DK3440205T3 - Ikke-invasiv diagnostik ved sekventering af 5-hydroxymethyleret cellefrit dna - Google Patents
Ikke-invasiv diagnostik ved sekventering af 5-hydroxymethyleret cellefrit dna Download PDFInfo
- Publication number
- DK3440205T3 DK3440205T3 DK17779593.7T DK17779593T DK3440205T3 DK 3440205 T3 DK3440205 T3 DK 3440205T3 DK 17779593 T DK17779593 T DK 17779593T DK 3440205 T3 DK3440205 T3 DK 3440205T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxymethyled
- sequence
- cell
- free dna
- invasive diagnostics
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319702P | 2016-04-07 | 2016-04-07 | |
| US201762444122P | 2017-01-09 | 2017-01-09 | |
| US201762461712P | 2017-02-21 | 2017-02-21 | |
| PCT/US2017/025735 WO2017176630A1 (en) | 2016-04-07 | 2017-04-03 | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3440205T3 true DK3440205T3 (da) | 2021-08-16 |
Family
ID=60000634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17779593.7T DK3440205T3 (da) | 2016-04-07 | 2017-04-03 | Ikke-invasiv diagnostik ved sekventering af 5-hydroxymethyleret cellefrit dna |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US10718010B2 (da) |
| EP (2) | EP3929290A1 (da) |
| JP (2) | JP7143221B2 (da) |
| CN (1) | CN109312399B (da) |
| AU (1) | AU2017246318B2 (da) |
| CA (1) | CA3019836A1 (da) |
| DK (1) | DK3440205T3 (da) |
| ES (1) | ES2882329T3 (da) |
| MX (1) | MX2018012156A (da) |
| PL (1) | PL3440205T3 (da) |
| PT (1) | PT3440205T (da) |
| RU (1) | RU2742355C2 (da) |
| SG (1) | SG11201808775PA (da) |
| WO (1) | WO2017176630A1 (da) |
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| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| ES2669214T3 (es) | 2011-12-13 | 2018-05-24 | Oslo Universitetssykehus Hf | Procedimientos y kits para la detección de estado de metilación |
| EP2925883B1 (en) | 2012-11-30 | 2018-03-28 | Cambridge Epigenetix Limited | Oxidising agent for modified nucleotides |
| CA2912666A1 (en) | 2013-05-28 | 2014-12-04 | Ramot At Tel-Aviv University Ltd. | Detection of hydroxymethylcytosine bases |
| US11459573B2 (en) | 2015-09-30 | 2022-10-04 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
| US20200299677A1 (en) | 2017-10-27 | 2020-09-24 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
| WO2019136413A1 (en) | 2018-01-08 | 2019-07-11 | Ludwig Institute For Cancer Research Ltd | Bisulfite-free, base-resolution identification of cytosine modifications |
| US11634748B2 (en) | 2018-02-14 | 2023-04-25 | Clearnote Health, Inc. | Methods for the epigenetic analysis of DNA, particularly cell-free DNA |
| JP2021514663A (ja) * | 2018-03-08 | 2021-06-17 | セント・ジョーンズ・ユニバーシティＳｔ． Ｊｏｈｎｓ Ｕｎｉｖｅｒｓｉｔｙ | 循環性血清無細胞ｄｎａバイオマーカー及び方法 |
| AU2019288835A1 (en) * | 2018-06-22 | 2021-01-28 | Clearnote Health, Inc. | Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use |
| SG11202102421PA (en) | 2018-09-19 | 2021-04-29 | Bluestar Genomics Inc | Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions |
| AU2019351130A1 (en) | 2018-09-27 | 2021-04-08 | Grail, Llc | Methylation markers and targeted methylation probe panel |
| SG11202102954QA (en) | 2018-10-04 | 2021-04-29 | Bluestar Genomics Inc | Simultaneous, sequencing-based analysis of proteins, nucleosomes, and cell-free nucleic acids from a single biological sample |
| CN112867495A (zh) * | 2018-10-19 | 2021-05-28 | 韩国生命工学研究院 | 包含syt11抑制剂作为活性成分的胃癌治疗组合物 |
| CN109321647A (zh) * | 2018-10-26 | 2019-02-12 | 苏州森苗生物科技有限公司 | 标记组合物及羟甲基化核酸文库的构建方法 |
| WO2020194057A1 (en) * | 2019-03-22 | 2020-10-01 | Cambridge Epigenetix Limited | Biomarkers for disease detection |
| CA3134941A1 (en) * | 2019-03-27 | 2020-10-01 | Juno Diagnostics, Inc. | Optimized ultra-low volume liquid biopsy methods, systems, and devices |
| EP3990548A4 (en) * | 2019-06-25 | 2023-07-26 | AccuraGen Holdings Limited | DISEASE DETECTION METHODS AND SYSTEMS |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| EP4127223A1 (en) * | 2020-03-30 | 2023-02-08 | Vilnius University | Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites |
| JP2023535636A (ja) | 2020-07-30 | 2023-08-18 | ケンブリッジ エピジェネティックス リミテッド | 核酸解析のための組成物および方法 |
| WO2022040306A1 (en) | 2020-08-19 | 2022-02-24 | Mayo Foundation For Medical Education And Research | Detecting non-hodgkin lymphoma |
| WO2022165247A1 (en) | 2021-01-29 | 2022-08-04 | Mayo Foundation For Medical Education And Research | Detecting the presence or absence of multiple types of cancer |
| CN113528616A (zh) * | 2021-07-26 | 2021-10-22 | 深圳泰莱生物科技有限公司 | 一种捕获cfDNA5hmC片段的检测方法 |
| CN115992203A (zh) * | 2022-07-26 | 2023-04-21 | 生工生物工程（上海）股份有限公司 | 一种全基因组羟甲基化捕获测序的文库构建方法 |
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| US5712126A (en) | 1995-08-01 | 1998-01-27 | Yale University | Analysis of gene expression by display of 3-end restriction fragments of CDNA |
| US5948902A (en) | 1997-11-20 | 1999-09-07 | South Alabama Medical Science Foundation | Antisense oligonucleotides to human serine/threonine protein phosphatase genes |
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| US20050233340A1 (en) | 2004-04-20 | 2005-10-20 | Barrett Michael T | Methods and compositions for assessing CpG methylation |
| US20100273151A1 (en) * | 2004-05-28 | 2010-10-28 | Fred Hutchinson Cancer Research Center | Genome-wide analysis of palindrome formation and dna methylation |
| WO2006133420A2 (en) * | 2005-06-08 | 2006-12-14 | Millennium Pharmaceuticals, Inc. | Treatment of patients with cancer therapy |
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| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| WO2010048337A2 (en) * | 2008-10-22 | 2010-04-29 | Illumina, Inc. | Preservation of information related to genomic dna methylation |
| US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
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| GB2489187B (en) * | 2010-01-20 | 2015-02-11 | New England Biolabs Inc | Compositions, methods and related uses for cleaving modified DNA |
| WO2011127136A1 (en) | 2010-04-06 | 2011-10-13 | University Of Chicago | Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc) |
| US20120034603A1 (en) * | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| DK2623613T3 (da) | 2010-09-21 | 2016-10-03 | Population Genetics Tech Ltd | Forøgelse af pålideligheden af allel-angivelser ved hjælp af molekylær tælling |
| US20120122087A1 (en) | 2010-11-17 | 2012-05-17 | Weiwei Li | 5-Hydroxymethylcytosine as a biomarker for early detection, treatment and prognostic monitoring of cancer |
| WO2012138973A2 (en) | 2011-04-06 | 2012-10-11 | The University Of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| EP3246416A1 (en) | 2011-04-15 | 2017-11-22 | The Johns Hopkins University | Safe sequencing system |
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| ES2828661T3 (es) | 2012-03-20 | 2021-05-27 | Univ Washington Through Its Center For Commercialization | Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| JP6009096B2 (ja) * | 2012-11-26 | 2016-10-19 | ザ・ユニバーシティ・オブ・トレド | 核酸の標準化された配列決定のための方法およびその使用 |
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| US20160340740A1 (en) * | 2014-01-30 | 2016-11-24 | The Regents Of The University Of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| GB201405226D0 (en) * | 2014-03-24 | 2014-05-07 | Cambridge Entpr Ltd | Nucleic acid preparation method |
| EP3152331B1 (en) * | 2014-06-06 | 2019-08-07 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| SG11201707650SA (en) * | 2015-03-24 | 2017-10-30 | Agency For Science Tech And Res (A*Star) | Normalization methods for measuring gene copy number and expression |
| US11162139B2 (en) | 2016-03-02 | 2021-11-02 | Shanghai Epican Genetech Co. Ltd. | Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine |
-
2017
- 2017-04-03 PL PL17779593T patent/PL3440205T3/pl unknown
- 2017-04-03 JP JP2018553116A patent/JP7143221B2/ja active Active
- 2017-04-03 RU RU2018138848A patent/RU2742355C2/ru active
- 2017-04-03 CA CA3019836A patent/CA3019836A1/en active Pending
- 2017-04-03 MX MX2018012156A patent/MX2018012156A/es unknown
- 2017-04-03 CN CN201780031390.0A patent/CN109312399B/zh active Active
- 2017-04-03 EP EP21167021.1A patent/EP3929290A1/en active Pending
- 2017-04-03 AU AU2017246318A patent/AU2017246318B2/en active Active
- 2017-04-03 SG SG11201808775PA patent/SG11201808775PA/en unknown
- 2017-04-03 WO PCT/US2017/025735 patent/WO2017176630A1/en active Application Filing
- 2017-04-03 EP EP17779593.7A patent/EP3440205B1/en active Active
- 2017-04-03 DK DK17779593.7T patent/DK3440205T3/da active
- 2017-04-03 PT PT177795937T patent/PT3440205T/pt unknown
- 2017-04-03 ES ES17779593T patent/ES2882329T3/es active Active
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2018
- 2018-09-28 US US16/146,807 patent/US10718010B2/en active Active
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2020
- 2020-04-14 US US16/848,482 patent/US20200283838A1/en active Pending
- 2020-04-14 US US16/848,498 patent/US20200248248A1/en not_active Abandoned
- 2020-04-14 US US16/848,515 patent/US20200248249A1/en not_active Abandoned
- 2020-04-15 US US16/849,067 patent/US20200277667A1/en not_active Abandoned
- 2020-04-15 US US16/848,989 patent/US20200277666A1/en active Pending
- 2020-04-15 US US16/849,071 patent/US20200299760A1/en not_active Abandoned
-
2022
- 2022-06-07 JP JP2022092184A patent/JP2022120007A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200299760A1 (en) | 2020-09-24 |
| CA3019836A1 (en) | 2017-10-12 |
| CN109312399B (zh) | 2023-02-03 |
| PT3440205T (pt) | 2021-08-06 |
| EP3929290A1 (en) | 2021-12-29 |
| ES2882329T3 (es) | 2021-12-01 |
| JP2022120007A (ja) | 2022-08-17 |
| AU2017246318B2 (en) | 2023-07-27 |
| US20200248249A1 (en) | 2020-08-06 |
| AU2017246318A1 (en) | 2018-11-08 |
| JP2019520791A (ja) | 2019-07-25 |
| EP3440205A1 (en) | 2019-02-13 |
| US20200277667A1 (en) | 2020-09-03 |
| EP3440205A4 (en) | 2019-04-03 |
| MX2018012156A (es) | 2019-02-07 |
| SG11201808775PA (en) | 2018-11-29 |
| US10718010B2 (en) | 2020-07-21 |
| AU2017246318A2 (en) | 2018-11-08 |
| US20200277666A1 (en) | 2020-09-03 |
| RU2018138848A3 (da) | 2020-12-15 |
| WO2017176630A1 (en) | 2017-10-12 |
| RU2742355C2 (ru) | 2021-02-05 |
| JP7143221B2 (ja) | 2022-09-28 |
| US20200248248A1 (en) | 2020-08-06 |
| US20190017109A1 (en) | 2019-01-17 |
| CN109312399A (zh) | 2019-02-05 |
| PL3440205T3 (pl) | 2021-11-22 |
| EP3440205B1 (en) | 2021-05-26 |
| RU2018138848A (ru) | 2020-05-12 |
| US20200283838A1 (en) | 2020-09-10 |
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