DK488489A - Fremgangsmaade til fremstilling af human-plasmino-genaktivator af vaevstype - Google Patents

Fremgangsmaade til fremstilling af human-plasmino-genaktivator af vaevstype Download PDF

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Publication number
DK488489A
DK488489A DK488489A DK488489A DK488489A DK 488489 A DK488489 A DK 488489A DK 488489 A DK488489 A DK 488489A DK 488489 A DK488489 A DK 488489A DK 488489 A DK488489 A DK 488489A
Authority
DK
Denmark
Prior art keywords
tpa
genactivator
plasmino
high concentration
medium
Prior art date
Application number
DK488489A
Other languages
English (en)
Other versions
DK488489D0 (da
Inventor
Shoichiro Miyahara
Atsunori Shindo
Maki Suzuki
Nobumi Kusuhara
Nobuyoshi Makiguchi
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63249081A external-priority patent/JP2648624B2/ja
Priority claimed from JP63316118A external-priority patent/JP2718726B2/ja
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of DK488489D0 publication Critical patent/DK488489D0/da
Publication of DK488489A publication Critical patent/DK488489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DK488489A 1988-10-04 1989-10-04 Fremgangsmaade til fremstilling af human-plasmino-genaktivator af vaevstype DK488489A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63249081A JP2648624B2 (ja) 1988-10-04 1988-10-04 ヒト組織型プラスミノーゲン活性化因子の製造方法
JP63316118A JP2718726B2 (ja) 1988-12-16 1988-12-16 ヒト組織型プラスミノーゲン活性化因子の製法

Publications (2)

Publication Number Publication Date
DK488489D0 DK488489D0 (da) 1989-10-04
DK488489A true DK488489A (da) 1990-04-05

Family

ID=26539082

Family Applications (1)

Application Number Title Priority Date Filing Date
DK488489A DK488489A (da) 1988-10-04 1989-10-04 Fremgangsmaade til fremstilling af human-plasmino-genaktivator af vaevstype

Country Status (11)

Country Link
US (1) US5183754A (da)
EP (1) EP0366285B1 (da)
KR (1) KR920007398B1 (da)
AT (1) ATE116363T1 (da)
AU (1) AU614429B2 (da)
CA (1) CA1335188C (da)
DE (1) DE68920269T2 (da)
DK (1) DK488489A (da)
FI (1) FI96039C (da)
NO (1) NO175787C (da)
NZ (1) NZ230856A (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151359A (en) * 1988-05-19 1992-09-29 Mitsui Toatsu Chemicals Incorporated Method for producing of human tissue type plasminogen activator
WO2012122625A1 (en) 2011-03-14 2012-09-20 National Research Council Of Canada Method of viral production in cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732146A (en) * 1970-12-22 1973-05-08 Behringwerke Ag Process for the isolation of native, highly purified plasminogen
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4724206A (en) * 1984-02-13 1988-02-09 Damon Biotech, Inc. Protein production using hypertonic media
US4661453A (en) * 1984-06-19 1987-04-28 American Biogenetic Sciences, Inc. Production of tissue plasminogen activator factor
JPS624233A (ja) * 1985-07-01 1987-01-10 Toyobo Co Ltd 組織性プラスミノ−ゲン活性化因子の製造法
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
CA1312030C (en) * 1987-11-18 1992-12-29 Brian Maiorella Method to increase antibody titer
US5151359A (en) * 1988-05-19 1992-09-29 Mitsui Toatsu Chemicals Incorporated Method for producing of human tissue type plasminogen activator

Also Published As

Publication number Publication date
KR920007398B1 (ko) 1992-08-31
EP0366285A1 (en) 1990-05-02
FI894657A (fi) 1990-04-05
NO175787B (no) 1994-08-29
ATE116363T1 (de) 1995-01-15
AU4254189A (en) 1990-04-12
CA1335188C (en) 1995-04-11
FI96039C (fi) 1996-04-25
AU614429B2 (en) 1991-08-29
DK488489D0 (da) 1989-10-04
DE68920269T2 (de) 1995-05-18
NO893929L (no) 1990-04-05
FI894657A0 (fi) 1989-10-02
NZ230856A (en) 1991-10-25
EP0366285B1 (en) 1994-12-28
US5183754A (en) 1993-02-02
FI96039B (fi) 1996-01-15
DE68920269D1 (de) 1995-02-09
KR900006509A (ko) 1990-05-08
NO175787C (no) 1994-12-07
NO893929D0 (no) 1989-10-03

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