DK4356969T3 - Smeltede tricykliske pyridazinonforbindelser, der er nyttige til behandling af orthomyxovirusinfektioner - Google Patents

Smeltede tricykliske pyridazinonforbindelser, der er nyttige til behandling af orthomyxovirusinfektioner

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Publication number
DK4356969T3
DK4356969T3 DK23217305.4T DK23217305T DK4356969T3 DK 4356969 T3 DK4356969 T3 DK 4356969T3 DK 23217305 T DK23217305 T DK 23217305T DK 4356969 T3 DK4356969 T3 DK 4356969T3
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DK
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Prior art keywords
treatment
compounds useful
fused tricyclic
pyridazinone compounds
orthomyxovirus infections
Prior art date
Application number
DK23217305.4T
Other languages
Danish (da)
English (en)
Inventor
Rama Jain
Dennis Christofer Koester
James R Manning
Vanessa Marx
Daniel Poon
James Clifford Sutton
Benjamin R Taft
Lifeng Wan
Aregahegn Yifru
Qian Zhao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK4356969T3 publication Critical patent/DK4356969T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK23217305.4T 2016-08-29 2017-08-25 Smeltede tricykliske pyridazinonforbindelser, der er nyttige til behandling af orthomyxovirusinfektioner DK4356969T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29
EP20210329.7A EP3848372B1 (en) 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

Publications (1)

Publication Number Publication Date
DK4356969T3 true DK4356969T3 (da) 2025-08-18

Family

ID=59923494

Family Applications (1)

Application Number Title Priority Date Filing Date
DK23217305.4T DK4356969T3 (da) 2016-08-29 2017-08-25 Smeltede tricykliske pyridazinonforbindelser, der er nyttige til behandling af orthomyxovirusinfektioner

Country Status (20)

Country Link
US (4) US10160764B2 (https=)
EP (4) EP3504214B1 (https=)
JP (3) JP7221861B2 (https=)
CN (2) CN113683614B (https=)
AR (1) AR109438A1 (https=)
CA (1) CA3035302A1 (https=)
DK (1) DK4356969T3 (https=)
ES (3) ES3042460T3 (https=)
FI (1) FI4356969T3 (https=)
HR (1) HRP20250885T1 (https=)
HU (1) HUE072776T2 (https=)
JO (1) JOP20170169A1 (https=)
LT (1) LT4356969T (https=)
MX (1) MX383124B (https=)
PL (3) PL3848372T3 (https=)
PT (3) PT3504214T (https=)
SI (3) SI3848372T1 (https=)
TW (3) TWI803467B (https=)
UY (2) UY37378A (https=)
WO (1) WO2018042303A1 (https=)

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Also Published As

Publication number Publication date
CN113683614B (zh) 2024-11-08
JP2025081322A (ja) 2025-05-27
PT3504214T (pt) 2021-03-04
LT4356969T (lt) 2025-09-10
US20220041610A1 (en) 2022-02-10
EP3848372A1 (en) 2021-07-14
TW202342482A (zh) 2023-11-01
SI4356969T1 (sl) 2025-10-30
MX383124B (es) 2025-03-13
TWI803467B (zh) 2023-06-01
HRP20250885T1 (hr) 2025-09-26
CN109863151B (zh) 2021-09-10
CA3035302A1 (en) 2018-03-08
US10160764B2 (en) 2018-12-25
EP3504214B1 (en) 2020-12-02
TWI869757B (zh) 2025-01-11
UY37378A (es) 2018-03-23
JOP20170169A1 (ar) 2019-01-30
CN113683614A (zh) 2021-11-23
US20180057501A1 (en) 2018-03-01
MX2019002438A (es) 2019-07-08
TW202517646A (zh) 2025-05-01
ES2974494T3 (es) 2024-06-27
ES3042460T3 (en) 2025-11-20
PL3848372T3 (pl) 2024-04-22
US11912715B2 (en) 2024-02-27
US20250011334A1 (en) 2025-01-09
HUE072776T2 (hu) 2025-12-28
EP4356969A2 (en) 2024-04-24
EP4356969A3 (en) 2024-05-22
AR109438A1 (es) 2018-11-28
ES2859510T3 (es) 2021-10-04
EP4640279A2 (en) 2025-10-29
JP7221861B2 (ja) 2023-02-14
UY40872A (es) 2024-09-13
EP3504214A1 (en) 2019-07-03
PL4356969T3 (pl) 2025-10-20
CN109863151A (zh) 2019-06-07
SI3504214T1 (sl) 2021-04-30
PL3504214T3 (pl) 2021-07-19
EP4640279A3 (en) 2025-12-24
JP2023027102A (ja) 2023-03-01
TW201811800A (zh) 2018-04-01
WO2018042303A1 (en) 2018-03-08
JP2019532033A (ja) 2019-11-07
FI4356969T3 (fi) 2025-08-15
EP4356969B1 (en) 2025-07-09
EP3848372B1 (en) 2023-12-20
PT3848372T (pt) 2024-03-22
US11098051B2 (en) 2021-08-24
US20200123167A1 (en) 2020-04-23
SI3848372T1 (sl) 2024-04-30
PT4356969T (pt) 2025-10-02

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