PL3440205T3 - Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowego - Google Patents
Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowegoInfo
- Publication number
- PL3440205T3 PL3440205T3 PL17779593T PL17779593T PL3440205T3 PL 3440205 T3 PL3440205 T3 PL 3440205T3 PL 17779593 T PL17779593 T PL 17779593T PL 17779593 T PL17779593 T PL 17779593T PL 3440205 T3 PL3440205 T3 PL 3440205T3
- Authority
- PL
- Poland
- Prior art keywords
- sequencing
- free dna
- hydroxymethylated
- cell
- noninvasive diagnostics
- Prior art date
Links
- 238000012163 sequencing technique Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319702P | 2016-04-07 | 2016-04-07 | |
| US201762444122P | 2017-01-09 | 2017-01-09 | |
| US201762461712P | 2017-02-21 | 2017-02-21 | |
| PCT/US2017/025735 WO2017176630A1 (en) | 2016-04-07 | 2017-04-03 | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
| EP17779593.7A EP3440205B1 (en) | 2016-04-07 | 2017-04-03 | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3440205T3 true PL3440205T3 (pl) | 2021-11-22 |
Family
ID=60000634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17779593T PL3440205T3 (pl) | 2016-04-07 | 2017-04-03 | Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowego |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US10718010B2 (pl) |
| EP (2) | EP3440205B1 (pl) |
| JP (2) | JP7143221B2 (pl) |
| CN (1) | CN109312399B (pl) |
| AU (1) | AU2017246318B2 (pl) |
| DK (1) | DK3440205T3 (pl) |
| ES (1) | ES2882329T3 (pl) |
| MX (1) | MX391039B (pl) |
| PL (1) | PL3440205T3 (pl) |
| PT (1) | PT3440205T (pl) |
| RU (1) | RU2742355C2 (pl) |
| SG (1) | SG11201808775PA (pl) |
| WO (1) | WO2017176630A1 (pl) |
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| ES2786984T3 (es) | 2012-11-30 | 2020-10-14 | Cambridge Epigenetix Ltd | Agente oxidante para nucleótidos modificados |
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| KR20250172724A (ko) | 2015-08-31 | 2025-12-09 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 위 신생물 검출 방법 |
| WO2017059245A2 (en) | 2015-09-30 | 2017-04-06 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
| US20170298422A1 (en) | 2016-04-18 | 2017-10-19 | The Board Of Trustees Of The Leland Stanford Junior University | Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation |
| JP2021500883A (ja) | 2017-10-27 | 2021-01-14 | ジュノ ダイアグノスティックス，インク． | 超微量リキッドバイオプシーのためのデバイス、システム、および方法 |
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| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CA2892617C (en) * | 2012-11-26 | 2017-01-24 | The University Of Toledo | Methods for standardized sequencing of nucleic acids and uses thereof |
| WO2014168711A1 (en) * | 2013-03-13 | 2014-10-16 | Sequenom, Inc. | Primers for dna methylation analysis |
| WO2015021282A1 (en) * | 2013-08-09 | 2015-02-12 | New England Biolabs, Inc. | Detecting, sequencing and/or mapping 5-hydroxymethylcytosine and 5-formylcytosine at single-base resolution |
| ES2805004T3 (es) * | 2013-08-19 | 2021-02-10 | Abbott Molecular Inc | Análogos de nucleótidos |
| AU2015205612B2 (en) * | 2014-01-07 | 2020-12-03 | Llorenc Coll Mulet | Method for generating double stranded DNA libraries and sequencing methods for the identification of methylated cytosines |
| CA2938451C (en) * | 2014-01-30 | 2023-10-17 | The Regents Of The University Of California | Methylation haplotyping for non-invasive diagnosis (monod) |
| GB201405226D0 (en) * | 2014-03-24 | 2014-05-07 | Cambridge Entpr Ltd | Nucleic acid preparation method |
| EP4170044B1 (en) * | 2014-06-06 | 2026-03-11 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| EP2975116B1 (en) * | 2014-07-16 | 2019-08-21 | Max-Delbrück-Centrum für Molekulare Medizin | Tgif2-induced reprogramming of hepatic cells to pancreatic progenitor cells and medical uses thereof |
| US20180046754A1 (en) * | 2015-03-24 | 2018-02-15 | Agency For Science, Technology And Research (A*Star) | Normalization methods for measuring gene copy number and expression |
| US11162139B2 (en) | 2016-03-02 | 2021-11-02 | Shanghai Epican Genetech Co. Ltd. | Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine |
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2017
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- 2017-04-03 SG SG11201808775PA patent/SG11201808775PA/en unknown
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- 2017-04-03 ES ES17779593T patent/ES2882329T3/es active Active
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2018
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2020
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| CN109312399A (zh) | 2019-02-05 |
| RU2018138848A3 (pl) | 2020-12-15 |
| EP3929290A1 (en) | 2021-12-29 |
| EP3440205A1 (en) | 2019-02-13 |
| WO2017176630A1 (en) | 2017-10-12 |
| PT3440205T (pt) | 2021-08-06 |
| MX2018012156A (es) | 2019-02-07 |
| US20200283838A1 (en) | 2020-09-10 |
| US20200299760A1 (en) | 2020-09-24 |
| AU2017246318B2 (en) | 2023-07-27 |
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| US20200277666A1 (en) | 2020-09-03 |
| JP2019520791A (ja) | 2019-07-25 |
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| AU2017246318A2 (en) | 2018-11-08 |
| JP7143221B2 (ja) | 2022-09-28 |
| SG11201808775PA (en) | 2018-11-29 |
| CA3019836A1 (en) | 2017-10-12 |
| DK3440205T3 (da) | 2021-08-16 |
| EP3440205B1 (en) | 2021-05-26 |
| US10718010B2 (en) | 2020-07-21 |
| RU2742355C2 (ru) | 2021-02-05 |
| AU2017246318A1 (en) | 2018-11-08 |
| RU2018138848A (ru) | 2020-05-12 |
| US20200248249A1 (en) | 2020-08-06 |
| US20190017109A1 (en) | 2019-01-17 |
| JP2022120007A (ja) | 2022-08-17 |
| MX391039B (es) | 2025-03-21 |
| CN109312399B (zh) | 2023-02-03 |
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