DK3440205T3 - Ikke-invasiv diagnostik ved sekventering af 5-hydroxymethyleret cellefrit dna - Google Patents
Ikke-invasiv diagnostik ved sekventering af 5-hydroxymethyleret cellefrit dna Download PDFInfo
- Publication number
- DK3440205T3 DK3440205T3 DK17779593.7T DK17779593T DK3440205T3 DK 3440205 T3 DK3440205 T3 DK 3440205T3 DK 17779593 T DK17779593 T DK 17779593T DK 3440205 T3 DK3440205 T3 DK 3440205T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxymethyled
- sequence
- cell
- free dna
- invasive diagnostics
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662319702P | 2016-04-07 | 2016-04-07 | |
US201762444122P | 2017-01-09 | 2017-01-09 | |
US201762461712P | 2017-02-21 | 2017-02-21 | |
PCT/US2017/025735 WO2017176630A1 (en) | 2016-04-07 | 2017-04-03 | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3440205T3 true DK3440205T3 (da) | 2021-08-16 |
Family
ID=60000634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17779593.7T DK3440205T3 (da) | 2016-04-07 | 2017-04-03 | Ikke-invasiv diagnostik ved sekventering af 5-hydroxymethyleret cellefrit dna |
Country Status (14)
Country | Link |
---|---|
US (7) | US10718010B2 (da) |
EP (2) | EP3929290A1 (da) |
JP (2) | JP7143221B2 (da) |
CN (1) | CN109312399B (da) |
AU (1) | AU2017246318B2 (da) |
CA (1) | CA3019836A1 (da) |
DK (1) | DK3440205T3 (da) |
ES (1) | ES2882329T3 (da) |
MX (1) | MX2018012156A (da) |
PL (1) | PL3440205T3 (da) |
PT (1) | PT3440205T (da) |
RU (1) | RU2742355C2 (da) |
SG (1) | SG11201808775PA (da) |
WO (1) | WO2017176630A1 (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
ES2669214T3 (es) | 2011-12-13 | 2018-05-24 | Oslo Universitetssykehus Hf | Procedimientos y kits para la detección de estado de metilación |
CN104955960A (zh) | 2012-11-30 | 2015-09-30 | 剑桥表现遗传学有限公司 | 用于修饰的核苷酸的氧化剂 |
US10351898B2 (en) | 2013-05-28 | 2019-07-16 | Ramot At Tel-Aviv University Ltd. | Detection of hydroxymethylcytosine bases |
US11459573B2 (en) | 2015-09-30 | 2022-10-04 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
AU2018355575A1 (en) | 2017-10-27 | 2020-05-21 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
SG11202006511YA (en) | 2018-01-08 | 2020-08-28 | Ludwig Inst For Cancer Res Ltd | Bisulfite-free, base-resolution identification of cytosine modifications |
WO2019160994A1 (en) | 2018-02-14 | 2019-08-22 | Bluestar Genomics, Inc. | Methods for the epigenetic analysis of dna, particularly cell-free dna |
US11767562B2 (en) | 2018-03-08 | 2023-09-26 | St. John's University | Circulating serum cell-free DNA biomarkers and methods |
DE202019005627U1 (de) | 2018-04-02 | 2021-05-31 | Grail, Inc. | Methylierungsmarker und gezielte Methylierungssondenpanels |
AU2019288835A1 (en) * | 2018-06-22 | 2021-01-28 | Clearnote Health, Inc. | Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use |
WO2020061380A1 (en) | 2018-09-19 | 2020-03-26 | Bluestar Genomics, Inc. | Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions |
CN113286881A (zh) | 2018-09-27 | 2021-08-20 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
CA3114606A1 (en) | 2018-10-04 | 2020-04-09 | Bluestar Genomics, Inc. | Simultaneous, sequencing-based analysis of proteins, nucleosomes, and cell-free nucleic acids from a single biological sample |
EP3868385A4 (en) * | 2018-10-19 | 2021-12-22 | Korea Research Institute of Bioscience and Biotechnology | GASTRIC CANCER TREATMENT COMPOSITION INCLUDING A SYT11 INHIBITOR AS AN ACTIVE INGREDIENT |
CN109321647A (zh) * | 2018-10-26 | 2019-02-12 | 苏州森苗生物科技有限公司 | 标记组合物及羟甲基化核酸文库的构建方法 |
WO2020194057A1 (en) * | 2019-03-22 | 2020-10-01 | Cambridge Epigenetix Limited | Biomarkers for disease detection |
JP2022525953A (ja) * | 2019-03-27 | 2022-05-20 | ジュノ ダイアグノスティックス,インク. | 最適化された超微量リキッドバイオプシーの方法、システム、およびデバイス |
EP3990548A4 (en) * | 2019-06-25 | 2023-07-26 | AccuraGen Holdings Limited | DISEASE DETECTION METHODS AND SYSTEMS |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
EP4127223A1 (en) * | 2020-03-30 | 2023-02-08 | Vilnius University | Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites |
EP4034676A1 (en) | 2020-07-30 | 2022-08-03 | Cambridge Epigenetix Limited | Compositions and methods for nucleic acid analysis |
US20230357852A1 (en) | 2020-08-19 | 2023-11-09 | Mayo Foundation For Medical Education And Research | Detecting non-hodgkin lymphoma |
EP4284951A1 (en) | 2021-01-29 | 2023-12-06 | Mayo Foundation for Medical Education and Research | Detecting the presence or absence of multiple types of cancer |
CN113528616A (zh) * | 2021-07-26 | 2021-10-22 | 深圳泰莱生物科技有限公司 | 一种捕获cfDNA5hmC片段的检测方法 |
CN115992203A (zh) * | 2022-07-26 | 2023-04-21 | 生工生物工程(上海)股份有限公司 | 一种全基因组羟甲基化捕获测序的文库构建方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5712126A (en) | 1995-08-01 | 1998-01-27 | Yale University | Analysis of gene expression by display of 3-end restriction fragments of CDNA |
US5948902A (en) | 1997-11-20 | 1999-09-07 | South Alabama Medical Science Foundation | Antisense oligonucleotides to human serine/threonine protein phosphatase genes |
US6287825B1 (en) | 1998-09-18 | 2001-09-11 | Molecular Staging Inc. | Methods for reducing the complexity of DNA sequences |
US20050233340A1 (en) | 2004-04-20 | 2005-10-20 | Barrett Michael T | Methods and compositions for assessing CpG methylation |
US20100273151A1 (en) * | 2004-05-28 | 2010-10-28 | Fred Hutchinson Cancer Research Center | Genome-wide analysis of palindrome formation and dna methylation |
WO2006133420A2 (en) * | 2005-06-08 | 2006-12-14 | Millennium Pharmaceuticals, Inc. | Treatment of patients with cancer therapy |
WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
CA2689356A1 (en) | 2007-06-01 | 2008-12-11 | 454 Life Sciences Corporation | System and meth0d for identification of individual samples from a multiplex mixture |
WO2009032167A1 (en) | 2007-08-29 | 2009-03-12 | Illumina Cambridge | Method for sequencing a polynucleotide template |
WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
WO2010048337A2 (en) * | 2008-10-22 | 2010-04-29 | Illumina, Inc. | Preservation of information related to genomic dna methylation |
US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
WO2010114599A1 (en) * | 2009-04-01 | 2010-10-07 | Dx Terity Diagnostics Inc. | Chemical ligation dependent probe amplification (clpa) |
WO2011025819A1 (en) * | 2009-08-25 | 2011-03-03 | New England Biolabs, Inc. | Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
GB2489187B (en) * | 2010-01-20 | 2015-02-11 | New England Biolabs Inc | Compositions, methods and related uses for cleaving modified DNA |
WO2011127136A1 (en) | 2010-04-06 | 2011-10-13 | University Of Chicago | Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc) |
US20120034603A1 (en) * | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
CN110878345A (zh) | 2010-09-21 | 2020-03-13 | 安捷伦科技有限公司 | 通过分子计数提高等位基因调用的置信度 |
US20120122087A1 (en) * | 2010-11-17 | 2012-05-17 | Weiwei Li | 5-Hydroxymethylcytosine as a biomarker for early detection, treatment and prognostic monitoring of cancer |
EP2694686B2 (en) * | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
US9476095B2 (en) | 2011-04-15 | 2016-10-25 | The Johns Hopkins University | Safe sequencing system |
LT3363901T (lt) | 2012-02-17 | 2021-04-12 | Fred Hutchinson Cancer Research Center | Kompozicijos ir būdai, skirti tiksliam mutacijų nustatymui |
ES2828661T3 (es) | 2012-03-20 | 2021-05-27 | Univ Washington Through Its Center For Commercialization | Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria |
US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
EP2922989B1 (en) * | 2012-11-26 | 2018-04-04 | The University of Toledo | Methods for standardized sequencing of nucleic acids and uses thereof |
EP3597774A1 (en) * | 2013-03-13 | 2020-01-22 | Sequenom, Inc. | Primers for dna methylation analysis |
US20160194696A1 (en) * | 2013-08-09 | 2016-07-07 | New England Biolabs, Inc. | Detecting, Sequencing and/or Mapping 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution |
US20150050697A1 (en) * | 2013-08-19 | 2015-02-19 | Abbott Molecular Inc. | Nucleotide analogs |
WO2015104302A1 (en) * | 2014-01-07 | 2015-07-16 | Fundació Privada Institut De Medicina Predictiva I Personalitzada Del Càncer | Method for generating double stranded dna libraries and sequencing methods for the identification of methylated cytosines |
CA2938451C (en) * | 2014-01-30 | 2023-10-17 | The Regents Of The University Of California | Methylation haplotyping for non-invasive diagnosis (monod) |
GB201405226D0 (en) * | 2014-03-24 | 2014-05-07 | Cambridge Entpr Ltd | Nucleic acid preparation method |
CA2950295C (en) * | 2014-06-06 | 2023-10-17 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
SG11201707650SA (en) * | 2015-03-24 | 2017-10-30 | Agency For Science Tech And Res (A*Star) | Normalization methods for measuring gene copy number and expression |
US11162139B2 (en) | 2016-03-02 | 2021-11-02 | Shanghai Epican Genetech Co. Ltd. | Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine |
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2017
- 2017-04-03 JP JP2018553116A patent/JP7143221B2/ja active Active
- 2017-04-03 RU RU2018138848A patent/RU2742355C2/ru active
- 2017-04-03 PL PL17779593T patent/PL3440205T3/pl unknown
- 2017-04-03 EP EP21167021.1A patent/EP3929290A1/en active Pending
- 2017-04-03 MX MX2018012156A patent/MX2018012156A/es unknown
- 2017-04-03 SG SG11201808775PA patent/SG11201808775PA/en unknown
- 2017-04-03 ES ES17779593T patent/ES2882329T3/es active Active
- 2017-04-03 CA CA3019836A patent/CA3019836A1/en active Pending
- 2017-04-03 PT PT177795937T patent/PT3440205T/pt unknown
- 2017-04-03 AU AU2017246318A patent/AU2017246318B2/en active Active
- 2017-04-03 CN CN201780031390.0A patent/CN109312399B/zh active Active
- 2017-04-03 DK DK17779593.7T patent/DK3440205T3/da active
- 2017-04-03 EP EP17779593.7A patent/EP3440205B1/en active Active
- 2017-04-03 WO PCT/US2017/025735 patent/WO2017176630A1/en active Application Filing
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2018
- 2018-09-28 US US16/146,807 patent/US10718010B2/en active Active
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2020
- 2020-04-14 US US16/848,498 patent/US20200248248A1/en not_active Abandoned
- 2020-04-14 US US16/848,515 patent/US20200248249A1/en not_active Abandoned
- 2020-04-14 US US16/848,482 patent/US20200283838A1/en active Pending
- 2020-04-15 US US16/849,071 patent/US20200299760A1/en not_active Abandoned
- 2020-04-15 US US16/848,989 patent/US20200277666A1/en active Pending
- 2020-04-15 US US16/849,067 patent/US20200277667A1/en not_active Abandoned
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2022
- 2022-06-07 JP JP2022092184A patent/JP2022120007A/ja active Pending
Also Published As
Publication number | Publication date |
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WO2017176630A1 (en) | 2017-10-12 |
US20190017109A1 (en) | 2019-01-17 |
JP2022120007A (ja) | 2022-08-17 |
AU2017246318A2 (en) | 2018-11-08 |
US20200299760A1 (en) | 2020-09-24 |
US20200248249A1 (en) | 2020-08-06 |
SG11201808775PA (en) | 2018-11-29 |
AU2017246318B2 (en) | 2023-07-27 |
MX2018012156A (es) | 2019-02-07 |
US20200283838A1 (en) | 2020-09-10 |
AU2017246318A1 (en) | 2018-11-08 |
RU2018138848A (ru) | 2020-05-12 |
PL3440205T3 (pl) | 2021-11-22 |
EP3440205B1 (en) | 2021-05-26 |
US10718010B2 (en) | 2020-07-21 |
US20200248248A1 (en) | 2020-08-06 |
CN109312399B (zh) | 2023-02-03 |
EP3440205A4 (en) | 2019-04-03 |
US20200277667A1 (en) | 2020-09-03 |
EP3440205A1 (en) | 2019-02-13 |
RU2742355C2 (ru) | 2021-02-05 |
EP3929290A1 (en) | 2021-12-29 |
CA3019836A1 (en) | 2017-10-12 |
JP2019520791A (ja) | 2019-07-25 |
PT3440205T (pt) | 2021-08-06 |
CN109312399A (zh) | 2019-02-05 |
JP7143221B2 (ja) | 2022-09-28 |
RU2018138848A3 (da) | 2020-12-15 |
US20200277666A1 (en) | 2020-09-03 |
ES2882329T3 (es) | 2021-12-01 |
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