12-10 Merck & Co., Inc. Cardiovascular composition
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US4678800A (en) * 1984-06-15 1987-07-07 Ciba-Geigy Corporation Gamma-r-glutamoyl derivatives
US4568489A (en) * 1984-06-29 1986-02-04 E. R. Squibb & Sons, Inc. N-Acyl-γ-glutamyl imino and amino acids and esters
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
US4626545A (en) * 1984-08-27 1986-12-02 Merck & Co., Inc. Amino acid derivatives as enzyme inhibitors
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US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
ATE360014T1 (de) * 2001-06-15 2007-05-15 Vicuron Pharm Inc Bicyclische pyrrolidinverbindungen
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US3335145A (en) * 1963-03-07 1967-08-08 Reilly Tar & Chem Corp N-carboxyacyl- and n-carboxyaroylcarboxy piperidines

Also Published As

Publication number Publication date
US4086338A (en) 1978-04-25
NL167688C (nl) 1982-01-18
GB1570921A (en) 1980-07-09
NZ183222A (en) 1979-07-11
YU33277A (en) 1982-08-31
NO145915B (no) 1982-03-15
NO770465L (no) 1977-08-16
CH602633A5 (pl) 1978-07-31
JPS6058751B2 (ja) 1985-12-21
SE7701562L (sv) 1977-09-23
NL167688B (nl) 1981-08-17
SU694070A3 (ru) 1979-10-25
PH12066A (en) 1978-10-18
CS197285B2 (en) 1980-04-30
IE45086L (en) 1977-08-13
FR2340933A1 (fr) 1977-09-09
PL106416B1 (pl) 1979-12-31
ZA77564B (en) 1977-12-28
US4128653A (en) 1978-12-05
FR2340933B1 (pl) 1980-04-11
DD129651A5 (de) 1978-02-01
IE45086B1 (en) 1982-06-16
CA1104059A (en) 1981-06-30
SE426169B (sv) 1982-12-13
DE2704985A1 (de) 1977-08-18
US4052511A (en) 1977-10-04
AT366030B (de) 1982-03-10
ATA96977A (de) 1981-07-15
AU2189877A (en) 1978-08-10
BE851363A (fr) 1977-08-11
JPS52100461A (en) 1977-08-23
HU177144B (en) 1981-07-28
NO145915C (no) 1982-06-23
DK59077A (da) 1977-08-14
NL7701463A (nl) 1977-08-16

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