ES9000011A1 - Procedimiento para transformar un cultivo de celulas de modo que produzca activador de plasminogeno de tejido (t-pa) humano - Google Patents
Procedimiento para transformar un cultivo de celulas de modo que produzca activador de plasminogeno de tejido (t-pa) humanoInfo
- Publication number
- ES9000011A1 ES9000011A1 ES557800A ES557800A ES9000011A1 ES 9000011 A1 ES9000011 A1 ES 9000011A1 ES 557800 A ES557800 A ES 557800A ES 557800 A ES557800 A ES 557800A ES 9000011 A1 ES9000011 A1 ES 9000011A1
- Authority
- ES
- Spain
- Prior art keywords
- mutants
- tissue plasminogen
- compositions
- methods
- plasminogen activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
COMPRENDE LAS SIGUIENTES OPERACIONES: 1. MEZCLAR EL CULTIVO DE CELULAS CON UN VECTOR DE EXPRESION REPLICABLE CAPAZ DE EXPRESAR, EN UNA CELULA HOSPEDANTE TRASFORMABLE, LA SECUENCIA DE ADN QUE CODIFICA LOS MUTANTES DEL ACTIVADOR DE PLASMINOGENO DE TEJIDO HUMANO OBTENIDOS EMPLEANDO MUTAGENESIS DIRIGIDA A UN LUGAR; 2. APORTAR A LA MEZCLA DE CULTIVO LOS NUTRIENTES NECESARIOS PARA EL CRECIMIENTO DE LAS CELULAS; 3. DEJAR QUE EL CULTIVO DE CELULAS SE DESENVUELVA EN LAS CONDICIONES DE CULTIVO USUALES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72546885A | 1985-04-22 | 1985-04-22 | |
US84669786A | 1986-04-01 | 1986-04-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557800A0 ES557800A0 (es) | 1990-03-01 |
ES9000011A1 true ES9000011A1 (es) | 1990-03-01 |
Family
ID=27111150
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554251A Expired ES8802184A1 (es) | 1985-04-22 | 1986-04-22 | Procedimiento para la produccion de un mutante de activador de plasminogeno de tejido (t-pa) humano. |
ES557800A Expired - Fee Related ES9000011A1 (es) | 1985-04-22 | 1988-01-15 | Procedimiento para transformar un cultivo de celulas de modo que produzca activador de plasminogeno de tejido (t-pa) humano |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES554251A Expired ES8802184A1 (es) | 1985-04-22 | 1986-04-22 | Procedimiento para la produccion de un mutante de activador de plasminogeno de tejido (t-pa) humano. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5147643A (es) |
EP (1) | EP0199574B1 (es) |
JP (2) | JPH0740940B2 (es) |
AT (1) | ATE68825T1 (es) |
AU (1) | AU596356B2 (es) |
CA (1) | CA1341580C (es) |
DD (1) | DD258026A5 (es) |
DE (2) | DE3613390C2 (es) |
DK (1) | DK175380B1 (es) |
ES (2) | ES8802184A1 (es) |
FI (1) | FI98930C (es) |
FR (1) | FR2581652B1 (es) |
GB (1) | GB2173804B (es) |
GR (1) | GR861037B (es) |
HU (1) | HU206520B (es) |
IE (1) | IE58574B1 (es) |
IL (1) | IL78571A (es) |
MY (1) | MY102550A (es) |
NO (1) | NO175216C (es) |
NZ (1) | NZ215920A (es) |
PT (1) | PT82429B (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58149871A (ja) * | 1982-02-27 | 1983-09-06 | 本田技研工業株式会社 | 二,三輪車の盗難防止装置 |
JPS6087751A (ja) * | 1983-10-20 | 1985-05-17 | House Food Ind Co Ltd | レトルト豆腐の製造法 |
EP0201153A3 (en) * | 1985-02-09 | 1987-10-07 | Beecham Group Plc | Modified enzyme and process for its preparation |
HUT41632A (en) * | 1985-03-06 | 1987-05-28 | Survival Technology | Process for preparing agents for the enhancement of protein absorption |
GR861037B (en) * | 1985-04-22 | 1986-07-16 | Genentech Inc | Novel human tissue plasminogen activator mutants |
US5736134A (en) * | 1985-04-22 | 1998-04-07 | Genentech, In.C | Tissue plasminogen activator variants |
US5756093A (en) * | 1985-04-22 | 1998-05-26 | Genentech, Inc. | Tissue plasminogen activator variants |
US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
DE3684680D1 (de) * | 1985-12-23 | 1992-05-07 | Chiron Corp | Peptidplasminogenaktivatoren. |
DK43387A (da) * | 1986-01-29 | 1987-07-30 | Beecham Group Plc | Fibrinolytisk enzym |
US5837518A (en) * | 1986-01-31 | 1998-11-17 | Genetics Institute, Inc. | Thrombolytic proteins |
WO1987004722A1 (en) * | 1986-01-31 | 1987-08-13 | Genetics Institute, Inc. | Novel thrombolytic proteins |
US5071972A (en) * | 1986-01-31 | 1991-12-10 | Genetics Institute, Inc. | DNA sequences encoding novel thrombolytic proteins |
US5258298A (en) * | 1986-01-31 | 1993-11-02 | Genetics Institute, Inc. | Deletion and glycosylation mutant of human tissue plasminogen activator |
IE81073B1 (en) * | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
US5589361A (en) * | 1986-03-18 | 1996-12-31 | Genentech, Inc. | Human tissue-type plasminogen activator variant |
AU7090887A (en) * | 1986-04-02 | 1987-10-08 | Beecham Group Plc | Plasminogen activators modified in first kringle domain |
PT84589B (en) * | 1986-04-02 | 1989-05-09 | Beecham Group Plc | Process for preparing a fibrinolytic enzyme |
US5169763A (en) * | 1986-04-08 | 1992-12-08 | Transgene S.A., Institut Pasteur | Viral vector coding glycoprotein of HIV-1 |
GB8701811D0 (en) * | 1987-01-28 | 1987-03-04 | Beecham Group Plc | Compounds |
MY103358A (en) * | 1987-04-15 | 1993-06-30 | Novartis Ag | Process for the production of protiens. |
FI882407A (fi) * | 1987-05-22 | 1988-11-23 | Zymogenetics Inc | Fibrinolytiska proteiner. |
US5200340A (en) * | 1987-05-22 | 1993-04-06 | Zymogenetics, Inc. | Thrombin-activated tissue plasminogen activators |
DK302288A (da) * | 1987-06-04 | 1989-02-03 | Zymogenetics Inc | Vaevsplasminogenaktivator med modificeret kringledomaene |
DE3853100T2 (de) * | 1987-06-04 | 1995-08-03 | Zymogenetics Inc | Gewebs-Plasminogen-Aktivator-Analoge mit modifizierten Wachstumsfaktordomänen. |
WO1989000197A1 (en) * | 1987-06-30 | 1989-01-12 | Genentech, Inc. | Improved processes for the treatment of vascular disease |
US5302390A (en) * | 1987-07-01 | 1994-04-12 | Beecham Group Plc | Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment |
IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it |
JP2708749B2 (ja) * | 1987-08-10 | 1998-02-04 | エーザイ株式会社 | 修飾型tPA含有注射用組成物 |
US5244676A (en) * | 1987-10-09 | 1993-09-14 | Monsanto Company | Modified tissue plasminogen activator with modified glycosylation site |
US4963357A (en) * | 1987-10-09 | 1990-10-16 | Monsanto Company | Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor |
US5037752A (en) * | 1987-10-09 | 1991-08-06 | Monsanto Company | Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277 |
EP0312346B1 (en) * | 1987-10-16 | 1994-08-17 | Genencor International, Inc. | E. coli sequence specific acid protease |
ATE125294T1 (de) * | 1987-10-29 | 1995-08-15 | Yamanouchi Pharma Co Ltd | Polypeptid-verbindungen. |
US5504001A (en) * | 1987-11-25 | 1996-04-02 | Zymogenetics, Inc. | Hybrid plasminogen activator |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
WO1990001540A1 (en) * | 1988-08-11 | 1990-02-22 | California Biotechnology Inc. | Method for stabilizing heterologous protein expression and vectors for use therein |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5258180A (en) * | 1988-09-02 | 1993-11-02 | Genetech, Inc. | Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment |
US5087572A (en) * | 1989-12-01 | 1992-02-11 | Genentech, Inc. | Dna encoding human plasminogen modified at the cleavage site |
US5190756A (en) * | 1989-12-01 | 1993-03-02 | Genentech, Inc. | Methods and materials for expression of human plasminogen variant |
DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
ATE145669T1 (de) * | 1991-12-16 | 1996-12-15 | Genentech Inc | T-pa substitutionsvarianten mit verbesserter fibrinspezifität |
CA2125403C (en) * | 1991-12-16 | 2002-08-27 | Herbert L. Heyneker | Novel tissue plasminogen activator variants |
DK0643772T3 (da) * | 1992-06-03 | 1998-02-02 | Genentech Inc | Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber |
GB2298821A (en) * | 1995-03-15 | 1996-09-18 | Prestek Ltd | A ribbon winding mechanism |
DK0827751T3 (da) * | 1996-09-06 | 2003-03-31 | Chemo Sero Therapeut Res Inst | Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid |
EP0950095A2 (en) * | 1996-11-12 | 1999-10-20 | The Scripps Research Institute | TISSUE TYPE PLASMINOGEN ACTIVATOR (t-PA) VARIANTS: COMPOSITIONS AND METHODS OF USE |
US6706504B1 (en) | 1996-11-12 | 2004-03-16 | The Scripps Research Institute | Tissue type plasminogen activator (t-PA) variants: compositions and methods of use |
US5837688A (en) * | 1996-11-27 | 1998-11-17 | Gelfand; Mathew I. | Use of thrombolytic reagents for prevention of vascular disease |
WO2002020802A1 (fr) | 2000-09-04 | 2002-03-14 | Hunan Royal Biotech | Lignee cellulaire exprimant un activateur de plasminogene tissulaire humain mutant, procede de recombinaison et procede de preparation de la proteine exprimee |
US7597895B2 (en) * | 2001-02-20 | 2009-10-06 | The Governing Council Of The University Of Toronto | Signal peptides, nucleic acid molecules and methods for treatment of caries |
US7556807B2 (en) | 2001-02-20 | 2009-07-07 | Kane Biotech, Inc. | Signal peptides, nucleic acid molecules and methods for treatment of caries |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR241654A1 (es) * | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
SU1662352A3 (ru) * | 1982-05-05 | 1991-07-07 | Генентек, Инк (Фирма) | Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа |
IL90047A (en) * | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
EP0201153A3 (en) * | 1985-02-09 | 1987-10-07 | Beecham Group Plc | Modified enzyme and process for its preparation |
GR861037B (en) * | 1985-04-22 | 1986-07-16 | Genentech Inc | Novel human tissue plasminogen activator mutants |
DK43387A (da) * | 1986-01-29 | 1987-07-30 | Beecham Group Plc | Fibrinolytisk enzym |
WO1987004722A1 (en) * | 1986-01-31 | 1987-08-13 | Genetics Institute, Inc. | Novel thrombolytic proteins |
-
1986
- 1986-04-21 GR GR861037A patent/GR861037B/el unknown
- 1986-04-21 IE IE105586A patent/IE58574B1/en not_active IP Right Cessation
- 1986-04-21 HU HU861676A patent/HU206520B/hu unknown
- 1986-04-21 DE DE3613390A patent/DE3613390C2/de not_active Expired - Lifetime
- 1986-04-21 DK DK198601812A patent/DK175380B1/da not_active IP Right Cessation
- 1986-04-21 EP EP86302980A patent/EP0199574B1/en not_active Expired - Lifetime
- 1986-04-21 FR FR868605756A patent/FR2581652B1/fr not_active Expired
- 1986-04-21 IL IL78571A patent/IL78571A/xx not_active IP Right Cessation
- 1986-04-21 NO NO861559A patent/NO175216C/no unknown
- 1986-04-21 GB GB8609683A patent/GB2173804B/en not_active Expired
- 1986-04-21 AT AT86302980T patent/ATE68825T1/de not_active IP Right Cessation
- 1986-04-21 FI FI861673A patent/FI98930C/fi not_active IP Right Cessation
- 1986-04-21 DD DD28944386A patent/DD258026A5/de unknown
- 1986-04-21 PT PT82429A patent/PT82429B/pt unknown
- 1986-04-21 DE DE8686302980T patent/DE3682104D1/de not_active Expired - Lifetime
- 1986-04-21 AU AU56416/86A patent/AU596356B2/en not_active Expired
- 1986-04-22 CA CA000507294A patent/CA1341580C/en not_active Expired - Fee Related
- 1986-04-22 NZ NZ215920A patent/NZ215920A/xx unknown
- 1986-04-22 ES ES554251A patent/ES8802184A1/es not_active Expired
- 1986-04-22 JP JP61094382A patent/JPH0740940B2/ja not_active Expired - Lifetime
-
1987
- 1987-09-21 MY MYPI87001800A patent/MY102550A/en unknown
-
1988
- 1988-01-15 ES ES557800A patent/ES9000011A1/es not_active Expired - Fee Related
-
1991
- 1991-08-05 US US07/741,120 patent/US5147643A/en not_active Expired - Lifetime
-
1994
- 1994-02-16 JP JP6019382A patent/JP2529816B2/ja not_active Expired - Lifetime
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