DK55192D0 - 1-piperazino-1,2-dihydroindenderivater - Google Patents
1-piperazino-1,2-dihydroindenderivaterInfo
- Publication number
- DK55192D0 DK55192D0 DK92551A DK55192A DK55192D0 DK 55192 D0 DK55192 D0 DK 55192D0 DK 92551 A DK92551 A DK 92551A DK 55192 A DK55192 A DK 55192A DK 55192 D0 DK55192 D0 DK 55192D0
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- hydrogen
- cycloalkylalkyl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK92551A DK55192D0 (da) | 1992-04-28 | 1992-04-28 | 1-piperazino-1,2-dihydroindenderivater |
IL105464A IL105464A (en) | 1992-04-28 | 1993-04-20 | Trans-compounds (1-piperazin-1-yl) -3-aryl-1,2-dihydroindene are converted to the 3-position of the piperazine ring and pharmaceutical mixtures containing or |
ZA932840A ZA932840B (en) | 1992-04-28 | 1993-04-22 | 1-piperazino-1,3-dihydroindene derivatives |
KR1019940703815A KR100267635B1 (ko) | 1992-04-28 | 1993-04-23 | 1-피페라지노-1, 2-디히드로인덴 유도체 |
CZ942619A CZ281676B6 (cs) | 1992-04-28 | 1993-04-23 | 1-piperazin-1,2-dihydroindenové deriváty, farmaceutické prostředky s jejich obsahem a použití uvedených látek pro výrobu farmaceutických prostředků |
DK93909807T DK0638073T3 (da) | 1992-04-28 | 1993-04-23 | 1-Piperazino-1,2-dihydroindenderivater |
HU9403098A HUT71419A (en) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindene derivatives and pharmaceutical compositions containing them |
ES93909807T ES2148227T3 (es) | 1992-04-28 | 1993-04-23 | Derivados de 1-piperazino-1,2-dihidroindeno. |
NZ252098A NZ252098A (en) | 1992-04-28 | 1993-04-23 | 1-aryl-3-piperazino indane derivatives and medicaments |
AT93909807T ATE194003T1 (de) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindenderivate |
CA002134566A CA2134566C (en) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindene derivatives |
PCT/DK1993/000136 WO1993022293A1 (en) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindene derivatives |
RU94045948A RU2114106C1 (ru) | 1992-04-28 | 1993-04-23 | Производные транс-изомеров 1-пиперазин-1,2-дигидроиндена |
DE69328901T DE69328901T2 (de) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindenderivate |
AU40599/93A AU669709B2 (en) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindene derivatives |
JP51884593A JP3255416B2 (ja) | 1992-04-28 | 1993-04-23 | 1‐ピペラジノ‐1,2‐ジヒドロインデン誘導体 |
PT93909807T PT638073E (pt) | 1992-04-28 | 1993-04-23 | Derivados de 1-piperazino-1, 2-dihidroindeno |
EP93909807A EP0638073B1 (en) | 1992-04-28 | 1993-04-23 | 1-piperazino-1,2-dihydroindene derivatives |
SK1293-94A SK281613B6 (sk) | 1992-04-28 | 1993-04-23 | Trans-izoméry derivátov 1-piperazín-1,2-dihydroindénu, farmaceutický prípravok s ich obsahom a ich použitie |
FI945042A FI113862B (fi) | 1992-04-28 | 1994-10-26 | Menetelmä uusien terapeuttisesti käyttökelpoisten 1-piperatsino-1,2-dihydroindeenijohdannaisten valmistamiseksi |
NO944090A NO306946B1 (no) | 1992-04-28 | 1994-10-27 | Trans-isomerer av 1-piperazino-1,2-dihydroindenforbindelser |
US08/331,213 US5807855A (en) | 1992-04-28 | 1994-10-28 | 1-piperazino-1,2-dihydroindene derivatives |
HU95P/P00587P HU211909A9 (en) | 1992-04-28 | 1995-06-29 | 1-piperazino-1,2-dihydroindene derivatives |
HK98115090A HK1013816A1 (en) | 1992-04-28 | 1998-12-23 | 1-Piperazino-1,2-dihydroindene derivatives |
GR20000402086T GR3034396T3 (en) | 1992-04-28 | 2000-09-13 | 1-piperazino-1,2-dihydroindene derivatives. |
CL200302050A CL2003002050A1 (es) | 1992-04-28 | 2003-10-10 | Compuestos derivados de 1-piperazin-1,2-dihidroindeno, su composicion farmaceutica y el uso de esta para tratar enfermedades del sistema nervioso central. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK92551A DK55192D0 (da) | 1992-04-28 | 1992-04-28 | 1-piperazino-1,2-dihydroindenderivater |
Publications (1)
Publication Number | Publication Date |
---|---|
DK55192D0 true DK55192D0 (da) | 1992-04-28 |
Family
ID=8094828
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92551A DK55192D0 (da) | 1992-04-28 | 1992-04-28 | 1-piperazino-1,2-dihydroindenderivater |
DK93909807T DK0638073T3 (da) | 1992-04-28 | 1993-04-23 | 1-Piperazino-1,2-dihydroindenderivater |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93909807T DK0638073T3 (da) | 1992-04-28 | 1993-04-23 | 1-Piperazino-1,2-dihydroindenderivater |
Country Status (24)
Country | Link |
---|---|
US (1) | US5807855A (fi) |
EP (1) | EP0638073B1 (fi) |
JP (1) | JP3255416B2 (fi) |
KR (1) | KR100267635B1 (fi) |
AT (1) | ATE194003T1 (fi) |
AU (1) | AU669709B2 (fi) |
CA (1) | CA2134566C (fi) |
CL (1) | CL2003002050A1 (fi) |
CZ (1) | CZ281676B6 (fi) |
DE (1) | DE69328901T2 (fi) |
DK (2) | DK55192D0 (fi) |
ES (1) | ES2148227T3 (fi) |
FI (1) | FI113862B (fi) |
GR (1) | GR3034396T3 (fi) |
HK (1) | HK1013816A1 (fi) |
HU (2) | HUT71419A (fi) |
IL (1) | IL105464A (fi) |
NO (1) | NO306946B1 (fi) |
NZ (1) | NZ252098A (fi) |
PT (1) | PT638073E (fi) |
RU (1) | RU2114106C1 (fi) |
SK (1) | SK281613B6 (fi) |
WO (1) | WO1993022293A1 (fi) |
ZA (1) | ZA932840B (fi) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010037398A1 (en) * | 2008-10-03 | 2010-04-08 | H. Lundbeck A/S | Oral formulation |
US6251893B1 (en) * | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
UA75392C2 (en) * | 2001-02-23 | 2006-04-17 | Merck & Co Inc | N-substituted non-aryl heterocyclic antagonists nmda/nr2b |
IS7282A (is) * | 2001-12-21 | 2004-05-21 | H. Lundbeck A/S | Amínóindan afleiður sem serótónín og noradrenalínupptökuhindrar |
IL162308A0 (en) * | 2001-12-21 | 2005-11-20 | Lundbeck & Co As H | Aminoindane derivatives as serotonin and norepinephrine uptakeinhibitors |
PL199016B1 (pl) † | 2002-06-20 | 2008-08-29 | Adamed Sp Z Oo | Sposób wytwarzania olanzapiny |
DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
AR045278A1 (es) * | 2003-08-18 | 2005-10-19 | Lundbeck & Co As H | Sales de succinato y malonato de trans-4-((1r, 3s)-6-cloro-3-fenilindan-1-il)-1,2,2-trimetilpiperazina y el uso como medicamento |
WO2005016900A1 (en) * | 2003-08-18 | 2005-02-24 | H. Lundbeck A/S | Succinate and malonate salt of trans-4-(ir,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament |
DE10361258A1 (de) * | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
DE102004014841B4 (de) * | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
TWI376373B (en) * | 2005-02-16 | 2012-11-11 | Lundbeck & Co As H | Crystalline base of a pharmaceutical compound |
MX2007009816A (es) * | 2005-02-16 | 2007-09-07 | Lundbeck & Co As H | Sales de tartrato y de malato de trans-1-((1r,3s)-6-cloro-3- fenilindan-1-i1)-3,3-dimetilpiperazina. |
TWI453198B (zh) * | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s)-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
TW200819426A (en) | 2006-08-31 | 2008-05-01 | Lundbeck & Co As H | Novel indane compounds |
NZ589571A (en) * | 2008-05-07 | 2012-07-27 | Lundbeck & Co As H | Method for treating cognitive deficits using trans-4-((1r,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine |
WO2010125134A1 (en) * | 2009-04-30 | 2010-11-04 | Abbott Gmbh & Co. Kg | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor |
TW201102370A (en) | 2009-07-07 | 2011-01-16 | Lundbeck & Co As H | Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine |
DK2639216T3 (en) | 2010-11-09 | 2018-09-24 | Kaneka Corp | Halogenated Indones and Methods for Preparation of Optically Active Indanones or Optically Active Indanols Using These |
CN103429577A (zh) * | 2011-01-07 | 2013-12-04 | H.隆德贝克有限公司 | 4-((1r,3s)-6-氯-3-苯基-茚满-1-基)-1,2,2-三甲基哌嗪和1-((1r,3s)-6-氯-3-苯基-茚满-1-基)-3,3-二甲基哌嗪的拆分方法 |
JP5668177B2 (ja) | 2011-06-20 | 2015-02-12 | ハー・ルンドベック・アクチエゼルスカベット | 統合失調症の治療のための重水素化1−ピペラジノ−3−フェニルインダン |
JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
MA52183A (fr) * | 2018-04-06 | 2021-02-17 | H Lundbeck As | Procédé de préparation de 2,2-diméthylpipérazine |
CN112930341A (zh) | 2018-10-29 | 2021-06-08 | H.隆德贝克有限公司 | 无定形的具有式(i)的化合物和无定形的具有式(i)的化合物的盐 |
US11535600B2 (en) | 2018-12-03 | 2022-12-27 | H. Lundbeck A/S | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine |
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GB1469108A (en) * | 1973-06-25 | 1977-03-30 | Kefalas As | Thiaxanthene derivative |
US4038395A (en) * | 1973-06-25 | 1977-07-26 | Kefalas A/S | Compositions of and method of treating with the alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof and acid addition salts of these compounds |
IE50867B1 (en) * | 1980-02-29 | 1986-08-06 | Kefalas As | Indane derivatives |
IE55972B1 (en) * | 1982-10-07 | 1991-03-13 | Kefalas As | Phenylindene derivatives,acid addition salts thereof,and methods of preparation |
HU198036B (en) * | 1983-08-22 | 1989-07-28 | Hoechst Roussel Pharma | Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them |
GB8427125D0 (en) * | 1984-10-26 | 1984-12-05 | Lundbeck & Co As H | Organic compounds |
EP0202322B1 (en) * | 1984-12-03 | 1991-05-08 | Hughes Aircraft Company | Variable lens and birefringence compensator for continuous operation |
IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
DE3521761A1 (de) * | 1985-06-19 | 1987-01-02 | Bayer Ag | Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
GB8628644D0 (en) * | 1986-12-01 | 1987-01-07 | Lunbeck A S H | Intermediates |
GB8704572D0 (en) * | 1987-02-26 | 1987-04-01 | Lundbeck & Co As H | Organic compounds |
MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
EP0302423A3 (en) * | 1987-08-07 | 1991-01-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments |
US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
WO1991009594A1 (en) * | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
DK152090D0 (da) * | 1990-06-22 | 1990-06-22 | Lundbaek A S H | Piperidylsubstituerede indolderivater |
DK158590D0 (da) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | Indolderivater |
US5643784A (en) * | 1990-12-04 | 1997-07-01 | H, Lundbeck A/S | Indan derivatives |
DK286990D0 (da) * | 1990-12-04 | 1990-12-04 | Lundbeck & Co As H | Indanderivater |
-
1992
- 1992-04-28 DK DK92551A patent/DK55192D0/da not_active Application Discontinuation
-
1993
- 1993-04-20 IL IL105464A patent/IL105464A/en not_active IP Right Cessation
- 1993-04-22 ZA ZA932840A patent/ZA932840B/xx unknown
- 1993-04-23 EP EP93909807A patent/EP0638073B1/en not_active Expired - Lifetime
- 1993-04-23 AU AU40599/93A patent/AU669709B2/en not_active Expired
- 1993-04-23 RU RU94045948A patent/RU2114106C1/ru active
- 1993-04-23 AT AT93909807T patent/ATE194003T1/de active
- 1993-04-23 CA CA002134566A patent/CA2134566C/en not_active Expired - Lifetime
- 1993-04-23 KR KR1019940703815A patent/KR100267635B1/ko not_active IP Right Cessation
- 1993-04-23 DK DK93909807T patent/DK0638073T3/da active
- 1993-04-23 CZ CZ942619A patent/CZ281676B6/cs not_active IP Right Cessation
- 1993-04-23 NZ NZ252098A patent/NZ252098A/en not_active IP Right Cessation
- 1993-04-23 WO PCT/DK1993/000136 patent/WO1993022293A1/en active IP Right Grant
- 1993-04-23 JP JP51884593A patent/JP3255416B2/ja not_active Expired - Lifetime
- 1993-04-23 PT PT93909807T patent/PT638073E/pt unknown
- 1993-04-23 ES ES93909807T patent/ES2148227T3/es not_active Expired - Lifetime
- 1993-04-23 HU HU9403098A patent/HUT71419A/hu unknown
- 1993-04-23 DE DE69328901T patent/DE69328901T2/de not_active Expired - Lifetime
- 1993-04-23 SK SK1293-94A patent/SK281613B6/sk not_active IP Right Cessation
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1994
- 1994-10-26 FI FI945042A patent/FI113862B/fi not_active IP Right Cessation
- 1994-10-27 NO NO944090A patent/NO306946B1/no not_active IP Right Cessation
- 1994-10-28 US US08/331,213 patent/US5807855A/en not_active Expired - Lifetime
-
1995
- 1995-06-29 HU HU95P/P00587P patent/HU211909A9/hu unknown
-
1998
- 1998-12-23 HK HK98115090A patent/HK1013816A1/xx not_active IP Right Cessation
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2000
- 2000-09-13 GR GR20000402086T patent/GR3034396T3/el unknown
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2003
- 2003-10-10 CL CL200302050A patent/CL2003002050A1/es unknown
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