DK41791D0 - Antibiotikum cc 1065-analoge - Google Patents

Antibiotikum cc 1065-analoge

Info

Publication number
DK41791D0
DK41791D0 DK91417A DK41791A DK41791D0 DK 41791 D0 DK41791 D0 DK 41791D0 DK 91417 A DK91417 A DK 91417A DK 41791 A DK41791 A DK 41791A DK 41791 D0 DK41791 D0 DK 41791D0
Authority
DK
Denmark
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
DK91417A
Other languages
English (en)
Other versions
DK175458B1 (da
DK41791A (da
Inventor
Paul A Aristoff
Robert C Kelly
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK41791D0 publication Critical patent/DK41791D0/da
Publication of DK41791A publication Critical patent/DK41791A/da
Application granted granted Critical
Publication of DK175458B1 publication Critical patent/DK175458B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Artificial Filaments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Amplifiers (AREA)
  • Television Receiver Circuits (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Stereophonic System (AREA)
  • Television Systems (AREA)
DK41791A 1988-09-12 1991-03-08 Antibiotikum CC 1065-analoge DK175458B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
US24335088 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits
US8903329 1989-08-07

Publications (3)

Publication Number Publication Date
DK41791D0 true DK41791D0 (da) 1991-03-08
DK41791A DK41791A (da) 1991-03-08
DK175458B1 DK175458B1 (da) 2004-11-01

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
DK41791A DK175458B1 (da) 1988-09-12 1991-03-08 Antibiotikum CC 1065-analoge

Country Status (14)

Country Link
US (1) US5541339A (da)
JP (1) JP3380237B2 (da)
KR (1) KR0137959B1 (da)
AT (1) ATE198335T1 (da)
AU (1) AU632288B2 (da)
CA (1) CA1340215C (da)
DE (1) DE68929275T2 (da)
DK (1) DK175458B1 (da)
FI (1) FI103668B1 (da)
GR (1) GR3035589T3 (da)
LV (1) LV12806B (da)
NO (1) NO303498B1 (da)
TW (1) TW217383B (da)
WO (1) WO1990002746A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076465C (en) * 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
ATE446317T1 (de) 2001-05-11 2009-11-15 Ludwig Inst For Cancer Res Ltd Spezifische bindungsproteine und ihre verwendung
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
NZ533310A (en) 2001-11-09 2004-12-24 Boehringer Ingelheim Pharma Benzimidazoles useful as protein kinase inhibitors
CA2494942A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
CA2501547A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
AU2004255566B2 (en) * 2003-07-07 2010-07-08 Merk Patent Gmbh Malonamide derivatives
US20050209284A1 (en) * 2004-02-12 2005-09-22 Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors
WO2007022258A1 (en) * 2005-08-17 2007-02-22 Schering Corporation Novel high affinity thiophene-based and furan-based kinase ligands
CN110613845B (zh) 2007-01-25 2025-08-26 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
ES2542152T3 (es) 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
HUE035798T2 (en) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates
UA112291C2 (uk) 2010-04-21 2016-08-25 Синтарґа Б.В. Кон'югати аналогів cc-1065 і біфункціональні лінкери
US20150265641A1 (en) 2012-10-22 2015-09-24 Arnold Glazier Methods for the Effective Treatment of Metastatic Cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates
ES2722103T3 (es) * 2014-01-27 2019-08-07 Pfizer Agentes citotóxicos bifuncionales
CA2954934C (en) 2014-06-30 2023-09-26 Glykos Finland Oy Drug derivative and conjugates
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
KR102046862B1 (ko) * 2015-03-20 2019-11-20 화이자 인코포레이티드 Cti 약물작용발생단을 함유하는 이관능성 세포독성제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
JP2598819B2 (ja) * 1986-12-19 1997-04-09 ジ・アップジョン・カンパニー 新規なｃｃ‐１０６５同族体

Also Published As

Publication number Publication date
WO1990002746A1 (en) 1990-03-22
TW217383B (da) 1993-12-11
FI103668B (fi) 1999-08-13
FI103668B1 (fi) 1999-08-13
US5541339A (en) 1996-07-30
NO910958D0 (no) 1991-03-11
AU632288B2 (en) 1992-12-24
NO910958L (no) 1991-05-10
KR0137959B1 (ko) 1998-05-15
KR900701801A (ko) 1990-12-04
ATE198335T1 (de) 2001-01-15
AU4192289A (en) 1990-04-02
JPH04500664A (ja) 1992-02-06
JP3380237B2 (ja) 2003-02-24
LV12806B (lv) 2002-05-20
CA1340215C (en) 1998-12-15
FI911193A0 (fi) 1991-03-11
LV12806A (en) 2002-03-20
DK175458B1 (da) 2004-11-01
DE68929275T2 (de) 2001-05-23
NO303498B1 (no) 1998-07-20
DE68929275D1 (de) 2001-02-01
GR3035589T3 (en) 2001-06-29
DK41791A (da) 1991-03-08

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