DK380788D0 - Fremgangsmaade til alkylering af en mevinolinforbindelse - Google Patents

Fremgangsmaade til alkylering af en mevinolinforbindelse

Info

Publication number
DK380788D0
DK380788D0 DK380788A DK380788A DK380788D0 DK 380788 D0 DK380788 D0 DK 380788D0 DK 380788 A DK380788 A DK 380788A DK 380788 A DK380788 A DK 380788A DK 380788 D0 DK380788 D0 DK 380788D0
Authority
DK
Denmark
Prior art keywords
mevinolic
alkyling
compound
mevinolin
alkylating
Prior art date
Application number
DK380788A
Other languages
English (en)
Other versions
DK172811B1 (da
DK380788A (da
Inventor
Thomas R Verhoeven
David Askin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22105351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK380788(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK380788D0 publication Critical patent/DK380788D0/da
Publication of DK380788A publication Critical patent/DK380788A/da
Application granted granted Critical
Publication of DK172811B1 publication Critical patent/DK172811B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
DK198803807A 1987-07-10 1988-07-08 Naphthalenderivat og fremgangsmåde til fremstilling deraf DK172811B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/072,066 US4820850A (en) 1987-07-10 1987-07-10 Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US7206687 1987-07-10

Publications (3)

Publication Number Publication Date
DK380788D0 true DK380788D0 (da) 1988-07-08
DK380788A DK380788A (da) 1989-02-15
DK172811B1 DK172811B1 (da) 1999-07-26

Family

ID=22105351

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198803807A DK172811B1 (da) 1987-07-10 1988-07-08 Naphthalenderivat og fremgangsmåde til fremstilling deraf

Country Status (22)

Country Link
US (1) US4820850A (da)
EP (1) EP0299656B1 (da)
JP (2) JPH0717663B2 (da)
KR (1) KR950009314B1 (da)
CN (1) CN1019395B (da)
AT (1) ATE59036T1 (da)
AU (1) AU604937B2 (da)
CA (1) CA1287063C (da)
CY (1) CY1613A (da)
DE (1) DE3861270D1 (da)
DK (1) DK172811B1 (da)
ES (1) ES2018710B3 (da)
FI (1) FI88719C (da)
GR (1) GR3001351T3 (da)
HK (1) HK98991A (da)
IE (1) IE61025B1 (da)
IL (1) IL86968A (da)
NO (1) NO172239C (da)
NZ (1) NZ225306A (da)
PT (1) PT87909B (da)
SG (1) SG84691G (da)
ZA (1) ZA884924B (da)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
GB9123933D0 (en) * 1991-11-11 1992-01-02 British Bio Technology Compounds
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
US5763653A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Key intermediates in the manufacture of simvastatin
CA2185961A1 (en) * 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US5763646A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
IL131044A (en) 1997-01-28 2003-07-31 Plus Chemicals Bv Process for the production of semi synthetic statins via novel intermediates
IN186880B (da) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186879B (da) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
EP0940395A1 (en) 1998-03-05 1999-09-08 Synthon B.V. Process for producing simvastatin and/or its derivatives
NO991045L (no) * 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
CA2240983A1 (en) * 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
SI20116A (sl) 1998-12-02 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za pripravo simvastatina in njegovih analogov
CO5140104A1 (es) 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
EP1228057A2 (en) 1999-10-27 2002-08-07 Merck & Co., Inc. Lactonization process
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
US6573392B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
WO2001066538A1 (en) 2000-03-03 2001-09-13 Biogal Gyogyszergyar Rt. A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
WO2002009697A1 (en) 2000-07-27 2002-02-07 Plus Chemicals, B.V Highly purified simvastatin compositions
WO2002024675A1 (en) * 2000-09-13 2002-03-28 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
WO2002094804A1 (en) * 2001-05-18 2002-11-28 Aurobindo Pharma Limited A process for lactonization to produce simvastatin
US6797831B2 (en) * 2001-05-18 2004-09-28 Aurobindo Pharma Limited Process for lactonization to produce simvastatin
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
US6472542B1 (en) * 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
WO2003086395A1 (en) 2002-04-12 2003-10-23 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2003226051A1 (en) * 2002-04-16 2003-11-03 Banyu Pharmaceutical Co., Ltd. Solid forms of salts with tyrosine kinase activity
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US20040198800A1 (en) * 2002-12-19 2004-10-07 Geoffrey Allan Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
JP2006513186A (ja) 2002-12-20 2006-04-20 ファイザー・プロダクツ・インク Ｃｅｔｐ阻害剤およびｈｍｇ−ｃｏａレダクターゼ阻害剤を含む剤形
US6995277B2 (en) * 2003-02-11 2006-02-07 Plus Chemicals, B.V. Process for preparing simvastatin having controlled ranges of simvastatin dimer content
KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
CN1839114A (zh) 2003-08-21 2006-09-27 默克弗罗斯特加拿大有限公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
US20050192340A1 (en) * 2003-11-05 2005-09-01 Moshe Flashner-Barak Simvastatin formulations and methods of making same
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
AU2004317826A1 (en) 2004-03-30 2005-10-13 Lupin Ltd An improved method for manufacture of 4-hydroxy pyran-2-one derivatives
AU2004323102A1 (en) * 2004-09-08 2006-03-16 Jubilant Organosys Limited An improved process for lactonization in the preparation of statins
EP1807070A1 (en) * 2004-09-29 2007-07-18 Schering Corporation Combinations of substituted azetidinones and cb1 antagonists
WO2006062876A2 (en) 2004-12-09 2006-06-15 Merck & Co., Inc. Estrogen receptor modulators
PT1855674E (pt) 2005-03-02 2014-10-08 Merck Canada Inc Composição para a inibição de catepsina k
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
EP1741427A1 (en) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
KR20080034190A (ko) * 2005-09-13 2008-04-18 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 심바스타틴 제조 방법 및 이의 중간체
US20070129437A1 (en) * 2005-12-06 2007-06-07 Ferenc Korodi Process for preparing simvastatin and intermediates thereof
CA2634940A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
JP2009521445A (ja) * 2005-12-21 2009-06-04 シェーリング コーポレイション Ｈ３アンタゴニスト／逆アゴニストと食欲抑制剤との組み合わせ
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
ES2654847T3 (es) 2006-04-19 2018-02-15 Novartis Ag Compuestos de benzoxazol y benzotiazol sustituidos en 6-O y métodos para inhibir la señalización CSF-1R
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
EP2698157B1 (en) 2006-09-22 2015-05-20 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2109608B1 (en) 2007-01-10 2011-03-23 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
MX2009009304A (es) 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
CN101754965B (zh) 2007-05-21 2014-03-19 诺华股份有限公司 Csf-1r抑制剂、组合物及使用方法
EP2167069B1 (en) 2007-05-23 2011-10-26 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
CA2709677C (en) * 2007-12-21 2017-03-14 Lin Zhi Selective androgen receptor modulators (sarms) and uses thereof
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
CN101381356B (zh) * 2008-10-23 2012-05-23 河北科技大学 辛伐他汀的制备方法
EP2204170A1 (en) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising ezetimibe and simvastatin
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
HUE046680T2 (hu) 2009-09-30 2020-03-30 Codexis Inc Javított Lov-D aciltranszferáz mediált acilezés
EP2486129B1 (en) 2009-10-08 2016-04-13 The Regents of The University of California LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
EP2488028B1 (en) 2009-10-14 2020-08-19 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
CN101704808A (zh) 2009-11-20 2010-05-12 西南合成制药股份有限公司 制备他汀类化合物的内酯化方法
EP2368543A1 (en) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
KR102072631B1 (ko) 2010-08-17 2020-02-03 시르나 쎄러퓨틱스 인코퍼레이티드 짧은 간섭 핵산 （ｓｉＮＡ）을 사용한 Ｂ형 간염 바이러스 （ＨＢＶ） 유전자 발현의 ＲＮＡ 간섭 매개 억제
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en) 2010-10-29 2021-01-20 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US20140046059A1 (en) 2011-04-21 2014-02-13 Piramal Enterprises Limited Process for the preparation of morpholino sulfonyl indole derivatives
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
ES2651347T3 (es) 2012-11-28 2018-01-25 Merck Sharp & Dohme Corp. Composiciones y métodos para el tratamiento del cáncer
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
RU2692799C2 (ru) 2013-10-08 2019-06-27 Мерк Шарп И Доум Корп. Ингибиторы цистеинпротеаз катепсинов
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US10441567B2 (en) 2014-01-17 2019-10-15 Ligand Pharmaceuticals Incorporated Methods and compositions for modulating hormone levels
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
CN106831424B (zh) * 2015-12-04 2019-08-02 浙江京新药业股份有限公司 由洛伐他汀制备辛伐他汀铵盐的方法
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2021126731A1 (en) 2019-12-17 2021-06-24 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0094443A1 (en) * 1982-05-17 1983-11-23 Merck & Co. Inc. 6(R)-(2-(8(S) (2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one, process for preparing and pharmaceutical composition containing the same
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
DE3481190D1 (de) * 1983-10-11 1990-03-08 Merck & Co Inc Verfahren zur herstellung von 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)-2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)-decahydronaphthyl-1(s))ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-on.
US4584389A (en) * 1983-10-11 1986-04-22 Merck & Co., Inc. Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
US4588820A (en) * 1984-06-11 1986-05-13 Merck & Co., Inc. Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one

Also Published As

Publication number Publication date
NZ225306A (en) 1990-06-26
AU1885088A (en) 1989-01-12
NO883062L (no) 1989-01-11
CA1287063C (en) 1991-07-30
JP2527535B2 (ja) 1996-08-28
GR3001351T3 (en) 1992-09-11
ATE59036T1 (de) 1990-12-15
CY1613A (en) 1992-07-10
DK172811B1 (da) 1999-07-26
NO172239B (no) 1993-03-15
KR890002199A (ko) 1989-04-08
CN1031086A (zh) 1989-02-15
IL86968A (en) 1992-12-01
SG84691G (en) 1991-11-22
ES2018710B3 (es) 1991-05-01
AU604937B2 (en) 1991-01-03
FI88719B (fi) 1993-03-15
PT87909A (pt) 1989-06-30
US4820850A (en) 1989-04-11
FI883184A0 (fi) 1988-07-04
FI88719C (fi) 1993-06-28
FI883184A (fi) 1989-01-11
JPH0717663B2 (ja) 1995-03-01
KR950009314B1 (ko) 1995-08-19
JPH07196641A (ja) 1995-08-01
EP0299656B1 (en) 1990-12-12
PT87909B (pt) 1995-03-01
HK98991A (en) 1991-12-13
IE882106L (en) 1989-01-10
DE3861270D1 (de) 1991-01-24
NO172239C (no) 1993-06-23
ZA884924B (en) 1989-01-17
NO883062D0 (no) 1988-07-08
IE61025B1 (en) 1994-09-07
DK380788A (da) 1989-02-15
IL86968A0 (en) 1988-12-30
JPS6470481A (en) 1989-03-15
EP0299656A1 (en) 1989-01-18
CN1019395B (zh) 1992-12-09

Similar Documents

Publication Publication Date Title
DK380788A (da) Fremgangsmaade til alkylering af en mevinolinforbindelse
ZA86968B (en) Production of light olefins from aliphatic hetero compounds
FI893929A (fi) Menetelmä stabiilin sinkki-protamiini- -interferonikompleksin valmistamiseksi
HUT41743A (en) Process for production of imidasole analogs of merolacton
FI97297C (fi) Menetelmä terapeuttisesti käyttökelpoisten booriaminohappojohdannaisten valmistamiseksi
FI895281A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten BU-3608-antibioottien seriinianalogien valmistamiseksi
FI90877C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi
PT86631A (pt) Process for the preparation of a novel crystalline form of potassium clavulanate
UA6330A1 (uk) Спосіб одержання похідних бензаміда
YU44699B (en) Process for optical separation of racemic mixtures of alpha naphtylpropionic acids
HU9203400D0 (en) Method for producing new n-substituted n-nitroso-amino-aceto-nitryl derivatives and pharmaceutical derivatives containing them
FI863471A (fi) Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi
HUT41729A (en) Process for preparing alkyl esters of 4-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid
HUT43036A (en) Process for preparing alkyl sulfonyl-alkyl chloro-benzene derivatives
AU6648586A (en) Arrangement for fastening the base plates of buckets to a belt
PT87780A (pt) A process for the preparation of cholecystokinin analogs for controlling appetite
FR2583628B3 (fr) Plaquette de suspension d'articles divers a un presentoir
EP0329595A3 (en) Process for preparing alkyl esters of alkenylphosphinic acid
GR3006806T3 (da)
PL270360A1 (en) Rubber compound of high adherence to steel
PL266211A2 (en) Method for manufacturing alkyl ester derivatives of n-phenyl-beta-alamine
PL253017A2 (en) Process for preparing novel hydrochloride of dimethylaminoethyl ester of 10-carboxymethylacridone
FI920693A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten triatsolyylikinoliinijohdannaisten valmistamiseksi
PL253584A1 (en) Process for preparing novel derivatives of penicillin

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired