DK3804648T3 - Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren - Google Patents

Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren Download PDF

Info

Publication number
DK3804648T3
DK3804648T3 DK20212126.5T DK20212126T DK3804648T3 DK 3804648 T3 DK3804648 T3 DK 3804648T3 DK 20212126 T DK20212126 T DK 20212126T DK 3804648 T3 DK3804648 T3 DK 3804648T3
Authority
DK
Denmark
Prior art keywords
permeability
blood
fields
electric
increase
Prior art date
Application number
DK20212126.5T
Other languages
Danish (da)
English (en)
Inventor
Carsten Hagemann
Mario Lohr
Almuth F Kessler
Malgorzata Burek
Carola Forster
Catherine BRAMI
Hadas Sara Hershkovich
Tali VOLOSHIN-SELA
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Application granted granted Critical
Publication of DK3804648T3 publication Critical patent/DK3804648T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Developmental Disabilities (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Social Psychology (AREA)
DK20212126.5T 2018-08-23 2019-08-22 Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren DK3804648T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862722100P 2018-08-23 2018-08-23
EP19780002.2A EP3773291B1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Publications (1)

Publication Number Publication Date
DK3804648T3 true DK3804648T3 (da) 2022-04-11

Family

ID=68104708

Family Applications (4)

Application Number Title Priority Date Filing Date
DK20212126.5T DK3804648T3 (da) 2018-08-23 2019-08-22 Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren
DK21170656.9T DK3878389T3 (da) 2018-08-23 2019-08-22 Anvendelse af vekslende elektriske felter til at øge permeabiliteten af blod-hjerne-barrieren
DK19780002.2T DK3773291T3 (da) 2018-08-23 2019-08-22 Anvendelse af alternerende elektriske felter til at forøge permeabilitet af blodhjernebarrieren
DK21170598.3T DK3892219T3 (da) 2018-08-23 2019-08-22 Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK21170656.9T DK3878389T3 (da) 2018-08-23 2019-08-22 Anvendelse af vekslende elektriske felter til at øge permeabiliteten af blod-hjerne-barrieren
DK19780002.2T DK3773291T3 (da) 2018-08-23 2019-08-22 Anvendelse af alternerende elektriske felter til at forøge permeabilitet af blodhjernebarrieren
DK21170598.3T DK3892219T3 (da) 2018-08-23 2019-08-22 Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren

Country Status (17)

Country Link
US (5) US11400269B2 (enExample)
EP (6) EP3804648B1 (enExample)
JP (4) JP6974671B2 (enExample)
KR (3) KR102805022B1 (enExample)
CN (6) CN113908432A (enExample)
AU (2) AU2019324585C1 (enExample)
BR (1) BR112020025422A2 (enExample)
CA (2) CA3242209A1 (enExample)
DK (4) DK3804648T3 (enExample)
ES (4) ES2898090T3 (enExample)
FI (1) FI3878389T3 (enExample)
HU (3) HUE058160T2 (enExample)
IL (2) IL279466B2 (enExample)
MX (5) MX2020013519A (enExample)
PL (3) PL3773291T3 (enExample)
SG (1) SG11202012592WA (enExample)
WO (1) WO2020039390A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
EP4454697A3 (en) 2016-06-30 2024-12-25 Novocure GmbH Arrays for longitudinal delivery of ttfields to a body
EP3571503A1 (en) 2017-01-19 2019-11-27 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
CN114082099A (zh) * 2018-07-03 2022-02-25 埃德温·阊 使用交变电场提高细胞膜通透性
US11583675B2 (en) 2018-07-10 2023-02-21 Novocure Gmbh Inhibiting viral infection using alternating electric fields
CA3242209A1 (en) * 2018-08-23 2020-02-27 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
US11020585B2 (en) 2018-09-07 2021-06-01 Novocure Gmbh Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
CN118925056A (zh) 2018-10-15 2024-11-12 诺沃库勒有限责任公司 生成遍及大脑具有高均匀性的肿瘤治疗场（ttfields）
CN112955208B (zh) 2018-10-25 2024-11-22 诺沃库勒有限责任公司 向受试者的脊柱解剖结构递送交变电场(例如，ttfields)的方法
IL280843B2 (en) 2018-11-19 2025-10-01 Novocure Gmbh Arrays for providing fields treat growth with selectively addressable sub-elements
CN118079235A (zh) 2018-11-29 2024-05-28 诺沃库勒有限责任公司 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列
JP7246486B2 (ja) 2019-01-08 2023-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価
EP3974022B1 (en) 2019-02-26 2024-04-17 Novocure GmbH Determining a frequency for ttfields treatment based on a physical parameter of targeted cancer cells
US11471676B2 (en) 2019-02-27 2022-10-18 Novocure Gmbh Delivering tumor treating fields (TTFields) using implantable transducer arrays
DK3946322T3 (da) 2019-03-29 2023-11-27 Novocure Gmbh Fremgangsmåder til genoprettelse af sensitivitet over for ttfields i ttfields-resistente kræftceller med ptger3-inhibitorer
HUE061231T2 (hu) 2019-04-17 2023-05-28 Novocure Gmbh Adatok feltöltése egy szigetelt rendszerbõl a szigetelés veszélyeztetése nélkül
US11654279B2 (en) 2019-07-31 2023-05-23 Novocure Gmbh Applying tumor treating fields (TTFields) via electrodes embedded into skull implants
US12343336B2 (en) 2019-08-05 2025-07-01 Novocure Gmbh Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity
JP2022545794A (ja) 2019-08-30 2022-10-31 ノボキュア ゲーエムベーハー 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加
KR102873347B1 (ko) 2019-09-10 2025-10-17 노보큐어 게엠베하 암 세포에 교번 전기장을 적용하고 체크포인트 억제제를 투여하여 암 세포의 활력성을 감소시키는 방법
CA3163316A1 (en) 2019-12-31 2021-07-08 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors
EP4054705B1 (en) 2019-12-31 2024-10-23 Novocure GmbH High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels
US12121739B2 (en) 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
US20210299440A1 (en) 2020-03-30 2021-09-30 Novocure Gmbh Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases
EP4138988A1 (en) * 2020-04-24 2023-03-01 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
US12114991B2 (en) 2020-09-25 2024-10-15 Novocure Gmbh Varying the metallization area on individual electrode elements in a tumor treating fields (TTFields) system to maximize current without overheating
IL303022A (en) 2020-11-25 2023-07-01 Novocure Gmbh Improving the efficiency of crop treatment fields by applying the crop treatment fields at peak power in less than half the time
WO2022130183A2 (en) * 2020-12-17 2022-06-23 Novocure Gmbh Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields)
CN113008403B (zh) * 2021-02-08 2022-08-12 清华大学 电场发生装置及测温电极装置
EP4240470A1 (en) 2021-02-17 2023-09-13 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas
US12440680B2 (en) 2021-03-12 2025-10-14 Novocure Gmbh Methods of treating disease by skewing macrophage phenotype with alternating electric fields
US12201831B2 (en) 2021-03-31 2025-01-21 Novocure Gmbh Impedance tomography using electrodes of a tumor treating fields (TTFields) system
CN117120140A (zh) * 2021-04-08 2023-11-24 诺沃库勒有限责任公司 用交变电场治疗神经退行性病症的方法
CN113509641A (zh) * 2021-06-29 2021-10-19 北京康源嘉成生物科技有限公司 一种非药物且非侵入性开放血脑屏障的装置和方法
US20230009366A1 (en) * 2021-06-30 2023-01-12 Novocure Gmbh Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits
CN114099963B (zh) * 2021-12-22 2025-10-03 江苏海莱新创医疗科技有限公司 肿瘤电场治疗系统
US20230098801A1 (en) * 2021-09-30 2023-03-30 Novocure Gmbh Reducing Electrosensation Whilst Treating A Subject Using Alternating Electric Fields
TW202333820A (zh) 2021-12-29 2023-09-01 瑞士商諾沃庫勒有限責任公司 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺
EP4456971A1 (en) 2021-12-30 2024-11-06 Novocure GmbH Selecting values of parameters for treatment using tumor treating fields (ttfields)
CN114367060A (zh) * 2022-01-13 2022-04-19 深圳大学 激光交变电场联合治疗仪
MX2024010256A (es) 2022-03-30 2024-08-28 Novocure Gmbh Reducción de la electrosensación durante el tratamiento de un sujeto mediante campos eléctricos alternos mediante el emparejamiento de matrices de transductores.
JP2025511071A (ja) 2022-03-30 2025-04-15 ノボキュア ゲーエムベーハー インターリーブ冷却期間による腫瘍治療場のピーク強度強化
WO2023242741A1 (en) 2022-06-13 2023-12-21 Novocure Gmbh Systems and methods for increasing intestinal absorption of therapeutic agents
JP2025522725A (ja) 2022-06-27 2025-07-17 ノボキュア ゲーエムベーハー 閉ループ技術を用いた、被験者を交流電場で治療すると同時の電気感覚の軽減
WO2024003791A1 (en) 2022-06-30 2024-01-04 Novocure Gmbh Electrode assembly for applying tumor treating fields (ttfields) that includes a plurality of thermally linked but electrically isolated graphite sheets
KR102637878B1 (ko) * 2022-09-02 2024-02-19 주식회사 뉴로스피어 대뇌병변 산화철의 전자-펜톤효과를 이용한 전기장 대뇌자극치료기기
US20240108892A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Changing the Orientation of Tumor Treating Fields (TTFields) by Adjusting the Amplitudes of Two or More Electric Fields that Are All In-Phase with Each Other
US20240108699A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for reducing electrosensation and/or skin irritation
WO2024069504A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Reducing electrosensation while treating a subject using alternating electric fields by controlling ramp-up characteristics
CN119947783A (zh) 2022-09-30 2025-05-06 诺沃库勒有限责任公司 通过去激活所选电极元件在使用交变电场治疗受试者时减小电感应
US20240207604A1 (en) 2022-12-27 2024-06-27 Novocure Gmbh Multi Channel Device for Directional Shaping of Electric Fields e.g., Tumor Treating Fields (TTFields)
US20240216679A1 (en) 2022-12-28 2024-07-04 Novocure Gmbh Positioning Electrode Elements on a Subject's Body to Provide Stronger Alternating Electric Fields (e.g.,TTFields) Without Overheating
TW202428320A (zh) 2022-12-29 2024-07-16 瑞士商諾沃庫勒有限責任公司 透過增加波形的斜坡上升部分的步階數量減少使用交流電場治療受試者時的電感覺
TW202434331A (zh) 2022-12-29 2024-09-01 瑞士商諾沃庫勒有限責任公司 透過確保在交流波形的相反相位期間發生振幅連續增加來減少施加交變電場期間的電感應
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
US20240269464A1 (en) 2023-02-10 2024-08-15 Novocure Gmbh Sequentially Positioning Sets of Electrode Arrays at Nonoverlapping Positions to Ameliorate Skin Irritation During Tumor Treating Fields (TTFields) Therapy
CN120957783A (zh) 2023-03-31 2025-11-14 诺沃库勒有限责任公司 通过逐渐增大旋转交变电场的幅度来降低在使用该电场治疗受试者时的电感觉
US20240399141A1 (en) 2023-03-31 2024-12-05 Novocure Gmbh Microneedles to overcome contact resistance
WO2025068924A1 (en) 2023-09-29 2025-04-03 Novocure Gmbh Using staggered changes in amplitude and frequency to ameliorate electrosensation during treatment with alternating electric fields
US20250108227A1 (en) 2023-09-29 2025-04-03 Novocure Gmbh Transducer Arrays for Tumor Treating Fields (TTFields) Therapy That Use a Dedicated Flex Circuit to Implement Temperature Sensing
WO2025068955A1 (en) 2023-09-29 2025-04-03 Novocure Gmbh Apparatus for applying an electrical signal using a multi-part electrode assembly
CN120983797A (zh) * 2023-12-26 2025-11-21 江苏海莱新创医疗科技有限公司 电极片及肿瘤电场治疗系统
US20250213849A1 (en) 2023-12-29 2025-07-03 Novocure Gmbh Electrode Assembly for Delivering Alternating Electric Fields (e.g., TTFields) with Peripherally-Positioned Temperature Sensors

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2536459T3 (es) * 1995-08-29 2015-05-25 Nitto Denko Corporation Microporación de piel humana para administración de fármacos y aplicaciones de supervisión
CN1206353A (zh) * 1995-11-21 1999-01-27 E·N·勒纳 提高有机体内生物活性物质和化合物释放的装置
CA2238055A1 (en) * 1995-11-21 1997-05-29 Eduard Lerner Device for enhanced delivery of biologically active substances and compounds in an organism
WO1997018855A1 (en) * 1995-11-21 1997-05-29 Eduard Naumovich Lerner Device for enhanced delivery of biologically active substances and compounds in an organism
US6678553B2 (en) * 1995-11-21 2004-01-13 Intraabrain International Nv Device for enhanced delivery of biologically active substances and compounds in an organism
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7890183B2 (en) 2000-02-17 2011-02-15 Novocure Ltd. Treating parasites with electric fields
US7599746B2 (en) * 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
CN1416466A (zh) 2000-02-17 2003-05-07 约朗姆·帕尔蒂 破坏正在分裂的细胞的方法和装置
US6546290B1 (en) * 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
JP4311904B2 (ja) * 2000-05-08 2009-08-12 ブレインスゲート リミテッド 血液脳関門及び脳血流の性質を改善するための翼口蓋神経節の刺激方法及び装置
US7332313B2 (en) 2001-06-05 2008-02-19 Applied Biophysics, Inc. Electrical wounding assay for cells in vitro
US6904322B2 (en) 2002-02-15 2005-06-07 Kalaco Scientific, Inc. Transcranial electrostimulation apparatus and method
US20030171738A1 (en) 2002-03-06 2003-09-11 Konieczynski David D. Convection-enhanced drug delivery device and method of use
WO2004037341A2 (en) 2002-05-07 2004-05-06 Schroeppel Edward A Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
EP1581186A2 (en) * 2002-12-03 2005-10-05 Blanchette Rockefeller Neurosciences Institute Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
JP4750784B2 (ja) 2004-04-23 2011-08-17 ノヴォキュアー・リミテッド 異なる周波数の電界による腫瘍等の治療
US7715921B2 (en) * 2004-12-07 2010-05-11 Standen Ltd. Electrodes for applying an electric field in-vivo over an extended period of time
CA2594231C (en) 2004-12-27 2016-04-19 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US20100049117A1 (en) 2005-04-18 2010-02-25 Pantec Biosolutions Ag Microporator for Porating a Biological Membrane and Integrated Permeant Administering System
WO2007035721A2 (en) * 2005-09-19 2007-03-29 The Trustees Of Columbia University In The City Of New York Ultrasound method to open blood brain barrier
CA2624624C (en) 2005-10-03 2016-07-19 Novocure Limited Optimizing characteristics of an electric field to increase the field's effect on proliferating cells
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
CN100515522C (zh) * 2006-09-18 2009-07-22 郭国祯 促进药物透过血脑屏障的电磁脉冲辐照系统和方法
CN102008782B (zh) * 2006-11-08 2014-11-26 株式会社P·曼德 神经营养因子产生促进装置
PT2167194T (pt) 2007-03-06 2017-06-15 Novocure Ltd Tratamento do cancro utilizando campos electromagnéticos em combinação com terapia fotodinámica
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
WO2009047365A1 (en) * 2007-10-12 2009-04-16 Capsulution Nanoscience Ag Drug delivery system
DE102008018170B4 (de) 2008-04-03 2010-05-12 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Mikrofluidisches System und Verfahren zum Aufbau und zur anschließenden Kultivierung sowie nachfolgender Untersuchung von komplexen Zellanordnungen
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10245098B2 (en) * 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
CN201205406Y (zh) * 2008-05-06 2009-03-11 迟立广 中频交变电场理疗装置
WO2016164930A1 (en) 2015-04-10 2016-10-13 Angiodynamics Inc. System and method for irreversible electroporation with thermally controlled electrodes
CN101318054B (zh) * 2008-07-18 2012-01-25 圣太科医疗科技（上海）有限公司 微电场网引导的肝脏靶向性细胞内药物传递装置
EP2153866A1 (en) * 2008-08-14 2010-02-17 Oncotherm Kft. Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
CA2771169A1 (en) 2009-08-24 2011-03-03 Ron L. Alterman Apparatus for trans-cerebral electrophoresis and methods of use thereof
CN101698121B (zh) * 2009-10-23 2011-06-22 西安交通大学 促进药物透过血脑屏障的适型超声系统
CN102100945A (zh) * 2009-12-18 2011-06-22 重庆新大地电子有限公司 生物负电子保健治疗仪设备系统
WO2012075337A2 (en) * 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
CN202096600U (zh) * 2011-04-09 2012-01-04 南宁市中新森泰科技有限公司 一种电位治疗仪
CN102284132A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于多针形电极的高压脉冲电场治疗装置
WO2013170379A1 (en) * 2012-05-13 2013-11-21 Corporation De L'ecole Polytechnique De Montreal Drug delivery across the blood-brain barrier using magnetically heatable entities
US20120323214A1 (en) 2012-05-16 2012-12-20 Totada R Shantha Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis
CN102836119A (zh) * 2012-08-21 2012-12-26 中国人民解放军第三军医大学第二附属医院 微泡在制备用于联合诊断级超声作为提高肿瘤微血管通透性药物的用途
ES2898374T3 (es) * 2012-09-06 2022-03-07 Covidien Lp Sistema de tratamiento neurológico
US9020605B2 (en) 2012-10-25 2015-04-28 Oncosec Medical Incorporated Electroporation device
US9682066B2 (en) 2012-12-04 2017-06-20 University Of Cincinnati Methods of treating primary brain tumors by administering letrozole
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
WO2016134367A1 (en) * 2015-02-20 2016-08-25 Rio Grande Neurosciences, Inc. Method and apparatus for electromagnetic treatment of multiple sclerosis
CA2985847C (en) 2015-05-14 2022-11-08 London Health Sciences Centre Research Inc. Intratumoral modulation therapy
CN106333926A (zh) * 2015-07-10 2017-01-18 复旦大学 一种稳定性多肽介导跨屏障膜的脑部肿瘤多重靶向递药系统
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
EP4454697A3 (en) 2016-06-30 2024-12-25 Novocure GmbH Arrays for longitudinal delivery of ttfields to a body
US20180008708A1 (en) * 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
CN109562258B (zh) 2016-08-18 2023-07-18 诺沃库勒有限责任公司 用于递送肿瘤治疗电场的阵列中的温度测量
BR112019012033A2 (pt) 2016-12-13 2020-03-03 Novocure Gmbh Tratamento de pacientes com ttfields com as posições de eletrodo otimizadas com o uso de gabaritos deformáveis
EP3571503A1 (en) 2017-01-19 2019-11-27 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
US11931569B2 (en) 2018-03-12 2024-03-19 Tel Hashomer Medical Research, Infrastructure & Services Ltd. Method for changing blood brain barrier permeability
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
CN112566665A (zh) 2018-04-09 2021-03-26 莫舍·吉拉迪 用TTFields和Aurora激酶抑制剂治疗肿瘤
JP7225373B2 (ja) 2018-04-10 2023-02-20 ゼーヴ・ボンゾン 異なる繰返し時間を有する２つのＭＲＩ画像から導出される低周波数（＜１ＭＨｚ）交流導電率推定
CN114082099A (zh) 2018-07-03 2022-02-25 埃德温·阊 使用交变电场提高细胞膜通透性
US11583675B2 (en) 2018-07-10 2023-02-21 Novocure Gmbh Inhibiting viral infection using alternating electric fields
CA3242209A1 (en) * 2018-08-23 2020-02-27 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier

Also Published As

Publication number Publication date
US20200269037A1 (en) 2020-08-27
HUE058160T2 (hu) 2022-07-28
EP3878389A1 (en) 2021-09-15
CN113908431A (zh) 2022-01-11
JP2025106473A (ja) 2025-07-15
BR112020025422A2 (pt) 2021-03-16
MX2024015909A (es) 2025-02-10
JP6974671B2 (ja) 2021-12-01
JP2021192835A (ja) 2021-12-23
JP7667045B2 (ja) 2025-04-22
JP2021106879A (ja) 2021-07-29
CA3242209A1 (en) 2020-02-27
MX2024015920A (es) 2025-02-10
US10967167B2 (en) 2021-04-06
DK3892219T3 (da) 2022-06-27
MX2024015910A (es) 2025-02-10
PL3773291T3 (pl) 2022-01-31
DK3878389T3 (da) 2025-09-01
JP7667045B6 (ja) 2025-06-05
CN113908430A (zh) 2022-01-11
IL279466A (en) 2021-01-31
MX2020013519A (es) 2021-05-12
CN113908432A (zh) 2022-01-11
AU2022268405A1 (en) 2023-01-05
CN112618956B (zh) 2025-06-27
EP3804648A1 (en) 2021-04-14
ES2911526T3 (es) 2022-05-19
PL3892219T3 (pl) 2022-10-03
EP3773291A1 (en) 2021-02-17
DK3773291T3 (da) 2021-11-15
NZ770867A (en) 2023-11-24
WO2020039390A1 (en) 2020-02-27
ES3043508T3 (en) 2025-11-25
HUE056950T2 (hu) 2022-03-28
US12290654B2 (en) 2025-05-06
CN113908433A (zh) 2022-01-11
JP7233453B2 (ja) 2023-03-06
CN112469352A (zh) 2021-03-09
HUE059062T2 (hu) 2022-10-28
US11351349B2 (en) 2022-06-07
ES2922576T3 (es) 2022-09-16
FI3878389T3 (fi) 2025-09-16
IL279466B2 (en) 2025-09-01
AU2019324585C1 (en) 2023-04-27
IL319986A (en) 2025-06-01
US20220265982A1 (en) 2022-08-25
CN112618956A (zh) 2021-04-09
KR20210071964A (ko) 2021-06-16
IL279466B1 (en) 2025-05-01
EP3878389B1 (en) 2025-08-06
ES2898090T3 (es) 2022-03-03
KR102651496B1 (ko) 2024-03-25
US20200061361A1 (en) 2020-02-27
US20200061360A1 (en) 2020-02-27
EP4609908A3 (en) 2025-10-01
JP2021522957A (ja) 2021-09-02
AU2019324585A1 (en) 2021-01-14
CA3100817A1 (en) 2020-02-27
EP3773291B1 (en) 2021-10-27
EP3892219A1 (en) 2021-10-13
US11400269B2 (en) 2022-08-02
PL3804648T3 (pl) 2022-06-06
CN112469352B (zh) 2021-10-08
KR20250069692A (ko) 2025-05-19
EP3892219B1 (en) 2022-06-01
EP3804648B1 (en) 2022-01-19
US20250381379A1 (en) 2025-12-18
MX2024015911A (es) 2025-02-10
CN113908433B (zh) 2025-12-19
KR102805022B1 (ko) 2025-05-08
EP4609908A2 (en) 2025-09-03
SG11202012592WA (en) 2021-01-28
AU2019324585B2 (en) 2022-12-08
EP3895643C0 (en) 2023-10-11
AU2022268405B2 (en) 2024-08-15
EP3895643A1 (en) 2021-10-20
CA3100817C (en) 2025-04-01
KR20240042240A (ko) 2024-04-01
EP3895643B1 (en) 2023-10-11

Similar Documents

Publication Publication Date Title
DK3804648T3 (da) Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren
DK3900777T3 (da) Anvendelse af vekslende elektriske felter til at øge cellemembranens permeabilitet
FR3004467B1 (fr) Fabrication d'une elpasolite stoechiometrique
EP2970511A4 (en) INSULIN CONJUGATES incretin
EP2843669A4 (en) TRANSDUCER OVERVOLTAGE SAFE INSULATED WIRE
DK2994159T3 (da) Forudsigelse af t-celleepitopers immunogenicitet
DK2981255T3 (da) Terapeutiske anvendelser af empagliflozin
EP2916690A4 (en) ADHESIVE-FREE CONSTRUCTION OF A POCKET SPRING UNIT
PL3058936T3 (pl) Kompozycja peptydów i jej zastosowania
FR3023655B1 (fr) Pole d'appareillage electrique recyclable
DK3434760T3 (da) Fremgangsmåder til forøgelse af mannose-indholdet i rekombinante proteiner
EP3378606A4 (en) AUXILIARY SET
EP3357485A4 (en) SUN PROTECTION COSMETIC
DK3003366T3 (da) På hinanden følgende overlappende peptider til behandling af allergi overfor husstøvmider
EP3347334A4 (en) DEHYDROHALOGENICATION OF FLUOROCHOLE HYDROGEN
EP2876721A4 (en) ELECTRODE ARRANGEMENT
ITUA20162709A1 (it) Regolatore buck sincrono con protezione delle fonti di cortocircuito alla tensione
EP3419846A4 (fr) Assemblage d'accumulateurs électriques
EP3418282A4 (en) TRICYCLIC CONNECTION AS IMMUNOMODULATOR
EP2988738A4 (en) THERAPEUTIC INDICATIONS OF KINASE INHIBITORS
EP3357483A4 (en) SUN PROTECTION COSMETIC
EP3531539A4 (en) resolver stator
EP2976354A4 (en) EIF4E-INTERAGING STACKING PEPTIDES
EP3387469A4 (en) ELEKTROFAZIENBESTIMMUNG
FI20160028A7 (fi) Tolpan perustus