DK453181A - Fremgangsmaade til fremstilling af 2-quanidino-4-heteroaryl-thiazolforbindelser eller syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 2-quanidino-4-heteroaryl-thiazolforbindelser eller syreadditionssalte deraf

Info

Publication number
DK453181A
DK453181A DK453181A DK453181A DK453181A DK 453181 A DK453181 A DK 453181A DK 453181 A DK453181 A DK 453181A DK 453181 A DK453181 A DK 453181A DK 453181 A DK453181 A DK 453181A
Authority
DK
Denmark
Prior art keywords
quanidino
heteroaryl
preparing
acid addition
addition salts
Prior art date
Application number
DK453181A
Other languages
Danish (da)
English (en)
Inventor
J L Lamattina
C A Lipinski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK453181A publication Critical patent/DK453181A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK453181A 1980-10-14 1981-10-13 Fremgangsmaade til fremstilling af 2-quanidino-4-heteroaryl-thiazolforbindelser eller syreadditionssalte deraf DK453181A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19623180A 1980-10-14 1980-10-14
US06/293,574 US4374843A (en) 1980-10-14 1981-08-20 2-Guanidino-4-heteroarylthiazoles

Publications (1)

Publication Number Publication Date
DK453181A true DK453181A (da) 1982-04-15

Family

ID=26891753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK453181A DK453181A (da) 1980-10-14 1981-10-13 Fremgangsmaade til fremstilling af 2-quanidino-4-heteroaryl-thiazolforbindelser eller syreadditionssalte deraf

Country Status (28)

Country Link
US (1) US4374843A (de)
EP (1) EP0050458B1 (de)
KR (1) KR850001858B1 (de)
AR (3) AR228675A1 (de)
AT (1) ATE11048T1 (de)
AU (2) AU530589B2 (de)
CA (1) CA1156239A (de)
CS (1) CS231182B2 (de)
DD (4) DD207913A5 (de)
DE (1) DE3168067D1 (de)
DK (1) DK453181A (de)
ES (4) ES8301978A1 (de)
FI (1) FI75821C (de)
GR (1) GR75098B (de)
HK (1) HK52387A (de)
HU (2) HU186788B (de)
IE (1) IE51642B1 (de)
IL (1) IL64035A (de)
KE (1) KE3707A (de)
MY (1) MY8700512A (de)
NO (1) NO159654C (de)
NZ (1) NZ198629A (de)
PH (3) PH17562A (de)
PL (3) PL134491B1 (de)
PT (1) PT73817B (de)
SG (1) SG23487G (de)
SU (1) SU1153829A3 (de)
YU (4) YU42434B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482723A (en) * 1983-04-11 1984-11-13 Pfizer Inc. Process for preparation of 4-acetyl-2-substituted-imidazoles
US4435396A (en) * 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
GB2122988B (en) * 1982-06-17 1986-06-11 Toyama Chemical Co Ltd Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative; intermediates
EP0156644A1 (de) * 1984-04-02 1985-10-02 Pfizer Inc. Verfahren und Zwischenprodukte für 4-Acetylimidazole
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
US4591595A (en) * 1984-10-11 1986-05-27 Pfizer Inc. 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis
US4567179A (en) * 1984-10-11 1986-01-28 Pfizer, Inc. Antiinflammatory salts of piroxicam
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
ES2031514T3 (es) * 1986-08-29 1992-12-16 Pfizer Inc. 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
EP0269239B1 (de) * 1986-10-29 1994-06-08 Pfizer Inc. Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
WO1992016526A1 (en) * 1991-03-13 1992-10-01 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
KR20080039979A (ko) * 2005-08-23 2008-05-07 우베 고산 가부시키가이샤 1-치환-5-아실이미다졸 화합물의 제법
EP2832731A4 (de) 2012-03-27 2015-08-19 Shionogi & Co Aromatische heterocyclische fünfgliedrige ringderivate mit trpv4-hemmwirkung
EP4196793A1 (de) 2020-08-11 2023-06-21 Université de Strasbourg Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516777A (fr) * 1966-08-02 1968-02-05 Innothera Lab Sa Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
US3519637A (en) * 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
US3950353A (en) * 1971-03-09 1976-04-13 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
HU168776B (de) * 1973-11-09 1976-07-28
DE2614189A1 (de) * 1976-04-02 1977-10-20 Hoechst Ag Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung
ZA782129B (en) * 1977-04-20 1979-03-28 Ici Ltd Hertocyclic derivatives
DE2961923D1 (en) * 1978-01-18 1982-03-11 Ici Plc Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
EP0014057B1 (de) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives

Also Published As

Publication number Publication date
CA1156239A (en) 1983-11-01
KE3707A (en) 1987-04-03
NO159654C (no) 1989-01-25
ES8306751A1 (es) 1983-06-01
FI75821C (fi) 1988-08-08
HK52387A (en) 1987-07-17
SG23487G (en) 1987-07-10
PH17562A (en) 1984-10-01
YU246481A (en) 1983-10-31
AU548992B2 (en) 1986-01-09
YU42078B (en) 1988-04-30
DD207718A5 (de) 1984-03-14
EP0050458B1 (de) 1985-01-02
ES8306749A1 (es) 1983-06-01
AR228674A1 (es) 1983-03-30
HU191895B (en) 1987-04-28
FI813177L (fi) 1982-04-15
ES506216A0 (es) 1982-12-16
DE3168067D1 (en) 1985-02-14
ES8306750A1 (es) 1983-06-01
DD207913A5 (de) 1984-03-21
DD202293A5 (de) 1983-09-07
CS750081A2 (en) 1984-02-13
ES515158A0 (es) 1983-06-01
ES515159A0 (es) 1983-06-01
US4374843A (en) 1983-02-22
ES8301978A1 (es) 1982-12-16
IE51642B1 (en) 1987-01-21
IL64035A0 (en) 1982-01-31
SU1153829A3 (ru) 1985-04-30
PT73817B (en) 1983-11-07
IL64035A (en) 1986-01-31
YU42076B (en) 1988-04-30
YU42077B (en) 1988-04-30
YU42434B (en) 1988-08-31
ES515157A0 (es) 1983-06-01
AR229703A1 (es) 1983-10-31
YU105283A (en) 1983-10-31
CS231182B2 (en) 1984-10-15
PL133712B1 (en) 1985-06-29
NO813442L (no) 1982-04-15
PL135331B1 (en) 1985-10-31
GR75098B (de) 1984-07-13
HU186788B (en) 1985-09-30
EP0050458A2 (de) 1982-04-28
ATE11048T1 (de) 1985-01-15
NZ198629A (en) 1985-02-28
AU3206284A (en) 1984-11-29
PL134491B1 (en) 1985-08-31
DD207719A5 (de) 1984-03-14
PL241643A1 (en) 1983-11-21
PL233430A1 (en) 1983-11-21
KR830007638A (ko) 1983-11-04
EP0050458A3 (en) 1982-09-01
FI75821B (fi) 1988-04-29
AR228675A1 (es) 1983-03-30
NO159654B (no) 1988-10-17
YU105383A (en) 1983-10-31
AU530589B2 (en) 1983-07-21
MY8700512A (en) 1987-12-31
IE812384L (en) 1982-04-14
KR850001858B1 (ko) 1985-12-28
PL241644A1 (en) 1983-11-21
PH17856A (en) 1985-01-09
YU105183A (en) 1983-10-31
PT73817A (en) 1981-11-01
AU7628781A (en) 1982-04-22
PH18467A (en) 1985-07-18

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