DK400884A - Tautomere trans-(+-)-alkylerede octahydropyrazolo(3,4-g)- og -(4,3-f)-quinoliner, fremgangsmaade til fremstilling heraf og mellemprodukt til brug ved fremgangsmaaden - Google Patents
Tautomere trans-(+-)-alkylerede octahydropyrazolo(3,4-g)- og -(4,3-f)-quinoliner, fremgangsmaade til fremstilling heraf og mellemprodukt til brug ved fremgangsmaaden Download PDFInfo
- Publication number
- DK400884A DK400884A DK400884A DK400884A DK400884A DK 400884 A DK400884 A DK 400884A DK 400884 A DK400884 A DK 400884A DK 400884 A DK400884 A DK 400884A DK 400884 A DK400884 A DK 400884A
- Authority
- DK
- Denmark
- Prior art keywords
- octahydropyrazolo
- quinolines
- tautomer
- alkylated
- intermediates
- Prior art date
Links
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53551983A | 1983-09-26 | 1983-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK400884D0 DK400884D0 (da) | 1984-08-22 |
| DK400884A true DK400884A (da) | 1985-03-27 |
Family
ID=24134591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK400884A DK400884A (da) | 1983-09-26 | 1984-08-22 | Tautomere trans-(+-)-alkylerede octahydropyrazolo(3,4-g)- og -(4,3-f)-quinoliner, fremgangsmaade til fremstilling heraf og mellemprodukt til brug ved fremgangsmaaden |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0145121B1 (enExample) |
| JP (4) | JPS6110583A (enExample) |
| KR (1) | KR870001159B1 (enExample) |
| CA (1) | CA1270488A (enExample) |
| DE (1) | DE3484925D1 (enExample) |
| DK (1) | DK400884A (enExample) |
| GB (1) | GB2146984B (enExample) |
| GR (1) | GR80200B (enExample) |
| HU (1) | HU199836B (enExample) |
| IL (1) | IL72729A (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6392722A (ja) * | 1986-10-03 | 1988-04-23 | Unitika Ltd | 熱接着繊維およびその不織布 |
| JPS6392723A (ja) * | 1986-10-06 | 1988-04-23 | Unitika Ltd | 湿潤性複合繊維およびその不織布 |
| JPS6420322A (en) * | 1987-07-13 | 1989-01-24 | Mitsubishi Petrochemical Co | Conjugated fiber |
| JPH01204617A (ja) * | 1988-02-09 | 1989-08-17 | Chisso Corp | 敷物 |
| GB8828669D0 (en) * | 1988-12-08 | 1989-01-11 | Lilly Industries Ltd | Organic compounds |
| KR20000008130A (ko) * | 1998-07-10 | 2000-02-07 | 조정래 | 폴리에스터계 탄성사용 공중합물의 제조방법 |
| WO2012094618A1 (en) | 2011-01-07 | 2012-07-12 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
| WO2013130420A1 (en) * | 2012-02-27 | 2013-09-06 | Corcept Therapeutics, Inc. | Phenyl heterocycloalkyl glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| ES2943542T3 (es) | 2013-11-25 | 2023-06-14 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides de azadecalina condensada con octahidro |
| AU2018244928B2 (en) | 2017-03-31 | 2023-10-19 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| CN113194931B (zh) | 2018-12-19 | 2023-11-10 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| NZ778399A (en) | 2019-02-22 | 2024-11-29 | Corcept Therapeutics Inc | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| JP7569492B2 (ja) | 2019-12-11 | 2024-10-18 | コーセプト セラピューティクス， インコーポレイテッド | 抗精神病薬誘発性体重増加のミリコリラントによる治療方法 |
| EP4157276A4 (en) | 2020-05-27 | 2024-06-12 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230861A (en) * | 1979-01-22 | 1980-10-28 | Eli Lilly And Company | 1-And/or 7-substituted-6-hydroxy (or oxo)-3-decahydroquinoline carboxylic acids |
| US4198415A (en) * | 1979-01-22 | 1980-04-15 | Eli Lilly And Company | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines |
| SU776048A1 (ru) * | 1979-06-05 | 1983-09-23 | Институт Бисорганической Химии Ан Бсср | Производные 8-аза-16-оксагона-17-онов, про вл ющие противовоспалительную,мембраностабилизирующую и антифибринолитическую активность,и способ их получени |
| US4252945A (en) * | 1979-07-11 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Process for preparing pyrazolo[1,5-c]-quinazoline derivatives and novel intermediates |
| US4367231A (en) * | 1979-09-14 | 1983-01-04 | Eli Lilly And Company | Method of using octahydro pyrazolo[3,4-g]quinolines |
| ES8504174A1 (es) * | 1982-11-03 | 1985-04-16 | Lilly Co Eli | Un procedimiento para la preparacion de derivados de pirazolo-quinolinas. |
-
1984
- 1984-08-20 CA CA000461330A patent/CA1270488A/en not_active Expired - Lifetime
- 1984-08-20 IL IL72729A patent/IL72729A/xx unknown
- 1984-08-21 GB GB08421159A patent/GB2146984B/en not_active Expired
- 1984-08-21 DE DE8484305685T patent/DE3484925D1/de not_active Expired - Lifetime
- 1984-08-21 EP EP84305685A patent/EP0145121B1/en not_active Expired - Lifetime
- 1984-08-22 DK DK400884A patent/DK400884A/da not_active Application Discontinuation
- 1984-08-22 HU HU843161A patent/HU199836B/hu not_active IP Right Cessation
- 1984-08-23 GR GR80200A patent/GR80200B/el unknown
- 1984-08-24 KR KR1019840005148A patent/KR870001159B1/ko not_active Expired
- 1984-08-24 JP JP59177382A patent/JPS6110583A/ja active Granted
-
1992
- 1992-09-16 JP JP4246440A patent/JPH0660183B2/ja not_active Expired - Lifetime
- 1992-09-16 JP JP4246412A patent/JPH05194511A/ja active Pending
- 1992-09-16 JP JP4246442A patent/JPH0625251A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6110583A (ja) | 1986-01-18 |
| IL72729A0 (en) | 1984-11-30 |
| IL72729A (en) | 1988-02-29 |
| JPH0660183B2 (ja) | 1994-08-10 |
| GB8421159D0 (en) | 1984-09-26 |
| HUT34750A (en) | 1985-04-28 |
| EP0145121A3 (en) | 1988-04-27 |
| EP0145121A2 (en) | 1985-06-19 |
| HU199836B (en) | 1990-03-28 |
| GB2146984A (en) | 1985-05-01 |
| DK400884D0 (da) | 1984-08-22 |
| JPH0625251A (ja) | 1994-02-01 |
| GB2146984B (en) | 1987-04-08 |
| CA1270488A (en) | 1990-06-19 |
| KR870001159B1 (ko) | 1987-06-13 |
| GR80200B (en) | 1985-01-02 |
| JPH0568475B2 (enExample) | 1993-09-29 |
| JPH05194511A (ja) | 1993-08-03 |
| KR850002480A (ko) | 1985-05-13 |
| JPH05194527A (ja) | 1993-08-03 |
| DE3484925D1 (de) | 1991-09-19 |
| EP0145121B1 (en) | 1991-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |