HK98991A - Process for alpha-c-alkylation of the 8-acyl group of mevinolin and analogs thereof - Google Patents

Process for alpha-c-alkylation of the 8-acyl group of mevinolin and analogs thereof

Info

Publication number
HK98991A
HK98991A HK989/91A HK98991A HK98991A HK 98991 A HK98991 A HK 98991A HK 989/91 A HK989/91 A HK 989/91A HK 98991 A HK98991 A HK 98991A HK 98991 A HK98991 A HK 98991A
Authority
HK
Hong Kong
Prior art keywords
mevinolin
analogs
alpha
alkylation
acyl group
Prior art date
Application number
HK989/91A
Other languages
English (en)
Inventor
Thomas R Verhoeven
David Askin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22105351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK98991(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK98991A publication Critical patent/HK98991A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
HK989/91A 1987-07-10 1991-12-05 Process for alpha-c-alkylation of the 8-acyl group of mevinolin and analogs thereof HK98991A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/072,066 US4820850A (en) 1987-07-10 1987-07-10 Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof

Publications (1)

Publication Number Publication Date
HK98991A true HK98991A (en) 1991-12-13

Family

ID=22105351

Family Applications (1)

Application Number Title Priority Date Filing Date
HK989/91A HK98991A (en) 1987-07-10 1991-12-05 Process for alpha-c-alkylation of the 8-acyl group of mevinolin and analogs thereof

Country Status (22)

Country Link
US (1) US4820850A (da)
EP (1) EP0299656B1 (da)
JP (2) JPH0717663B2 (da)
KR (1) KR950009314B1 (da)
CN (1) CN1019395B (da)
AT (1) ATE59036T1 (da)
AU (1) AU604937B2 (da)
CA (1) CA1287063C (da)
CY (1) CY1613A (da)
DE (1) DE3861270D1 (da)
DK (1) DK172811B1 (da)
ES (1) ES2018710B3 (da)
FI (1) FI88719C (da)
GR (1) GR3001351T3 (da)
HK (1) HK98991A (da)
IE (1) IE61025B1 (da)
IL (1) IL86968A (da)
NO (1) NO172239C (da)
NZ (1) NZ225306A (da)
PT (1) PT87909B (da)
SG (1) SG84691G (da)
ZA (1) ZA884924B (da)

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Also Published As

Publication number Publication date
KR890002199A (ko) 1989-04-08
KR950009314B1 (ko) 1995-08-19
DK380788D0 (da) 1988-07-08
CA1287063C (en) 1991-07-30
IE61025B1 (en) 1994-09-07
JPH0717663B2 (ja) 1995-03-01
IL86968A0 (en) 1988-12-30
NO883062L (no) 1989-01-11
FI883184A0 (fi) 1988-07-04
EP0299656B1 (en) 1990-12-12
NO883062D0 (no) 1988-07-08
PT87909B (pt) 1995-03-01
ZA884924B (en) 1989-01-17
IL86968A (en) 1992-12-01
FI883184A (fi) 1989-01-11
EP0299656A1 (en) 1989-01-18
JPS6470481A (en) 1989-03-15
PT87909A (pt) 1989-06-30
IE882106L (en) 1989-01-10
CY1613A (en) 1992-07-10
JPH07196641A (ja) 1995-08-01
GR3001351T3 (en) 1992-09-11
AU1885088A (en) 1989-01-12
ATE59036T1 (de) 1990-12-15
FI88719B (fi) 1993-03-15
AU604937B2 (en) 1991-01-03
NZ225306A (en) 1990-06-26
DE3861270D1 (de) 1991-01-24
FI88719C (fi) 1993-06-28
NO172239B (no) 1993-03-15
NO172239C (no) 1993-06-23
US4820850A (en) 1989-04-11
SG84691G (en) 1991-11-22
JP2527535B2 (ja) 1996-08-28
CN1031086A (zh) 1989-02-15
ES2018710B3 (es) 1991-05-01
DK380788A (da) 1989-02-15
DK172811B1 (da) 1999-07-26
CN1019395B (zh) 1992-12-09

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