DK3820874T3 - Selektive estrogenreceptornedbrydere - Google Patents
Selektive estrogenreceptornedbrydere Download PDFInfo
- Publication number
- DK3820874T3 DK3820874T3 DK19746252.6T DK19746252T DK3820874T3 DK 3820874 T3 DK3820874 T3 DK 3820874T3 DK 19746252 T DK19746252 T DK 19746252T DK 3820874 T3 DK3820874 T3 DK 3820874T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor antagonists
- estrogen receptor
- selective estrogen
- selective
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862697100P | 2018-07-12 | 2018-07-12 | |
| US201962825172P | 2019-03-28 | 2019-03-28 | |
| PCT/US2019/041342 WO2020014440A1 (en) | 2018-07-12 | 2019-07-11 | Selective estrogen receptor degraders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3820874T3 true DK3820874T3 (da) | 2022-12-12 |
Family
ID=67480324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19746252.6T DK3820874T3 (da) | 2018-07-12 | 2019-07-11 | Selektive estrogenreceptornedbrydere |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20210260052A1 (da) |
| EP (1) | EP3820874B1 (da) |
| JP (1) | JP7085056B2 (da) |
| KR (1) | KR102577142B1 (da) |
| CN (1) | CN112424205B (da) |
| AU (1) | AU2019299952B2 (da) |
| BR (1) | BR112020025381A2 (da) |
| CA (1) | CA3105491C (da) |
| CL (1) | CL2021000046A1 (da) |
| CO (1) | CO2021000041A2 (da) |
| CR (1) | CR20210006A (da) |
| DK (1) | DK3820874T3 (da) |
| EC (1) | ECSP21001786A (da) |
| ES (1) | ES2932867T3 (da) |
| FI (1) | FI3820874T3 (da) |
| HR (1) | HRP20230080T1 (da) |
| HU (1) | HUE061032T2 (da) |
| IL (1) | IL279990B2 (da) |
| JO (1) | JOP20210004A1 (da) |
| LT (1) | LT3820874T (da) |
| MD (1) | MD3820874T2 (da) |
| MX (1) | MX2021000377A (da) |
| NZ (1) | NZ771719A (da) |
| PE (1) | PE20211245A1 (da) |
| PH (1) | PH12021550048A1 (da) |
| PL (1) | PL3820874T3 (da) |
| PT (1) | PT3820874T (da) |
| RS (1) | RS63876B1 (da) |
| SA (1) | SA521421006B1 (da) |
| SG (1) | SG11202100145YA (da) |
| SI (1) | SI3820874T1 (da) |
| UA (1) | UA125890C2 (da) |
| WO (1) | WO2020014440A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180071274A (ko) | 2015-10-01 | 2018-06-27 | 올레마 파마슈티컬스 인코포레이티드 | 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물 |
| US11730726B2 (en) | 2018-07-11 | 2023-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| IL310339A (en) | 2021-08-31 | 2024-03-01 | Eisai R&D Man Co Ltd | A method for the production of a monocyclic pyridine derivative |
| WO2023150056A1 (en) | 2022-02-01 | 2023-08-10 | Eli Lilly And Company | Processes for the preparation of selective estrogen receptor degraders |
| WO2024042157A1 (en) | 2022-08-25 | 2024-02-29 | Sanofi | Novel substituted quinoline and tetrahydronaphthalene carboxylic acid derivatives and therapeutic uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5521214A (en) * | 1995-01-25 | 1996-05-28 | Eli Lilly And Company | Methods of inhibiting environmental estrogens |
| JPH10204082A (ja) * | 1996-10-25 | 1998-08-04 | Eli Lilly & Co | 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物 |
| DE60210283T2 (de) * | 2001-05-22 | 2006-11-09 | Eli Lilly And Co., Indianapolis | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren |
| US7329654B2 (en) * | 2001-12-19 | 2008-02-12 | Janssen Pharmaceutica N.V. | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| MXPA04010433A (es) * | 2002-04-19 | 2005-08-19 | Signal Pharm Inc | Compuestos benzopiranona, composiciones de estos y los metodos para el tratamiento con estos. |
| DE20301728U1 (de) * | 2002-10-11 | 2004-03-11 | Ligand Pharmaceuticals, Inc., San Diego | 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen |
| CL2004000985A1 (es) * | 2003-05-16 | 2005-01-14 | Wyeth Corp | Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc |
| EP1709021B1 (en) | 2004-01-22 | 2010-08-04 | Eli Lilly And Company | Selective estrogen receptor modulators for the treatment of vasomotor symptoms |
| AU2005282554A1 (en) * | 2004-09-07 | 2006-03-16 | Wyeth | 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents |
| US20080221163A1 (en) * | 2005-01-18 | 2008-09-11 | Jeffrey Alan Dodge | Selective Estrogen Receptor Modulators |
| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| US9845291B2 (en) * | 2014-12-18 | 2017-12-19 | Genentech, Inc. | Estrogen receptor modulators and uses thereof |
| JP6768711B2 (ja) * | 2015-05-26 | 2020-10-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 複素環式エストロゲン受容体モジュレーター及びその使用 |
| EP3440067B1 (en) * | 2016-04-08 | 2021-05-26 | F. Hoffmann-La Roche AG | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof |
| MX2019008158A (es) * | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
-
2019
- 2019-07-11 SI SI201930407T patent/SI3820874T1/sl unknown
- 2019-07-11 WO PCT/US2019/041342 patent/WO2020014440A1/en unknown
- 2019-07-11 MD MDE20210464T patent/MD3820874T2/ro unknown
- 2019-07-11 ES ES19746252T patent/ES2932867T3/es active Active
- 2019-07-11 CR CR20210006A patent/CR20210006A/es unknown
- 2019-07-11 FI FIEP19746252.6T patent/FI3820874T3/fi active
- 2019-07-11 JO JOP/2021/0004A patent/JOP20210004A1/ar unknown
- 2019-07-11 HU HUE19746252A patent/HUE061032T2/hu unknown
- 2019-07-11 PE PE2021000017A patent/PE20211245A1/es unknown
- 2019-07-11 AU AU2019299952A patent/AU2019299952B2/en active Active
- 2019-07-11 BR BR112020025381-2A patent/BR112020025381A2/pt unknown
- 2019-07-11 RS RS20230014A patent/RS63876B1/sr unknown
- 2019-07-11 KR KR1020217000473A patent/KR102577142B1/ko active IP Right Grant
- 2019-07-11 MX MX2021000377A patent/MX2021000377A/es unknown
- 2019-07-11 US US17/254,991 patent/US20210260052A1/en active Pending
- 2019-07-11 HR HRP20230080TT patent/HRP20230080T1/hr unknown
- 2019-07-11 EP EP19746252.6A patent/EP3820874B1/en active Active
- 2019-07-11 UA UAA202100103A patent/UA125890C2/uk unknown
- 2019-07-11 CA CA3105491A patent/CA3105491C/en active Active
- 2019-07-11 JP JP2021500586A patent/JP7085056B2/ja active Active
- 2019-07-11 CN CN201980046170.4A patent/CN112424205B/zh active Active
- 2019-07-11 LT LTEPPCT/US2019/041342T patent/LT3820874T/lt unknown
- 2019-07-11 SG SG11202100145YA patent/SG11202100145YA/en unknown
- 2019-07-11 PL PL19746252.6T patent/PL3820874T3/pl unknown
- 2019-07-11 NZ NZ771719A patent/NZ771719A/en unknown
- 2019-07-11 DK DK19746252.6T patent/DK3820874T3/da active
- 2019-07-11 PT PT197462526T patent/PT3820874T/pt unknown
-
2021
- 2021-01-06 IL IL279990A patent/IL279990B2/en unknown
- 2021-01-06 CO CONC2021/0000041A patent/CO2021000041A2/es unknown
- 2021-01-07 CL CL2021000046A patent/CL2021000046A1/es unknown
- 2021-01-08 PH PH12021550048A patent/PH12021550048A1/en unknown
- 2021-01-11 EC ECSENADI20211786A patent/ECSP21001786A/es unknown
- 2021-01-12 SA SA521421006A patent/SA521421006B1/ar unknown
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